Pathogenesis of hyperinflation in chronic obstructive pulmonary disease

References

• VestboJHurdSSAgustiAGGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summaryAm J Respir Crit Care Med2013187434736522878278
   PubMed Web of Science ®Google Scholar
• ManninoDMGagnonRCPettyTLLydickEObstructive lung disease and low lung function in adults in the United States: data from the National Health and Nutrition Examination Survey, 1988–1994Arch Intern Med2000160111683168910847262
   PubMed Web of Science ®Google Scholar
• HillKGoldsteinRSGuyattGHPrevalence and underdiagnosis of chronic obstructive pulmonary disease among patients at risk in primary careCMAJ2010182767367820371646
   PubMed Web of Science ®Google Scholar
• HalbertRJNatoliJLGanoABadamgaravEBuistASManninoDMGlobal burden of COPD: systematic review and meta-analysisEur Respir J200628352353216611654
   PubMed Web of Science ®Google Scholar
• BuistASMcBurnieMAVollmerWMInternational variation in the prevalence of COPD (the BOLD Study): a population-based prevalence studyLancet2007370958974175017765523
   PubMed Web of Science ®Google Scholar
• KohansalRMartinez-CamblorPAgustiABuistASManninoDMSorianoJBThe natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohortAm J Respir Crit Care Med2009180131019342411
   PubMed Web of Science ®Google Scholar
• [No authors listed]Dyspnea. Mechanisms, assessment, and management: a consensus statement. American Thoracic SocietyAm J Respir Crit Care Med199915913213409872857
   PubMed Web of Science ®Google Scholar
• O’DonnellDELavenezianaPDyspnea and activity limitation in COPD: mechanical factorsCOPD20074322523617729066
   PubMedGoogle Scholar
• SorianoJBVisickGTMuellerovaHPayvandiNHansellALPatterns of comorbidities in newly diagnosed COPD and asthma in primary careChest200512842099210716236861
   PubMed Web of Science ®Google Scholar
• O’DonnellDELamMWebbKASpirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med1999160254254910430726
   PubMed Web of Science ®Google Scholar
• Garcia-RioFLoresVMedianoODaily physical activity in patients with chronic obstructive pulmonary disease is mainly associated with dynamic hyperinflationAm J Respir Crit Care Med2009180650651219542481
   PubMed Web of Science ®Google Scholar
• JonesPWActivity limitation and quality of life in COPDCOPD20074327327817729072
   PubMedGoogle Scholar
• O’DonnellDERevillSMWebbKADynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2001164577077711549531
   PubMed Web of Science ®Google Scholar
• O’DonnellDEHyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary diseaseProc Am Thorac Soc20063218018416565429
   PubMedGoogle Scholar
• PepinVSaeyDLavioletteLMaltaisFExercise capacity in chronic obstructive pulmonary disease: mechanisms of limitationCOPD20074319520417729063
   PubMedGoogle Scholar
• AlivertiAMacklemPTThe major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor musclesJ Appl Physiol2008105274975118678622
   PubMed Web of Science ®Google Scholar
• DebigareRMaltaisFThe major limitation to exercise performance in COPD is lower limb muscle dysfunctionJ Appl Physiol2008105275175318678623
   PubMed Web of Science ®Google Scholar
• O’DonnellDEWebbKAThe major limitation to exercise performance in COPD is dynamic hyperinflationJ Appl Physiol2008105275375518678624
   PubMed Web of Science ®Google Scholar
• WatzHWaschkiBMeyerTDecreasing cardiac chamber sizes and associated heart dysfunction in COPD: role of hyperinflationChest20101381323820190002
   PubMed Web of Science ®Google Scholar
• TzaniPAielloMEliaDDynamic hyperinflation is associated with a poor cardiovascular response to exercise in COPD patientsRespir Res20111215022074289
   PubMed Web of Science ®Google Scholar
• LoringSHGarcia-JacquesMMalhotraAPulmonary characteristics in COPD and mechanisms of increased work of breathingJ Appl Physiol2009107130931419359620
   PubMed Web of Science ®Google Scholar
• OfirDLavenezianaPWebbKALamYMO’DonnellDEMechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2008177662262918006885
   PubMed Web of Science ®Google Scholar
• O’DonnellDELavenezianaPOraJWebbKALamYMOfirDEvaluation of acute bronchodilator reversibility in patients with symptoms of GOLD stage I COPDThorax200964321622319052054
   PubMed Web of Science ®Google Scholar
• GagnonPSaeyDProvencherSWalking exercise response to bronchodilation in mild COPD: a randomized trialRespir Med2012106121695170522999808
   PubMed Web of Science ®Google Scholar
• HenkeKGSharrattMPegelowDDempseyJARegulation of end-expiratory lung volume during exerciseJ Appl Physiol19886411351463356631
   PubMed Web of Science ®Google Scholar
• O’DonnellDELavenezianaPPhysiology and consequences of lung hyperinflation in COPDEur Respir Rev2006151006167
   Google Scholar
• MeadJTurnerJMMacklemPTLittleJBSignificance of the relationship between lung recoil and maximum expiratory flowJ Appl Physiol1967221951086017658
   PubMed Web of Science ®Google Scholar
• PrideNBAgeing and changes in lung mechanicsEur Respir J200526456356516204583
   PubMed Web of Science ®Google Scholar
• ThurlbeckWMOverview of the pathology of pulmonary emphysema in the humanClin Chest Med1983433373506357598
   PubMed Web of Science ®Google Scholar
• GrimbyGGoldmanMMeadJRespiratory muscle action inferred from rib cage and abdominal V-P partitioningJ Appl Physiol1976415 Pt 1739751993162
   PubMed Web of Science ®Google Scholar
• DoddDSBrancatisanoTEngelLAChest wall mechanics during exercise in patients with severe chronic air-flow obstructionAm Rev Respir Dis1984129133386230971
   PubMed Web of Science ®Google Scholar
• O’DonnellDELavenezianaPThe clinical importance of dynamic lung hyperinflation in COPDCOPD20063421923217361503
   PubMedGoogle Scholar
• BarnesPJChronic obstructive pulmonary diseaseN Engl J Med2000343426928010911010
   PubMed Web of Science ®Google Scholar
• Milic-EmiliJDynamic pulmonary hyperinflation and intrinsic PEEP: consequences and management in patients with chronic obstructive pulmonary diseaseRecenti Prog Med19908111733737 Italian2126881
   PubMedGoogle Scholar
• HaluszkaJChartrandDAGrassinoAEMilic-EmiliJIntrinsic PEEP and arterial PCO2 in stable patients with chronic obstructive pulmonary diseaseAm Rev Respir Dis19901415 Pt 1119411972111105
   PubMed Web of Science ®Google Scholar
• BarnesNBushAHowling for the moonThorax201166864564621415246
   PubMed Web of Science ®Google Scholar
• HoggJCChuFUtokaparchSThe nature of small-airway obstruction in chronic obstructive pulmonary diseaseN Engl J Med2004350262645265315215480
   PubMed Web of Science ®Google Scholar
• McDonoughJEYuanRSuzukiMSmall-airway obstruction and emphysema in chronic obstructive pulmonary diseaseN Engl J Med2011365171567157522029978
   PubMed Web of Science ®Google Scholar
• CorbinRPLovelandMMartinRRMacklemPTA four-year follow-up study of lung mechanics in smokersAm Rev Respir Dis19791202293304475151
   PubMed Web of Science ®Google Scholar
• DeesomchokAWebbKAForkertLLung hyperinflation and its reversibility in patients with airway obstruction of varying severityCOPD20107642843721166631
   PubMedGoogle Scholar
• GuenetteJAChinRCCoryJMWebbKAO’DonnellDEInspiratory capacity during exercise: measurement, analysis, and interpretationPulm Med2013201395608123476765
   PubMedGoogle Scholar
• GuenetteJAWebbKAO’DonnellDEDoes dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD?Eur Respir J201240232232922183485
   PubMed Web of Science ®Google Scholar
• ChinRCGuenetteJAChengSDoes the respiratory system limit exercise in mild chronic obstructive pulmonary disease?Am J Respir Crit Care Med2013187121315132323590271
   PubMed Web of Science ®Google Scholar
• BabbTGRodarteJRLung volumes during low-intensity steady-state cyclingJ Appl Physiol19917029349372022587
   PubMed Web of Science ®Google Scholar
• O’DonnellDEVoducNFitzpatrickMWebbKAEffect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary diseaseEur Respir J2004241869415293609
   PubMed Web of Science ®Google Scholar
• O’DonnellDEFlugeTGerkenFEffects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPDEur Respir J200423683284015218994
   PubMed Web of Science ®Google Scholar
• NederJAFuldJPOverendTEffects of formoterol on exercise tolerance in severely disabled patients with COPDRespir Med2007101102056206417658249
   PubMed Web of Science ®Google Scholar
• MaltaisFCelliBCasaburiRAclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPDRespir Med2011105458058721183326
   PubMed Web of Science ®Google Scholar
• CalverleyPMKoulourisNGFlow limitation and dynamic hyperinflation: key concepts in modern respiratory physiologyEur Respir J200525118619915640341
   PubMed Web of Science ®Google Scholar
• JohnsonBDDempseyJADemand vs capacity in the aging pulmonary systemExerc Sport Sci Rev1991191712101936085
   PubMedGoogle Scholar
• JohnsonBDReddanWGPegelowDFSeowKCDempseyJAFlow limitation and regulation of functional residual capacity during exercise in a physically active aging populationAm Rev Respir Dis19911435 Pt 19609672024851
   PubMed Web of Science ®Google Scholar
• JohnsonBDReddanWGSeowKCDempseyJAMechanical constraints on exercise hyperpnea in a fit aging populationAm Rev Respir Dis19911435 Pt 19689772024852
   PubMed Web of Science ®Google Scholar
• LavenezianaPParkerCMO’DonnellDEVentilatory constraints and dyspnea during exercise in chronic obstructive pulmonary diseaseAppl Physiol Nutr Metab20073261225123818059601
   PubMed Web of Science ®Google Scholar
• O’DonnellDEWebbKAExertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflationAm Rev Respir Dis19931485135113578239175
   PubMed Web of Science ®Google Scholar
• BelmanMJBotnickWCShinJWInhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med199615339679758630581
   PubMed Web of Science ®Google Scholar
• O’DonnellDEHamiltonALWebbKASensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPDJ Appl Physiol200610141025103516675610
   PubMed Web of Science ®Google Scholar
• O’DonnellDETraversJWebbKAReliability of ventilatory parameters during cycle ergometry in multicentre trials in COPDEur Respir J200934486687419282342
   PubMed Web of Science ®Google Scholar
• SimilowskiTYanSGauthierAPMacklemPTBellemareFContractile properties of the human diaphragm during chronic hyperinflationN Engl J Med1991325139179231881417
   PubMed Web of Science ®Google Scholar
• SinderbyCSpahijaJBeckJDiaphragm activation during exercise in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med200116371637164111401887
   PubMed Web of Science ®Google Scholar
• PolkeyMIHamnegardCHHughesPDRaffertyGFGreenMMoxhamJInfluence of acute lung volume change on contractile properties of human diaphragmJ Appl Physiol1998854132213289760323
   PubMed Web of Science ®Google Scholar
• GeaJCasadevallCPascualSOrozco-LeviMBarreiroERespiratory diseases and muscle dysfunctionExpert Rev Respir Med201261759022283581
   PubMed Web of Science ®Google Scholar
• ShindohCHidaWKikuchiYOxygen consumption of respiratory muscles in patients with COPDChest199410537907978131542
   PubMed Web of Science ®Google Scholar
• ByrdRBHyattREMaximal respiratory pressures in chronic obstructive lung diseaseAm Rev Respir Dis19689858488565683479
   PubMed Web of Science ®Google Scholar
• SinghBEastwoodPRFinucaneKEVolume displaced by diaphragm motion in emphysemaJ Appl Physiol20019151913192311641325
   PubMed Web of Science ®Google Scholar
• MadorMJKufelTJPinedaLASharmaGKDiaphragmatic fatigue and high-intensity exercise in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2000161111812310619807
   PubMed Web of Science ®Google Scholar
• LevineSKaiserLLeferovichJTikunovBCellular adaptations in the diaphragm in chronic obstructive pulmonary diseaseN Engl J Med199733725179918069400036
   PubMed Web of Science ®Google Scholar
• DoucetMDebigareRJoanisseDRAdaptation of the diaphragm and the vastus lateralis in mild-to-moderate COPDEur Respir J200424697197915572541
   PubMed Web of Science ®Google Scholar
• Orozco-LeviMGeaJLloretaJLSubcellular adaptation of the human diaphragm in chronic obstructive pulmonary diseaseEur Respir J199913237137810065684
   PubMed Web of Science ®Google Scholar
• RiberaFN’GuessanBZollJMitochondrial electron transport chain function is enhanced in inspiratory muscles of patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2003167687387912493645
   PubMed Web of Science ®Google Scholar
• St CroixCMMorganBJWetterTJDempseyJAFatiguing inspiratory muscle work causes reflex sympathetic activation in humansJ Physiol2000529Pt 249350411101657
   PubMed Web of Science ®Google Scholar
• SheelAWDerchakPAMorganBJPegelowDFJacquesAJDempseyJAFatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humansJ Physiol2001537Pt 127728911711580
   PubMed Web of Science ®Google Scholar
• DempseyJASheelAWSt CroixCMMorganBJRespiratory influences on sympathetic vasomotor outflow in humansRespir Physiol Neurobiol2002130132012380012
   PubMed Web of Science ®Google Scholar
• RomerLMLoveringATHaverkampHCPegelowDFDempseyJAEffect of inspiratory muscle work on peripheral fatigue of locomotor muscles in healthy humansJ Physiol2006571Pt 242543916373384
   PubMed Web of Science ®Google Scholar
• AmannMReganMSKobitaryMImpact of pulmonary system limitations on locomotor muscle fatigue in patients with COPDAm J Physiol Regul Integr Comp Physiol20102991R314R32420445160
   PubMed Web of Science ®Google Scholar
• ChiappaGRQueirogaFJrMedaEHeliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2009179111004101019299497
   PubMed Web of Science ®Google Scholar
• LavenezianaPPalangePOraJMartoliniDO’DonnellDEBronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPDEur J Appl Physiol2009107663364319711095
   PubMed Web of Science ®Google Scholar
• LouvarisZZakynthinosSAlivertiAHeliox increases quadriceps muscle oxygen delivery during exercise in COPD patients with and without dynamic hyperinflationJ Appl Physiol201211371012102322879534
   PubMed Web of Science ®Google Scholar
• MahlerDABrentBNLokeJZaretBLMatthayRARight ventricular performance and central circulatory hemodynamics during upright exercise in patients with chronic obstructive pulmonary diseaseAm Rev Respir Dis198413057227296388444
   PubMed Web of Science ®Google Scholar
• LightRWMintzHMLindenGSBrownSEHemodynamics of patients with severe chronic obstructive pulmonary disease during progressive upright exerciseAm Rev Respir Dis198413033913956476589
   PubMed Web of Science ®Google Scholar
• Montes de OcaMRassuloJCelliBRRespiratory muscle and cardiopulmonary function during exercise in very severe COPDAm J Respir Crit Care Med19961545128412898912737
   PubMed Web of Science ®Google Scholar
• VizzaCDLynchJPOchoaLLRichardsonGTrulockEPRight and left ventricular dysfunction in patients with severe pulmonary diseaseChest199811335765839515827
   PubMed Web of Science ®Google Scholar
• RanieriVMDambrosioMBrienzaNIntrinsic PEEP and cardiopulmonary interaction in patients with COPD and acute ventilatory failureEur Respir J199696128312928804950
   PubMed Web of Science ®Google Scholar
• Oswald-MammosserMApprillMBachezPEhrhartMWeitzenblumEPulmonary hemodynamics in chronic obstructive pulmonary disease of the emphysematous typeRespiration1991585–63043101792422
   PubMed Web of Science ®Google Scholar
• WrobelJPThompsonBRWilliamsTJMechanisms of pulmonary hypertension in chronic obstructive pulmonary disease: a pathophysiologic reviewJ Heart Lung Transplant201231655756422502811
   PubMed Web of Science ®Google Scholar
• VassauxCTorre-BouscouletLZeineldineSEffects of hyperinflation on the oxygen pulse as a marker of cardiac performance in COPDEur Respir J20083251275128218550609
   PubMed Web of Science ®Google Scholar
• Stark-LeyvaKNBeckKCJohnsonBDInfluence of expiratory loading and hyperinflation on cardiac output during exerciseJ Appl Physiol20049651920192714729724
   PubMed Web of Science ®Google Scholar
• VogiatzisIZakynthinosSFactors limiting exercise tolerance in chronic lung diseasesCompr Physiol2012231779181723723024
   PubMed Web of Science ®Google Scholar
• DiazOVillafrancaCGhezzoHRole of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at restEur Respir J200016226927510968502
   PubMed Web of Science ®Google Scholar
• O’DonnellDELamMWebbKAMeasurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med19981585 Pt 1155715659817708
   PubMed Web of Science ®Google Scholar
• PetersMMWebbKAO’DonnellDECombined physiological effects of bronchodilators and hyperoxia on exertional dyspnoea in normoxic COPDThorax200661755956716467067
   PubMed Web of Science ®Google Scholar
• [No authors listed]Obesity: preventing and managing the global epidemic. Report of a WHO consultationWorld Health Organ Tech Rep Ser2000894ixii125311234459
   PubMed Web of Science ®Google Scholar
• LittletonSWImpact of obesity on respiratory functionRespirology2012171434922040049
   PubMed Web of Science ®Google Scholar
• SalomeCMKingGGBerendNPhysiology of obesity and effects on lung functionJ Appl Physiol2010108120621119875713
   PubMed Web of Science ®Google Scholar
• LeoneNCourbonDThomasFLung function impairment and metabolic syndrome: the critical role of abdominal obesityAm J Respir Crit Care Med2009179650951619136371
   PubMed Web of Science ®Google Scholar
• SutherlandTJGouldingAGrantAMThe effect of adiposity measured by dual-energy X-ray absorptiometry on lung functionEur Respir J2008321859118353855
   PubMed Web of Science ®Google Scholar
• BabbTGWyrickBLDeLoreyDSChasePJFengMYFat distribution and end-expiratory lung volume in lean and obese men and womenChest2008134470471118641101
   PubMed Web of Science ®Google Scholar
• OfirDLavenezianaPWebbKAO’DonnellDEVentilatory and perceptual responses to cycle exercise in obese womenJ Appl Physiol200710262217222617234804
   PubMed Web of Science ®Google Scholar
• HamouiNAnthoneGCrookesPFThe value of pulmonary function testing prior to bariatric surgeryObes Surg200616121570157317217631
   PubMed Web of Science ®Google Scholar
• JonesRLNzekwuMMThe effects of body mass index on lung volumesChest2006130382783316963682
   PubMed Web of Science ®Google Scholar
• ParameswaranKToddDCSothMAltered respiratory physiology in obesityCan Respir J200613420321016779465
   PubMedGoogle Scholar
• JubberASRespiratory complications of obesityInt J Clin Pract200458657358015311557
   PubMed Web of Science ®Google Scholar
• CanoyDLubenRWelchAAbdominal obesity and respiratory function in men and women in the EPIC-Norfolk Study, United KingdomAm J Epidemiol2004159121140114915191931
   PubMed Web of Science ®Google Scholar
• KoenigSMPulmonary complications of obesityAm J Med Sci2001321424927911307867
   PubMed Web of Science ®Google Scholar
• RochesterDFObesity and pulmonary functionAlpertMAlexanderJThe Heart and Lung in ObesityArmonk, NY, USAFutura Publishing Co1998
   Google Scholar
• PankowWPodszusTGutheilTPenzelTPeterJVon WichertPExpiratory flow limitation and intrinsic positive end-expiratory pressure in obesityJ Appl Physiol1998854123612439760311
   PubMed Web of Science ®Google Scholar
• LazarusRGoreCJBoothMOwenNEffects of body composition and fat distribution on ventilatory function in adultsAm J Clin Nutr199868135419665094
   PubMed Web of Science ®Google Scholar
• CollinsLCHobertyPDWalkerJFFletcherECPeirisANThe effect of body fat distribution on pulmonary function testsChest19951075129813027750322
   PubMed Web of Science ®Google Scholar
• ZerahFHarfAPerlemuterLLorinoHLorinoAMAtlanGEffects of obesity on respiratory resistanceChest19931035147014768486029
   PubMed Web of Science ®Google Scholar
• JenkinsSCMoxhamJThe effects of mild obesity on lung functionRespir Med19918543093111947368
   PubMed Web of Science ®Google Scholar
• RubinsteinIZamelNDuBarryLHoffsteinVAirflow limitation in morbidly obese, nonsmoking menAnn Intern Med1990112118288322378649
   PubMed Web of Science ®Google Scholar
• SurattPMWilhoitSCHsiaoHSAtkinsonRLRochesterDFCompliance of chest wall in obese subjectsJ Appl Physiol Respir Environ Exerc Physiol19845724034076469810
   PubMed Web of Science ®Google Scholar
• RayCSSueDYBrayGHansenJEWassermanKEffects of obesity on respiratory functionAm Rev Respir Dis198312835015066614644
   PubMed Web of Science ®Google Scholar
• LadoskyWBotelhoMAAlbuquerqueJPJrChest mechanics in morbidly obese non-hypoventilated patientsRespir Med200195428128611316110
   PubMed Web of Science ®Google Scholar
• KellyTMJensenRLElliottCGCrapoROMaximum respiratory pressures in morbidly obese subjectsRespiration198854273773231898
   PubMed Web of Science ®Google Scholar
• ThomasPSCowenERHulandsGMilledgeJSRespiratory function in the morbidly obese before and after weight lossThorax19894453823862503905
   PubMed Web of Science ®Google Scholar
• EmirgilCSobolBJThe effects of weight reduction on pulmonary function and the sensitivity of the respiratory center in obesityAm Rev Respir Dis197310848318424741877
   PubMed Web of Science ®Google Scholar
• BiringMSLewisMILiuJTMohsenifarZPulmonary physiologic changes of morbid obesityAm J Med Sci1999318529329710555090
   PubMed Web of Science ®Google Scholar
• PelosiPCrociMRavagnanIThe effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesiaAnesth Analg19988736546609728848
   PubMed Web of Science ®Google Scholar
• ColletFMallartABervarJFPhysiologic correlates of dyspnea in patients with morbid obesityInt J Obes (Lond)200731470070617006440
   PubMed Web of Science ®Google Scholar
• WatsonRAPrideNBPostural changes in lung volumes and respiratory resistance in subjects with obesityJ Appl Physiol200598251251715475605
   PubMed Web of Science ®Google Scholar
• BurkiNKBakerRWVentilatory regulation in eucapnic morbid obesityAm Rev Respir Dis198412945385436424520
   PubMed Web of Science ®Google Scholar
• SchachterLMSalomeCMPeatJKWoolcockAJObesity is a risk for asthma and wheeze but not airway hyperresponsivenessThorax20015614811120896
   PubMed Web of Science ®Google Scholar
• SinDDJonesRLManSFObesity is a risk factor for dyspnea but not for airflow obstructionArch Intern Med2002162131477148112090884
   PubMedGoogle Scholar
• BabbTGWyrickBLChasePJWeight loss via diet and exercise improves exercise breathing mechanics in obese menChest2011140245446021273293
   PubMed Web of Science ®Google Scholar
• BoisellePMLitmanovichDEMichaudGDynamic expiratory tracheal collapse in morbidly obese COPD patientsCOPD201310560461023837455
   PubMedGoogle Scholar
• OraJLavenezianaPWadellKPrestonMWebbKAO’DonnellDEEffect of obesity on respiratory mechanics during rest and exercise in COPDJ Appl Physiol20111111101921350021
   PubMed Web of Science ®Google Scholar
• SavaFLavioletteLBernardSBretonMJBourbeauJMaltaisFThe impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPDBMC Pulm Med2010105521054892
   PubMed Web of Science ®Google Scholar
• LavioletteLSavaFO’DonnellDEEffect of obesity on constant workrate exercise in hyperinflated men with COPDBMC Pulm Med2010103320509967
   PubMed Web of Science ®Google Scholar
• OraJLavenezianaPOfirDDeesomchokAWebbKAO’DonnellDECombined effects of obesity and chronic obstructive pulmonary disease on dyspnea and exercise toleranceAm J Respir Crit Care Med20091801096497119897773
   PubMed Web of Science ®Google Scholar
• StocksJQuanjerPHReference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory SocietyEur Respir J1995834925067789503
   PubMed Web of Science ®Google Scholar
• QuanjerPHTammelingGJCotesJEPedersenOFPeslinRYernaultJCLung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory SocietyEur Respir J Suppl1993165408499054
   PubMedGoogle Scholar
• McClaranSRHarmsCAPegelowDFDempseyJASmaller lungs in women affect exercise hyperpneaJ Appl Physiol (1985)1998846187218819609779
   PubMed Web of Science ®Google Scholar
• GuenetteJAWittJDMcKenzieDCRoadJDSheelAWRespiratory mechanics during exercise in endurance-trained men and womenJ Physiol2007581Pt 31309132217412775
   PubMed Web of Science ®Google Scholar
• DeruelleFNourryCMucciPDifference in breathing strategies during exercise between trained elderly men and womenScand J Med Sci Sports200818221322017490460
   PubMed Web of Science ®Google Scholar
• LavioletteLLacasseYDoucetMChronic obstructive pulmonary disease in womenCan Respir J2007142939817372636
   PubMed Web of Science ®Google Scholar
• MartinezFJCurtisJLSciurbaFSex differences in severe pulmonary emphysemaAm J Respir Crit Care Med2007176324325217431226
   PubMed Web of Science ®Google Scholar
• CampPGCoxsonHOLevyRDSex differences in emphysema and airway disease in smokersChest200913661480148819617404
   PubMed Web of Science ®Google Scholar
• LavioletteLO’DonnellDEWebbKAHamiltonALKestenSMaltaisFPerformance during constant workrate cycling exercise in women with COPD and hyperinflationCOPD20096534035119863363
   PubMedGoogle Scholar
• GuenetteJAJensenDWebbKAOfirDRaghavanNO’DonnellDESex differences in exertional dyspnea in patients with mild COPD: physiological mechanismsRespir Physiol Neurobiol2011177321822721524719
   PubMed Web of Science ®Google Scholar
• WangerJClausenJLCoatesAStandardisation of the measurement of lung volumesEur Respir J200526351152216135736
   PubMed Web of Science ®Google Scholar
• PellegrinoRViegiGBrusascoVInterpretative strategies for lung function testsEur Respir J200526594896816264058
   PubMed Web of Science ®Google Scholar
• CoatesALPeslinRRodensteinDStocksJMeasurement of lung volumes by plethysmographyEur Respir J1997106141514279192953
   PubMed Web of Science ®Google Scholar
• FishmanAMartinezFNaunheimKA randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysemaN Engl J Med2003348212059207312759479
   PubMed Web of Science ®Google Scholar
• BurkiNKKrumpelmanJLCorrelation of pulmonary function with the chest roentgenogram in chronic airway obstructionAm Rev Respir Dis198012122172237362131
   PubMed Web of Science ®Google Scholar
• SimonGPrideNBJonesNLRaimondiACRelation between abnormalities in the chest radiograph and changes in pulmonary function in chronic bronchitis and emphysemaThorax197328115234685207
   PubMed Web of Science ®Google Scholar
• NakanoYMuroSSakaiHComputed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung functionAm J Respir Crit Care Med20001623 Pt 11102110810988137
   PubMed Web of Science ®Google Scholar
• de JongPAMullerNLParePDCoxsonHOComputed tomographic imaging of the airways: relationship to structure and functionEur Respir J200526114015215994401
   PubMed Web of Science ®Google Scholar
• StubbingDGPengellyLDMorseJLJonesNLPulmonary mechanics during exercise in subjects with chronic airflow obstructionJ Appl Physiol Respir Environ Exerc Physiol19804935115157204175
   PubMed Web of Science ®Google Scholar
• VogiatzisIGeorgiadouOGolematiSPatterns of dynamic hyperinflation during exercise and recovery in patients with severe chronic obstructive pulmonary diseaseThorax200560972372915964912
   PubMed Web of Science ®Google Scholar
• MaltaisFHamiltonAMarciniukDImprovements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPDChest200512831168117816162703
   PubMed Web of Science ®Google Scholar
• CasanovaCCoteCde TorresJPInspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2005171659159715591470
   PubMed Web of Science ®Google Scholar
• AlivertiAStevensonNDellacaRLLo MauroAPedottiACalverleyPMRegional chest wall volumes during exercise in chronic obstructive pulmonary diseaseThorax200459321021614985554
   PubMed Web of Science ®Google Scholar
• ClarenbachCFSennOBrackTKohlerMBlochKEMonitoring of ventilation during exercise by a portable respiratory inductive plethysmographChest200512831282129016162719
   PubMed Web of Science ®Google Scholar
• van’t HulAKwakkelGGosselinkRThe acute effects of noninvasive ventilatory support during exercise on exercise endurance and dyspnea in patients with chronic obstructive pulmonary disease: a systematic reviewJ Cardiopulm Rehabil200222429029712202851
   PubMedGoogle Scholar
• van’t HulAGosselinkRHollanderPPostmusPKwakkelGAcute effects of inspiratory pressure support during exercise in patients with COPDEur Respir J2004231344014738228
   PubMed Web of Science ®Google Scholar
• O’DonnellDEVentilatory limitations in chronic obstructive pulmonary diseaseMed Sci Sports Exerc200133Suppl 7S647S65511462073
   PubMed Web of Science ®Google Scholar
• O’DonnellDESaniiRYounesMImprovement in exercise endurance in patients with chronic airflow limitation using continuous positive airway pressureAm Rev Respir Dis19881386151015143059897
   PubMed Web of Science ®Google Scholar
• PetrofBJCalderiniEGottfriedSBEffect of CPAP on respiratory effort and dyspnea during exercise in severe COPDJ Appl Physiol19906911791882203722
   PubMed Web of Science ®Google Scholar
• MaltaisFReissmannHGottfriedSBPressure support reduces inspiratory effort and dyspnea during exercise in chronic airflow obstructionAm J Respir Crit Care Med19951514102710337697226
   PubMed Web of Science ®Google Scholar
• PolkeyMIKyroussisDMillsGHInspiratory pressure support reduces slowing of inspiratory muscle relaxation rate during exhaustive treadmill walking in severe COPDAm J Respir Crit Care Med19961544 Pt 1114611508887619
   PubMed Web of Science ®Google Scholar
• Orozco-LeviMStructure and function of the respiratory muscles in patients with COPD: impairment or adaptation?Eur Respir J Suppl20034641s51s14621106
   PubMedGoogle Scholar
• RochesterDFThe respiratory muscles in COPD. State of the artChest198485Suppl 647S50S6373180
   PubMed Web of Science ®Google Scholar
• AmbrosinoNStrambiSNew strategies to improve exercise tolerance in chronic obstructive pulmonary diseaseEur Respir J200424231332215332404
   PubMed Web of Science ®Google Scholar
• HarmsCABabcockMAMcClaranSRRespiratory muscle work compromises leg blood flow during maximal exerciseJ Appl Physiol1997825157315839134907
   PubMed Web of Science ®Google Scholar
• HarmsCAWetterTJSt CroixCMPegelowDFDempseyJAEffects of respiratory muscle work on exercise performanceJ Appl Physiol200089113113810904044
   PubMed Web of Science ®Google Scholar
• Borghi-SilvaAOliveiraCCCarrascosaCRespiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPDThorax2008631091091518492743
   PubMed Web of Science ®Google Scholar
• BradleyJMLassersonTElbornSMacmahonJO’NeillBA systematic review of randomized controlled trials examining the short-term benefit of ambulatory oxygen in COPDChest2007131127828517218587
   PubMed Web of Science ®Google Scholar
• O’DonnellDED’ArsignyCWebbKAEffects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2001163489289811282762
   PubMed Web of Science ®Google Scholar
• SomfayAPorszaszJLeeSMCasaburiRDose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patientsEur Respir J2001181778411510809
   PubMed Web of Science ®Google Scholar
• DolmageTEEvansRAGoldsteinRSDefining hyperinflation as ‘dynamic’: moving toward the slopeRespir Med2013107795395823478191
   PubMed Web of Science ®Google Scholar
• PalangePValliGOnoratiPEffect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patientsJ Appl Physiol20049751637164215234959
   PubMed Web of Science ®Google Scholar
• HuntTWilliamsMTFrithPSchembriDHeliox, dyspnoea and exercise in COPDEur Respir Rev201019115303820956163
   PubMedGoogle Scholar
• EvesNDPetersenSRHaykowskyMJWongEYJonesRLHelium-hyperoxia, exercise, and respiratory mechanics in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2006174776377116840742
   PubMed Web of Science ®Google Scholar
• HussainOCollinsEGAdiguzelNLangbeinWETobinMJLaghiFContrasting pressure-support ventilation and helium-oxygen during exercise in severe COPDRespir Med2011105349450520851591
   PubMed Web of Science ®Google Scholar
• QueirogaFJrNunesMMedaEExercise tolerance with helium-hyperoxia versus hyperoxia in hypoxaemic patients with COPDEur Respir J201342236237023180584
   PubMed Web of Science ®Google Scholar
• O’DonnellDEWebbKABertleyJCChauLKConlanAAMechanisms of relief of exertional breathlessness following unilateral bullectomy and lung volume reduction surgery in emphysemaChest1996110118278681624
   PubMed Web of Science ®Google Scholar
• BendittJOWoodDEMcCoolFDLewisSAlbertRKChanges in breathing and ventilatory muscle recruitment patterns induced by lung volume reduction surgeryAm J Respir Crit Care Med199715512792849001325
   PubMed Web of Science ®Google Scholar
• MartinezFJde OcaMMWhyteRIStetzJGaySECelliBRLung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle functionAm J Respir Crit Care Med19971556198419909196106
   PubMed Web of Science ®Google Scholar
• LaghiFJubranATopeliAEffect of lung volume reduction surgery on neuromechanical coupling of the diaphragmAm J Respir Crit Care Med199815724754839476861
   PubMed Web of Science ®Google Scholar
• BendittJOLewisSWoodDEKlimaLAlbertRKLung volume reduction surgery improves maximal O2 consumption, maximal minute ventilation, O2 pulse, and dead space-to-tidal volume ratio during leg cycle ergometryAm J Respir Crit Care Med19971562 Pt 15615669279240
   PubMed Web of Science ®Google Scholar
• CordovaFO’BrienGFurukawaSKuzmaAMTravalineJCrinerGJStability of improvements in exercise performance and quality of life following bilateral lung volume reduction surgery in severe COPDChest199711249079159377952
   PubMed Web of Science ®Google Scholar
• KellerCARuppelGHibbettAOsterlohJNaunheimKSThoracoscopic lung volume reduction surgery reduces dyspnea and improves exercise capacity in patients with emphysemaAm J Respir Crit Care Med1997156160679230727
   PubMed Web of Science ®Google Scholar
• MarchandEGayan-RamirezGDe LeynPDecramerMPhysiological basis of improvement after lung volume reduction surgery for severe emphysema: where are we?Eur Respir J199913368669610232448
   PubMed Web of Science ®Google Scholar
• FesslerHEScharfSMIngenitoEPMcKennaRJJrSharafkhanehAPhysiologic basis for improved pulmonary function after lung volume reductionProc Am Thorac Soc20085441642018453348
   PubMedGoogle Scholar
• LacasseYGuyattGHGoldsteinRSThe components of a respiratory rehabilitation program: a systematic overviewChest19971114107710889106590
   PubMed Web of Science ®Google Scholar
• CasaburiRPorszaszJReduction of hyperinflation by pharmacologic and other interventionsProc Am Thorac Soc20063218518916565430
   PubMedGoogle Scholar
• CasaburiRZuWallackRPulmonary rehabilitation for management of chronic obstructive pulmonary diseaseN Engl J Med2009360131329133519321869
   PubMed Web of Science ®Google Scholar
• O’DonnellDEOraJWebbKALavenezianaPJensenDMechanisms of activity-related dyspnea in pulmonary diseasesRespir Physiol Neurobiol2009167111613219450767
   PubMed Web of Science ®Google Scholar
• TroostersTGosselinkRJanssensWDecramerMExercise training and pulmonary rehabilitation: new insights and remaining challengesEur Respir Rev201019115242920956162
   PubMedGoogle Scholar
• PorszaszJEmtnerMGotoSSomfayAWhippBJCasaburiRExercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPDChest200512842025203416236851
   PubMed Web of Science ®Google Scholar
• Puente-MaestuLAbadYMPedrazaFSanchezGStringerWWA controlled trial of the effects of leg training on breathing pattern and dynamic hyperinflation in severe COPDLung2006184315916716902841
   PubMed Web of Science ®Google Scholar
• SpahijaJMarchieMGhezzoHGrassinoAFactors discriminating spontaneous pursed-lips breathing use in patients with COPDCOPD20107425426120673034
   PubMedGoogle Scholar
• CasciariRJFairshterRDHarrisonAMorrisonJTBlackburnCWilsonAFEffects of breathing retraining in patients with chronic obstructive pulmonary diseaseChest19817943933987226902
   PubMed Web of Science ®Google Scholar
• GarrodRDallimoreKCookJDaviesVQuadeKAn evaluation of the acute impact of pursed lips breathing on walking distance in nonspontaneous pursed lips breathing chronic obstructive pulmonary disease patientsChron Respir Dis200522677216279153
   PubMedGoogle Scholar
• CollinsEGLangbeinWEFehrLCan ventilation-feedback training augment exercise tolerance in patients with chronic obstructive pulmonary disease?Am J Respir Crit Care Med2008177884485218202351
   PubMed Web of Science ®Google Scholar
• GosselinkRDe VosJvan den HeuvelSPSegersJDecramerMKwakkelGImpact of inspiratory muscle training in patients with COPD: what is the evidence?Eur Respir J201137241642521282809
   PubMed Web of Science ®Google Scholar
• PetrovicMReiterMZipkoHPohlWWankeTEffects of inspiratory muscle training on dynamic hyperinflation in patients with COPDInt J Chron Obstruct Pulmon Dis2012779780523233798
   PubMed Web of Science ®Google Scholar