A miRNA-21-Mediated PTEN/Akt/NF-κB Axis Promotes Chronic Obstructive Pulmonary Disease Pathogenesis

References

• Christenson SA, Smith BM, Bafadhel M, Putcha N. Chronic obstructive pulmonary disease. Lancet. 2022;399(10342):2227–2242. doi:10.1016/s0140-6736(22)00470-6
   PubMed Web of Science ®Google Scholar
• Domej W, Oettl K, Renner W. Oxidative stress and free radicals in COPD--implications and relevance for treatment. Int J Chron Obstruct Pulmon Dis. 2014;9:1207–1224. doi:10.2147/copd.S51226
   PubMed Web of Science ®Google Scholar
• Guo P, Li R, Piao TH, Wang CL, Wu XL, Cai HY. Pathological mechanism and targeted drugs of COPD. Int J Chron Obstruct Pulmon Dis. 2022;17:1565–1575. doi:10.2147/copd.S366126
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Oxidative stress-based therapeutics in COPD. Redox Biol. 2020;33:101544. doi:10.1016/j.redox.2020.101544
   PubMed Web of Science ®Google Scholar
• Salvi SS, Barnes PJ. Chronic obstructive pulmonary disease in non-smokers. Lancet. 2009;374(9691):733–743. doi:10.1016/s0140-6736(09)61303-9
   PubMed Web of Science ®Google Scholar
• Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med. 2009;360(23):2445–2454. doi:10.1056/NEJMra0804752
   PubMed Web of Science ®Google Scholar
• Vij N, Chandramani-Shivalingappa P, Van Westphal C, Hole R, Bodas M. Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis. Am J Physiol Cell Physiol. 2018;314(1):C73–C87. doi:10.1152/ajpcell.00110.2016
   PubMed Web of Science ®Google Scholar
• Ortiz-Quintero B, Martínez-Espinosa I, Pérez-Padilla R. Mechanisms of lung damage and development of COPD due to household biomass-smoke exposure: inflammation, oxidative stress, MicroRNAs, and gene polymorphisms. Cells. 2022;12(1):3.
   PubMed Web of Science ®Google Scholar
• Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35(4):495–516. doi:10.1080/01926230701320337
   PubMed Web of Science ®Google Scholar
• Demedts IK, Demoor T, Bracke KR, Joos GF, Brusselle GG. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res. 2006;7(1):53. doi:10.1186/1465-9921-7-53
   PubMedGoogle Scholar
• Zinellu E, Zinellu A, Fois AG, Carru C, Pirina P. Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review. Respir Res. 2016;17(1):150. doi:10.1186/s12931-016-0471-z
   PubMedGoogle Scholar
• Song Q, Chen P, Liu XM. The role of cigarette smoke-induced pulmonary vascular endothelial cell apoptosis in COPD. Respir Res. 2021;22(1):39. doi:10.1186/s12931-021-01630-1
   PubMed Web of Science ®Google Scholar
• Stolzenburg LR, Harris A. The role of microRNAs in chronic respiratory disease: recent insights. Biol Chem. 2018;399(3):219–234. doi:10.1515/hsz-2017-0249
   PubMed Web of Science ®Google Scholar
• Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435(7043):834–838. doi:10.1038/nature03702
   PubMed Web of Science ®Google Scholar
• Wu H, Neilson JR, Kumar P, et al. miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One. 2007;2(10):e1020. doi:10.1371/journal.pone.0001020
   PubMed Web of Science ®Google Scholar
• Xie L, Wu M, Lin H, et al. An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers. Mol Biosyst. 2014;10(5):1072–1081. doi:10.1039/c3mb70564a
   PubMedGoogle Scholar
• He S, Chen D, Hu M, et al. Bronchial epithelial cell extracellular vesicles ameliorate epithelial-mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization. Nanomedicine. 2019;18:259–271. doi:10.1016/j.nano.2019.03.010
   PubMed Web of Science ®Google Scholar
• He S, Li L, Sun S, Zeng Z, Lu J, Xie L. A novel murine chronic obstructive pulmonary disease model and the pathogenic role of MicroRNA-21. Front Physiol. 2018;9:503. doi:10.3389/fphys.2018.00503
   PubMed Web of Science ®Google Scholar
• Abeyrathna P, Su Y. The critical role of Akt in cardiovascular function. Vascul Pharmacol. 2015;74:38–48. doi:10.1016/j.vph.2015.05.008
   PubMed Web of Science ®Google Scholar
• Sun L, Li W, Li W, Xiong L, Li G, Ma R. Astragaloside IV prevents damage to human mesangial cells through the inhibition of the NADPH oxidase/ROS/Akt/NF‑κB pathway under high glucose conditions. Int J Mol Med. 2014;34(1):167–176. doi:10.3892/ijmm.2014.1741
   PubMed Web of Science ®Google Scholar
• Han SS, Yun H, Son DJ, et al. NF-kappaB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma. Mol Cancer. 2010;9:97. doi:10.1186/1476-4598-9-97
   PubMed Web of Science ®Google Scholar
• Yanagisawa S, Baker JR, Vuppusetty C, et al. Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD. Am J Physiol Lung Cell Mol Physiol. 2017;313(2):L230–L239. doi:10.1152/ajplung.00382.2016
   PubMed Web of Science ®Google Scholar
• Sun X, Chen L, He Z. PI3K/Akt-Nrf2 and anti-inflammation effect of macrolides in chronic obstructive pulmonary disease. Curr Drug Metab. 2019;20(4):301–304. doi:10.2174/1389200220666190227224748
   PubMed Web of Science ®Google Scholar
• Xie X, Qu P, Wu H, et al. Circulating exosomal miR-21 mediates HUVEC proliferation and migration through PTEN/PI3K/AKT in Crohn’s disease. Ann Transl Med. 2022;10(5):258. doi:10.21037/atm-22-475
   PubMed Web of Science ®Google Scholar
• Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol. 2009;4:435–459. doi:10.1146/annurev.pathol.4.110807.092145
   PubMed Web of Science ®Google Scholar
• Cai B, Yang L, Do Jung Y, et al. PTEN: an emerging potential target for therapeutic intervention in respiratory diseases. Oxid Med Cell Longev. 2022;2022:4512503. doi:10.1155/2022/4512503
   PubMed Web of Science ®Google Scholar
• Qiu T, Tian Y, Gao Y, et al. PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation. Aging. 2019;11(18):7492–7509. doi:10.18632/aging.102262
   PubMedGoogle Scholar
• Boosani CS, Gunasekar P, Agrawal DK. An update on PTEN modulators - a patent review. Expert Opin Ther Pat. 2019;29(11):881–889. doi:10.1080/13543776.2019.1669562
   PubMed Web of Science ®Google Scholar
• Anderson GP, Bozinovski S. Acquired somatic mutations in the molecular pathogenesis of COPD. Trends Pharmacol Sci. 2003;24(2):71–76. doi:10.1016/s0165-6147(02)00052-4
   PubMed Web of Science ®Google Scholar
• Hosgood HD, Menashe I, He X, Chanock S, Lan Q. PTEN identified as important risk factor of chronic obstructive pulmonary disease. Respir Med. 2009;103(12):1866–1870. doi:10.1016/j.rmed.2009.06.016
   PubMed Web of Science ®Google Scholar
• Li M, Zhong X, Xu WT. Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells. Cell Cycle. 2022;21(20):2179–2191. doi:10.1080/15384101.2022.2092166
   PubMed Web of Science ®Google Scholar
• Jiang B, Guan Y, Shen HJ, et al. Akt/PKB signaling regulates cigarette smoke-induced pulmonary epithelial-mesenchymal transition. Lung Cancer. 2018;122:44–53. doi:10.1016/j.lungcan.2018.05.019
   PubMed Web of Science ®Google Scholar
• Tsai MJ, Chang WA, Jian SF, Chang KF, Sheu CC, Kuo PL. Possible mechanisms mediating apoptosis of bronchial epithelial cells in chronic obstructive pulmonary disease - A next-generation sequencing approach. Pathol Res Pract. 2018;214(9):1489–1496. doi:10.1016/j.prp.2018.08.002
   PubMed Web of Science ®Google Scholar
• Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24(5):981–990. doi:10.1016/j.cellsig.2012.01.008
   PubMed Web of Science ®Google Scholar
• Sheedy FJ. Turning 21: induction of miR-21 as a key switch in the inflammatory response. Front Immunol. 2015;6:19. doi:10.3389/fimmu.2015.00019
   PubMed Web of Science ®Google Scholar
• Zhang S, Sun P, Xiao X, Hu Y, Qian Y, Zhang Q. MicroRNA-21 promotes epithelial-mesenchymal transition and migration of human bronchial epithelial cells by targeting poly (ADP-ribose) polymerase-1 and activating PI3K/AKT signaling. Korean J Physiol Pharmacol. 2022;26(4):239–253. doi:10.4196/kjpp.2022.26.4.239
   PubMed Web of Science ®Google Scholar
• Pace E, Di Vincenzo S, Di Salvo E, et al. MiR-21 upregulation increases IL-8 expression and tumorigenesis program in airway epithelial cells exposed to cigarette smoke. J Cell Physiol. 2019;234(12):22183–22194. doi:10.1002/jcp.28786
   PubMed Web of Science ®Google Scholar