References
- HolgateSTInnate and adaptive immune responses in asthmaNat Med20121867368322561831
- Global Initiative for AsthmaGlobal Strategy for Asthma Management and PreventionBethesda (MD)GINA2016
- O’ByrnePMNajiNGauvreauGMSevere asthma: future treatmentsClin Exp Allergy20124270671122515391
- SchuligoiRSturmELuschnigPCRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseasesPharmacology20108537238220559016
- HiraiHTanakaKYoshieOProstaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2J Exp Med200119325526111208866
- MjösbergJMTrifariSCrellinNKHuman IL-25- and IL-33- responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161Nat Immunol2011121055106221909091
- KrauseAZisowskyJStrasserDSPharmacokinetic/pharmacodynamic modelling of receptor internalization with CRTH2 antagonists to optimize dose selectionClin Pharmacokinet20165581382126692193
- HallIPFowlerAFGuptaAEfficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatmentPulm Pharmacol Ther201532374425861737
- XueLSalimiMPanseIProstaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cellsJ Allergy Clin Immunol20141331184119424388011
- ChangYJDeKruyffRHUmetsuDTThe role of type 2 innate lymphoid cells in asthmaJ Leukoc Biol20139493394023801654
- BalzarSFajtMLComhairSAMast cell phenotype, location, and activation in severe asthma: data from the Severe Asthma Research ProgramAm J Respir Crit Care Med2011183329930920813890
- FajtMLGelhausSLFreemanBProstaglandin D2 pathway upregulation: relation to asthma severity, control, and TH2 inflammationJ Allergy Clin Immunol20131311504151223506843
- UllerLMathiesenJMAlenmyrLAntagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammationRespir Res200781617328802
- LukacsNWBerlinAAFranz-BaconKCRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammationAm J Physiol Lung Cell Mol Physiol2008295L767L77918757520
- StebbinsKJBroadheadARCorreaLDTherapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammationEur J Pharmacol201063814214920447387
- SinghDCaddenPHunterMInhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459Eur Respir J201341465222496329
- BarnesNPavordIChuchalinAA randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthmaClin Exp Allergy201242384821762224
- LukerTBonnertRSchmidtJSubstituted indole-1-acetic acids as potent and selective CRTH2 antagonists: discovery of AZD1981Bioorg Med Chem Lett2011216288629221944852
- GonemSBerairRSingapuriAFevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trialLancet Respir Med2016469970727503237
- ErpenbeckVJPopovTAMillerDThe oral CRTH2 antagonist QAW039 (fevipiprant): a phase II study in uncontrolled allergic asthmaPulm Pharmacol Ther201639546327354118
- PettipherRHunterMGPerkinsCMHeightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459Allergy2014691223123224866478
- SchmidtJBFAkamEBiochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthmaBr J Pharmacol201316816261638
- KunaPBjermerLTornlingGTwo phase II randomized trials on the CR Th2 antagonist AZD1981 in adults with asthmaDrug Des Devel Ther20161027592770
- QuanjerPHTammelingGJCotesJEPedersenOFPeslinRYernaultJCLung volumes and forced ventilatory flowsEur Respir J19936Suppl 16540
- MerrettJMerrettTGPhadiatop: a novel IgE antibody screening testClin Allergy1987174094163315300
- JuniperEFO’ByrnePMRobertsJNMeasuring asthma control in group studies: do we need airway calibre and rescue β2-agonist use?Respir Med20019531932311392570
- MillerMRHankinsonJBrusascoVStandardisation of spirometryEur Respir J20052631933816055882
- JuniperEFBuistASCoxFMFerriePJKingDRValidation of a standardized version of the Asthma Quality of Life QuestionnaireChest19991151265127010334138
- CorrenJLemanskeRFHananiaNALebrikizumab treatment in adults with asthmaN Engl J Med20113651088109821812663
- PettipherRHanselTTArmerRAntagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseasesNat Rev Drug Discov2007631332517396136
- BusseWWWenzelSEMeltzerEOSafety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patientsJ Allergy Clin Immunol201313133934523174659
- HallISarnoMDisseBEfficacy and safety of BI 671800, an oral CRTH2 antagonist, as add on therapy in poorly controlled asthma patients prescribed an inhaled corticosteroidEur Respir J201240Suppl 563085
- SutherlandRTetzlaffKNivensCEfficacy and safety of BI 671800, an oral CRTH2 antagonist in controller naïve patients with poorly-controlled asthmaEur Respir J201240Suppl 563084
- MillerDWoodCBatemanEA randomized study of BI 671800, a CRTH2 antagonist, as add-on therapy in poorly controlled asthmaAllergy Asthma Proc20173815716428234053
- CalbetMAndrésMArmengolCPharmacological characterization of CRTH2 antagonist LAS191859: long receptor residence time translates into long-lasting in vivo efficacyPharmacol Res201611120821627317944
- SykesDABradleyMERiddyDMFevipiprant (QAW039), a slowly dissociating CRTH2 antagonist with the potential for improved clinical efficacyMol Pharmacol20168959360526916831
- OtulanaBBowdenAYenYPuthukkerilSDevelopment of pitrakinra: an interleukin receptor antagonist to treat eosinophilic asthmaRespir Drug Deliv201212128
- PavordIDKornSHowarthPMepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trialLancet201238065165922901886
- SzeflerSJPhillipsBRMartinezFDCharacterization of within-subject responses to fluticasone and montelukast in childhood asthmaJ Allergy Clin Immunol200511523324215696076
- WoodruffPGModrekBChoyDFT-helper type 2-driven inflammation defines major subphenotypes of asthmaAm J Respir Crit Care Med200918038839519483109
- BatemanEGuerrerosABrockhausFFevipiprant, an oral prostaglandin DP2 receptor (CRTH2) antagonist, in allergic asthma uncontrolled on low-dose inhaled corticosteroidsEur Respir Med2017501700670