154
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Penetration of Flurbiprofen from a Locally Applied Sore Throat Lozenge and Spray into Cadaveric Human Pharynx Tissue: A Novel ex vivo Model and Microautoradiography Method

, , ORCID Icon, , , & show all
Pages 13-20 | Published online: 19 Jan 2021

References

  • Francis NA, Butler CC, Hood K, Simpson S, Wood F, Nuttall J. Effect of using an interactive booklet about childhood respiratory tract infections in primary care consultations on reconsulting and antibiotic prescribing: a cluster randomised controlled trial. BMJ. 2009;339:b2885. doi:10.1136/bmj.b288519640941
  • Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013;Cd000247. doi:10.1002/14651858.CD000247.pub323733381
  • Schachtel BP, Fillingim JM, Beiter DJ, Lane AC, Schwartz LA. Subjective and objective features of sore throat. Arch Intern Med. 1984;144:497–500. doi:10.1001/archinte.1984.003501500810266703820
  • Eccles R. Mechanisms of symptoms of the common cold and influenza. Br J Hosp Med (Lond). 2007;68:71–75. doi:10.12968/hmed.2007.68.2.2282417370703
  • Worrall GJ. Acute sore throat. Can Fam Physician. 2007;53:1961–1962.18000276
  • Ebell MH, Smith MA, Barry HC, Ives K, Carey M. The rational clinical examination. Does this patient have strep throat? JAMA. 2000;284:2912–2918. doi:10.1001/jama.284.22.291211147989
  • Renner B, Mueller CA, Shephard A. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res. 2012;61:1041–1052. doi:10.1007/s00011-012-0540-922890476
  • Schachtel B, Shephard A, Schachtel E, Lorton MB, Shea T, Aspley S. Qualities of sore throat index (QuaSTI): measuring descriptors of sore throat in a randomized, placebo-controlled trial. Pain Manag. 2018;8:85–94. doi:10.2217/pmt-2017-004129381110
  • Addey D, Shephard A. Incidence, causes, severity and treatment of throat discomfort: a four-region online questionnaire survey. BMC Ear Nose Throat Disord. 2012;12:9. doi:10.1186/1472-6815-12-922883470
  • Pelucchi C, Grigoryan L, Galeone C, et al. Guideline for the management of acute sore throat. Clin Microbiol Infect. 2012;18(Suppl 1):1–28. doi:10.1111/j.1469-0691.2012.03766.x
  • Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database Syst Rev. 2013:Cd000023.24190439
  • Hildreth CJ, Burke AE, Glass RM. JAMA patient page. Inappropriate use of antibiotics. JAMA. 2009;302:816. doi:10.1001/jama.302.7.81619690318
  • Oxford JS, Leuwer M. Acute sore throat revisited: clinical and experimental evidence for the efficacy of over-the-counter AMC/DCBA throat lozenges. Int J Clin Pract. 2011;65:524–530. doi:10.1111/j.1742-1241.2011.02644.x21489076
  • Zaman SB, Hussain MA, Nye R, Mehta V, Mamun KT, Hossain N. A review on antibiotic resistance: alarm bells are ringing. Cureus. 2017;9:e1403.28852600
  • Burova N, Bychkova V, Shephard A. Improvements in throat function and qualities of sore throat from locally applied flurbiprofen 8.75 mg in spray or lozenge format: findings from a randomized trial of patients with upper respiratory tract infection in the Russian Federation. J Pain Res. 2018;11:1045–1055. doi:10.2147/JPR.S14933129910633
  • Schachtel B, Aspley S, Shephard A, et al. Onset of action of a lozenge containing flurbiprofen 8.75 mg: a randomized, double-blind, placebo-controlled trial with a new method for measuring onset of analgesic activity. Pain. 2014;155:422–428. doi:10.1016/j.pain.2013.11.00124231654
  • de Looze F, Russo M, Bloch M, Montgomery B, Shephard A, DeVito R. Meaningful relief with flurbiprofen 8.75 mg spray in patients with sore throat due to upper respiratory tract infection. Pain Manag. 2018;8:79–83. doi:10.2217/pmt-2017-010029376761
  • de Looze F, Russo M, Bloch M, et al. Efficacy of flurbiprofen 8.75 mg spray in patients with sore throat due to an upper respiratory tract infection: A randomised controlled trial. Eur J Gen Pract. 2016;22:111–118. doi:10.3109/13814788.2016.114565027028316
  • Schachtel B, Aspley S, Shephard A, Schachtel E, Lorton MB, Shea T. Onset of analgesia by a topically administered flurbiprofen lozenge: a randomised controlled trial using the double stopwatch method. Br J Pain. 2018;12:208–216. doi:10.1177/204946371875615230349694
  • Schachtel BP, Cleves GS, Konerman JP, Brown AT, Markham AO. A placebo-controlled model to assay the onset of action of nonprescription-strength analgesic drugs. Clin Pharmacol Ther. 1994;55:464–470. doi:10.1038/clpt.1994.568162673
  • Barsuhn CL, Olanoff LS, Gleason DD, Adkins EL, Ho NF. Human buccal absorption of flurbiprofen. Clin Pharmacol Ther. 1988;44:225–231. doi:10.1038/clpt.1988.1413293876
  • Gonzalez-Younes I, Wagner JG, Gaines DA, Ferry JJ, Hageman JM. Absorption of flurbiprofen through human buccal mucosa. J Pharm Sci. 1991;80:820–823. doi:10.1002/jps.26008009031800701
  • Turner R, Wevrett S, Edmunds S, Brown M, Atkinson R, Shea T. Determination of the permeation and penetration of flurbiprofen from a locally acting sore throat lozenge and spray into human pharynx tissue using a novel ex vivo model and a validated analytical method. Naunyn Schmiedeberg Arch Pharmacol. 2018;391:1–93.
  • Turner R, Wevrett SR, Edmunds S, et al. Determination of the permeation and penetration of flurbiprofen into cadaveric human pharynx tissue. Clin Pharmacol. 2020;12:13–20. doi:10.2147/CPAA.S23422732273779
  • Turner R, Wevrett SR, Edmunds S, Brown M, Atkinson R, Shea T. Validation of an analytical method to quantify the permeation and penetration of flurbiprofen into human pharynx tissue. Biomed Chromatogr. 2019;33:e4499. doi:10.1002/bmc.449930667527
  • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH Harmonised Tripartite Guideline. Pharmaceutical Quality System Q10. Available from: https://database.ich.org/sites/default/files/Q10_Guideline.pdf. Accessed 7 2020.
  • Franz TJ. Percutaneous absorption on the relevance of in vitro data. J Invest Dermatol. 1975;64:190–195. doi:10.1111/1523-1747.ep12533356123263
  • Walsh JH, Leigh MS, Paduch A, et al. Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea. J Sleep Res. 2008;17:230–238. doi:10.1111/j.1365-2869.2008.00647.x18422508
  • Peres JC, Rouquette JL, Miocevic O, Warner MC, Slowey PD, Shirtcliff EA. New techniques for augmenting saliva collection: bacon rules and lozenge drools. Clin Ther. 2015;37:515–522. doi:10.1016/j.clinthera.2015.02.01525773460
  • Limb M, Connor A, Pickford M, et al. Scintigraphy can be used to compare delivery of sore throat formulations. Int J Clin Pract. 2009;63:606–612. doi:10.1111/j.1742-1241.2008.01984.x19222617
  • Takeuchi H, Mano Y, Terasaka S, et al. Usefulness of rat skin as a substitute for human skin in the in vitro skin permeation study. Exp Anim. 2011;60:373–384. doi:10.1538/expanim.60.37321791877
  • Ayoub R, Muraza G, Imran M, et al. Formulation and permeation kinetic studies of flurbiprofen gel. Trop J Pharm Res. 2015;14:195–203. doi:10.4314/tjpr.v14i2.2
  • Hussain A, Khan GM, Jan SU, et al. Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer. Pak J Pharm Sci. 2012;25:365–369.22459463