Treatment for primary hypothyroidism: current approaches and future possibilities

References

• Hollowell JG Staehling NW Flanders WD Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III) J Clin Endocrinol Metab 2002 87 2 489 499 11836274
   PubMed Web of Science ®Google Scholar
• Vanderpump MP Tunbridge WM French JM The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey Clin Endocrinol (Oxf) 1995 43 1 55 68 7641412
   PubMed Web of Science ®Google Scholar
• Leese GP Flynn RV Jung RT Macdonald TM Murphy MJ Morris AD Increasing prevalence and incidence of thyroid disease in Tayside, Scotland: the Thyroid Epidemiology Audit and Research Study (TEARS) Clin Endocrinol 2008 68 2 311 316
   Web of Science ®Google Scholar
• Tunbridge WM Evered DC Hall R The spectrum of thyroid disease in a community: the Whickham survey Clin Endocrinol 1977 7 6 481 493
   PubMed Web of Science ®Google Scholar
• Laurberg P Global or Gaelic epidemic of hypothyroidism? Lancet 2005 365 9461 738 740 15733704
   PubMed Web of Science ®Google Scholar
• Information Centre for Health and Social Care Prescription Cost Analysis 2010 2010 Available from: http://www.ic.nhs.uk/pubs/prescostanalysis2010 Accessed September 1, 2011
   Google Scholar
• Canaris GJ Manowitz NR Mayor G Ridgway EC The Colorado thyroid disease prevalence study Arch Intern Med 2000 160 4 526 534 10695693
   PubMed Web of Science ®Google Scholar
• Somwaru LL Arnold AM Joshi N Fried LP Cappola AR High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over J Clin Endocrinol Metab 2009 94 4 1342 1345 19126628
   PubMed Web of Science ®Google Scholar
• Okosieme OE Belludi G Spittle K Kadiyala R Richards J Adequacy of thyroid hormone replacement in a general population QJM 2011 104 5 395 401 21109503
   PubMed Web of Science ®Google Scholar
• Parle JV Franklyn JA Cross KW Jones SR Sheppard MC Thyroxine prescription in the community: serum thyroid stimulating hormone level assays as an indicator of undertreatment or overtreatment Br J Gen Pract 1993 43 368 107 109 8323787
   PubMed Web of Science ®Google Scholar
• Saravanan P Chau WF Roberts N Vedhara K Greenwood R Dayan CM Psychological well-being in patients on ‘adequate’ doses of l-thyroxine: results of a large, controlled community-based questionnaire study Clin Endocrinol (Oxf) 2002 57 5 577 585 12390330
   PubMed Web of Science ®Google Scholar
• Roberts CG Ladenson PW Hypothyroidism Lancet 2004 363 9411 793 803 15016491
   PubMed Web of Science ®Google Scholar
• Harris KB Pass KA Increase in congenital hypothyroidism in New York State and in the United States Mol Genet Metab 2007 91 3 268 277 17512233
   PubMed Web of Science ®Google Scholar
• Canaris GJ Steiner JF Ridgway EC Do traditional symptoms of hypothyroidism correlate with biochemical disease? J Gen Intern Med 1997 12 9 544 550 9294788
   PubMed Web of Science ®Google Scholar
• Spencer CA Hollowell JG Kazarosyan M Braverman LE National Health and Nutrition Examination Survey III thyroid-stimulating hormone (TSH)-thyroperoxidase antibody relationships demonstrate that TSH upper reference limits may be skewed by occult thyroid dysfunction J Clin Endocrinol Metab 2007 92 11 4236 4240 17684054
   PubMed Web of Science ®Google Scholar
• Wartofsky L Dickey RA The evidence for a narrower thyrotropin reference range is compelling J Clin Endocrinol Metab 2005 90 9 5483 5488 16148345
   PubMed Web of Science ®Google Scholar
• Surks MI Goswami G Daniels GH The thyrotropin reference range should remain unchanged J Clin Endocrinol Metab 2005 90 9 5489 5496 16148346
   PubMed Web of Science ®Google Scholar
• Brabant G Beck-Peccoz P Jarzab B Is there a need to redefine the upper normal limit of TSH? Eur J Endocrinol 2006 154 5 633 637 16645008
   PubMed Web of Science ®Google Scholar
• Abalovich M Amino N Barbour LA Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline J Clin Endocrinol Metab 2007 92 8 Suppl S1 47 17948378
   PubMed Web of Science ®Google Scholar
• Stagnaro-Green A Abalovich M Alexander E Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and postpartum Thyroid 2011 21 10 1081 1125 21787128
   PubMed Web of Science ®Google Scholar
• Surks MI Boucai L Age- and race-based serum thyrotropin reference limits J Clin Endocrinol Metab 2010 95 2 496 502 19965925
   PubMed Web of Science ®Google Scholar
• Andersen S Pedersen KM Bruun NH Laurberg P Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to the understanding of subclinical thyroid disease J Clin Endocrinol Metab 2002 87 3 1068 1072 11889165
   PubMed Web of Science ®Google Scholar
• Arnaud-Lopez L Usala G Ceresini G Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function Am J Hum Genet 2008 82 6 1270 1280 18514160
   PubMed Web of Science ®Google Scholar
• Medici M van der Deure WM Verbiest M A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels Eur J Endocrinol 2011 164 5 781 788 21367965
   PubMed Web of Science ®Google Scholar
• Taylor PN Panicker V Sayers A A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement Eur J Endocrinol 2011 164 5 773 780 21317282
   PubMed Web of Science ®Google Scholar
• Atzmon G Barzilai N Surks MI Gabriely I Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity J Clin Endocrinol Metab 2009 94 12 4768 4775 19837933
   PubMed Web of Science ®Google Scholar
• Shields BM Freathy RM Knight BA Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy J Clin Endocrinol Metab 2009 94 11 4608 4612 19820008
   PubMed Web of Science ®Google Scholar
• Lindholm J Laurberg P Hypothyroidism and thyroid substitution: historical aspects J Thyroid Res 2011 2011 809341 21760981
   PubMedGoogle Scholar
• Murray GR Note on the treatment of myxoedema by hypodermic injections of an extract of the thyroid gland of a sheep Br Med J 1891 2 1606 796 797
   PubMedGoogle Scholar
• Fox EL A case of myxoedema treated by taking extract of thyroid by the mouth Br Med J 1892 2 1661 941
   PubMedGoogle Scholar
• Gross J Pitt-Rivers R 3:5:3′-triiodothyronine. 1. Isolation from thyroid gland and synthesis Biochem J 1953 53 4 645 650 13032123
   PubMed Web of Science ®Google Scholar
• Roos A Linn-Rasker SP van Domburg RT Tijssen JP Berghout A The starting dose of levothyroxine in primary hypothyroidism treatment: a prospective, randomized, double-blind trial Arch Intern Med 2005 165 15 1714 1720 16087818
   PubMed Web of Science ®Google Scholar
• Bolk N Visser TJ Kalsbeek A van Domburg RT Berghout A Effects of evening vs morning thyroxine ingestion on serum thyroid hormone profiles in hypothyroid patients Clin Endocrinol 2007 66 1 43 48
   Web of Science ®Google Scholar
• Bolk N Visser TJ Nijman J Jongste IJ Tijssen JG Berghout A Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial Arch Intern Med 2010 170 22 1996 2003 21149757
   PubMed Web of Science ®Google Scholar
• Elliott DP Effect of levothyroxine administration time on serum TSH in elderly patients Ann Pharmacother 2001 35 5 529 532 11346056
   PubMed Web of Science ®Google Scholar
• Bach-Huynh TG Nayak B Loh J Soldin S Jonklaas J Timing of levothyroxine administration affects serum thyrotropin concentration J Clin Endocrinol Metab 2009 94 10 3905 3912 19584184
   PubMed Web of Science ®Google Scholar
• Rajput R Chatterjee S Rajput M Can levothyroxine be taken as evening dose? Comparative evaluation of morning versus evening dose of levothyroxine in treatment of hypothyroidism J Thyroid Res 2011 2011 505239 21785690
   PubMedGoogle Scholar
• Viswanath AK Avenell A Philip S Is annual surveillance of all treated hypothyroid patients necessary BMC Endocr Disord 2007 7 4 17605766
   PubMedGoogle Scholar
• Vaidya B Pearce SH Management of hypothyroidism in adults BMJ 2008 337 a801 18662921
   PubMed Web of Science ®Google Scholar
• Carr D McLeod DT Parry G Thornes HM Fine adjustment of thyroxine replacement dosage: comparison of the thyrotrophin releasing hormone test using a sensitive thyrotrophin assay with measurement of free thyroid hormones and clinical assessment Clin Endocrinol 1988 28 3 325 333
   Web of Science ®Google Scholar
• Walsh JP Ward LC Burke V Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being, or quality of life: results of a double-blind, randomized clinical trial J Clin Endocrinol Metab 2006 91 7 2624 2630 16670161
   PubMed Web of Science ®Google Scholar
• Boeving A Paz-Filho G Radominski RB Graf H de Carvalho GA Low-normal or high-normal thyrotropin target levels during treatment of hypothyroidism: a prospective, comparative study Thyroid 2011 21 4 355 360 21323599
   PubMed Web of Science ®Google Scholar
• Arafah BM Increased need for thyroxine in women with hypothyroidism during estrogen therapy N Engl J Med 2001 344 23 1743 1749 11396440
   PubMed Web of Science ®Google Scholar
• Saravanan P Dayan CM Understanding thyroid hormone action and the effects of Thyroid hormone replacement – just the beginning not the end Hot Thyroidology 2004 1 Available from: http://www.hotthyroidology.com/editorial_135.html Accessed October 5, 2011
   Google Scholar
• Meier C Trittibach P Guglielmetti M Staub JJ Muller B Serum thyroid stimulating hormone in assessment of severity of tissue hypothyroidism in patients with overt primary thyroid failure: cross sectional survey BMJ 2003 326 7384 311 312 12574044
   PubMed Web of Science ®Google Scholar
• Wekking EM Appelhof BC Fliers E Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism Eur J Endocrinol 2005 153 6 747 753 16322379
   PubMed Web of Science ®Google Scholar
• Jonklaas J Davidson B Bhagat S Soldin SJ Triiodothyronine levels in athyreotic individuals during levothyroxine therapy JAMA 2008 299 7 769 777 18285588
   PubMed Web of Science ®Google Scholar
• Gullo D Latina A Frasca F Le Moli R Pellegriti G Vigneri R Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients PLoS One 2011 6 8 e22552 21829633
   PubMed Web of Science ®Google Scholar
• Escobar-Morreale HF Obregon MJ Escobar del Rey F Morreale de Escobar G Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats J Clin Invest 1995 96 6 2828 2838 8675653
   PubMed Web of Science ®Google Scholar
• Bunevicius R Kazanavicius G Zalinkevicius R Prange AJJr Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism N Engl J Med 1999 340 6 424 429 9971866
   PubMed Web of Science ®Google Scholar
• Grozinsky-Glasberg S Fraser A Nahshoni E Weizman A Leibovici L Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials J Clin Endocrinol Metab 2006 91 7 2592 2599 16670166
   PubMed Web of Science ®Google Scholar
• Appelhof BC Peeters RP Wiersinga WM Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3′-triiodothyronine therapy J Clin Endocrinol Metab 2005 90 11 6296 6299 16144953
   PubMed Web of Science ®Google Scholar
• Escobar-Morreale HF Botella-Carretero JI Gomez-Bueno M Galan JM Barrios V Sancho J Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone Ann Intern Med 2005 142 6 412 424 15767619
   PubMed Web of Science ®Google Scholar
• Saravanan P Siddique H Simmons DJ Greenwood R Dayan CM Twenty-four hour hormone profiles of TSH, Free T3 and free T4 in hypothyroid patients on combined T3/T4 therapy Exp Clin Endocrinol Diabetes 2007 115 4 261 267 17479444
   PubMed Web of Science ®Google Scholar
• Panicker V Saravanan P Vaidya B Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients J Clin Endocrinol Metab 2009 94 5 1623 1629 19190113
   PubMed Web of Science ®Google Scholar
• Escobar-Morreale HF Botella-Carretero JI Escobar del Rey F Morreale de Escobar G REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine J Clin Endocrinol Metab 2005 90 8 4946 4954 15928247
   PubMed Web of Science ®Google Scholar
• Celi FS Zemskova M Linderman JD Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine J Clin Endocrinol Metab 2011 96 3466 3474 21865366
   PubMed Web of Science ®Google Scholar
• Parle JV Franklyn JA Cross KW Jones SC Sheppard MC Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom Clin Endocrinol 1991 34 1 77 83
   PubMed Web of Science ®Google Scholar
• Meyerovitch J Rotman-Pikielny P Sherf M Battat E Levy Y Surks MI Serum thyrotropin measurements in the community: five-year follow-up in a large network of primary care physicians Arch Intern Med 2007 167 14 1533 1538 17646608
   PubMedGoogle Scholar
• Lekakis J Papamichael C Alevizaki M Flow-mediated, endothelium- dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal serum thyrotropin (TSH) values Thyroid 1997 7 3 411 414 9226212
   PubMed Web of Science ®Google Scholar
• Rodondi N den Elzen WP Bauer DC Subclinical hypothyroidism and the risk of coronary heart disease and mortality JAMA 2010 304 12 1365 1374 20858880
   PubMed Web of Science ®Google Scholar
• Ceresini G Lauretani F Maggio M Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study J Am Geriatr Soc 2009 57 1 89 93 19054181
   PubMed Web of Science ®Google Scholar
• Villar HC Saconato H Valente O Atallah AN Thyroid hormone replacement for subclinical hypothyroidism Cochrane Database Syst Rev 2007 3 CD003419 17636722
   PubMed Web of Science ®Google Scholar
• Razvi S Ingoe L Keeka G Oates C McMillan C Weaver JU The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial J Clin Endocrinol Metab 2007 92 5 1715 1723 17299073
   PubMed Web of Science ®Google Scholar
• Parle J Roberts L Wilson S A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study J Clin Endocrinol Metab 2010 95 8 3623 3632 20501682
   PubMed Web of Science ®Google Scholar
• Surks MI Ortiz E Daniels GH Subclinical thyroid disease: scientific review and guidelines for diagnosis and management JAMA 2004 291 2 228 238 14722150
   PubMed Web of Science ®Google Scholar
• Association for Clinical Biochemistry, British Thyroid Association, British Thyroid Foundation UK guidelines for the use of thyroid function tests 2006 Available from: http://www.british-thyroid-association.org/info-for-patients/Docs/TFT_guideline_final_version_July_2006.pdf Accessed September 1, 2011
   Google Scholar
• de Escobar GM Obregon MJ del Rey FE Maternal thyroid hormones early in pregnancy and fetal brain development Best Pract Res Clin Endocrinol Metab 2004 18 2 225 248 15157838
   PubMed Web of Science ®Google Scholar
• Haddow JE Palomaki GE Allan WC Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child N Engl J Med 1999 341 8 549 555 10451459
   PubMed Web of Science ®Google Scholar
• Pop VJ Kuijpens JL van Baar AL Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy Clin Endocrinol 1999 50 2 149 155
   PubMed Web of Science ®Google Scholar
• Henrichs J Bongers-Schokking JJ Schenk JJ Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study J Clin Endocrinol Metab 2010 95 9 4227 4234 20534757
   PubMed Web of Science ®Google Scholar
• Allan WC Haddow JE Palomaki GE Maternal thyroid deficiency and pregnancy complications: implications for population screening J Med Screen 2000 7 3 127 130 11126160
   PubMed Web of Science ®Google Scholar
• Abalovich M Gutierrez S Alcaraz G Maccallini G Garcia A Levalle O Overt and subclinical hypothyroidism complicating pregnancy Thyroid 2002 12 1 63 68 11838732
   PubMed Web of Science ®Google Scholar
• Casey BM Dashe JS Wells CE Subclinical hypothyroidism and pregnancy outcomes Obstet Gynecol 2005 105 2 239 245 15684146
   PubMed Web of Science ®Google Scholar
• Krassas GE Poppe K Glinoer D Thyroid function and human reproductive health Endocrine Reviews 2010 31 5 702 755 20573783
   PubMed Web of Science ®Google Scholar
• Negro R Schwartz A Gismondi R Tinelli A Mangieri T Stagnaro-Green A Increased pregnancy loss rate in thyroid antibody negative women with TSH levels between 2.5 and 5.0 in the first trimester of pregnancy J Clin Endocrinol Metab 2010 95 9 E44 48 20534758
   PubMed Web of Science ®Google Scholar
• Mandel SJ Larsen PR Seely EW Brent GA Increased need for thyroxine during pregnancy in women with primary hypothyroidism N Engl J Med 1990 323 2 91 96 2359428
   PubMed Web of Science ®Google Scholar
• Alexander EK Marqusee E Lawrence J Jarolim P Fischer GA Larsen PR Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism N Engl J Med 2004 351 3 241 249 15254282
   PubMed Web of Science ®Google Scholar
• Vaidya B Anthony S Bilous M Detection of thyroid dysfunction in early pregnancy: Universal screening or targeted high-risk case finding? J Clin Endocrinol Metab 2007 92 1 203 207 17032713
   PubMed Web of Science ®Google Scholar
• Rotondi M Mazziotti G Sorvillo F Effects of increased thyroxine dosage pre-conception on thyroid function during early pregnancy Eur J Endocrinol 2004 151 6 695 700 15588235
   PubMed Web of Science ®Google Scholar
• Yassa L Marqusee E Fawcett R Alexander EK Thyroid hormone early adjustment in pregnancy (the THERAPY) trial J Clin Endocrinol Metab 2010 95 7 3234 3241 20463094
   PubMed Web of Science ®Google Scholar
• Rosenbaum RL Barzel US Levothyroxine replacement dose for primary hypothyroidism decreases with age Ann Intern Med 1982 96 1 53 55 7053703
   PubMed Web of Science ®Google Scholar
• Sawin CT Herman T Molitch ME London MH Kramer SM Aging and the thyroid. Decreased requirement for thyroid hormone in older hypothyroid patients Am J Med 1983 75 2 206 209 6881172
   PubMed Web of Science ®Google Scholar
• Gregerman RI Gaffney GW Shock NW Crowder SE Thyroxine turnover in euthyroid man with special reference to changes with age J Clin Invest 1962 41 2065 2074 13950233
   PubMed Web of Science ®Google Scholar
• Cunningham JJ Barzel US Lean body mass is a predictor of the daily requirement for thyroid hormone in older men and women J Am Geriatr Soc 1984 32 3 204 207 6699335
   PubMed Web of Science ®Google Scholar
• Gussekloo J van Exel E de Craen AJ Meinders AE Frolich M Westendorp RG Thyroid status, disability and cognitive function, and survival in old age JAMA 2004 292 21 2591 2599 15572717
   PubMed Web of Science ®Google Scholar
• Atzmon G Barzilai N Hollowell JG Surks MI Gabriely I Extreme longevity is associated with increased serum thyrotropin J Clin Endocrinol Metab 2009 94 4 1251 1254 19158193
   PubMed Web of Science ®Google Scholar
• Faber J Galloe AM Changes in bone mass during prolonged subclinical hyperthyroidism due to L-thyroxine treatment: a meta-analysis Eur J Endocrinol 1994 130 4 350 356 8162163
   PubMed Web of Science ®Google Scholar
• Uzzan B Campos J Cucherat M Nony P Boissel JP Perret GY Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis J Clin Endocrinol Metab 1996 81 12 4278 4289 8954028
   PubMed Web of Science ®Google Scholar
• Bauer DC Ettinger B Nevitt MC Stone KL Risk for fracture in women with low serum levels of thyroid-stimulating hormone Ann Intern Med 2001 134 7 561 568 12803168
   PubMed Web of Science ®Google Scholar
• Turner MR Camacho X Fischer HD Levothyroxine dose and risk of fractures in older adults: nested case-control study BMJ 2011 342 d2238 21527461
   PubMed Web of Science ®Google Scholar
• Sawin CT Geller A Wolf PA Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons N Engl J Med 1994 331 19 1249 1252 7935681
   PubMed Web of Science ®Google Scholar
• Cappola AR Fried LP Arnold AM Thyroid status, cardiovascular risk, and mortality in older adults JAMA 2006 295 9 1033 1041 16507804
   PubMed Web of Science ®Google Scholar
• Gammage MD Parle JV Holder RL Association between serum free thyroxine concentration and atrial fibrillation Arch Intern Med 2007 167 9 928 934 17502534
   PubMedGoogle Scholar
• Vadiveloo T Donnan PT Cochrane L Leese GP The Thyroid Epidemiology, Audit, and Research Study (TEARS): morbidity in patients with endogenous subclinical hyperthyroidism J Clin Endocrinol Metab 2011 96 5 1344 1351 21346066
   PubMed Web of Science ®Google Scholar
• Levine HD Compromise therapy in the patient with angina pectoris and hypothyroidism. A clinical assessment Am J Med 1980 69 3 411 418 6106386
   PubMed Web of Science ®Google Scholar
• Ellyin FM Kumar Y Somberg JC Hypothyroidism complicated by angina pectoris: therapeutic approaches J Clin Pharmacol 1992 32 9 843 847 1358924
   PubMed Web of Science ®Google Scholar
• Grebe SK Cooke RR Ford HC Treatment of hypothyroidism with once weekly thyroxine J Clin Endocrinol Metab 1997 82 3 870 875 9062499
   PubMed Web of Science ®Google Scholar
• Pollock MA Sturrock A Marshall K Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial BMJ 2001 323 7318 891 895 11668132
   PubMed Web of Science ®Google Scholar
• Marcocci C Kahaly GJ Krassas GE Selenium and the course of mild Graves’ orbitopathy N Engl J Med 2011 364 20 1920 1931 21591944
   PubMed Web of Science ®Google Scholar
• Hennemann G Docter R Visser TJ Postema PT Krenning EP Thyroxine plus low-dose, slow-release triiodothyronine replacement in hypothyroidism: proof of principle Thyroid 2004 14 4 271 275 15142360
   PubMed Web of Science ®Google Scholar
• Panicker V Cluett C Shields B A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine J Clin Endocrinol Metab 2008 93 8 3075 3081 18492748
   PubMed Web of Science ®Google Scholar