58
Views
9
CrossRef citations to date
0
Altmetric
Original Research

Tiotropium inhibits methacholine-induced extracellular matrix production via β-catenin signaling in human airway smooth muscle cells

, , , &
Pages 1469-1481 | Published online: 03 May 2018

References

  • HirotaNMartinJGMechanisms of airway remodelingChest201314431026103224008953
  • MauadTDolhnikoffMPathologic similarities and differences between asthma and chronic obstructive pulmonary diseaseCurr Opin Pulm Med2008141313818043273
  • HoggJCMcDonoughJEGosselinkJVHayashiSWhat drives the peripheral lung–remodeling process in chronic obstructive pulmonary disease?Proc Am Thorac Soc20096866867220008873
  • AnnoniRLançasTYukimatsu TanigawaRExtracellular matrix composition in COPDEur Respir J20124061362137322496324
  • van der GeldYMvan StraatenJFMPostmaDSTimensWLenfantCRole of proteoglycans in development and pathogenesis of emphysemaGargHGRoughleyPJHalesCAProteoglycans in Lung DiseaseNew YorkMarcel Dekker2002241267
  • JonesFSJonesPLThe tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodellingDev Dyn2000218223525910842355
  • GosselinkJVHayashiSElliottWMDifferential expression of tissue repair genes in the pathogenesis of COPDAm J Respir Crit Care Med2010181121329133520075389
  • DesleeGWoodsJCMooreCMElastin expression in very severe human COPDEur Respir J200934232433119357152
  • McDonoughJEYuanRSuzukiMSmall-airway obstruction and emphysema in chronic obstructive pulmonary diseaseN Engl J Med2011365171567157522029978
  • PrakashYSAirway smooth muscle in airway reactivity and remodeling: what have we learned?Am J Physiol Lung Cell Mol Physiol201330512L912L93324142517
  • MeursHDekkersBGMaarsinghHHalaykoAJZaagsmaJGosensRMuscarinic receptors on airway mesenchymal cells: novel findings for an ancient targetPulm Pharmacol Ther201326114515522842340
  • KistemakerLEGosensRAcetylcholine beyond bronchoconstriction roles in inflammation and remodelingTrends Pharmacol Sci201536316417125511176
  • TschumperlinDJLiuFTagerAMBiomechanical regulation of mesenchymal cell functionCurr Opin Rheumatol20132519210023114589
  • TschumperlinDJDrazenJMChronic effects of mechanical force on airwaysAnnu Rev Physiol20066856358316460284
  • GraingeCLLauLCWardJAEffect of bronchoconstriction on airway remodeling in asthmaN Engl J Med2011364212006201521612469
  • PeraTZuidhofAValadasJTiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPDEur Respir J201138478979621349917
  • ValentaTHausmannGBaslerKThe many faces and functions of beta-cateninEMBO J201231122714273622617422
  • KumawatKKoopmansTGosensRβ-Catenin as a regulator and therapeutic target for asthmatic airway remodelingExpert Opin Ther Targets20141891023103425005144
  • KarakiulakisGRothMMuscarinic receptors and their antagonists in COPD: anti-inflammatory and anti remodeling effectsMediators Inflamm20122012840958023226927
  • ParameswaranKWillems-WidyastutiAAlagappanVKRadfordKKranenburgARSharmaHSRole of extracellular matrix and its regulators in human airway smooth muscle biologyCell Biochem Biophys200644113914616456242
  • LambersCQiYEleniPExtracellular matrix composition is modified by β2-agonists through cAMP in COPDBiochem Pharmacol201491340040825107701
  • PeraTGosensRLesterhuisAHCigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotypeRespir Res2010114820429916
  • JohnsonSRKnoxAJSynthetic functions of airway smooth muscle in asthmaTrends Pharmacol Sci19971882882929277132
  • GosensRGraingeCBronchoconstriction and airway biology: potential impact and therapeutic opportunitiesChest2015147379880325732446
  • GosensRZaagsmaJMeursHHalaykoAJMuscarinic receptor signaling in the pathophysiology of asthma and COPDRespir Res200677316684353
  • KistemakerLEOenemaTAMeursHGosensRRegulation of airway inflammation and remodeling by muscarinic receptors: perspectives on anticholinergic therapy in asthma and COPDLife Sci20129121–221126113322406302
  • MatthiesenSBahulayanAKempkensSMuscarinic receptors mediate stimulation of human lung fibroblast proliferationAm J Respir Cell Mol Biol200635662162716902194
  • HaagSMatthiesenSJuergensURRackeKMuscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblastsEur Respir J200832355556218480105
  • AsanoKShikamaYShojiNHiranoKSuzakiHNakajimaHTiotropium bromide inhibits TGF-β-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitroInt J Chron Obstruct Pulmon Dis2010527728620856827
  • AsanoKShikamaYShibuyYSuppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitroInt J Chron Obstruct Pulmon Dis20083478178919281093
  • ZhouYZhongNSLiXTiotropium in early-stage chronic obstructive pulmonary diseaseN Engl J Med20173771092393528877027
  • GoughNRWnt/beta-catenin signaling in development and diseaseSci Signal20125206eg222234609
  • FordeJEDaleTCGlycogen synthase kinase 3: a key regulator of cellular fateCell Mol Life Sci2007641930194417530463
  • BaarsmaHAMenzenMHHalaykoAJMeursHKerstjensHAGosensRβ-Catenin signaling is required for TGF-β1-induced extracellular matrix production by airway smooth muscle cellsAm J Physiol Lung Cell Mol Physiol2011301L956L96521908588
  • HoffmanBDGrashoffCSchwartzMADynamic molecular processes mediate cellular mechanotransductionNature201147531632321776077