References
- World Health OrganizationCancer fact sheet [updated February 2015]. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/Accessed December 29, 2016
- SiegelRLMillerKDJemalACancer statistics, 2016CA Cancer J Clin2016661 7 3026742998
- KalluriRWeinbergRAThe basics of epithelial-mesenchymal transitionJ Clin Invest20101205 1786
- ThieryJPEpithelial–mesenchymal transitions in tumour progressionNat Rev Cancer200226 442 45412189386
- YangJWeinbergRAEpithelial-mesenchymal transition: at the crossroads of development and tumor metastasisDev Cell2008146 818 82918539112
- ZeisbergMNeilsonEGBiomarkers for epithelial-mesenchymal transitionsJ Clin Invest20091196 1429 143719487819
- ThieryJPAcloqueHHuangRNietoMAEpithelial-mesenchymal transitions in development and diseaseCell20091395 871 89019945376
- AcloqueHAdamsMSFishwickKBronner-FraserMNietoMAEpithelial-mesenchymal transitions: the importance of changing cell state in development and diseaseJ Clin Invest20091196 1438 144919487820
- PolyakKWeinbergRATransitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traitsNat Rev Cancer200994 265 27319262571
- DerynckRAkhurstRJDifferentiation plasticity regulated by TGF-β family proteins in development and diseaseNat Cell Biol200799 1000 100417762890
- WakefieldLMRobertsABTGF-β signaling: positive and negative effects on tumorigenesisCurr Opin Genet Dev2002121 22 2911790550
- GregoryPABertAGPatersonELThe miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Nat Cell Biol2008105 593 60118376396
- VrbaLJensenTJGarbeJCRole for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cellsPLoS One201051 e869720084174
- NevesRScheelCWeinholdSRole of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cellsBMC Res Notes20103 21920682048
- WiklundEDBramsenJBHulfTCoordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancerInt J Cancer20111286 1327 133420473948
- ChoiSHByunHMKwanJMIssaPJYangASHydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibitionBr J Haematol20071385 616 62317686055
- YoshiuraKKanaiYOchiaiAShimoyamaYSugimuraTHirohashiSSilencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomasProc Natl Acad Sci U S A19959216 7416 74197543680
- CornPGSmithBDRuckdeschelESDouglasDBaylinSBHermanJGE-cadherin expression is silenced by 5′ CpG island methylation in acute leukemiaClin Cancer Res2000611 4243 424811106238
- NamJSInoYKanaiYSakamotoMHirohashiS5-Aza-2′-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasisClin Exp Metastasis2004211 49 5615065602
- ParkSMGaurABLengyelEPeterMEThe miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Genes Dev2008227 894 90718381893
- WangZLiZWangYVersican silencing improves the anti-tumor efficacy of endostatin by alleviating its induced inflammatory and immunosuppressive changes in the tumorOncol Rep2015336 2981 299125872924
- RobertsABSpornMBThe transforming growth factor-βsPeptide Growth Fact Recept I1990951 419 472
- GregoryJHAndrewJCSimonDSGrahamJBOverexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherinCancer Res200767 7972 797617804704
- CraeneDBBerxGRegulatory networks defining EMT during cancer initiation and progressionNat Rev Cancer2013132 97 11023344542
- ShanBYaoTNguyenHTRequirement of HDAC6 for transforming growth factor-β1-induced epithelial-mesenchymal transitionJ Biol Chem200828330 21065 2107318499657
- DavalosVMoutinhoCVillanuevaADynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesisOncogene20123116 2062 207421874049
- AkhurstRJDerynckRTGF-β signaling in cancer–a double-edged swordTrends Cell Biol20011111 S44 S5111684442
- PardaliKMoustakasAActions of TGF-β as tumor suppressor and pro-metastatic factor in human cancerBiochim Biophys Acta200717751 21 6216904831
- GollobJASciambiCJPetersonBLPhase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinomaClin Cancer Res20061215 4619 462716899610
- GibbonsDLLinWCreightonCJContextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expressionGenes Dev20092318 2140 215119759262
- ShienKToyookaSYamamotoHAcquired resistance to EGFR inhibitors is associated with a manifestation of stem cell–like properties in cancer cellsCancer Res20137310 3051 306123542356
- ZhouXWangYShanBThe downregulation of miR-200c/141 promotes ZEB1/2 expression and gastric cancer progressionMed Oncol2015321 42825502084
- IssaJJGharibyanVCortesJPhase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylateJ Clin Oncol20052317 3948 395615883410
- SerranoATanzarellaSLionelloIRexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2′-deoxycytidine treatmentInt J Cancer2001942 243 25111668505
- WeiserTSShengGZOhnmachtGASequential 5-Aza-2′-deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1J Immunother2001242 151 16111265773
- CoralSSigalottiLAltomonteM5-aza-2′-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implicationsClin Cancer Res200288 2690 269512171902