Advanced search
Publication Cover
International Journal of Chronic Obstructive Pulmonary Disease Volume 16, 2021 - Issue
Submit an article Journal homepage
104
Views
3
CrossRef citations to date
0
Altmetric
Original Research

Influence of Cell Quality on Inflammatory Biomarkers in COPD Sputum Supernatant

Frauke Pedersen1 Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany;2 LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, GermanyCorrespondence[email protected]
,
Frederik Trinkmann3 Pneumology and Critical Care Medicine, Thoraxklinik at University Hospital Heidelberg, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, GermanyORCID Iconhttps://orcid.org/0000-0001-5877-877X
ORCID Icon,
Mustafa Abdo2 LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany
,
Anne-Marie Kirsten1 Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany
,
Klaus F Rabe2 LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany
,
Henrik Watz1 Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany
,
Simonetta Baraldo4 Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Respiratory Diseases Clinic, University of Padova, Padova, ItalyORCID Iconhttps://orcid.org/0000-0001-8923-7511
ORCID Icon,
Marina Saetta4 Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Respiratory Diseases Clinic, University of Padova, Padova, ItalyORCID Iconhttps://orcid.org/0000-0002-1547-2102
ORCID Icon,
Jens M Hohlfeld5 Fraunhofer ITEM, Clinical Airway Research - Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany;6 Department of Respiratory Medicine, Hannover Medical School (MHH), Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, GermanyORCID Iconhttps://orcid.org/0000-0003-2646-6186
ORCID Icon &
Olaf Holz5 Fraunhofer ITEM, Clinical Airway Research - Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany
 show all
Pages 487-493 | Published online: 01 Mar 2021

References

  • Guo C, Sun X, Diao W, Shen N, He B. Correlation of clinical symptoms and sputum inflammatory markers with air pollutants in stable COPD patients in Beijing area. Int J Chron Obstruct Pulmon Dis. 2020;15::1507–1517. doi:10.2147/COPD.S254129
  • Watz H, Uddin M, Pedersen F, et al. Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma. Pulm Pharmacol Ther. 2017;45:121–123. doi:10.1016/j.pupt.2017.05.012
  • Pedersen F, Zissler U, Watz H, et al. Rating sputum cell quality in clinical trials for asthma and COPD treatment. Int J Chron Obstruct Pulmon Dis. 2019;14:195–198. doi:10.2147/COPD.S188033
  • Hoenderdos K, Condliffe A. The neutrophil in chronic obstructive pulmonary disease too little, too late or too much, too soon? Am J Respir Cell Mol Biol. 2013;48(5):531–539. doi:10.1165/rcmb.2012-0492TR
  • Holz O, Khalilieh S, Ludwig-Sengpiel A, et al. SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects. Eur Respir J. 2010;35:564–570. doi:10.1183/09031936.00048509
  • Leaker BR, Barnes PJ, O’Connor B. Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist. Respir Res. 2013;14:137. doi:10.1186/1465-9921-14-137
  • Walsh MG. Biologics targeting IL-5, IL-4 or IL-13 for the treatment of asthma - an update. Expert Rev Clin Immunol. 2017;13(2):143–149. doi:10.1080/1744666X.2016.1216316
  • D’silva L, Hassan N, Wang HY, et al. Heterogeneity of bronchitis in airway diseases in tertiary care clinical practice. Can Respir J. 2011;18(3):144–148. doi:10.1155/2011/430317
  • Bhowmik A, Seemungal TA, Sapsford RJ, Devalia JL, Wedzicha JA. Comparison of spontaneous and induced sputum for investigation of airway inflammation in chronic obstructive pulmonary disease. Thorax. 1998;53(11):953–956. doi:10.1136/thx.53.11.953
  • Ronchi MC, Galli G, Zonefrati R, et al. Sputum processing: a new method to improve cytospin quality. Clin Exp Allergy. 2002;32(5):674–680. doi:10.1046/j.1365-2222.2002.01387.x
  • Rabe KF, Watz H, Baraldo S, et al. Anti-inflammatory effects of roflumilast in chronic obstructive pulmonary disease (ROBERT): a 16-week, randomised, placebo-controlled trial. Lancet Respir Med. 2018;6(11):827–836. doi:10.1016/S2213-2600(18)30331-X
  • Pedersen F, Holz O, Lauer G, et al. Multi-analyte profiling of inflammatory mediators in COPD sputum – the effects of processing. Cytokine. 2015;71:401–404. doi:10.1016/j.cyto.2014.10.008
  • Kelly MM, Keatings V, Leigh R, et al. Analysis of fluid-phase mediators. Eur Respir J Suppl. 2002;37:24–39.
  • Röpcke S, Holz O, Lauer G, et al. Repeatability of and relationship between potential COPD biomarkers in bronchoalveolar lavage, bronchial biopsies, serum, and induced sputum. PLoS One. 2012;7(10):e46207. doi:10.1371/journal.pone.0046207

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.