Myostatin/HIF2α-Mediated Ferroptosis is Involved in Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

References

• Vogelmeier CAA, Anzueto A, Barnes P, Bourbeau J, Criner G. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. In: 2021 Report. Global Initiat Chronic Obstruct Lung Dis. http://www.goldcopd.org.
   Google Scholar
• Jones SE, Maddocks M, Kon SS, et al. Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation. Thorax. 2015;70(3):213–218. doi:10.1136/thoraxjnl-2014-206440
   PubMed Web of Science ®Google Scholar
• Sepúlveda-Loyola W, Osadnik C, Phu S, Morita AA, Duque G, Probst VS. Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2020;11(5):1164–1176. doi:10.1002/jcsm.12600
   PubMed Web of Science ®Google Scholar
• Jaitovich A, Barreiro E. Skeletal muscle dysfunction in chronic obstructive pulmonary disease what we know and can do for our patients. Am J Respir Crit Care Med. 2018;198(2):175–186. doi:10.1164/rccm.201710-2140CI
   PubMed Web of Science ®Google Scholar
• Cebron Lipovec N, Schols AM, van den Borst B, et al. Sarcopenia in advanced COPD affects cardiometabolic risk reduction by short-term high-intensity pulmonary rehabilitation. J Am Med Dir Assoc. 2016;17(9):814–820. doi:10.1016/j.jamda.2016.05.002
   PubMed Web of Science ®Google Scholar
• Passey SL, Hansen MJ, Bozinovski S, McDonald CF, Holland AE, Vlahos R. Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease. Pharmacol Ther. 2016;166:56–70. doi:10.1016/j.pharmthera.2016.06.013
   PubMed Web of Science ®Google Scholar
• Plant PJ, Brooks D, Faughnan M, et al. Cellular markers of muscle atrophy in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2010;42(4):461–471. doi:10.1165/rcmb.2008-0382OC
   PubMed Web of Science ®Google Scholar
• Guo Y, Gosker HR, Schols AM, et al. Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;188(11):1313–1320. doi:10.1164/rccm.201304-0732OC
   PubMed Web of Science ®Google Scholar
• Agusti A, Morla M, Sauleda J, Saus C, Busquets X. NF-kappaB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight. Thorax. 2004;59(6):483–487. doi:10.1136/thx.2003.017640
   PubMed Web of Science ®Google Scholar
• Cohen S, Nathan JA, Goldberg AL. Muscle wasting in disease: molecular mechanisms and promising therapies. Nat Rev Drug Discov. 2015;14(1):58–74. doi:10.1038/nrd4467
   PubMed Web of Science ®Google Scholar
• Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107–125. doi:10.1038/s41422-020-00441-1
   PubMed Web of Science ®Google Scholar
• Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266–282. doi:10.1038/s41580-020-00324-8
   PubMed Web of Science ®Google Scholar
• Ikeda Y, Imao M, Satoh A, et al. Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3-E3 ubiquitin ligase-dependent pathway. J Trace Elem Med Biol. 2016;35:66–76. doi:10.1016/j.jtemb.2016.01.011
   PubMed Web of Science ®Google Scholar
• Barnes PJ, Baker J, Donnelly LE. Cellular senescence as a mechanism and target in chronic lung diseases. Am J Respir Crit Care Med. 2019;200(5):556–564. doi:10.1164/rccm.201810-1975TR
   PubMed Web of Science ®Google Scholar
• Zhou RP, Chen Y, Wei X, et al. Novel insights into ferroptosis: implications for age-related diseases. Theranostics. 2020;10(26):11976–11997. doi:10.7150/thno.50663
   PubMed Web of Science ®Google Scholar
• Huang Y, Wu B, Shen D, Chen J, Yu Z, Chen C. Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8). Int J Biol Sci. 2021;17(1):151–162. doi:10.7150/ijbs.53126
   PubMed Web of Science ®Google Scholar
• Xiong J, Le Y, Rao Y, et al. RANKL mediates muscle atrophy and dysfunction in a cigarette smoke-induced model of COPD. Am J Respir Cell Mol Biol. 2021;64(5):617–628. doi:10.1165/rcmb.2020-0449OC
   PubMed Web of Science ®Google Scholar
• Vanoirbeek J, Devos F, Maaske A, et al. Lung function measurements in mouse models of lung disease: what to expect from FEV0.1? Eur Res J. 2016;48(suppl60):PA4131. doi:10.1183/13993003.congress-2016.PA4131
   Web of Science ®Google Scholar
• Zhou L, Le Y, Tian J, et al. Cigarette smoke-induced RANKL expression enhances MMP-9 production by alveolar macrophages. Int J Chron Obstruct Pulmon Dis. 2019;14:81–91. doi:10.2147/COPD.S190023
   PubMed Web of Science ®Google Scholar
• Gellner CA, Reynaga DD, Leslie FM. Cigarette smoke extract: a preclinical model of tobacco dependence. Curr Protoc Neurosci. 2016;77:954. doi:10.1002/cpns.14
   Google Scholar
• Zembruski NC, Stache V, Haefeli WE, Weiss J. 7-Aminoactinomycin D for apoptosis staining in flow cytometry. Anal Biochem. 2012;429(1):79–81. doi:10.1016/j.ab.2012.07.005
   PubMed Web of Science ®Google Scholar
• Sancho-Muñoz A, Guitart M, Rodríguez DA, Gea J, Martínez-Llorens J, Barreiro E. Deficient muscle regeneration potential in sarcopenic COPD patients: role of satellite cells. J Cell Physiol. 2021;236(4):3083–3098. doi:10.1002/jcp.30073
   PubMed Web of Science ®Google Scholar
• Polkey MI, Praestgaard J, Berwick A, et al. Activin Type II receptor blockade for treatment of muscle depletion in chronic obstructive pulmonary disease. A randomized trial. Am J Respir Crit Care Med. 2019;199(3):313–320. doi:10.1164/rccm.201802-0286OC
   PubMed Web of Science ®Google Scholar
• Willis-Owen SAG, Thompson A, Kemp PR, et al. COPD is accompanied by coordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix. Sci Rep. 2018;8. doi:10.1038/s41598-018-29789-6
   PubMed Web of Science ®Google Scholar
• Zhao G. Is iron accumulation a possible risk factor for sarcopenia? Biol Trace Elem Res. 2018;186(2):379–383. doi:10.1007/s12011-018-1332-z
   PubMed Web of Science ®Google Scholar
• Ding HR, Chen SJ, Pan XH, et al. Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis. J Cachexia Sarcopeni. 2021;12(3):746–768. doi:10.1002/jcsm.12700
   PubMed Web of Science ®Google Scholar
• He S, Li R, Peng Y, et al. ACSL4 contributes to ferroptosis-mediated rhabdomyolysis in exertional heat stroke. J Cachexia Sarcopenia Muscle. 2022;13(3):1717–1730. doi:10.1002/jcsm.12953
   PubMed Web of Science ®Google Scholar
• Zhang Q, Qu H, Chen Y, et al. Atorvastatin induces mitochondria-dependent ferroptosis via the modulation of Nrf2-xCT/GPx4 Axis. Front Cell Dev Biol. 2022;10:806081. doi:10.3389/fcell.2022.806081
   PubMed Web of Science ®Google Scholar
• Zhang Y, Swanda RV, Nie L, et al. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021;12(1):1589. doi:10.1038/s41467-021-21841-w
   PubMed Web of Science ®Google Scholar
• Ingold I, Berndt C, Schmitt S, et al. Selenium Utilization by GPX4 Is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172(3):409. doi:10.1016/j.cell.2017.11.048
   PubMed Web of Science ®Google Scholar
• Xu W, Deng H, Hu S, et al. Role of ferroptosis in lung diseases. J Inflamm Res. 2021;14:2079–2090. doi:10.2147/JIR.S307081
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nat Chem Biol. 2014;10(1):9–17. doi:10.1038/nchembio.1416
   PubMed Web of Science ®Google Scholar
• Park E, Chung SW. ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation. Cell Death Dis. 2019;10(11):822. doi:10.1038/s41419-019-2064-5
   PubMed Web of Science ®Google Scholar
• Mou Y, Wu J, Zhang Y, Abdihamid O, Duan C, Li B. Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma. BMC Cancer. 2021;21(1):18. doi:10.1186/s12885-020-07726-z
   PubMed Web of Science ®Google Scholar
• Lee P, Chandel NS, Simon MC. Cellular adaptation to hypoxia through hypoxia inducible factors and beyond. Nat Rev Mol Cell Bio. 2020;21(5):268–283. doi:10.1038/s41580-020-0227-y
   PubMed Web of Science ®Google Scholar
• Singhal R, Mitta SR, Das NK, et al. HIF-2alpha activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron. J Clin Invest. 2021;131(12). doi:10.1172/JCI143691
   Web of Science ®Google Scholar
• Xie L, Yin A, Nichenko AS, Beedle AM, Call JA, Yin H. Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J Clin Invest. 2018;128(6):2339–2355. doi:10.1172/JCI96208
   PubMed Web of Science ®Google Scholar