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International Journal of Chronic Obstructive Pulmonary Disease Volume 17, 2022 - Issue
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Research Letter

Association of Airway Eosinophilia with Small Airway Dysfunction in Patients with Mild and at Risk for COPD

Mustafa Abdo1 LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3300-1398View further author information
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Frauke Pedersen1 LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany;2 Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, GermanyView further author information
,
Frederik Trinkmann3 Pneumology and Critical Care Medicine, Thoraxklinik at University Hospital Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Heidelberg, Germany;4 Department of Biomedical Informatics (DBMI) at the Center for Preventive Medicine and Digital Health Baden-Württemberg (CPD-BW), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyORCID Iconhttps://orcid.org/0000-0001-5877-877XView further author information
ORCID Icon,
Felix J F Herth3 Pneumology and Critical Care Medicine, Thoraxklinik at University Hospital Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Heidelberg, GermanyORCID Iconhttps://orcid.org/0000-0002-7638-2506View further author information
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Klaus F Rabe1 LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, GermanyORCID Iconhttps://orcid.org/0000-0002-7020-1401View further author information
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Anne-Marie Kirsten2 Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, GermanyORCID Iconhttps://orcid.org/0000-0002-2611-2962View further author information
ORCID Icon &
Henrik Watz2 Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, GermanyView further author information
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Pages 1403-1408 | Published online: 17 Jun 2022

References

  • Hoenderdos K, Condliffe A. The neutrophil in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2013;48(5):531–539. doi:10.1165/rcmb.2012-0492TR
  • Hastie AT, Martinez FJ, Curtis JL, et al. Sputum or blood eosinophil association with clinical measures of COPD severity in the SPIROMICS cohort. Lancet Respir Med. 2017;5(12):956–967. doi:10.1016/S2213-2600(17)30432-0
  • Singh D, Agusti A, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019. Eur Respir J. 2019;53(5):1900164. doi:10.1183/13993003.00164-2019
  • McDonough JE, Yuan R, Suzuki M, et al. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med. 2011;365(17):1567–1575. doi:10.1056/NEJMoa1106955
  • Abdo M, Pedersen F, Kirsten A-M, et al. Longitudinal impact of sputum inflammatory phenotypes on small airway dysfunction and disease outcomes in asthma. J Allergy Clin Immunol. 2022;10:1545–1553.e2. doi:10.1016/j.jaip.2022.02.020
  • Pedersen F, Trinkmann F, Abdo M, et al. Influence of cell quality on inflammatory biomarkers in COPD sputum supernatant. Int J Chron Obstruct Pulmon Dis. 2021;16:487–493. doi:10.2147/COPD.S284938
  • Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004;350(26):2645–2653. doi:10.1056/NEJMoa032158
  • Lams BE, Sousa AR, Rees PJ, Lee TH. Subepithelial immunopathology of the large airways in smokers with and without chronic obstructive pulmonary disease. Eur Respir J. 2000;15(3):512–516. doi:10.1034/j.1399-3003.2000.15.14.x
  • Pauwels RA, Löfdahl CG, Laitinen LA, et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European respiratory society study on chronic obstructive pulmonary disease. N Engl J Med. 1999;340(25):1948–1953. doi:10.1056/NEJM199906243402503

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