References
- Burden of COPD [in:] Chronic respiratory diseases Available from: http://www.who.int/respiratory/copd/burden/enAccessed 26th Dec 2015
- Global Initiative for Chronic Obstructive Pulmonary DiseaseGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease Available from: http://goldcopd.org/gold-2017-global-strategy-diagnosis-management-prevention-copd/Accessed 4th July 2017
- BartalMCOPD and tobacco smokeMonaldi Arch Chest Dis200563421322516454221
- ChibaYMurataMUshikuboHEffect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in ratsAm J Respir Cell Mol Biol200533657458116166743
- ChenZHKimHPSciurbaFCEgr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary diseasePLoS One2008310e331618830406
- SoulitzisNNeofytouEPsarrouMDownregulation of lung mitochondrial prohibitin in COPDRespir Med2012106795496122521224
- van RijtSHKellerIEJohnGAcute cigarette smoke exposure impairs proteasome function in the lungAm J Physiol Lung Cell Mol Physiol20123039L814L82322962013
- MeyerAZollJCharlesALSkeletal muscle mitochondrial dysfunction during chronic obstructive pulmonary disease: central actor and therapeutic targetExp Physiol20139861063107823377494
- HancockDBEijgelsheimMWilkJBMeta-analyses of genome-wide association studies identify multiple loci associated with pulmonary functionNat Genet2010421455220010835
- PillaiSGGeDICGN InvestigatorsA genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility lociPLoS Genet200953e100042119300482
- WilkJBChenTHGottliebDJA genome-wide association study of pulmonary function measures in the Framingham Heart StudyPLoS Genet200953e100042919300500
- HunninghakeGMChoMHTesfaigziYMMP12, lung function, and COPD in high-risk populationsN Engl J Med2009361272599260820018959
- LambrechtsDBuysschaertIZanenPThe 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysemaAm J Respir Crit Care Med2010181548649320007924
- ZöllerBLiXSundquistJSundquistKFamilial transmission of chronic obstructive pulmonary disease in adoptees: a Swedish nationwide family studyBMJ Open201554e007310
- ItoKMercadoNSTOP accelerating lung aging for the treatment of COPDExp Gerontol201459212724709339
- Miłkowska-DymanowskaJBiałasAJMakowskaJWardzynskaAGórskiPPiotrowskiWJGeroprotectors as a therapeutic strategy for COPD – where are we now?Clin Interv Aging2017121811181729123386
- AgustíACelliBFanerRWhat does endotyping mean for treatment in chronic obstructive pulmonary disease?Lancet20173901009898098728872030
- Miłkowska-DymanowskaJBiałasAJZalewska-JanowskaAGórskiPPiotrowskiWJUnderrecognized comorbidities of chronic obstructive pulmonary diseaseInt J Chron Obstruct Pulmon Dis2015101331134126203239
- HanssonGKInflammationHGKInflammation, atherosclerosis, and coronary artery diseaseN Engl J Med2005352161685169515843671
- LibbyPInflammation in atherosclerosisNature2002420691786887412490960
- HarrisonMTShortPWilliamsonPASinganayagamAChalmersJDSchembriSThrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy?Thorax201469760961524743560
- BiałasAJPedoneCPiotrowskiWJAntonelli IncalziRPlatelet distribution width as a prognostic factor in patients with COPD – pilot studyInt J Chron Obstruct Pulmon Dis2017122261226728814854
- AravamudanBThompsonMAPabelickCMPrakashYSMitochondria in lung diseasesExpert Rev Respir Med20137663164623978003
- LiuYFiskumGSchubertDGeneration of reactive oxygen species by the mitochondrial electron transport chainJ Neurochem200280578078711948241
- BoverisAChanceBThe mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygenBiochem J197313437077164749271
- BiałasAJSitarekPMiłkowska-DymanowskaJPiotrowskiWJGórskiPThe role of mitochondria and oxidative/antioxidative imbalance in pathobiology of chronic obstructive pulmonary diseaseOxid Med Cell Longev20162016
- ChenSSuYWangJROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturationCell Death Dis201347e72223846224
- KosmiderLSobczakASzołtysek-BołdysIAssessment of nicotine concentration in electronic nicotine delivery system (ENDS) liquids and precision of dosing to aerosolPrzegl Lek2015721050050426946554
- SjövallFMorotaSHanssonMJFribergHGnaigerEElmérETemporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsisCrit Care2010146R21421106065
- ParameswaranHMajumdarAItoSAlencarAMSukiBQuantitative characterization of airspace enlargement in emphysemaJ Appl Physiol2006100118619316166240
- JacobRECarsonJPGideonKMAmidanBGSmithCLLeeKMComparison of two quantitative methods of discerning airspace enlargement in smoke-exposed micePLoS One200948e667019688093
- YamatoHSunJPChurgAWrightJLCigarette smoke-induced emphysema in guinea pigs is associated with diffusely decreased capillary density and capillary narrowingLab Invest19967522112198765321
- MacneeWABC of chronic obstructive pulmonary disease. Pathology, pathogenesis, and pathophysiologyBMJ2006332755112021204
- BrusselleGGDemoorTBrackeKRBrandsmaCATimensWLymphoid follicles in (very) severe COPD: beneficial or harmful?Eur Respir J200934121923019567605
- KelsenSGAksoyMOGeorgyMLymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3Am J Respir Crit Care Med2009179979980519218194
- DalenHAn ultrastructural study of the tracheal epithelium of the guinea-pig with special reference to the ciliary structureJ Anat1983136Pt 147676833121
- RessmeyerARLarssonAKVollmerEDahlènSEUhligSMartinCCharacterisation of guinea pig precision-cut lung slices: comparison with human tissuesEur Respir J200628360361116737991
- MuccitelliRMTuckerSSHayDWTorphyTJWassermanMAIs the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine- and antigen-induced contractionsJ Pharmacol Exp Ther198724324674732824746
- CanningBJChouYUsing guinea pigs in studies relevant to asthma and COPDPulm Pharmacol Ther200821570272018462968
- GhoraniVBoskabadyMHKhazdairMRKianmeherMExperimental animal models for COPD: a methodological reviewTob Induc Dis2017152528469539
- JastrochMDivakaruniASMookerjeeSTrebergJRBrandMDMitochondrial proton and electron leaksEssays Biochem201047536720533900
- QuinlanCLPerevoshchikovaIVHey-MogensenMOrrALBrandMDSites of reactive oxygen species generation by mitochondria oxidizing different substratesRedox Biol2013130431224024165
- TalbotDALambertAJBrandMDProduction of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3FEBS Lett20045561–311111514706836
- BrookesPSMitochondrial proton leak and superoxide generation: an hypothesisBiochem Soc Trans1998264S33110047845
- SkulachevVPRole of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductantsQ Rev Biophys19962921692028870073
- KuHHSohalRSComparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potentialMech Ageing Dev199372167768114521
- PapaioannouAIRossiosCKostikasKItoKCan we delay the accelerated lung aging in COPD? Anti-aging molecules and interventionsCurr Drug Targets201314214915723256715
- BegonjaAJGambaryanSGeigerJPlatelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathwayBlood200510682757276015976180
- KrötzFSohnHYPohlUReactive oxygen species: players in the platelet gameArterioscler Thromb Vasc Biol200424111988199615374851
- JangJYMinJHChaeYHReactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidationAntioxid Redox Signal201420162528254024093153
- QiaoJArthurJFGardinerEEAndrewsRKZengLXuKRegulation of platelet activation and thrombus formation by reactive oxygen speciesRedox Biol20181412613028888895
- WangWQZhangHFGaoGXBaiQXLiRWangXMAdiponectin inhibits hyperlipidemia-induced platelet aggregation via attenuating oxidative/nitrative stressPhysiol Res201160234735421114366
- IulianoLPraticòDGhiselliABonavitaMSVioliFSuperoxide dismutase triggers activation of “primed” plateletsArch Biochem Biophys199128911801831910314
- HandinRIKarabinRBoxerGJEnhancement of platelet function by superoxide anionJ Clin Invest1977595959965192766
- Garcia-SouzaLFOliveiraMFMitochondria: biological roles in platelet physiology and pathologyInt J Biochem Cell Biol20145015616024569121
- ChooHJSaafirTBMkumbaLWagnerMBJobeSMMitochondrial calcium and reactive oxygen species regulate agonist-initiated platelet phosphatidylserine exposureArterioscler Thromb Vasc Biol201232122946295523087357
- BakdashNWilliamsMSSpatially distinct production of reactive oxygen species regulates platelet activationFree Radic Biol Med200845215816618452718
- PignatelliPPulcinelliFMLentiLGazzanigaPPVioliFHydrogen peroxide is involved in collagen-induced platelet activationBlood19989124844909427701
- ArthurJFQiaoJShenYITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathwaysJ Thromb Haemost20121061133114122489915
- InoueOSuzuki-InoueKMccartyOJLaminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVIBlood200610741405141216219796
- AlshehriOMHughesCEMontagueSFibrin activates GPVI in human and mouse plateletsBlood2015126131601160826282541
- CarrimNWalshTGConsonniATortiMBerndtMCMetharomPRole of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formationPLoS One2014911e11367925415317
- PraticóDPasinMBarryOPIron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase CCirculation199999243118312410377074
- CacceseDPraticòDGhiselliASuperoxide anion and hydroxyl radical release by collagen-induced platelet aggregation – role of arachidonic acid metabolismThromb Haemost200083348549010744158
- ArthurJFShenYGardinerEETNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human plateletsJ Thromb Haemost20119116317220946164
- KatsumeAOkigakiMMatsuiAEarly inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 systemArterioscler Thromb Vasc Biol20113151084109221372295
- FerroniPVazzanaNRiondinoSCuccurulloCGuadagniFDavìGPlatelet function in health and disease: from molecular mechanisms, redox considerations to novel therapeutic opportunitiesAntioxid Redox Signal201217101447148522458931
- SchildknechtSvan der LooBWeberKTiefenthalerKDaiberABachschmidMMEndogenous peroxynitrite modulates PGHS-1- dependent thromboxane A2 formation and aggregation in human plateletsFree Radic Biol Med200845451252018514074
- KrötzFSohnHYGloeTNAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitmentBlood2002100391792412130503
- Núñez-CórdobaJMMartínez-GonzálezMAAntioxidant vitamins and cardiovascular diseaseCurr Top Med Chem201111141861186921506930
- AnfossiGRussoIMassuccoPMattielloLCavalotFTrovatiMN-acetyl-L-cysteine exerts direct anti-aggregating effect on human plateletsEur J Clin Invest200131545246111380598
- FowdarKChenHHeZThe effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: a meta-analysis and systematic reviewHeart Lung201746212012828109565
- SalveVTAtramJSN-acetylcysteine combined with home based physical activity: effect on health related quality of life in stable COPD patients: a randomised controlled trialJ Clin Diagn Res20161012OC16OC19