Comorbid Heart Disease in Patients with COPD is Associated with Increased Hospitalization and Mortality – A 15-Year Follow-Up

References

• Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for prevention, diagnosis and management of COPD; 2022 report; 2022. Available from: https://goldcopd.org/2022-gold-reports-2/. Accessed November 9, 2022.
   Google Scholar
• Adeloye D, Chua S, Lee C, et al. Global and regional estimates of COPD prevalence: systematic review and meta-analysis. J Glob Health. 2015;5(2):020415. doi:10.7189/jogh.05-020415
   PubMed Web of Science ®Google Scholar
• Chen W, Thomas J, Sadatsafavi M, FitzGerald JM. Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Lancet Respir Med. 2015;3(8):631–639. doi:10.1016/s2213-2600(15)00241-6
   PubMed Web of Science ®Google Scholar
• Maclay JD, MacNee W. Cardiovascular disease in COPD: mechanisms. Chest. 2013;143(3):798–807. doi:10.1378/chest.12-0938
   PubMed Web of Science ®Google Scholar
• Sidney S, Sorel M, Quesenberry CP, DeLuise C, Lanes S, Eisner MD. COPD and incident cardiovascular disease hospitalizations and mortality: kaiser permanente medical care program. Chest. 2005;128(4):2068–2075. doi:10.1378/chest.128.4.2068
   PubMed Web of Science ®Google Scholar
• Müllerova H, Agusti A, Erqou S, Mapel DW. Cardiovascular comorbidity in COPD: systematic literature review. Chest. 2013;144(4):1163–1178. doi:10.1378/chest.12-2847
   PubMed Web of Science ®Google Scholar
• Carter P, Lagan J, Fortune C, et al. Association of cardiovascular disease with respiratory disease. J Am Coll Cardiol. 2019;73(17):2166–2177. doi:10.1016/j.jacc.2018.11.063
   PubMed Web of Science ®Google Scholar
• Ellingsen J, Johansson G, Larsson K, et al. Impact of comorbidities and commonly used drugs on mortality in COPD - real-world data from a primary care setting. Int J Chron Obstruct Pulmon Dis. 2020;15:235–245. doi:10.2147/copd.S231296
   PubMed Web of Science ®Google Scholar
• Genao L, Durheim MT, Mi X, Todd JL, Whitson HE, Curtis LH. Early and long-term outcomes of older adults after acute care encounters for chronic obstructive pulmonary disease exacerbation. Ann Am Thorac Soc. 2015;12(12):1805–1812. doi:10.1513/AnnalsATS.201504-250OC
   PubMed Web of Science ®Google Scholar
• Santibáñez M, Garrastazu R, Ruiz-Nuñez M, et al. Predictors of hospitalized exacerbations and mortality in chronic obstructive pulmonary disease. PLoS One. 2016;11(6):e0158727. doi:10.1371/journal.pone.0158727
   PubMed Web of Science ®Google Scholar
• Kunisaki KM, Dransfield MT, Anderson JA, et al. Exacerbations of chronic obstructive pulmonary disease and cardiac events. A post hoc cohort analysis from the SUMMIT randomized clinical trial. Am J Respir Crit Care Med. 2018;198(1):51–57. doi:10.1164/rccm.201711-2239OC
   PubMed Web of Science ®Google Scholar
• Canepa M, Temporelli PL, Rossi A, et al. Prevalence and prognostic impact of chronic obstructive pulmonary disease in patients with chronic heart failure: data from the GISSI-HF trial. Cardiology. 2017;136(2):128–137. doi:10.1159/000448166
   PubMed Web of Science ®Google Scholar
• Westerik JA, Metting EI, van Boven JF, Tiersma W, Kocks JW, Schermer TR. Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD. Respir Res. 2017;18(1):31. doi:10.1186/s12931-017-0512-2
   PubMed Web of Science ®Google Scholar
• Mullerova H, Shukla A, Hawkins A, Quint J. Risk factors for acute exacerbations of COPD in a primary care population: a retrospective observational cohort study. BMJ open. 2014;4(12):e006171. doi:10.1136/bmjopen-2014-006171
   PubMed Web of Science ®Google Scholar
• Dalal AA, Shah M, Lunacsek O, Hanania NA. Clinical and economic burden of patients diagnosed with COPD with comorbid cardiovascular disease. Respir Med. 2011;105(10):1516–1522. doi:10.1016/j.rmed.2011.04.005
   PubMed Web of Science ®Google Scholar
• Jones PW, Mullerova H, Agusti A, et al. Cardiovascular disease does not predict exacerbation rate or mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;197(3):400–403. doi:10.1164/rccm.201706-1066LE
   PubMed Web of Science ®Google Scholar
• Zhang J, Rutten FH, Cramer MJ, Lammers JW, Zuithoff NP, Hoes AW. The importance of cardiovascular disease for mortality in patients with COPD: a prognostic cohort study. Fam Pract. 2011;28(5):474–481. doi:10.1093/fampra/cmr024
   PubMed Web of Science ®Google Scholar
• Sundh J, Stallberg B, Lisspers K, Montgomery SM, Janson C. Co-morbidity, body mass index and quality of life in COPD using the clinical COPD questionnaire. COPD. 2011;8(3):173–181. doi:10.3109/15412555.2011.560130
   PubMedGoogle Scholar
• RStandardized lung function testing. Report working party. Bull Eur Physiopathol Respir. 1983;19(Suppl 5):1–95.
   PubMedGoogle Scholar
• Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax. 1999;54(7):581–586. doi:10.1136/thx.54.7.581
   PubMed Web of Science ®Google Scholar
• Laforest L, Roche N, Devouassoux G, et al. Frequency of comorbidities in chronic obstructive pulmonary disease, and impact on all-cause mortality: a population-based cohort study. Respir Med. 2016;117:33–39. doi:10.1016/j.rmed.2016.05.019
   PubMed Web of Science ®Google Scholar
• Abukhalaf J, Davidson R, Villalobos N, et al. Chronic obstructive pulmonary disease mortality, a competing risk analysis. Clin Respir J. 2018;12(11):2598–2605. doi:10.1111/crj.12963
   PubMed Web of Science ®Google Scholar
• Stallberg B, Janson C, Larsson K, et al. Real-world retrospective cohort study Arctic shows burden of comorbidities in Swedish COPD versus non-COPD patients. NPJ Primary Care Respir Med. 2018;28(1):33. doi:10.1038/s41533-018-0101-y
   PubMedGoogle Scholar
• Kaszuba E, Odeberg H, Rastam L, Halling A. Heart failure and levels of other comorbidities in patients with chronic obstructive pulmonary disease in a Swedish population: a register-based study. BMC Res Notes. 2016;9:215. doi:10.1186/s13104-016-2008-4
   PubMedGoogle Scholar
• de Miguel-Diez J, Carrasco-Garrido P, Rejas-Gutierrez J, et al. The influence of heart disease on characteristics, quality of life, use of health resources, and costs of COPD in primary care settings. BMC Cardiovasc Disord. 2010;10:8. doi:10.1186/1471-2261-10-8
   PubMed Web of Science ®Google Scholar
• Chen Y, Li Q, Johansen H. Age and sex variations in hospital readmissions for COPD associated with overall and cardiac comorbidity. Int J Tuberc Lung Dis. 2009;13(3):394–399.
   PubMed Web of Science ®Google Scholar
• Sawalha S, Hedman L, Backman H, et al. The impact of comorbidities on mortality among men and women with COPD: report from the OLIN COPD study. Ther Adv Respir Dis.2019;13:1753466619860058. doi:10.1177/1753466619860058.
   Google Scholar
• Gershon A, Hwee J, Victor JC, et al. Mortality trends in women and men with COPD in Ontario, Canada, 1996–2012. Thorax. 2015;70(2):121–126. doi:10.1136/thoraxjnl-2014-205956
   PubMed Web of Science ®Google Scholar
• Westerman S, Wenger NK. Women and heart disease, the underrecognized burden: sex differences, biases, and unmet clinical and research challenges. Clin Sci. 2016;130(8):551–563. doi:10.1042/cs20150586
   Web of Science ®Google Scholar
• Hansell AL, Walk JA, Soriano JB. What do chronic obstructive pulmonary disease patients die from? A multiple cause coding analysis. Eur Respir J. 2003;22(5):809–814. doi:10.1183/09031936.03.00031403
   PubMed Web of Science ®Google Scholar
• Drummond MB, Wise RA, John M, Zvarich MT, McGarvey LP. Accuracy of death certificates in COPD: analysis from the TORCH trial. COPD. 2010;7(3):179–185. doi:10.3109/15412555.2010.481695
   PubMedGoogle Scholar
• Jensen HH, Godtfredsen NS, Lange P, Vestbo J. Potential misclassification of causes of death from COPD. Eur Respir J. 2006;28(4):781–785. doi:10.1183/09031936.06.00152205
   PubMed Web of Science ®Google Scholar