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Drug Design, Development and Therapy Volume 11, 2017 - Issue

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Original Research

Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate

Hae Won Lee1 Clinical Trial Center, Kyungpook National University Hospital

Sook Jin Seong1 Clinical Trial Center, Kyungpook National University Hospital

Boram Ohk1 Clinical Trial Center, Kyungpook National University Hospital;2 Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School

Woo Youl Kang1 Clinical Trial Center, Kyungpook National University Hospital;2 Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School

Mi-Ri Gwon1 Clinical Trial Center, Kyungpook National University Hospital

Bo Kyung Kim1 Clinical Trial Center, Kyungpook National University Hospital;2 Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School

Hyun-Ju Kim3 Cell and Matrix Research Institute, Daegu, Republic of Korea

Young-Ran Yoon1 Clinical Trial Center, Kyungpook National University Hospital;2 Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate SchoolCorrespondence[email protected]

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Pages 2719-2725 | Published online: 13 Sep 2017

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MasuokaHCChalasaniNNonalcoholic fatty liver disease: an emerging threat to obese and diabetic individualsAnn N Y Acad Sci20131281 106 12223363012
PubMed Web of Science ®Google Scholar
CohenJCHortonJDHobbsHHHuman fatty liver disease: old questions and new insightsScience20113326037 1519 152321700865
PubMed Web of Science ®Google Scholar
LomonacoRSunnyNEBrilFCusiKNonalcoholic fatty liver disease: current issues and novel treatment approachedDrugs2013731 1 1423329465
PubMed Web of Science ®Google Scholar
HardyTAnsteeQMDayCPNonalcoholic fatty liver disease: new treatmentsCurr Opin Gastroenterol2015313 175 18325774446
PubMed Web of Science ®Google Scholar
MalhotraNBeatonMDManagement of non-alcoholic fatty liver disease in 2015World J Hepatol2015730 2962 296726730275
PubMedGoogle Scholar
SanyalAJChalasaniNKowdleyKVPioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitisN Eng J Med201036218 1675 1685
PubMed Web of Science ®Google Scholar
Schaffner-SabbaKSchmidt-RuppinKHWehrliWSchuerchARWasleyJWbeta-Lapachone: synthesis of derivatives and activities in tumor modelsJ Med Chem1984278 990 9946205152
PubMed Web of Science ®Google Scholar
PinkJJPlanchonSMTagliarinoCVarnesMESiegelDBoothmanDANAD(P)H:quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicityJ Biol Chem20002758 5416 542410681517
PubMed Web of Science ®Google Scholar
AlbenaATTalalayPNAD(P)H:quinone acceptor oxidoreductase 1(NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotectorArch Biochem Biophys20105011 116 12320361926
PubMed Web of Science ®Google Scholar
LeeEJKoHMJeongYHParkEMKimHSβ-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microgliaJ Neuroinflammation201512 13326173397
PubMed Web of Science ®Google Scholar
JeonYJBangWChoiYHShimJHChaeJIBeta-lapachone suppresses non-small cell lung cancer proliferation through the regulation of specificity protein 1Biol Pharm Bull2015389 1302 130826328485
PubMed Web of Science ®Google Scholar
BangWJeonYJChoJHβ-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1Oncol Rep2016352 1109 111626718788
PubMed Web of Science ®Google Scholar
KungHNYangMJChangCFChauYPLuKSIn vitro and in vivo wound healing-promoting activities of beta-lapachoneAm J Physiol Cell Physiol20082954 C931 C94318650264
PubMed Web of Science ®Google Scholar
KimYHHwangJHNohJRActivation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activityCardiovasc Res2011913 519 52721502369
PubMed Web of Science ®Google Scholar
KimYHHwangJHKimKSNAD(P)H:quinone oxidoreductase 1 activation reduces blood pressure through regulation of endothelial nitric oxide synthase acetylation in spontaneously hypertensive ratsAm J Hypertens2015281 50 5724951727
PubMed Web of Science ®Google Scholar
HwangJHKimDWJoEJPharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in miceDiabetes2009584 965 97419136651
PubMed Web of Science ®Google Scholar
ShinSParkJLiYβ-Lapachone alleviates alcoholic fatty liver disease in ratsCell Signal2014262 295 30524269941
PubMed Web of Science ®Google Scholar
ChoiWHAhnJJungCHJangYJHaTYβ-Lapachone prevents diet-induced obesity by increasing energy expenditure and stimulating the browning of white adipose tissue via downregulation of miR-382 expressionDiabetes2016659 2490 250127246910
PubMed Web of Science ®Google Scholar
KimIKimHRoJPreclinical pharmacokinetic evaluation of β-lapachone: characteristics of oral bioavailability and first-pass metabolism in ratsBiomol Ther (Seoul)2015233 296 30025995830
PubMed Web of Science ®Google Scholar
SavageREHallTBrescianoKBaileyJStaraceMChanTCDevelopment and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ARQ 501 (beta-lapachone) in plasma and tumors from nu/nu mouse xenograftsJ Chromatogr B Analyt Technol Biomed Life Sci20088721–2 148 153
Web of Science ®Google Scholar
LiuHLiQChengXWangHWangGHaoHUDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of β-lapachone in human colon cancer cellsPLoS One2015102 e011705125692465
PubMed Web of Science ®Google Scholar
ChengXLiuFYanTMetabolic profile, enzyme kinetics, and reaction phenotyping of β-Lapachone metabolism in human liver and intestine in vitroMol Pharm2012912 3476 348523134532
PubMed Web of Science ®Google Scholar
NebertDWRoeALVandaleSEBinghamEOakleyGGNAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE reviewGenet Med200242 62 7011882782
PubMed Web of Science ®Google Scholar
Martinez-HernándezACórdovaEJRosillo-SalazarOAssociation of HMOX1 and NQO1 polymorphisms with metabolic syndrome componentsPLoS One2015105 e012331325933176
PubMed Web of Science ®Google Scholar
ZhengBWangZChaiRNQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysisArch Med Sci2014104 651 66025276147
PubMed Web of Science ®Google Scholar
KelseyKTRossDTraverRDEthnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapyBr J Cancer1997767 852 8549328142
PubMed Web of Science ®Google Scholar

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