References
- National Asthma Education ProgramGuidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute. Expert Panel ReportJ Allergy Clin Immunol1991883 Pt 24255341890276
- ChungKFWenzelSEBrozekJLInternational ERS/ATS guidelines on definition, evaluation and treatment of severe asthmaEur Respir J201443234337324337046
- National Asthma Education Prevention and ProgramExpert Panel Report 3 (EPR-3): guidelines for the Diagnosis and Management of Asthma-Summary Report 2007J Allergy Clin Immunol20071205 SupplS94S13817983880
- ReddelHKTaylorDRBatemanEDAn official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practiceAm J Respir Crit Care Med20091801599919535666
- Global Asthma NetworkGlobal Asthma Report 2014Auckland, New ZealandGlobal Asthma Network Available from: http://www.globalasthmanetwork.org/publications/Global_Asthma_Report_2014.pdfAccessed January 10, 2016
- Global Initiative for AsthmaGlobal Strategy for Asthma Management and PreventionGINA Reports2015 Available from: http://ginasthma.org/2016-gina-report-global-strategy-for-asthma-management-and-prevention/Accessed January 10, 2016
- American Thoracic SocietyProceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questionsAm J Respir Crit Care Med200016262341235111112161
- Al EfraijKFitzGeraldJMCurrent and emerging treatments for severe asthmaJ Thorac Dis2015711E522E52526716048
- KellyHWRationale for the major changes in the pharmacotherapy section of the National Asthma Education and Prevention Program guidelinesJ Allergy Clin Immunol20071205989994 quiz 995–99617983867
- KerstjensHADisseBSchroder-BaboWTiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trialJ Allergy Clin Immunol2011128230831421636120
- AbadogluOBerkSTiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life dataClin Respir J201610442142725335652
- KellerMKampDSevere asthma: the evolution of patient-directed managementClin Pulm Med20142111825580071
- WilhelmCPChippsBEBronchial thermoplasty: a review of the evidenceAnn Allergy Asthma Immunol20161162929826654482
- ZhouJPFengYWangQZhouLNWanHYLiQYLong-term efficacy and safety of bronchial thermoplasty in patients with moderate-to-severe persistent asthma: a systemic review and meta-analysisJ Asthma20165319410026383773
- BostantzoglouCDelimpouraVSamitasKZervasEKanniessFGagaMClinical asthma phenotypes in the real world: opportunities and challengesBreathe201511318619326632421
- QuirceSBoboleaIDominguez-OrtegaJBarrancoPFuture biologic therapies in asthmaArch Bronconeumol201450835536124685200
- MenzellaFLusuardiMGaleoneCZucchiLTailored therapy for severe asthmaMultidiscip Respir Med2015101125671117
- GalliSJTsaiMIgE and mast cells in allergic diseaseNat Med201218569370422561833
- HamelmannEThe rationale for treating allergic asthma with anti-IgEEur Respir J2007161046166
- SchulmanESDevelopment of a monoclonal anti-immunoglobulin E antibody (omalizumab) for the treatment of allergic respiratory disordersAm J Respir Crit Care Med20011648 Pt 2S6S1111704611
- MacGlashanDJrLichtensteinLMMcKenzie-WhiteJUpregulation of FcεRI on human basophils by IgE antibody is mediated by interaction of IgE with FcεRIJ Allergy Clin Immunol19991042 Pt 149249810452777
- BeckLAMarcotteGVMacGlashanDTogiasASainiSOmalizumab-induced reductions in mast cell Fcε RI expression and functionJ Allergy Clin Immunol2004114352753015356552
- MacGlashanDWJrBochnerBSAdelmanDCDown-regulation of Fc(ε)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibodyJ Immunol19971583143814459013989
- SamitasKDelimpouraVZervasEGagaMAnti-IgE treatment, airway inflammation and remodelling in severe allergic asthma: current knowledge and future perspectivesEur Respir Rev20152413859460126621973
- CorrenJCasaleTBLanierBBuhlRHolgateSJimenezPSafety and tolerability of omalizumabClin Exp Allergy200939678879719302249
- CorrenJFroehlichJSchoenhoffMPhase I study of anti-IgE recombinant humanized monoclonal antibody rhuMAB-E25 (E25) in adults with moderate to severe asthmaJ Allergy and Clin Immunol1996971245
- FroehlichJInitial human study with a humanized recombinant anti-IgE monoclonal antibody: safety, tolerance and pharmacokinetic (PK)/dynamic profileClin Pharmacol Ther1995572162
- HumbertMBeasleyRAyresJBenefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATEAllergy200560330931615679715
- WalkerSMonteilMPhelanKLassersonTJWaltersEHAnti-IgE for chronic asthma in adults and childrenCochrane Database Syst Rev20062CD00355916625585
- MolimardMde BlayFDidierALe GrosVEffectiveness of omalizumab (Xolair) in the first patients treated in real-life practice in FranceRespir Med20081021717617920257
- BrusselleGMichilsALouisR“Real-life” effectiveness of omalizumab in patients with severe persistent allergic asthma: the PERSIST studyRespir Med2009103111633164219619998
- BarnesNMenzies-GowAMansurAHEffectiveness of omalizumab in severe allergic asthma: a retrospective UK real-world studyJ Asthma201350552953623574000
- CazzolaMCamiciottoliGBonaviaMItalian real-life experience of omalizumabRespir Med2010104101410141620483574
- BraunstahlGJChenCWMaykutRGeorgiouPPeacheyGBruceJThe eXpeRience registry: the ‘real-world’ effectiveness of omalizumab in allergic asthmaRespir Med201310781141115123721684
- LanierBBridgesTKulusMTaylorAFBerhaneIVidaurreCFOmalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthmaJ Allergy Clin Immunol200912461210121619910033
- MilgromHBergerWNayakATreatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab)Pediatrics20011082E3611483846
- NormansellRWalkerSMilanSJWaltersEHNairPOmalizumab for asthma in adults and childrenCochrane Database Syst Rev20141CD00355924414989
- DeschildreAMarguetCSalleronJAdd-on omalizumab in children with severe allergic asthma: a 1-year real life surveyEur Respir J20134251224123323520319
- OdajimaHEbisawaMNagakuraTOmalizumab in Japanese children with severe allergic asthma uncontrolled with standard therapyAllergol Int201564436437026433533
- MaykutRJKianifardFGebaGPResponse of older patients with IgE-mediated asthma to omalizumab: a pooled analysisJ Asthma200845317318118415822
- KornSSchumannCKropfCEffectiveness of omalizumab in patients 50 years and older with severe persistent allergic asthmaAnn Allergy Asthma Immunol2010105431331920934632
- VermaPRandhawaIKlaustermeyerWBClinical efficacy of omalizumab in an elderly veteran population with severe asthmaAllergy Asthma Proc201132534635022195686
- HolgateSTHow to evaluate a patient’s response to anti-IgEEur Respir Rev2007161047884
- BousquetJRabeKHumbertMPredicting and evaluating response to omalizumab in patients with severe allergic asthmaRespir Med200710171483149217339107
- BousquetJSiergiejkoZSwiebockaEPersistency of response to omalizumab therapy in severe allergic (IgE-mediated) asthmaAllergy201166567167821255035
- LinHBoeselKMGriffithDTOmalizumab rapidly decreases nasal allergic response and FcεRI on basophilsJ Allergy Clin Immunol2004113229730214767445
- PrussinCGriffithDTBoeselKMLinHFosterBCasaleTBOmalizumab treatment downregulates dendritic cell FcεRI expressionJ Allergy Clin Immunol200311261147115414657874
- CorrenJShapiroGReimannJAllergen skin tests and free IgE levels during reduction and cessation of omalizumab therapyJ Allergy Clin Immunol2008121250651118269927
- SlavinRGFerioliCTannenbaumSJMartinCBloggMLowePJAsthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrationsJ Allergy Clin Immunol20091231107.e3113.e319130931
- NoppAJohanssonSGAdedoyinJAnkerstJPalmqvistMOmanHAfter 6 years with Xolair; a 3-year withdrawal follow-upAllergy2010651566019796193
- NoppAJohanssonSGAnkerstJPalmqvistMOmanHCD-sens and clinical changes during withdrawal of Xolair after 6 years of treatmentAllergy200762101175118117845588
- LowePJRenardDOmalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgEBr J Clin Pharmacol201172230632021392073
- MolimardMMalaLBourdeixILe GrosVObservational study in severe asthmatic patients after discontinuation of omalizumab for good asthma controlRespir Med2014108457157624565601
- BusseWTrazskomaBOmachiTEvaluating omalizumab persistency of response after long-term therapy (XPORT)Eur Respir J201444Suppl 583485
- Ministry of Health and WelfareCause of Death Data from Department of StatisticsMinistry of Health and Welfare Available from: http://www.mohw.gov.tw/cht/DOS/Statistic.aspx?f_list_no=312&fod_list_no=2473Accessed January 10, 2016
- WuWFWanKSWangSJYangWLiuWLPrevalence, severity, and time trends of allergic conditions in 6-to-7-year-old schoolchildren in TaipeiJ Invest Allergol Clin Immunol2011217556562
- KuoHPEffectiveness, safety and treatment persistence of add-on omalizumab in Taiwanese patients with uncontrolled severe persistent asthma (the EXACT study)Presented at: 4th IPCRG Scientific MeetingMay 28–30, 2015Singapore
- ChenHCHuangCDChangEKuoHPEfficacy of omalizumab (XolairR) in patients with moderate to severe predominately chronic oral steroid dependent asthma in Taiwan: a retrospective, population-based database cohort studyBMC Pulm Med2016161326747278
- HugginsKGBrostoffJLocal production of specific IgE antibodies in allergic-rhinitis patients with negative skin testsLancet19752792614815049744
- DomingoCOmalizumab for severe asthma: efficacy beyond the atopic patient?Drugs201474552153324691707
- GarciaGMagnanAChironRA proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthmaChest2013144241141923579324
- GevaertPCalusLVan ZeleTOmalizumab is effective in allergic and nonallergic patients with nasal polyps and asthmaJ Allergy Clin Immunol20131311110.e1116.e123021878
- de LlanoLPVennera MdelCAlvarezFJEffects of omalizumab in non-atopic asthma: results from a Spanish multicenter registryJ Asthma201350329630123350994
- OwenCEImmunoglobulin E: role in asthma and allergic disease: lessons from the clinicPharmacol Ther2007113112113317000005
- ChervinskyPCasaleTTownleyROmalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitisAnn Allergy Asthma Immunol200391216016712952110
- VignolaAMHumbertMBousquetJEfficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with concomitant allergic asthma and persistent allergic rhinitis: SOLARAllergy200459770971715180757
- AdelrothERakSHaahtelaTRecombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitisJ Allergy Clin Immunol2000106225325910932067
- NagakuraTOginoSOkuboKSatoNTakahashiMIshikawaTOmalizumab is more effective than suplatast tosilate in the treatment of Japanese cedar pollen-induced seasonal allergic rhinitisClin Exp Allergy200838232933718070163
- OkuboKOginoSNagakuraTIshikawaTOmalizumab is effective and safe in the treatment of Japanese cedar pollen-induced seasonal allergic rhinitisAllergol Int200655437938617130680
- PintoJMMehtaNDiTineoMWangJBaroodyFMNaclerioRMA randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitisRhinology201048331832421038023
- BachertCGevaertPHoltappelsGJohanssonSGvan CauwenbergePTotal and specific IgE in nasal polyps is related to local eosinophilic inflammationJ Allergy Clin Immunol2001107460761411295647
- VerbruggenKVan CauwenbergePBachertCAnti-IgE for the treatment of allergic rhinitis – and eventually nasal polyps?Int Arch Allergy Immunol20091482879818799888
- PennRMikulaSThe role of anti-IgE immunoglobulin therapy in nasal polyposis: a pilot studyAm J Rhinol200721442843217882911
- GarmhausenDHagemannTBieberTCharacterization of different courses of atopic dermatitis in adolescent and adult patientsAllergy201368449850623452057
- HarskampCTArmstrongAWImmunology of atopic dermatitis: novel insights into mechanisms and immunomodulatory therapiesSemin Cutan Med Surg201332313213924175400
- MaqboolSHsiehFMcDonnellJVasasDLangDSafety and efficacy of omalizumab in atopic dermatitis: a preliminary reportJ Allergy Clin Immunol20051152S106
- VigoPGHussainIGirgisKRPfuetzeBLCritchlowMEFisherJEffect of anti-IgE therapy on atopic eczema symptoms in patients with asthmaJ Allergy Clin Immunol20051152S104
- HeilPMMaurerDKleinBHultschTStinglGOmalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course – a randomized, placebo-controlled and double blind pilot studyJ Dtsch Dermatol Ges201081299099820678148
- HotzeMBaurechtHRodriguezEIncreased efficacy of omalizumab in atopic dermatitis patients with wild-type filaggrin status and higher serum levels of phosphatidylcholinesAllergy201469113213524111531
- IyengarSRHoyteEGLozaAImmunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trialInt Arch Allergy Immunol20131621899323816920
- RomanoCSellittoADe FanisUOmalizumab for difficult-to-treat dermatological conditions: clinical and immunological features from a retrospective real-life experienceClin Drug Invest2015353159168
- ZinkAGensbaurAZirbsMTargeting IgE in severe atopic dermatitis with a combination of immunoadsorption and omalizumabActa Derm Venereol2016961727626059424
- JacksonDJSykesAMalliaPJohnstonSLAsthma exacerbations: origin, effect, and preventionJ Allergy Clin Immunol201112861165117422133317
- SearsMRJohnstonNWUnderstanding the September asthma epidemicJ Allergy Clin Immunol2007120352652917658590
- OborneJMortimerKHubbardRBTattersfieldAEHarrisonTWQuadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: a randomized, double-blind, placebo-controlled, parallel-group clinical trialAm J Respir Crit Care Med2009180759860219590019
- StrunkRCBacharierLBPhillipsBRAzithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma studyJ Allergy Clin Immunol200812261138.e41144.e418951618
- WeissKBGernJEJohnstonNWThe Back to School asthma study: the effect of montelukast on asthma burden when initiated prophylactically at the start of the school yearAnn Allergy Asthma Immunol2010105217418120674830
- JohnstonSLPattemorePKSandersonGThe relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysisAm J Respir Crit Care Med19961543 Pt 16546608810601
- TeachSJGillMATogiasAPreseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbationsJ Allergy Clin Immunol201513661476148526518090