Blood eosinophils and inhaled corticosteroids in patients with COPD: systematic review and meta-analysis

References

• FergusonGTAnzuetoAFeiREmmettAKnobilKKalbergCEffect of fluticasone propionate/salmeterol (250/25 microg) or salmeterol (50 microg) on COPD exacerbationsRespir Med200810281099110818614347
   PubMed Web of Science ®Google Scholar
• DransfieldMTBourbeauJJonesPWOnce-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trialsLancet Respir Med20131321022324429127
   PubMed Web of Science ®Google Scholar
• SzafranskiWCukierARamirezAEfficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary diseaseEur Respir J2003211748112570112
   PubMed Web of Science ®Google Scholar
• SharafkhanehASouthardJGGoldmanMUryniakTMartinUJEffect of budesonide/formoterol pMDI on COPD exacerbations: a double-blind, randomized studyRespir Med2012106225726822033040
   PubMed Web of Science ®Google Scholar
• AgarwalRAggarwalANGuptaDJindalSKInhaled corticosteroids vs placebo for preventing COPD exacerbations: a systematic review and metaregression of randomized controlled trialsChest2010137231832519783669
   PubMed Web of Science ®Google Scholar
• SuissaSNumber needed to treat in COPD: exacerbations versus pneumoniasThorax201368654054323125170
   PubMed Web of Science ®Google Scholar
• SahaSBrightlingCEEosinophilic airway inflammation in COPDInt J Chron Obstruct Pulmon Dis200611394718046901
   PubMedGoogle Scholar
• BrightlingCEClinical applications of induced sputumChest200612951344134816685028
   PubMed Web of Science ®Google Scholar
• SinghDKolsumUBrightlingCEEosinophilic inflammation in COPD: prevalence and clinical characteristicsEur Respir J20144461697170025323230
   PubMed Web of Science ®Google Scholar
• BafadhelMMcKennaSTerrySAcute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkersAm J Respir Crit Care Med2011184666267121680942
   PubMed Web of Science ®Google Scholar
• McDonaldVMHigginsIWoodLGGibsonPGMultidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?Thorax201368769169423503624
   PubMed Web of Science ®Google Scholar
• LeighRPizzichiniMMMorrisMMMaltaisFHargreaveFEPizzichiniEStable COPD: predicting benefit from high-dose inhaled corticosteroid treatmentEur Respir J200627596497116446316
   PubMed Web of Science ®Google Scholar
• BrightlingCEMonteiroWWardRSputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trialLancet200035692401480148511081531
   PubMed Web of Science ®Google Scholar
• BrightlingCEMcKennaSHargadonBSputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary diseaseThorax200560319319815741434
   PubMed Web of Science ®Google Scholar
• PizzichiniEPizzichiniMMGibsonPSputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitisAm J Respir Crit Care Med19981585 Pt 1151115179817701
   PubMed Web of Science ®Google Scholar
• PavordIDBafadhelMExhaled nitric oxide and blood eosinophilia: independent markers of preventable riskJ Allergy Clin Immunol2013132482882924001802
   PubMed Web of Science ®Google Scholar
• BainesKJPavordIDGibsonPGThe role of biomarkers in the management of airways diseaseInt J Tuberc Lung Dis201418111264126825299856
   PubMed Web of Science ®Google Scholar
• PavordIDGibsonPGInflammometry: the current state of playThorax201267319119222344396
   PubMed Web of Science ®Google Scholar
• YapEChuaWMJayaramLZengIVandalACGarrettJCan we predict sputum eosinophilia from clinical assessment in patients referred to an adult asthma clinic?Intern Med J2013431465221790924
   PubMed Web of Science ®Google Scholar
• KorevaarDAWesterhofGAWangJDiagnostic accuracy of minimally invasive markers for detection of airway eosinophilia in asthma: a systematic review and meta-analysisLancet Respir Med20153429030025801413
   PubMed Web of Science ®Google Scholar
• WesterhofGAKorevaarDAAmelinkMBiomarkers to identify sputum eosinophilia in different adult asthma phenotypesEur Respir J201546368869626113672
   PubMed Web of Science ®Google Scholar
• ZhangXYSimpsonJLPowellHFull blood count parameters for the detection of asthma inflammatory phenotypesClin Exp Allergy20144491137114524849076
   PubMed Web of Science ®Google Scholar
• FowlerSJTavernierGNivenRHigh blood eosinophil counts predict sputum eosinophilia in patients with severe asthmaJ Allergy Clin Immunol2015135382282425445828
   PubMed Web of Science ®Google Scholar
• WagenerAHde NijsSBLutterRExternal validation of blood eosinophils in asthmaThorax201570211512025422384
   PubMed Web of Science ®Google Scholar
• EltboliOMistryVBarkerBBrightlingCERelationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary diseaseRespirology201520466767025645275
   PubMed Web of Science ®Google Scholar
• BafadhelMMcKennaSTerrySBlood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trialAm J Respir Crit Care Med20121861485522447964
   PubMed Web of Science ®Google Scholar
• PascoeSLocantoreNDransfieldMTBarnesNCPavordIDBlood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trialsLancet Respir Med20153643544225878028
   PubMed Web of Science ®Google Scholar
• SiddiquiSHGuasconiAVestboJBlood eosinophils: a biomarker of response to extrafine beclomethasone/formoterol in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2015192452352526051430
   PubMed Web of Science ®Google Scholar
• BarnesNCSharmaRLettisSCalverleyPMBlood eosinophils as a marker of response to inhaled corticosteroids in COPDEur Respir J20164751374138226917606
   PubMed Web of Science ®Google Scholar
• PavordIDLettisSLocantoreNBlood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPDThorax201671211812526585525
   PubMed Web of Science ®Google Scholar
• WatzHTetzlaffKWoutersEFBlood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trialLancet Respir Med20164539039827066739
   PubMed Web of Science ®Google Scholar
• RocheNChapmanKRVogelmeierCFBlood eosinophils and response to maintenance chronic obstructive pulmonary disease treatment. Data from the FLAME trialAm J Respir Crit Care Med201719591189119728278391
   PubMed Web of Science ®Google Scholar
• BarnesPJThe cytokine network in chronic obstructive pulmonary diseaseAm J Respir Cell Mol Biol200941663163819717810
   PubMed Web of Science ®Google Scholar
• BarnesPJImmunology of asthma and chronic obstructive pulmonary diseaseNat Rev Immunol20088318319218274560
   PubMed Web of Science ®Google Scholar
• BathoornELieskerJJPostmaDSChange in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbationInt J Chron Obstruct Pulmon Dis2009410110919436694
   PubMedGoogle Scholar
• FujimotoKYasuoMUrushibataKHanaokaMKoizumiTKuboKAirway inflammation during stable and acutely exacerbated chronic obstructive pulmonary diseaseEur Respir J200525464064615802337
   PubMed Web of Science ®Google Scholar
• IyerASDransfieldMTSerum eosinophils as a COPD biomarker: ready for prime time?Lancet Respir Med20164534134327066738
   PubMed Web of Science ®Google Scholar
• GeorgeLBrightlingCEEosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary diseaseTher Adv Chronic Dis201671345126770668
   PubMed Web of Science ®Google Scholar
• NixonJNewboldPMustelinTAndersonGPKolbeckRMonoclonal antibody therapy for the treatment of asthma and chronic obstructive pulmonary disease with eosinophilic inflammationPharmacol Ther2017169577727773786
   PubMed Web of Science ®Google Scholar
• HasegawaKCamargoCAPrevalence of blood eosinophilia in hospitalized patients with acute exacerbation of COPDRespirology201621476176426699685
   PubMed Web of Science ®Google Scholar
• PriceDRigazioAPostmaDBlood eosinophilia and the number of exacerbations in COPD patientsEur Respir J201444Suppl 584416
   Google Scholar
• HospersJJSchoutenJPWeissSTPostmaDSRijckenBEosinophilia is associated with increased all-cause mortality after a follow-up of 30 years in a general population sampleEpidemiology200011326126810784241
   PubMed Web of Science ®Google Scholar
• BarnesPJGlucocorticosteroids: current and future directionsBr J Pharmacol20111631294321198556
   PubMed Web of Science ®Google Scholar
• BarnesPJInhaled corticosteroidsPharmaceuticals20103351454027713266
   PubMedGoogle Scholar
• MeagherLCCousinJMSecklJRHaslettCOpposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytesJ Immunol199615611442244288666816
   PubMed Web of Science ®Google Scholar
• PerngDWWuCCSuKCLeeYCPerngRPTaoCWInhaled fluticasone and salmeterol suppress eosinophilic airway inflammation in chronic obstructive pulmonary disease: relations with lung function and bronchodilator reversibilityLung2006184421722217006748
   PubMed Web of Science ®Google Scholar
• HindsDRDisantostefanoRLLeHVPascoeSIdentification of responders to inhaled corticosteroids in a chronic obstructive pulmonary disease population using cluster analysisBMJ Open201666e010099
   PubMed Web of Science ®Google Scholar
• WedzichaJAPriceDMezziKFogelRBanerjiDQVA149 compared with salmeterol/fluticasone (SFC) on exacerbations and its correlation with baseline blood eosinophils: a pooled analysis of LANTERN and ILLUMINATEEur Respir J201546Suppl 59PA1005
   Google Scholar
• Global Initiative for Asthma (GINA) and Global Initiative for Chronic Obstructive Lung Disease (GOLD) [webpage on the Internet]Diagnosis of diseases of chronic airway limitation: asthma, COD and asthma–COPD overlap syndrome (ACOS) [updated 2015] Available from: http://goldcopd.org/asthma-copd-asthma-copd-overlap-syndrome/Accessed April 27, 2017
   Google Scholar
• BaarnesCBKjeldgaardPNielsenMMiravitllesMUlrikCSIdentifying possible asthma–COPD overlap syndrome in patients with a new diagnosis of COPD in primary careNPJ Prim Care Respir Med2017271608428055002
   PubMed Web of Science ®Google Scholar
• CosioBGSorianoJBLópez-CamposJLDefining the asthma–COPD overlap syndrome in a COPD cohortChest20161491455226291753
   PubMed Web of Science ®Google Scholar
• GershonASCampitelliMACroxfordRCombination long-acting β-agonists and inhaled corticosteroids compared with long-acting β-agonists alone in older adults with chronic obstructive pulmonary diseaseJAMA2014312111114112125226477
   PubMed Web of Science ®Google Scholar
• HardinMChoMMcDonaldMLThe clinical and genetic features of COPD–asthma overlap syndromeEur Respir J201444234135024876173
   PubMed Web of Science ®Google Scholar
• HardinMSilvermanEKBarrRGThe clinical features of the overlap between COPD and asthmaRespir Res20111212721951550
   PubMed Web of Science ®Google Scholar
• MarshSETraversJWeatherallMProportional classifications of COPD phenotypesThorax200863976176718728201
   PubMed Web of Science ®Google Scholar
• MenezesAMBMontes de OcaMPérez-PadillaRIncreased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD–asthmaChest2014145229730424114498
   PubMed Web of Science ®Google Scholar
• RheeCKYoonHKYooKHMedical utilization and cost in patients with overlap syndrome of chronic obstructive pulmonary disease and asthmaCOPD201411216317024111662
   PubMedGoogle Scholar
• KauppiPKupiainenHLindqvistAOverlap syndrome of asthma and COPD predicts low quality of lifeJ Asthma201148327928521323613
   PubMed Web of Science ®Google Scholar
• MiravitllesMSorianoJBAncocheaJCharacterisation of the overlap COPD–asthma phenotype. Focus on physical activity and health statusRespir Med201310771053106023597591
   PubMed Web of Science ®Google Scholar
• KitaguchiYKomatsuYFujimotoKHanaokaMKuboKSputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthmaInt J Chron Obstruct Pulmon Dis2012728328922589579
   PubMed Web of Science ®Google Scholar
• LeeSYParkHYKimEKCombination therapy of inhaled steroids and long-acting beta2-agonists in asthma–COPD overlap syndromeInt J Chron Obstruct Pulmon Dis2016112797280327877033
   PubMed Web of Science ®Google Scholar
• VogelmeierCFCrinerGJMartinezFJGlobal strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summaryAm J Respir Crit Care Med2017195555758228128970
   PubMed Web of Science ®Google Scholar
• HastieATMartinezFJCurtisJLAssociation of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohortLancet Respir Med201751295696729146301
   PubMed Web of Science ®Google Scholar
• ItoKLimSCaramoriGChungKFBarnesPJAdcockIMCigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophagesFASEB J20011561110111211292684
   PubMedGoogle Scholar
• BarnesPJItoKAdcockIMCorticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylaseLancet2004363941073173315001333
   PubMed Web of Science ®Google Scholar
• TamimiASerdarevicDHananiaNAThe effects of cigarette smoke on airway inflammation in asthma and COPD: therapeutic implicationsRespir Med2012106331932822196881
   PubMed Web of Science ®Google Scholar
• CalverleyPPauwelsRVestboJFor TRial of Inhaled STeroids ANd long-acting beta2 agonists study group. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trialLancet2003361935644945612583942
   PubMed Web of Science ®Google Scholar
• GlaxoSmithKlineClinical study register. SFCT 01/SCO30002 Available from: http://www.gsk-clinicalstudyregister.com/files/pdf/23674.pdfAccessed April 6, 2017
   Google Scholar
• WedzichaJACalverleyPMSeemungalTAThe prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromideAm J Respir Crit Care Med20081771192617916806
   PubMed Web of Science ®Google Scholar
• BurgePSCalverleyPMJonesPWSpencerSAndersonJAMaslenTKRandomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trialBMJ200032072451297130310807619
   PubMed Web of Science ®Google Scholar
• MagnussenHDisseBRodriguez-RoisinRWithdrawal of inhaled glucocorticoids and exacerbations of COPDN Engl J Med2014371141285129425196117
   PubMed Web of Science ®Google Scholar