87
Views
17
CrossRef citations to date
0
Altmetric
Original Research

Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis

, , , , , , , , & show all
Pages 2691-2699 | Published online: 26 Aug 2016

References

  • BombeliTSchwartzBRHarlanJMAdhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), alphavbeta3 integrin, and GPIbalphaJ Exp Med199818733293399449713
  • GawazMRole of platelets in coronary thrombosis and reperfusion of ischemic myocardiumCardiovasc Res200461349851114962480
  • HuoYSchoberAForlowSBCirculating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein ENat Med200391616712483207
  • ProjahnDKoenenRRPlatelets: key players in vascular inflammationJ Leukoc Biol20129261167117522923486
  • MassbergSBrandKGrünerSA critical role of platelet adhesion in the initiation of atherosclerotic lesion formationJ Exp Med2002196788789612370251
  • PaulACallejaLCampsJThe continuous administration of aspirin attenuates atherosclerosis in apolipoprotein E-deficient miceLife Sci200068445746511205894
  • KarshovskaEZhaoZBlanchetXHyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic miceCirc Res2015116458759925472975
  • CAPRIE Steering CommitteeA randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering CommitteeLancet19963489038132913398918275
  • YusufSZhaoFMehtaSRChrolaviciusSTognoniGFoxKKClopidogrel in Unstable Angina to Prevent Recurrent Events Trial InvestigatorsEffects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST segment elevationN Engl J Med2001345749450211519503
  • WallentinLBeckerRBudajAPLATO InvestigatorsTicagrelor versus clopidogrel in patients with acute coronary syndromesN Engl J Med2009361111045105719717846
  • WiviottSDBraunwaldEMcCabeCHTRITON-TIMI 38 InvestigatorsPrasugrel versus clopidogrel in patients with acute coronary syndromesN Engl J Med2007357202001201517982182
  • BonacaMPBhattDLCohenMPEGASUS-TIMI 54 Steering Committee and InvestigatorsLong-term use of ticagrelor in patients with prior myocardial infarctionN Engl J Med201537219179180025773268
  • LiuOJiaLLiuXClopidogrel, a platelet P2Y12 receptor inhibitor, reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progressionPLoS One201271251707
  • GunsPJHendrickxJVan AsscheTFransenPBultHP2Y receptors and atherosclerosis in apolipoprotein E deficient miceBr J Pharmacol2010159232633620050854
  • ThomasMRStoreyRFEffect of P2Y12 inhibitors on inflammation and immunityThromb Haemost2015114349049726156883
  • WestLESteinerTJudgeHMFrancisSEStoreyRFVessel wall, not platelet, P2Y12 potentiates early atherogenesisCardiovasc Res2014102342943524510394
  • LiDWangYZhangLRoles of purinergic receptor P2Y, G protein-coupled 12 in the development of atherosclerosis in apolipoprotein E-deficient miceArterioscler Thromb Vasc Biol20123288189
  • SillenHCookMDavisPDetermination of ticagrelor and two metabolites in plasma samples by liquid chromatography and mass spectrometryJ Chromatogr B Analyt Technol Biomed Life Sci20108782522992306
  • MovatHZDemonstration of all connective tissue elements in a single section; pentachrome stainsAMA Arch Pathol195560328929513248341
  • MorrellCNAggreyAAChapmanLMModjeskiKLEmerging roles for platelets as immune and inflammatory cellsBlood2014123182759276724585776
  • SempleJWItalianoJEJrFreedmanJPlatelets and the immune continuumNat Rev Immunol201111426427421436837
  • AmisonRPageCPitchfordSPharmacological modulation of the inflammatory actions of plateletsHandb Exp Pharmacol201221044746822918742
  • RauchBHRosenkranzACErmlerSRegulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesionsArterioscler Thromb Vasc Biol2010302434244221071695
  • SteinhublSRBadimonJJBhattDLClinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic diseaseVasc Med20071211312217615799
  • RosenfeldMEAverillMMBennettBJSchwartzSMProgression and disruption of advanced atherosclerotic plaques in murine modelsCurr Drug Targets20089321021618336239
  • MamedovaLKGaoZGJacobsonKARegulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptorsBiochem Pharmacol20067281031104116934758
  • ZhangSYeJZhangYP2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivationJ Thromb Haemost201311114916023140172
  • WebsterCMHokariMMcManusAMicroglial P2Y12 deficiency/inhibition protects against brain ischemiaPLoS One20138870927