Wound Healing Effect of Acokanthera schimperi Schweinf (Apocynaceae) Methanol Leaf Extract Ointment in Mice and Its in-vitro Antioxidant Activity

References

• Cutting KF, Tong A. Wound Physiology & Moist Wound Healing: Medical Communications UK. 2003.
   Google Scholar
• Bowler PG. Wound pathophysiology, infection and therapeutic options. Ann Med. 2002;34(6):419–427.12523497
   PubMed Web of Science ®Google Scholar
• Zafar A, Anwar N, Ejaz H. Bacteriology of infected wounds a study conducted at children hospital Lahore. Biomedica. 2007;23(8):1–4.
   Google Scholar
• Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol. 2007;25(1):19–25.17276197
   PubMed Web of Science ®Google Scholar
• Mohanty A, Sahu P, Das C. Wound healing activities of methanolic extract of Cissus quadrangularis on albino rat. Int J Drug Formul Res. 2010;1:176–184.
   Google Scholar
• Kokane DD, More RY, Kale MB, Nehete MN, Mehendale PC, Gadgoli CH. Evaluation of wound healing activity of root of Mimosa pudica. J Ethnopharmacol. 2009;124(2):311–315.19397984
   PubMed Web of Science ®Google Scholar
• Soni H, Singhai AK. A recent update of botanicals for wound healing activity. Int Res J Pharm. 2012;3(7):1–7.
   Google Scholar
• Ghosh PK, Gaba A. Phyto-extracts in wound healing. Int J Pharm Pharm Sci. 2013;16(5):760–820.
   Web of Science ®Google Scholar
• Teklehaymanot T, Giday M. Ethnobotanical study of medicinal plants used by people in Zegie Peninsula, Northwestern Ethiopia. J Ethnobiol Ethnomed. 2007;3(1):12.17355645
   PubMed Web of Science ®Google Scholar
• Bitew H, Gebregergs H, Tuem KB, Yeshak MY. Ethiopian medicinal plants traditionally used for wound treatment: a systematic review. Ethiop J Health Dev. 2019;33(2).
   Web of Science ®Google Scholar
• Abebe D, Ayehu A. Medicinal Plants and Enigmatic Health Practices of Northern Ethiopia. 1993.
   Google Scholar
• Omino E, Kokwaro J. Ethnobotany of apocynaceae species in Kenya. J Ethnopharmacol. 1993;40(3):167–180.8145572
   PubMed Web of Science ®Google Scholar
• Taye B, Giday M, Animut A, Seid J. Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia. Asian Pac J Trop Biomed. 2011;1(5):370–375.23569795
   PubMedGoogle Scholar
• Tadeg H, Mohammed E, Asres K, Gebre-Mariam T. Antimicrobial activities of some selected traditional Ethiopian medicinal plants used in the treatment of skin disorders. J Ethnopharmacol. 2005;100(1–2):168–175.16054532
   PubMed Web of Science ®Google Scholar
• Chaithanya K, Abrha B, Gopalakrishnan V, Hagos Z, Hiruy M, Devaki K. Phytochemical screening and in vitro antioxidant activities of ethanolic extract of Acokanthera schimperi leaves. J Pharm Res. 2018.
   Google Scholar
• Gebre-Mariam T, Neubert R, Schmidt P, Wutzler P, Schmidtke M. Antiviral activities of some Ethiopian medicinal plants used for the treatment of dermatological disorders. J Ethnopharmacol. 2006;104(1–2):182–187.16233967
   PubMed Web of Science ®Google Scholar
• Mohammed T, Erko B, Giday M. Evaluation of antimalarial activity of leaves of acokanthera schimperi and croton macrostachyus against plasmodium berghei in swiss albino mice. BMC Complement Altern Med. 2014;14(1):314.25155821
   PubMed Web of Science ®Google Scholar
• National Research Council. Guide for the Care and Use of Laboratory Animals. National Academies Press; 2010.
   Google Scholar
• Festing MF, Altman DG. Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR J. 2002;43(4):244–258.12391400
   PubMedGoogle Scholar
• Karapolat S, Karapolat B, Buran A, et al. The effects of nitrofurazone on wound healing in thoracoabdominal full-thickness skin defects. Wounds. 2020;32(5):134–141.32804664
   PubMed Web of Science ®Google Scholar
• British Pharmacopoeia. Department of Health and Social Security Scottish Home and Health Department. Vol. 2 UK: Office of the British Pharmacopoeia Commission; 1988:713.
   Google Scholar
• Trease G, Evans M. Text Book of Pharmacognosy. 13th ed. London, Toronto: Bailiere Tindall; 1989:200–201.
   Google Scholar
• Debella A. Manual for Phytochemical Screening of Medicinal Plants, Department of Drug Research, Ethiopian Nutrition and Research Institute. Addis Ababa, Ethiopia; 2002:45–71.
   Google Scholar
• Amcoff P. Appendix 5: OECD guidelines for the testing of chemicals. Altern Lab Anim. 2005;33(1_suppl):223–228.
   Google Scholar
• Wilhelm K-P, Maibach HI. 33 OECD guidelines for testing of chemicals. Dermatotoxicology. 2007;303.
   Google Scholar
• Morton J, Malone M. Evaluation of vulneray activity by an open wound procedure in rats. Arch Int Pharmacodyn Ther. 1972;196(1):117.5059357
   PubMedGoogle Scholar
• Mulisa E, Asres K, Engidawork E. Evaluation of wound healing and anti-inflammatory activity of the rhizomes of rumex abyssinicus J. (polygonaceae) in mice. BMC Complement Altern Med. 2015;15(1):341.26423525
   PubMed Web of Science ®Google Scholar
• Yesuf A, Asres K. Wound healing and antiinflammatory properties of Allophylus abyssinicus (Hochst.) Radlk. Phytopharmacology. 2013;4(2):442–453.
   Google Scholar
• Ehrich H. Effect of cortisone and anabolic steroids on tensile strength of healing wound. Ann Surg. 1969;170(2):203–206.5796705
   PubMed Web of Science ®Google Scholar
• Lee K. Studies on the mechanism of action of salicylates III. Effect of vitamin A on the wound healing retardation action of aspirin. J Pharm Sci. 1968;57(7):1238–1240.4232621
   PubMed Web of Science ®Google Scholar
• Demilew W, Adinew GM, Asrade S. Evaluation of the wound healing activity of the crude extract of leaves of acanthus polystachyus delile (acanthaceae). Evid Based Complement Alternat Med. 2018;2018.
   Web of Science ®Google Scholar
• Bastos MLA, Houly RLS, Conserva LM, Andrade VS, Rocha EMM, Lyra Lemos R. Antimicrobial and wound healing activities of Piper hayneanum. J Chem Pharm Res. 2011;3:213–222.
   Google Scholar
• Braca A, De Tommasi N, Di Bari L, Pizza C, Politi M, Morelli I. Antioxidant principles from bauhinia t arapotensis. J Nat Prod. 2001;64(7):892–895.11473417
   PubMed Web of Science ®Google Scholar
• Ansel HC. Introduction to Pharmaceutical Dosage Forms. 1969.
   Google Scholar
• Manjunatha B, Vidya S, Rashmi K, Mankani K, Shilpa H, Singh SJ. Evaluation of wound-healing potency of Vernonia arborea Hk. Indian J Pharmacol. 2005;37(4):223.
   Google Scholar
• Arunachalam KD, Subhashini S, Annamalai S. Wound healing and antigenotoxic activities of Aegle marmelos with relation to its antioxidant properties. J Pharm Res. 2012;5(3):1492–1502.
   Google Scholar
• Le N T, Ho D V, Quoc Doan T, et al. Biological activities of essential oils from leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) swingle. Antibiotics. 2020;9(4):207.
   Web of Science ®Google Scholar
• Donadu MG, Trong Le N, Viet Ho D, et al. Phytochemical compositions and biological activities of essential oils from the leaves, rhizomes and whole plant of Hornstedtia bella Škorničk. Antibiotics. 2020;9(6):334.
   Web of Science ®Google Scholar
• Getie M, Gebre-Mariam T, Rietz R, et al. Evaluation of the anti-microbial and anti-inflammatory activities of the medicinal plants Dodonaea viscosa, Rumex nervosus and Rumex abyssinicus. Fitoterapia. 2003;74(1–2):139–143.12628410
   PubMed Web of Science ®Google Scholar
• Ondua M, Adebayo S, Shai L, Lebelo S. The Anti-Inflammatory and Anti-Nociceptive Activities of Some Medicinal Plant Species Used to Treat Inflammatory Pain Conditions in Southern Africa. 2016.
   Google Scholar
• Adebayo S, Ondua M, Shai L, Lebelo S. Inhibition of nitric oxide production and free radical scavenging activities of four South African medicinal plants. J Inflamm Res. 2019;12:195.31496781
   PubMed Web of Science ®Google Scholar
• Otang-Mbeng W, Afolayan AJ. Antimicrobial and antioxidant efficacy of Acokanthera oblongifolia Hochst (apocynaceae). Int J Pharmacol. 2017;13(8):1086–1091.
   Web of Science ®Google Scholar
• Matebie WA, Zhang W, Zhang S, Xie G. Triterpenoids from Acokanthera schimperi in Ethiopia. Rec Nat Prod. 2019;13(3):182–188.
   Web of Science ®Google Scholar
• Bodenstein J, Du Toit K. The susceptibility of Staphylococcus aureus and Klebsiella pneumoniae to naturally derived selected classes of flavonoids. Antimicrob Agents. 2012;73–84.
   Google Scholar
• Petr D, Marian H, David V, et al. Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica. Nat Prod Rep. 2006;23:394–411.16741586
   PubMed Web of Science ®Google Scholar
• Getie M, Gebre-Mariam T, Rietz R, Neubert R. Evaluation of the release profiles of flavonoids from topical formulations of the crude extract of the leaves of Dodonea viscosa (Sapindaceae). Pharmazie. 2002;57(5):320–322.12061256
   PubMed Web of Science ®Google Scholar
• Armstrong DG, Jude EB. The role of matrix metalloproteinases in wound healing. J Am Podiatr Med Assoc. 2002;92(1):12–18.11796794
   PubMed Web of Science ®Google Scholar
• Ling S-K, Tanaka T, Kouno I. Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by β-glucosidase in the presence of amino acids. Biol Pharm Bull. 2003;26(3):352–356.12612446
   PubMed Web of Science ®Google Scholar