250
Views
43
CrossRef citations to date
0
Altmetric
Original Research

Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening

, , , , , , , , & show all
Pages 1307-1322 | Published online: 01 Apr 2016

References

  • KuehnBMCDC estimates 300,000 US cases of Lyme disease annuallyJAMA2013310111024045727
  • VollmerSAFeilEJChuCYSpatial spread and demographic expansion of Lyme borreliosis spirochaetes in EurasiaInfect Genet Evol20131414715523219915
  • BrownsteinJSHolfordTRFishDEffect of climate change on Lyme disease risk in North AmericaEcohealth20052384619008966
  • EspositoSBosisSSabatiniCTagliaferriLPrincipiNBorrelia burgdorferi infection and Lyme disease in childrenInt J Infect Dis201317e153e15823141587
  • BorchersATKeenCLHuntleyACGershwinMELyme disease: a rigorous review of diagnostic criteria and treatmentJ Autoimmun2015578211525451629
  • BockenstedtLKRadolfJDXenodiagnosis for posttreatment Lyme disease syndrome: resolving the conundrum or adding to it?Clin Infect Dis20145894694824523213
  • FengJWangTShiWIdentification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug libraryEmerg Microbes Infect20143e4926038747
  • BockenstedtLKGonzalezDGHabermanAMBelperronAASpirochete antigens persist near cartilage after murine Lyme borreliosis therapyJ Clin Invest20121222652266022728937
  • HodzicEFengSHoldenKFreetKJBartholdSWPersistence of Borrelia burgdorferi following antibiotic treatment in miceAntimicrob Agents Chemother2008521728173618316520
  • DiterichIRauterCKirschningCJHartungTBorrelia burgdorferi-induced tolerance as a model of persistence via immunosuppressionInfect Immun2003713979398712819085
  • SteereACSchoenRTTaylorEThe clinical evolution of Lyme arthritisAnn Intern Med19871077257313662285
  • BartholdSWde SouzaMSJanotkaJLSmithALPersingDHChronic Lyme borreliosis in the laboratory mouseAm J Pathol19931439599718362988
  • BabadyNEHallLAbbenyiATEvaluation of Mycobacterium avium complex clarithromycin susceptibility testing using SLOMYCO Sensititre panels and JustOne stripsJ Clin Microbiol2010481749175220335412
  • EmbersMEBartholdSWBordaJTPersistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infectionPLoS One20127e2991422253822
  • HodzicEImaiDFengSBartholdSWResurgence of persisting non-cultivable Borrelia burgdorferi following antibiotic treatment in micePLoS One20149e8690724466286
  • StraubingerRKSummersBAChangYFAppelMJPersistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatmentJ Clin Microbiol1997351111168968890
  • MarquesATelfordSR3rdTurkSPXenodiagnosis to detect Borrelia burgdorferi infection: a first-in-human studyClin Infect Dis20145893794524523212
  • BrorsonØBrorsonSHScythesJMacAllisterJWierAMargulisLDestruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic tigecyclineProc Natl Acad Sci U S A2009106186561866119843691
  • MiklossyJKasasSZurnADMcCallSYuSMcGeerPLPersisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosisJ Neuroinflammation2008511818171484
  • LantosPMAuwaerterPGWormserGPA systematic review of Borrelia burgdorferi morphologic variants does not support a role in chronic Lyme diseaseClin Infect Dis20145866367124336823
  • SharmaBBrownAVMatluckNEHuLTLewisKBorrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cellsAntimicrob Agents Chemother2015594616462426014929
  • FengJAuwaerterPGZhangYDrug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycyclinePLoS One201510e011720725806811
  • SapiEKaurNAnyanwuSEvaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferiInfect Drug Resist201149711321753890
  • PaviaCInchiosaMAJrWormserGPEfficacy of short-course ceftriaxone therapy for Borrelia burgdorferi infection in C3H miceAntimicrob Agents Chemother20024613213411751123
  • WormserGPDanielsTJBittkerSCooperDWangGPaviaCSFailure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ miceJ Infect Dis201220599199421930606
  • PaviaCSWormserGPCulture of the entire mouse to determine whether cultivable Borrelia burgdorferi persists in infected mice treated with a five-day course of CeftriaxoneAntimicrob Agents Chemother2014586701670325155590
  • LefasGChaconasGHigh-throughput screening identifies three inhibitor classes of the telomere resolvase from the Lyme disease spirocheteAntimicrob Agents Chemother2009534441444919596868
  • CornellKAPrimusSMartinezJAParveenNAssessment of methylthioadenosine/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as targets for novel antimicrobials using a novel high-throughput methodJ Antimicrob Chemother2009631163117219376840
  • FengJShiWZhangSZhangYIdentification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collectionEmerg Microbes Infect20154e3126954881
  • FengJWeitnerMShiWZhangSSullivanDZhangYIdentification of additional anti-persister activity against Borrelia burgdorferi from an FDA drug libraryAntibiotics2015439727025631
  • NygrenPLarssonRDrug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancerActa Oncol20145342742824160353
  • JahchanNSDudleyJTMazurPKA drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumorsCancer Discov201331364137724078773
  • WaghDPothineniVRInayathullahMLiuSKimKMRajadasJBorreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibitionDrug Des Devel Ther20159805
  • KraiczyPWeigandJWichelhausTAIn vitro activities of fluoroquinolones against the spirochete Borrelia burgdorferiAntimicrob Agents Chemother2001452486249411502519
  • HunfeldKPRodelRWichelhausTAIn vitro activity of eight oral cephalosporins against Borrelia burgdorferiInt J Antimicrob Agents20032131331812672576
  • VeinovicGCerarTStrleFIn vitro susceptibility of European human Borrelia burgdorferi sensu stricto strains to antimicrobial agentsInt J Antimicrob Agents20134128829123312603
  • FengJWangTZhangSShiWZhangYAn optimized SYBR Green I/PI assay for rapid viability assessment and antibiotic susceptibility testing for Borrelia burgdorferiPLoS One20149e11180925365247
  • FengJWangTShiWIdentification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug libraryEmerg Microbes Infect20143e4926038747
  • MarquesAChronic Lyme disease: a reviewInfect Dis Clin North Am200822341360viiviii18452806
  • TerekhovaDSartakovaMLWormserGPSchwartzICabelloFCErythromycin resistance in Borrelia burgdorferiAntimicrob Agents Chemother2002463637364012384380
  • KannanKKanabarPSchryerDThe general mode of translation inhibition by macrolide antibioticsProc Natl Acad Sci U S A2014111159581596325349425
  • SteelHCTheronAJCockeranRAndersonRFeldmanCPathogen-and host-directed anti-inflammatory activities of macrolide antibioticsMediators Inflamm2012201258426222778497
  • ShinkaiMHenkeMORubinBKMacrolide antibiotics as immunomodulatory medications: proposed mechanisms of actionPharmacol Ther200811739340518289694
  • LeachKLBricknerSJNoeMCMillerPFLinezolid, the first oxazolidinone antibacterial agentAnn N Y Acad Sci20111222495421434942
  • Van BambekeFMacrolides and ketolidesVinksADerendorfHMoutonJWFundamentals of Antimicrobial Pharmacokinetics and PharmacodynamicsNew York, NYSpringer2014257278
  • Yuan-shuQQi-nanWYu-fuJPharmacokinetic study of leucomycin in healthy volunteers [J]Zhongguo Kang Sheng Su Za Zhi19902008
  • LinAHMurrayRWVidmarTJMarottiKRThe oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycinAntimicrob Agents Chemother199741212721319333036
  • DrydenMSLinezolid pharmacokinetics and pharmacodynamics in clinical treatmentJ Antimicrob Chemother201166Suppl 4iv7iv1521521707
  • KeelRASchaeftleinAKloftCPharmacokinetics of intravenous and oral linezolid in adults with cystic fibrosisAntimicrob Agents Chemother2011553393339821518837
  • ViaggiBPaoloADDanesiRLinezolid in the central nervous system: comparison between cerebrospinal fluid and plasma pharmacokineticsScand J Infect Dis20114372172721585240
  • Kutscha-LissbergFHeblerUMuhrGKöllerMLinezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococciAntimicrob Agents Chemother2003473964396614638510
  • Pérez-ArnaizCBustoNLealJMGarcíaBNew insights into the mechanism of the DNA/doxorubicin interactionJ Phys Chem B20141181288129524417409
  • KizekRAdamVHrabetaJAnthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advancesPharmacol Ther2012133263921839775
  • DanesiRFogliSGennariAContePDel TaccaMPharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugsClin Pharmacokinet20024143144412074691
  • PucciMJWilesJABacterial Topoisomerase Inhibitors: Quinolones and BeyondAntimicrobialsNew York, NYSpringer2014307326
  • StassHKubitzaDPharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in manJ Antimicrob Chemother199943Suppl B839010382880
  • MalikMDrlicaKMoxifloxacin lethality against Mycobacterium tuberculosis in the presence and absence of chloramphenicolAntimicrob Agents Chemother2006502842284416870782
  • NikiYPharmacokinetics and safety assessment of tosufloxacin tosilateJ Infect Chemother2002811811957114
  • FernandesRAmadorPPrudêncioCβ-Lactams: chemical structure, mode of action and mechanisms of resistanceRev Med Microbiol201324717
  • GuayDRCefdinir: an expanded-spectrum oral cephalosporinAnn Pharmacother2000341469147711144705
  • BerezinSKValinomycin as a classical anionophore: mechanism and ion selectivityJ Membr Biol201524871372625736817
  • Zaldívar-MachorroVJLópez-OrtizMDemarePReglaIMuñoz-ClaresRAThe disulfiram metabolites S-methyl-N,N- diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial growthBiochimie20119328629520933050