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Review

Clinical issues of mucus accumulation in COPD

, &
Pages 139-150 | Published online: 24 Jan 2014

References

  • VestboJHurdSSAgustíAGGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summaryAm J Respir Crit Care Med2013187434736522878278
  • World Health OrganizationWorld Health Statistics 2008Geneva, SwitzerlandWorld Health Organization2008 Available from: http://www.who.int/whosis/whostat/EN_WHS08_Full.pdfAccessed July 23, 2013
  • VoynowJARubinBKMucins, mucus, and sputumChest2009135250551219201713
  • ShadeDJrCordovaFCNormal lung structureCrinerGJD’AlonzoGEPulmonary Pathophysiology1st ed199920
  • FahyJVDickeyBFAirway mucus function and dysfunctionN Engl J Med2010363232233224721121836
  • ThorntonDJRousseauKMcGuckinMAStructure and function of the polymeric mucins in airways mucusAnnu Rev Physiol20087045948617850213
  • KimVCrinerGJChronic bronchitis and chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2013187322823723204254
  • ReidLMeasurement of the bronchial mucous gland layer: A diagnostic yardstick in chronic bronchitisThorax19601513214114437095
  • MullenJBWrightJLWiggsBRParePDHoggJCReassessment of inflammation of airways in chronic bronchitisBr Med J (Clin Res Ed)1985291650412351239
  • EbertRVTerracioMJThe bronchiolar epithelium in cigarette smokers. Observations with the scanning electron microscopeAm Rev Respir Dis197511114111111397
  • DeshmukhHSCaseLMWesselkamperSCMetalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activationAm J Respir Crit Care Med2005171430531415531749
  • HoltzmanMJTynerJWKimEYAcute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary diseaseProc Am Thorac Soc20052213214016113481
  • BurgelPRNadelJARoles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epitheliumThorax2004591199299615516478
  • HoggJCChuFUtokaparchSThe nature of small-airway obstruction in chronic obstructive pulmonary diseaseN Engl J Med2004350262645265315215480
  • VerraFEscudierELebargyFBernaudinJFDe CrémouxHBignonJCiliary abnormalities in bronchial epithelium of smokers, ex-smokers, and nonsmokersAm J Respir Crit Care Med19951513 Pt 16306347881648
  • WilliamsOWSharafkhanehAKimVDickeyBFEvansCMAirway mucus: From production to secretionAm J Respir Cell Mol Biol200634552753616415249
  • SaettaMTuratoGBaraldoSGoblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitationAm J Respir Crit Care Med20001613 Pt 11016102110712357
  • InnesALWoodruffPGFerrandoREEpithelial mucin stores are increased in the large airways of smokers with airflow obstructionChest200613041102110817035444
  • DransfieldMTWilhelmAMFlanaganBAcquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPDChest2013144249850623538783
  • TakeyamaKJungBShimJJActivation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smokeAm J Physiol Lung Cell Mol Physiol20012801L165L17211133506
  • GuddoFVignolaAMSaettaMUpregulation of basic fibroblast growth factor in smokers with chronic bronchitisEur Respir J200627595796316510460
  • VignolaAMChanezPChiapparaGTransforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitisAm J Respir Crit Care Med19971562 Pt 15915999279245
  • HuangSLSuCHChangSCTumor necrosis factor-alpha gene polymorphism in chronic bronchitisAm J Respir Crit Care Med19971565143614399372657
  • KimVHanMKVanceGBCOPDGene InvestigatorsThe chronic bronchitic phenotype of COPD: an analysis of the COPDGene StudyChest2011140362663321474571
  • AgustiACalverleyPMCelliBEvaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigatorsRespir Res20101112220831787
  • de OcaMMHalbertRJLopezMVThe chronic bronchitis phenotype in subjects with and without COPD: the PLATINO studyEur Respir J2012401283622282547
  • SpeizerFEFayMEDockeryDWFerrisBGJrChronic obstructive pulmonary disease mortality in six US citiesAm Rev Respir Dis19891403 Pt 2S49S552782760
  • American Lung AssociationTrends in COPD (Chronic Bronchitis and Emphysema): Morbidity and MortalityWashington, DCAmerican Lung Association2013
  • HarmsenLThomsenSFIngebrigtsenTChronic mucus hypersecretion: prevalence and risk factors in younger individualsInt J Tuberc Lung Dis20101481052105820626952
  • EhrlichRIWhiteNNormanRPredictors of chronic bronchitis in South African adultsInt J Tuberc Lung Dis20048336937615139477
  • PelkonenMNotkolaILNissinenATukiainenHKoskelaHThirty-year cumulative incidence of chronic bronchitis and COPD in relation to 30-year pulmonary function and 40-year mortality: a follow-up in middle-aged rural menChest200613041129113717035447
  • MathesonMCBenkeGRavenJBiological dust exposure in the workplace is a risk factor for chronic obstructive pulmonary diseaseThorax200560864565116061705
  • TrupinLEarnestGSan PedroMThe occupational burden of chronic obstructive pulmonary diseaseEur Respir J200322346246914516136
  • SmyrniosNAIrwinRSCurleyFJChronic cough with a history of excessive sputum production. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapyChest199510849919977555175
  • ShermanCBXuXSpeizerFEFerrisBGJrWeissSTDockeryDWLongitudinal lung function decline in subjects with respiratory symptomsAm Rev Respir Dis199214648558591416410
  • VestboJPrescottELangePAssociation of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study GroupAm J Respir Crit Care Med19961535153015358630597
  • de MarcoRAccordiniSCerveriIIncidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegmAm J Respir Crit Care Med20071751323917008642
  • GuerraSSherrillDLVenkerCCeccatoCMHalonenMMartinezFDChronic bronchitis before age 50 years predicts incident airflow limitation and mortality riskThorax2009641089490019581277
  • LindbergAErikssonBLarssonLGRönmarkESandströmTLundbäckBSeven-year cumulative incidence of COPD in an age-stratified general population sampleChest2006129487988516608933
  • BurgelPRNesme-MeyerPChanezPInitiatives Bronchopneumopathie Chronique Obstructive Scientific CommitteeCough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjectsChest2009135497598219017866
  • PrescottELangePVestboJChronic mucus hypersecretion in COPD and death from pulmonary infectionEur Respir J199588133313387489800
  • LangePNyboeJAppleyardMJensenGSchnohrPRelation of ventilatory impairment and of chronic mucus hypersecretion to mortality from obstructive lung disease and from all causesThorax19904585795852402719
  • AnnesiIKauffmannFIs respiratory mucus hypersecretion really an innocent disorder? A 22-year mortality survey of 1,061 working menAm Rev Respir Dis198613446886933767125
  • TockmanMSComstockGWRespiratory risk factors and mortality: longitudinal studies in Washington County, MarylandAm Rev Respir Dis19891403 Pt 2S56S632782761
  • ManninoDMBuistASPettyTLEnrightPLReddSCLung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up studyThorax200358538839312728157
  • MullenJBWrightJLWiggsBRParéPDHoggJCStructure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: relationship to lung functionThorax198742118438483424265
  • SwanGEHodgkinJERobyTMittmanCJacoboNPetersJReversibility of airways injury over a 12-month period following smoking cessationChest199210136076121541120
  • WarnockLGatesAvan der SchansCPChest physiotherapy compared to no chest physiotherapy for cystic fibrosisCochrane Database Syst Rev20139CD00140124006212
  • van der SchansCPConventional chest physical therapy for obstructive lung diseaseRespir Care200752911981206 discussion 1206–120917716386
  • RubinBKMucolytics, expectorants, and mucokinetic medicationsRespir Care200752785986517594730
  • ThomsonMLPaviaDMcNicolMWA preliminary study of the effect of guaiphenesin on mucociliary clearance from the human lungThorax19732867427474595814
  • LevinMHSullivanSNielsonDYangBFinkbeinerWEVerkmanASHypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporinsJ Biol Chem200628135258032581216829520
  • BoucherRCCystic fibrosis: a disease of vulnerability to airway surface dehydrationTrends Mol Med200713623124017524805
  • ValderramasSRAtallahANEffectiveness and safety of hypertonic saline inhalation combined with exercise training in patients with chronic obstructive pulmonary disease: a randomized trialRespir Care200954332733319245725
  • FahyJVSteigerDJLiuJBasbaumCBFinkbeinerWEBousheyHAMarkers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjectsAm Rev Respir Dis19931475113211378484621
  • O’DonnellAEBarkerAFIlowiteJSFickRBTreatment of idiopathic bronchiectasis with aerosolized recombinant human DNase I. rhDNase Study GroupChest19981135132913349596315
  • TamaokiJKondoMTakizawaTEffect of cAMP on ciliary function in rabbit tracheal epithelial cellsJ Appl Physiol (1985)1989663103510392468639
  • DevaliaJLSapsfordRJRusznakCToumbisMJDaviesRJThe effects of salmeterol and salbutamol on ciliary beat frequency of cultured human bronchial epithelial cells, in vitroPulm Pharmacol1992542572631362105
  • SalatheMEffects of beta-agonists on airway epithelial cellsJ Allergy Clin Immunol2002110Suppl 6S275S28112464936
  • NguyenLPOmoluabiOParraSChronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma modelAm J Respir Cell Mol Biol200838325626218096872
  • NguyenLPLinRParraSBeta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine modelProc Natl Acad Sci U S A200910672435244019171883
  • WannerAEffects of methylxanthines on airway mucociliary functionAm J Med1985796A16213002175
  • AndersonGPeelETPardoeTJonesRSustained-release theophylline in chronic bronchitisBr J Dis Chest19827632612656751366
  • TaylorDRBuickBKinneyCLowryRCMcDevittDGThe efficacy of orally administered theophylline, inhaled salbutamol, and a combination of the two as chronic therapy in the management of chronic bronchitis with reversible air-flow obstructionAm Rev Respir Dis198513157477514003919
  • FosterWMLangenbackEGBergofskyEHLung mucociliary function in man: interdependence of bronchial and tracheal mucus transport velocities with lung clearance in bronchial asthma and healthy subjectsAnn Occup Hyg1982261–42272447181267
  • JonesPWBoshTKQuality of life changes in COPD patients treated with salmeterolAm J Respir Crit Care Med19971554128312899105068
  • MahlerDADonohueJFBarbeeRAEfficacy of salmeterol xinafoate in the treatment of COPDChest1999115495796510208192
  • van NoordJAAumannJLJanssensEEffects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPDChest2006129350951716537846
  • MelloniBGermoutyJThe influence of a new beta agonist: formoterol on mucociliary functionRev Mal Respir199295503507 French1439090
  • BatemanEDRennardSBarnesPJAlternative mechanisms for tiotropiumPulm Pharmacol Ther200922653354219635581
  • WineJJJooNSSubmucosal glands and airway defenseProc Am Thorac Soc200411475316113412
  • GhafouriMAPatilKDKassISputum changes associated with the use of ipratropium bromideChest19848633873936236043
  • BennettWDChapmanWFMascarellaJMThe acute effect of ipratropium bromide bronchodilator therapy on cough clearance in COPDChest199310324884958432142
  • CasaburiRBriggsDDJrDonohueJFSerbyCWMenjogeSSWitekTJJrThe spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. The US Tiotropium Study GroupChest200011851294130211083677
  • HasaniATomsNAgnewJESarnoMHarrisonAJDilworthPThe effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPDChest200412551726173415136383
  • HattotuwaKLGizyckiMJAnsariTWJefferyPKBarnesNCThe effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy studyAm J Respir Crit Care Med2002165121592159612070058
  • InnesALCarringtonSDThorntonDJEx vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthmaAm J Respir Crit Care Med2009180320321019423716
  • LeungSYEynottPNathPChungKFEffects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling featuresJ Allergy Clin Immunol2005115598999615867856
  • ChenYNickolaTJDiFronzoNLColberg-PoleyAMRoseMCDexamethasone-mediated repression of MUC5AC gene expression in human lung epithelial cellsAm J Respir Cell Mol Biol200634333834716239644
  • O’RiordanTGMaoYOteroRLopezJSabaterJRAbrahamWMBudesonide affects allergic mucociliary dysfunctionJ Appl Physiol (1985)1998853108610919729587
  • BurgePSCalverleyPMJonesPWSpencerSAndersonJAMaslenTKRandomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trialBMJ200032072451297130310807619
  • CalverleyPPauwelsRVestboJTRial of Inhaled STeroids ANd long-acting beta2 agonists study groupCombined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trialLancet2003361935644945612583942
  • SzafranskiWCukierARamirezAEfficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary diseaseEur Respir J2003211748112570112
  • ChongJPoolePLeungBBlackPNPhosphodiesterase 4 inhibitors for chronic obstructive pulmonary diseaseCochrane Database Syst Rev2011CD00230921563134
  • CalverleyPMRabeKFGoehringUMKristiansenSFabbriLMMartinezFJM2-124 and M2-125 study groupsRoflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trialsLancet2009374969168569419716960
  • FabbriLMCalverleyPMIzquierdo-AlonsoJLM2-127 and M2-128 study groupsRoflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trialsLancet2009374969169570319716961
  • MacNeeWOxidants/antioxidants and COPDChest20001175 Suppl 1303S317S10843965
  • IshibashiYTakayamaGInouyeYTaniguchiACarbocisteine normalizes the viscous property of mucus through regulation of fucosylated and sialylated sugar chain on airway mucinsEur J Pharmacol20106412–322622820553908
  • DecramerMRutten-van MölkenMDekhuijzenPNEffects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trialLancet200536594701552156015866309
  • TseHNRaiteriLWongKYHigh-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE studyChest2013144110611823348146
  • ZhengJPKangJHuangSGEffect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled studyLancet200837196292013201818555912
  • PoolePBlackPNCatesCJMucolytic agents for chronic bronchitis or chronic obstructive pulmonary diseaseCochrane Database Syst Rev20128CD00128722895919
  • GotfriedMHMacrolides for the treatment of chronic sinusitis, asthma, and COPDChest2004125Suppl 252S60S quiz 60S–61S14872001
  • SeemungalTAWilkinsonTMHurstJRPereraWRSapsfordRJWedzichaJALong-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbationsAm J Respir Crit Care Med2008178111139114718723437
  • AlbertRKConnettJBaileyWCCOPD Clinical Research NetworkAzithromycin for prevention of exacerbations of COPDN Engl J Med2011365868969821864166
  • BioMarck Pharmaceuticals [webpage on the Internet]BioMarck Pharmaceutical Reports Phase II Study Results for COPD Inhalation Solution: BREATH 1 study assessed effectiveness and safety of BIO-11006 inhalation solutionRaleigh, NCBioMarck Pharmaceuticals2011 Available from: http://www.biomarck.com/downloads/biomarck-pharmaceuticals-reports-phase-ii.swfAccessed October 21, 2013
  • StockleyRAO’BrienCPyeAHillSLRelationship of sputum color to nature and outpatient management of acute exacerbations of COPDChest200011761638164510858396