94
Views
22
CrossRef citations to date
0
Altmetric
Original Research

Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay

, , , , &
Pages 2669-2676 | Published online: 22 Aug 2016

References

  • MaruyamaTMiyamotoYNakamuraTIdentification of membrane-type receptor for bile acids (M-BAR)Biochem Biophys Res Commun2002298571471912419312
  • KawamataYFujiiRHosoyaMA G protein-coupled receptor responsive to bile acidsJ Biol Chem2003278119435944012524422
  • ThomasCGioielloANoriegaLTGR5-mediated bile acid sensing controls glucose homeostasisCell Metab200910316717719723493
  • CoppleBLLiTPharmacology of bile acid receptors: evolution of bile acids from simple detergents to complex signaling moleculesPharmacol Res201610492126706784
  • De Aguiar VallimTQTarlingEJEdwardsPAPleiotropic roles of bile acids in metabolismCell Metab201317565766923602448
  • FickertPFuchsbichlerAMarschallHULithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in miceAm J Pathol2006168241042216436656
  • TakikawaHHHirookaMSasakiMThe first synthesis of (±)-brevione B, an allelopathic agent isolated from Penicillium spTetrahedron Lett2003442852355238
  • BlazevskiJPetkovicFMomcilovicMBetulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitroActa Pharmacol Sin201334342443123377550
  • GenetCStrehleASchmidtCStructure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetesJ Med Chem201053117819019911773
  • WangXYZhangSYLiJLiuHNXieXNanFJHighly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacyActa Pharmacol Sin201435111463147225283506
  • SilvaFSGOliveiraPJDuarteMFOleanolic, ursolic and betulinic acids as food supplements or pharmaceutical agents for type 2 diabetes – promise or illusion?J Agric Food Chem201664152991300827012451
  • KimKParkMLeeYMRhyuMRKimHYGinsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activationArch Pharm Res20143791193120024590628
  • HuangCHChenMFChungHHChengJTAntihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic ratsJ Nat Prod20127581465146822880723
  • ChengKCLiYXAsakawaACharacterization of preptin-induced insulin secretion in pancreatic β-cellsJ Endocrinol20122151434922787110
  • VettorazziJFRibeiroRABorckPCThe bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cellsMetabolism2016653546326892516
  • SteinertREBeglingerCNutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptidesPhysiol Behav20111051627021376067
  • KuhreREWewer AlbrechtsenNJDeaconCFPeptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cellsJ Mol Endocrinol201656320121126819328
  • Le NevéBDanielHSelected tetrapeptides lead to a GLP-1 release from the human enteroendocrine cell line NCI-H716Regul Pept20111671142021070823
  • ReimannFTolhurstGGribbleFMG-protein coupled receptors in intestinal chemosensationCell Metab201215442143122482725
  • BehrensMMeyerhofWGustatory and extragustatory functions of mammalian taste receptorsPhysiol Behav2011105141321324331
  • KuhreREHolstJJKappeCThe regulation of function, growth and survival of GLP-1-producing L-cellsClin Sci (Lond)20161302799126637406
  • DruckerDJThe biology of incretin hormonesCell Metab20063315316516517403
  • LimGEBrubakerPLGlucagon-like peptide 1 secretion by the L-cell: the view from withinDiabetes200655Suppl 2S70S77
  • PolsTWNoriegaLGNomuraMAuwerxJSchoonjansKThe bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammationJ Hepatol20115461263127221145931