108
Views
16
CrossRef citations to date
0
Altmetric
Original Research

Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway

, , , , , , & show all
Pages 3675-3684 | Published online: 01 Nov 2018

References

  • DoroszkoAJanusASzahidewicz-KrupskaEMazurGDerkaczAResistant HypertensionAdv Clin Exp Med201625117318326935512
  • Rodriguez-IturbeBPonsHJohnsonRJRole of the Immune System in HypertensionPhysiol Rev20179731127116428566539
  • YangLBaiYLiNVascular VPO1 expression is related to the endothelial dysfunction in spontaneously hypertensive ratsBiochem Biophys Res Commun2013439451151624021280
  • HuangKSongYTHeYHFengXLHealth system strengthening and hypertension management in ChinaGlob Health Res Policy201611329202062
  • Al DisiSSAnwarMAEidAHAnti-hypertensive Herbs and their Mechanisms of Action: Part IFront Pharmacol2016632326834637
  • MarantaFSpoladoreRFragassoGPathophysiological mechanisms and correlates of therapeutic pharmacological interventions in essential arterial hypertensionAdv Exp Med Biol2017956375927864806
  • YuanTYChenYCZhangHFDL0805-2, a novel indazole derivative, relaxes angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxesActa Pharmacol Sin201637560461627041459
  • CarthyERAutonomic dysfunction in essential hypertension: A systematic reviewAnn Med Surg (Lond)2014312725568776
  • XiongXYangXLiuYZhangYWangPWangJChinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern scienceHypertens Res201336757057923552514
  • VanhouttePMShimokawaHFeletouMTangEHEndothelial dysfunction and vascular disease – a 30th anniversary updateActa Physiol (Oxf)20172191229626706498
  • Khaddaj MallatRMathew JohnCKendrickDJBraunAPThe vascular endothelium: A regulator of arterial tone and interface for the immune systemCrit Rev Clin Lab Sci2017547–845847029084470
  • KonukogluDUzunHEndothelial dysfunction and hypertensionAdv Exp Med Biol201795651154028035582
  • VersariDDaghiniEVirdisAGhiadoniLTaddeiSEndothelium-dependent contractions and endothelial dysfunction in human hypertensionBr J Pharmacol2009157452753619630832
  • NagyJCsikyBKovácsTWittmannIEndothelial dysfunctionOrv Hetil20011423116671672 Hungarian11556260
  • MiaoQWangQDongLWangYTanYZhangXThe expression of p66shc in peripheral blood monocytes is increased in patients with coronary heart disease and correlated with endothelium-dependent vasodilatationHeart Vessels201530445145724676406
  • LandmesserUDrexlerHEndothelial function and hypertensionCurr Opin Cardiol200722431632017556884
  • ZhaoYChenBNWangSBWangSHDuGHVasorelaxant effect of formononetin in the rat thoracic aorta and its mechanismsJ Asian Nat Prod Res2012141465422263593
  • LuoLYFanMXZhaoHYLiMXWuXGaoWYPharmacokinetics and Bioavailability of the Isoflavones Formononetin and Ononin and Their in Vitro Absorption in Ussing Chamber and Caco-2 Cell ModelsJ Agric Food Chem201866112917292429504397
  • HaoPJiangFChengJMaLZhangYZhaoYTraditional Chinese medicine for cardiovascular disease: evidence and potential mechanismsJ Am Coll Cardiol201769242952296628619197
  • ZhangYShiPYaoHShaoQFanXMetabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (Qishen yiqi pills) in ratsCurr Drug Metab201213551052322292791
  • HeYduBFanHBeneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-β1/Smad3 PathwayEvid Based Complement Alternat Med2015201529863126604970
  • HanJYLiQMaZZFanJYEffects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusionPharmacol Ther201717714617328322971
  • SunTWangJHuangLHCaoYXAntihypertensive effect of for-mononetin through regulating the expressions of eNOS, 5-HT2A/1B receptors and α1-adrenoceptors in spontaneously rat arteriesEur J Pharmacol20136991–324124923123056
  • SunTCaoLPingNNWuYLiuDZCaoYXFormononetin upregulates nitric oxide synthase in arterial endothelium through estrogen receptors and MAPK pathwaysJ Pharm Pharmacol201668334235126786718
  • TsengHHVongCTLeungGPCalycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance Ca2+-Activated K+ Channels (BKCa)Evid Based Complement Alternat Med20162016527253127994632
  • LiuZGuoFWangYBATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese MedicineSci Rep201662114626879404
  • ZhouJLiuTCuiHXuefu zhuyu decoction improves cognitive impairment in experimental traumatic brain injury via synaptic regulationOncotarget2017842720697208129069769
  • WuJKeXMaNFormononetin, an active compound of Astragalus membranaceus (Fisch) Bunge, inhibits hypoxia-induced retinal neovascularization via the HIF-1α/VEGF signaling pathwayDrug Des Devel Ther20161030713081
  • LiSXuJYaoWSevoflurane pretreatment attenuates TNF-α-induced human endothelial cell dysfunction through activating eNOS/NO pathwayBiochem Biophys Res Commun2015460387988625838201
  • FuJChenYLiFAttenuation of MicroRNA-495 Derepressed PTEN to Effectively Protect Rat Cardiomyocytes from HypertrophyCardiology2018139424525429566365
  • NakakidoMDengZSuzukiTDohmaeNNakamuraYHamamotoRDysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTENNeoplasia201517436737325925379
  • SiangjongLGoldmanDHKriskaTVascular hepoxilin and trioxilins mediate vasorelaxation through TP receptor inhibition in mouse arteriesActa Physiol (Oxf)2017219118820126666460
  • WuJHLiQWuMYFormononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathwaysJ Nutr Biochem201021761362019570671
  • TrottDWLuttrellMJSeawrightJWWoodmanCRAging impairs PI3K/Akt signaling and NO-mediated dilation in soleus muscle feed arteriesEur J Appl Physiol201311382039204623563601
  • LauYSLingWCMuruganDKwanCYMustafaMREndothelium-Dependent Relaxation Effect of Apocynum venetum Leaf Extract via Src/PI3K/Akt Signalling PathwayNutrients2015775239525326133970
  • van LaarhovenTNabuursSBMarchioriEGaussian interaction profile kernels for predicting drug-target interactionBioinformatics201127213036304321893517
  • ChengTHaoMTakedaTBryantSHWangYLarge-Scale Prediction of Drug-Target Interaction: a Data-Centric ReviewAAPS J20171951264127528577120
  • RizviSMShakilSZeeshanMAn enzoinformatics study targeting polo-like kinases-1 enzyme: Comparative assessment of anticancer potential of compounds isolated from leaves of Ageratum houstonianumPharmacogn Mag201410Suppl 1S14S2124914294
  • HuangJJShiYQLiRLAngiogenesis effect of therapeutic ultrasound on HUVECs through activation of the PI3K-Akt-eNOS signal pathwayAm J Transl Res2015761106111526279754
  • XingZXiaZPengWXuefu Zhuyu decoction, a traditional Chinese medicine, provides neuroprotection in a rat model of traumatic brain injury via an anti-inflammatory pathwaySci Rep201662004026818584
  • YuneTYByunJYExpression of PTEN and phosphorylated Akt in human cholesteatoma epitheliumActa Otolaryngol2009129550150618615333
  • GhigoALiMPhosphoinositide 3-kinase: friend and foe in cardiovascular diseaseFront Pharmacol2015616926321955
  • ZhangYWangSJHanZHPI3K/AKT signaling pathway plays a role in enhancement of eNOS activity by recombinant human angiotensin converting enzyme 2 in human umbilical vein endothelial cellsInt J Clin Exp Pathol20147118112811725550859
  • AnwarMASamahaAABallanSSalehAIIratniREidAHSalvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling PathwaySci Rep20177168628386068