Coenzyme Q10 Stimulate Reproductive Vatality

References

• Bentinger M, Brismar K, Dallner G. The antioxidant role of coenzyme Q. Mitochondrion. 2007;7:S41–50. doi:10.1016/j.mito.2007.02.006
   PubMed Web of Science ®Google Scholar
• Pallotti F, Bergamini C, Lamperti C, Fato R. The roles of coenzyme Q in disease: direct and indirect involvement in cellular functions. Int J Mol Sci. 2021;23(1):128. doi:10.3390/ijms23010128
   PubMed Web of Science ®Google Scholar
• Raizner AE. Coenzyme Q10. Methodist Debakey Cardiovasc J. 2019;15(3):185–191. doi:10.14797/mdcj-15-3-185
   PubMedGoogle Scholar
• Li X, Zhan J, Hou Y, et al. Coenzyme Q10 regulation of apoptosis and oxidative stress in H2O2 induced BMSC death by modulating the Nrf-2/NQO-1 signaling pathway and its application in a model of spinal cord injury. Oxid Med Cell Longev. 2019;2019:6493081. doi:10.1155/2019/6493081
   PubMed Web of Science ®Google Scholar
• Sadeghiyan Galeshkalami N, Abdollahi M, Najafi R, et al. Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis. Life Sci. 2019;216:101–110. doi:10.1016/j.lfs.2018.10.055
   PubMed Web of Science ®Google Scholar
• Said RS, Mohamed HA, Kamal MM. Coenzyme Q10 mitigates ionizing radiation-induced testicular damage in rats through inhibition of oxidative stress and mitochondria-mediated apoptotic cell death. Toxicol Appl Pharmacol. 2019;383:114780. doi:10.1016/j.taap.2019.114780
   PubMed Web of Science ®Google Scholar
• Quinzii CM, Luna-Sanchez M, Ziosi M, Hidalgo-Gutierrez A, Kleiner G, Lopez LC. The role of sulfide oxidation impairment in the pathogenesis of primary CoQ deficiency. Front Physiol. 2017;8:525. doi:10.3389/fphys.2017.00525
   PubMed Web of Science ®Google Scholar
• Sabbatinelli J, Orlando P, Galeazzi R, et al. Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: a randomized clinical trial. Nutrients. 2020;12(4):1098. doi:10.3390/nu12041098
   PubMed Web of Science ®Google Scholar
• Ayer A, Fazakerley DJ, Suarna C, et al. Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q. Redox Biol. 2021;46:102127. doi:10.1016/j.redox.2021.102127
   PubMed Web of Science ®Google Scholar
• Nolfi-Donegan D, Braganza A, Shiva S. Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement. Redox Biol. 2020;37:101674. doi:10.1016/j.redox.2020.101674
   PubMed Web of Science ®Google Scholar
• AL-Zubaidi U, Liu J, Cinar O, Robker RL, Adhikari D, Carroll J. The spatio-temporal dynamics of mitochondrial membrane potential during oocyte maturation. Mol Hum Reprod. 2019;25(11):695–705. doi:10.1093/molehr/gaz055
   PubMed Web of Science ®Google Scholar
• Lenaz G, Genova ML. Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subject. Antioxid Redox Signal. 2010;12(8):961–1008. doi:10.1089/ars.2009.2704
   PubMed Web of Science ®Google Scholar
• Bersuker K, Hendricks JM, Li Z, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688–692. doi:10.1038/s41586-019-1705-2
   PubMed Web of Science ®Google Scholar
• Hargreaves I, Heaton RA, Mantle D. Disorders of human coenzyme Q10 metabolism: an overview. Int J Mol Sci. 2020;21(18):6695. doi:10.3390/ijms21186695
   PubMed Web of Science ®Google Scholar
• Wang Y, Hekimi S. Understanding ubiquinone. Trends Cell Biol. 2016;26(5):367–378. doi:10.1080/09513590.2017.1381680
   PubMed Web of Science ®Google Scholar
• Hargreaves IP, Mantle D. Coenzyme Q10 supplementation in fibrosis and aging. Adv Exp Med Biol. 2019;1178:103–112. doi:10.1007/978-3-030-25650-0_6
   PubMed Web of Science ®Google Scholar
• Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;10(1):49. doi:10.1186/1477-7827-10-49
   PubMedGoogle Scholar
• Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial Reactive Oxygen Species (ROS) and ROS-induced ROS release. Physiol Rev. 2014;94(3):909–950. doi:10.1152/physrev.00026.2013
   PubMed Web of Science ®Google Scholar
• Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol. 2014;24(10):R453–462. doi:10.1016/j.cub.2014.03.034
   PubMed Web of Science ®Google Scholar
• Lambert AJ, Brand MD. Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH: ubiquinone oxidoreductase (complex I). J Biol Chem. 2004;279(38):39414–39420. doi:10.1074/jbc.M406576200
   PubMed Web of Science ®Google Scholar
• Chen Z, Wang C, Yu N, et al. INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway. Biomed Pharmacother. 2019;111:151–161. doi:10.1016/j.biopha.2018.12.046
   PubMed Web of Science ®Google Scholar
• Subramanian K, Jochem A, Le Vasseur M, et al. Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER–mitochondria contacts. J Cell Biol. 2019;218(4):1353–1369. doi:10.1083/jcb.201808044
   PubMed Web of Science ®Google Scholar
• Kemmerer ZA, Robinson KP, Schmitz JM, et al. UbiB proteins regulate cellular CoQ distribution in saccharomyces cerevisiae. Nat Commun. 2021;12(1):4769. doi:10.1038/s41467-021-25084-7
   PubMed Web of Science ®Google Scholar
• van der Reest J, Nardini Cecchino G, Haigis MC, Kordowitzki P. Mitochondria: their relevance during oocyte ageing. Ageing Res Rev. 2021;70:101378. doi:10.1016/j.arr.2021.101378
   PubMed Web of Science ®Google Scholar
• Van Blerkom J. Mitochondria in early mammalian development. Semin Cell Dev Biol. 2009;20(3):354–364. doi:10.1016/j.semcdb.2008.12.005
   PubMed Web of Science ®Google Scholar
• Ding H, Li Z, Li X, et al. FTO alleviates CdCl2-induced apoptosis and oxidative stress via the AKT/Nrf2 pathway in bovine granulosa cells. Int J Mol Sci. 2022;23(9):4948. doi:10.3390/ijms23094948
   PubMed Web of Science ®Google Scholar
• Wang Y, Yang C, Elsheikh NAH, et al. HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress. Aging. 2019;11(15):5535–5547. doi:10.18632/aging.102136
   PubMedGoogle Scholar
• Sammad A, Luo H, Hu L, Zhu H, Wang Y. Transcriptome reveals granulosa cells coping through redox, inflammatory and metabolic mechanisms under acute heat stress. Cells. 2022;11(9):1443. doi:10.3390/cells11091443
   PubMed Web of Science ®Google Scholar
• Garlanda C, Maina V, Martinez de la Torre Y, Nebuloni M, Locati M. Inflammatory reaction and implantation: the new entries PTX3 and D6. Placenta. 2008;29(Suppl B):129–134. doi:10.1016/j.placenta.2008.06.008
   PubMedGoogle Scholar
• Wang K, Wang K, Wang J, Yu F, Ye C, Fu Y. Protective effect of Clostridium butyricum on Escherichia coli-induced endometritis in mice via ameliorating endometrial barrier and inhibiting inflammatory response. Microbiol Spectr. 2022;10(6):e0328622. doi:10.1128/spectrum.03286-22
   PubMed Web of Science ®Google Scholar
• Niu Y-J, Zhou W, Nie Z-W, et al. Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs. Aging. 2020;12(2):1256–1271. doi:10.18632/aging.102681
   PubMedGoogle Scholar
• Xu Y, Nisenblat V, Lu C, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16(1):29. doi:10.1186/s12958-018-0343-0
   PubMedGoogle Scholar
• Sangsefidi ZS, Yaghoubi F, Hajiahmadi S, Hosseinzadeh M. The effect of coenzyme Q10 supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled clinical trials. Food Sci Nutr. 2020;8(4):1766–1776. doi:10.1002/fsn3.1492
   PubMed Web of Science ®Google Scholar
• Gutierrez-Mariscal FM, Arenas-de Larriva AP, Limia-Perez L, Romero-Cabrera JL, Yubero-Serrano EM, López-Miranda J. Coenzyme Q10 supplementation for the reduction of oxidative stress: clinical implications in the treatment of chronic diseases. Int J Mol Sci. 2020;21(21):7870. doi:10.3390/ijms21217870
   PubMed Web of Science ®Google Scholar
• Alahmar AT, Calogero AE, Sengupta P, Dutta S. Coenzyme Q10 improves sperm parameters, oxidative stress markers and sperm DNA fragmentation in infertile patients with idiopathic oligoasthenozoospermia. World J Mens Health. 2021;39(2):346–351. doi:10.5534/wjmh.190145
   PubMedGoogle Scholar
• Beaujouan E. Latest-late fertility? Decline and resurgence of late parenthood across the low-fertility countries. Popul Dev Rev. 2020;46(2):219–247. doi:10.1111/padr.12334
   PubMed Web of Science ®Google Scholar
• Sasaki H, Hamatani T, Kamijo S, et al. Impact of oxidative stress on age-associated decline in oocyte developmental competence. Front Endocrinol. 2019;10:811. doi:10.3389/fendo.2019.00811
   PubMed Web of Science ®Google Scholar
• Huang Y, Hu C, Ye H, et al. Inflamm-aging: a new mechanism affecting premature ovarian insufficiency. J Immunol Res. 2019;2019:8069898. doi:10.1155/2019/8069898
   PubMed Web of Science ®Google Scholar
• Babayev E, Wang T, Szigeti-Buck K, et al. Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and MtDNA quantity. Maturitas. 2016;93:121–130. doi:10.1016/j.maturitas.2016.06.015
   PubMed Web of Science ®Google Scholar
• Oxidative stress induces telomere dysfunction and shortening in human oocytes of advanced age donors Available from: https://pubmed.ncbi.nlm.nih.gov/34440635/. Accessed December 14, 2022.
   Google Scholar
• Zhu C, Zhang C, Cui X, Wu J, Cui Z, Shen X. Trichosanthin inhibits cervical cancer by regulating oxidative stress-induced apoptosis. Bioengineered. 2021;12:2779–2790. doi:10.1080/21655979.2021.1930335
   PubMed Web of Science ®Google Scholar
• Wang L, Lu Z, Zhao J, et al. Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells. Aging Cell. 2021;20:e13513. doi:10.1111/acel.13513
   PubMed Web of Science ®Google Scholar
• Zhao D, Liang Y, Dai S, et al. Dose-response effect of coenzyme Q10 supplementation on blood pressure among patients with cardiometabolic disorders: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. Adv Nutr. 2022;13(6):2180–2194. doi:10.1093/advances/nmac100
   PubMed Web of Science ®Google Scholar
• Testai L, Martelli A, Flori L, Cicero AFG, Colletti A. Coenzyme Q10: clinical applications beyond cardiovascular diseases. Nutrients. 2021;13:1697. doi:10.3390/nu13051697
   PubMed Web of Science ®Google Scholar
• Sheykhhasan M, Amini R, Soleimani Asl S, Saidijam M, Hashemi SM, Najafi R. Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer’s Disease. Biomed Pharmacother. 2022;152:113224. doi:10.1016/j.biopha.2022.113224
   PubMed Web of Science ®Google Scholar
• Park HW, Park CG, Park M, et al. Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson’s Disease rat model. Sci Rep. 2020;10:9572. doi:10.1038/s41598-020-66493-w
   PubMed Web of Science ®Google Scholar
• Shin JY, Choi J-W, Kim D-G, et al. Protective effects of coenzyme Q10 against acute pancreatitis. Int Immunopharmacol. 2020;88:106900. doi:10.1016/j.intimp.2020.106900
   PubMed Web of Science ®Google Scholar
• G L, Lmi J, I F, et al. Coenzyme Q10 and melatonin for the treatment of male infertility: a narrative review. Nutrients. 2022;14. doi:10.3390/nu14214585
   PubMed Web of Science ®Google Scholar
• Arroyo A, Kim B, Yeh J. Luteinizing hormone action in human oocyte maturation and quality: signaling pathways, regulation, and clinical impact. Reprod Sci. 2020;27:1223–1252. doi:10.1007/s43032-019-00137-x
   PubMed Web of Science ®Google Scholar
• Yen H-C, Yeh W-Y, Lee S-H, Feng Y-H, Yang S-L. Characterization of human mitochondrial PDSS and COQ proteins and their roles in maintaining coenzyme Q10 levels and each other’s stability. Biochim Biophys Acta Bioenerg. 2020;1861(7):148192. doi:10.1016/j.bbabio.2020.148192
   PubMed Web of Science ®Google Scholar
• Ben-Meir A, Burstein E, Borrego-Alvarez A, et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015;14:887–895. doi:10.1111/acel.12368
   PubMed Web of Science ®Google Scholar
• Ben-Meir A, Kim K, McQuaid R, et al. Co-enzyme Q10 supplementation rescues cumulus cells dysfunction in a maternal aging model. Antioxidants. 2019;8(3):58. doi:10.3390/antiox8030058
   Web of Science ®Google Scholar
• Richani D, Dunning KR, Thompson JG, Gilchrist RB. Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence. Hum Reprod Update. 2021;27(1):27–47. doi:10.1093/humupd/dmaa043
   PubMed Web of Science ®Google Scholar
• Ma L, Cai L, Hu M, et al. Coenzyme Q10 supplementation of human oocyte in vitro maturation reduces postmeiotic aneuploidies. Fertil Steril. 2020;114(2):331–337. doi:10.1016/j.fertnstert.2020.04.002
   PubMed Web of Science ®Google Scholar
• Nagaoka SI, Hassold TJ, Hunt PA. Human aneuploidy: mechanisms and new insights into an age-old problem. Nat Rev Genet. 2012;13(7):493–504. doi:10.1038/nrg3245
   PubMed Web of Science ®Google Scholar
• Mikwar M, MacFarlane AJ, Marchetti F. Mechanisms of oocyte aneuploidy associated with advanced maternal age. Mutat Res Rev Mutat Res. 2020;785:108320. doi:10.1016/j.mrrev.2020.108320
   PubMed Web of Science ®Google Scholar
• Kowalska E, Bartnicki F, Fujisawa R, et al. Inhibition of DNA replication by an Anti-PCNA Aptamer/PCNA complex. Nucleic Acids Res. 2018;46(1):25–41. doi:10.1093/nar/gkx1184
   PubMed Web of Science ®Google Scholar
• Xu B, Hua J, Zhang Y, et al. Proliferating Cell Nuclear Antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries. PLoS One. 2011;6(1):e16046. doi:10.1371/journal.pone.0016046
   PubMed Web of Science ®Google Scholar
• Ginther OJ. An FSH booster surge for resurgence of the preovulatory follicle in heifers. Domest Anim Endocrinol. 2018;65:90–94. doi:10.1016/j.domaniend.2018.06.002
   PubMed Web of Science ®Google Scholar
• Moolhuijsen LME, Visser JA. Anti-müllerian hormone and ovarian reserve: update on assessing ovarian function. J Clin Endocrinol Metab. 2020;105(11):3361–3373. doi:10.1210/clinem/dgaa513
   PubMed Web of Science ®Google Scholar
• Delkhosh A, Delashoub M, Tehrani AA, et al. Upregulation of FSHR and PCNA by administration of coenzyme Q10 on cyclophosphamide-induced premature ovarian failure in a mouse model. J Biochem Mol Toxicol. 2019;33(11):e22398. doi:10.1002/jbt.22398
   PubMed Web of Science ®Google Scholar
• Özcan P, Fıçıcıoğlu C, Kizilkale O, et al. Can coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage? J Assist Reprod Genet. 2016;33(9):1223–1230. doi:10.1007/s10815-016-0751-z
   PubMed Web of Science ®Google Scholar
• Lee HJ, Park MJ, Joo BS, et al. Effects of coenzyme Q10 on ovarian surface epithelium-derived ovarian stem cells and ovarian function in a 4-vinylcyclohexene diepoxide-induced murine model of ovarian failure. Reprod Biol Endocrinol. 2021;19(1):59. doi:10.1186/s12958-021-00736-x
   PubMed Web of Science ®Google Scholar
• Gilchrist RB, Lane M, Thompson JG. Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality. Hum Reprod Update. 2008;14(2):159–177. doi:10.1093/humupd/dmm040
   PubMed Web of Science ®Google Scholar
• Kim E, Cai L, Hyun S-H. Effects of stem cell factor/c-kit signaling on in vitro maturation of porcine oocytes and subsequent developmental competence after fertilization. Front Vet Sci. 2021;8:745488. doi:10.3389/fvets.2021.745488
   PubMed Web of Science ®Google Scholar
• Yang L, Wang H, Song S, et al. Systematic understanding of anti-aging effect of coenzyme Q10 on oocyte through a network pharmacology approach. Front Endocrinol. 2022;13:813772. doi:10.3389/fendo.2022.813772
   PubMed Web of Science ®Google Scholar
• Kim J-Y, Zhou D, Cui X-S. Bezafibrate prevents aging in in vitro-matured porcine oocytes. J Anim Sci Technol. 2021;63(4):766–777. doi:10.5187/jast.2021.e64
   PubMed Web of Science ®Google Scholar
• Tiefenbach J, Magomedova L, Liu J, et al. Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases. Dis Model Mech. 2018;11(9):dmm034801. doi:10.1242/dmm.034801
   PubMed Web of Science ®Google Scholar
• Hosseinzadeh E, Zavareh S, Lashkarbolouki T. Antioxidant properties of coenzyme Q10-pretreated mouse pre-antral follicles derived from vitrified ovaries. J Obstet Gynaecol Res. 2017;43(1):140–148. doi:10.1111/jog.13173
   PubMed Web of Science ®Google Scholar
• Yuan X, Tian GG, Pei X, Hu X, Wu J. Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/P62 expression. Cell Biosci. 2021;11(1):107. doi:10.1186/s13578-021-00614-4
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhu D, Mei X, et al. Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy. Bioact Mater. 2021;6(7):1957–1972. doi:10.1016/j.bioactmat.2020.12.008
   PubMed Web of Science ®Google Scholar
• Giannubilo SR, Orlando P, Silvestri S, et al. CoQ10 supplementation in patients undergoing IVF-ET: the relationship with follicular fluid content and oocyte maturity. Antioxidants. 2018;7(10):141. doi:10.3390/antiox7100141
   Web of Science ®Google Scholar
• Yang J, Feng T, Li S, Zhang X, Qian Y. Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages. Reprod Biol Endocrinol. 2020;18(1):74. doi:10.1186/s12958-020-00631-x
   PubMed Web of Science ®Google Scholar
• Ben-Meir A, Yahalomi S, Moshe B, Shufaro Y, Reubinoff B, Saada A. Coenzyme Q-dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging. Fertil Steril. 2015;104(3):724–727. doi:10.1016/j.fertnstert.2015.05.023
   PubMed Web of Science ®Google Scholar
• Opstad TB, Alexander J, Aaseth JO, Larsson A, Seljeflot I, Alehagen U. Selenium and coenzyme Q10 intervention prevents telomere attrition, with association to Reduced Cardiovascular Mortality-Sub-Study of a randomized clinical trial. Nutrients. 2022;14(16):3346. doi:10.3390/nu14163346
   PubMed Web of Science ®Google Scholar
• Dapas M, Dunaif A. Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification. Endocr Rev. 2022;43:927–965. doi:10.1210/endrev/bnac001
   PubMed Web of Science ®Google Scholar
• Wang J, Wu D, Guo H, Li M. Hyperandrogenemia and insulin resistance: the chief culprit of polycystic ovary syndrome. Life Sci. 2019;236:116940. doi:10.1016/j.lfs.2019.116940
   PubMed Web of Science ®Google Scholar
• Lu J, Wang Z, Cao J, Chen Y, Dong Y. A novel and compact review on the role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2018;16(1):80. doi:10.1186/s12958-018-0391-5
   PubMed Web of Science ®Google Scholar
• Li W, Liu C, Yang Q, Zhou Y, Liu M, Shan H. Oxidative stress and antioxidant imbalance in ovulation disorder in patients with polycystic ovary syndrome. Front Nutr. 2022;9:1018674. doi:10.3389/fnut.2022.1018674
   PubMed Web of Science ®Google Scholar
• Teede HJ, Tay CT, Joham AE. Polycystic ovary syndrome: an intrinsic risk factor for diabetes compounded by obesity. Fertil Steril. 2021;115(6):1449–1450. doi:10.1016/j.fertnstert.2021.03.024
   PubMedGoogle Scholar
• Bacchetti T, Morresi C, Vignini A, et al. HDL functionality in follicular fluid in normal-weight and obese women undergoing assisted reproductive treatment. J Assist Reprod Genet. 2019;36(8):1657. doi:10.1007/s10815-019-01523-9
   PubMed Web of Science ®Google Scholar
• Mizgier M, Jarząbek-Bielecka G, Wendland N, et al. Relation between inflammation, oxidative stress, and macronutrient intakes in normal and excessive body weight adolescent girls with clinical features of polycystic ovary syndrome. Nutrients. 2021;13(3):896. doi:10.3390/nu13030896
   PubMed Web of Science ®Google Scholar
• Wang Q, Ratchford AM, Chi MM-Y, et al. Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Mol Endocrinol. 2009;23(10):1603–1612. doi:10.1210/me.2009-0033
   PubMedGoogle Scholar
• Boots CE, Boudoures A, Zhang W, Drury A, Moley KH. Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model. Hum Reprod. 2016;31:2090–2097. doi:10.1093/humrep/dew181
   PubMed Web of Science ®Google Scholar
• Huo P, Li M, Le J, Zhu C, Yao J, Zhang S. Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1. Syst Biol Reprod Med. 2022;1–13. doi:10.1080/19396368.2022.2125855
   PubMed Web of Science ®Google Scholar
• Rutanen J, Yaluri N, Modi S, et al. SIRT1 MRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes. 2010;59(4):829–835. doi:10.2337/db09-1191
   PubMed Web of Science ®Google Scholar
• Fox CW, Zhang L, Sohni A, et al. Inflammatory stimuli trigger increased androgen production and shifts in gene expression in theca-interstitial cells. Endocrinology. 2019;160(12):2946–2958. doi:10.1210/en.2019-00588
   PubMed Web of Science ®Google Scholar
• Rosenfield RL. Current concepts of polycystic ovary syndrome pathogenesis. Curr Opin Pediatr. 2020;32(5):698–706. doi:10.1097/MOP.0000000000000945
   PubMed Web of Science ®Google Scholar
• Taghizadeh S, Izadi A, Shirazi S, Parizad M, Pourghassem Gargari B. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients. Gynecol Endocrinol. 2021;37(1):26–30. doi:10.1080/09513590.2020.1779689
   PubMed Web of Science ®Google Scholar
• Rahmani E, Jamilian M, Samimi M, et al. The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome. Gynecol Endocrinol. 2018;34(3):217–222. doi:10.1210/clinem/dgaa513
   PubMed Web of Science ®Google Scholar
• Jie J, Ling L, Yi Y, et al. Tributyltin triggers lipogenesis in macrophages via modifying PPARγ pathway. Environ Pollut. 2021;271:116331. doi:10.1111/jog.13173
   PubMed Web of Science ®Google Scholar
• Yu Q, Zheng H, Zhang Y. Inducible degrader of LDLR: a potential novel therapeutic target and emerging treatment for hyperlipidemia. Vascul Pharmacol. 2021;140:106878. doi:10.3390/antiox7100141
   PubMed Web of Science ®Google Scholar
• Lee SK, Lee JO, Kim JH, et al. Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPARα induction in 3T3-L1 preadipocytes. Cell Signal. 2012;24(12):2329–2336. doi:10.1210/endrev/bnac001
   PubMed Web of Science ®Google Scholar
• Chen K, Chen X, Xue H, et al. Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway. Food Funct. 2019;10(2):814–823. doi:10.1007/s10815-019-01523-9
   PubMed Web of Science ®Google Scholar
• Xu Z, Huo J, Ding X, et al. Coenzyme Q10 improves lipid metabolism and ameliorates obesity by regulating CaMKII-mediated PDE4 inhibition. Sci Rep. 2017;7(1):8253. doi:10.1097/MOP.0000000000000945
   PubMedGoogle Scholar
• Raitakari OT, McCredie RJ, Witting P, et al. Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radic Biol Med. 2000;28:1100–1105. doi:10.1016/s0891-5849(00)00201-x
   PubMed Web of Science ®Google Scholar
• Tsai K-L, Huang Y-H, Kao C-L, et al. A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways. J Nutr Biochem. 2012;23(5):458–468. doi:10.1016/j.jnutbio.2011.01.011
   PubMed Web of Science ®Google Scholar
• Sun Y, Li S, Liu H, et al. Oxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome. Fertil Steril. 2021;116(6):1641–1650. doi:10.1016/j.fertnstert.2021.07.1203
   PubMed Web of Science ®Google Scholar
• Izadi A, Ebrahimi S, Shirazi S, et al. Hormonal and metabolic effects of coenzyme Q10 and/or Vitamin E in patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2019;104:319–327. doi:10.1210/jc.2018-01221
   PubMed Web of Science ®Google Scholar
• Zhang J, Xing C, Zhao H, He B. The effectiveness of coenzyme Q10, Vitamin E, Inositols, and Vitamin D in improving the endocrine and metabolic profiles in women with polycystic ovary syndrome: a network meta-analysis. Gynecol Endocrinol. 2021;37(12):1063–1071. doi:10.1080/09513590.2021.1926975
   PubMed Web of Science ®Google Scholar
• de Jesus DS, Bargi-Souza P, Cruzat V, Yechoor V, Carpinelli AR, Peliciari-Garcia RA. BMAL1 modulates ROS generation and insulin secretion in pancreatic β-cells: an effect possibly mediated via NOX2. Mol Cell Endocrinol. 2022;555:111725. doi:10.1016/j.mce.2022.111725
   PubMed Web of Science ®Google Scholar
• Cheng Y-C, Chu L-W, Chen J-Y, et al. Loganin attenuates high glucose-induced schwann cells pyroptosis by inhibiting ROS generation and NLRP3 inflammasome activation. Cells. 2020;9(9):1948. doi:10.3390/cells9091948
   PubMed Web of Science ®Google Scholar
• Schroeder MM, Belloto RJ, Hudson RA, McInerney MF. Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets. Immunopharmacol Immunotoxicol. 2005;27(1):109–122. doi:10.1081/iph-51755
   PubMed Web of Science ®Google Scholar
• Refaeey AE, Selem A, Badawy A. Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome. Reprod Biomed Online. 2014;29(1):119–124. doi:10.1016/j.rbmo.2014.03.011
   PubMed Web of Science ®Google Scholar
• Lin X, Dai Y, Tong X, et al. Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility. Redox Biol. 2020;30:101431. doi:10.1016/j.redox.2020.101431
   PubMed Web of Science ®Google Scholar
• Hayashi S, Nakamura T, Motooka Y, et al. Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice. Redox Biol. 2020;37:101726. doi:10.1016/j.redox.2020.101726
   PubMed Web of Science ®Google Scholar
• Akarca-Dizakar SÖ, Demirel MA, Coşkun Akçay N, et al. The therapeutic effects of coenzyme Q10 on surgically induced endometriosis in sprague dawley rats. J Obstet Gynaecol. 2022;42(7):3290–3298. doi:10.1080/01443615.2022.2114322
   PubMedGoogle Scholar
• Govatati S, Deenadayal M, Shivaji S, Bhanoori M. Mitochondrial NADH: ubiquinone oxidoreductase alterations are associated with endometriosis. Mitochondrion. 2013;13(6):782–790. doi:10.1016/j.mito.2013.05.003
   PubMed Web of Science ®Google Scholar
• Ravel J, Moreno I, Simón C. Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. Am J Obstet Gynecol. 2021;224(3):251–257. doi:10.1016/j.ajog.2020.10.019
   PubMed Web of Science ®Google Scholar
• Aimo A, Castiglione V, Borrelli C, et al. Oxidative stress and inflammation in the evolution of heart failure: from pathophysiology to therapeutic strategies. Eur J Prev Cardiol. 2020;27(5):494–510. doi:10.1177/2047487319870344
   PubMed Web of Science ®Google Scholar
• Muñoz M, López-Oliva ME, Rodríguez C, et al. Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity. Redox Biol. 2020;28:101330. doi:10.1016/j.redox.2019.101330
   PubMed Web of Science ®Google Scholar
• Shahin HI, Radnaa E, Tantengco OAG, et al. Microvesicles and exosomes released by amnion epithelial cells under oxidative stress cause inflammatory changes in uterine cells†. Biol Reprod. 2021;105(2):464–480. doi:10.1093/biolre/ioab088
   PubMed Web of Science ®Google Scholar
• Song P, Liu C, Sun M, et al. Oxidative stress induces bovine endometrial epithelial cell damage through mitochondria-dependent pathways. Animals. 2022;12(18):2444. doi:10.3390/ani12182444
   Web of Science ®Google Scholar
• Boni R, Cecchini Gualandi S. Relationship between oxidative stress and endometritis: exploiting knowledge gained in mares and cows. Animals. 2022;12(18):2403. doi:10.3390/ani12182403
   Web of Science ®Google Scholar
• López-Pedrera C, Villalba JM, Patiño-Trives AM, et al. Therapeutic potential and immunomodulatory role of coenzyme Q10 and its analogues in systemic autoimmune diseases. Antioxidants. 2021;10(4):600. doi:10.3390/antiox10040600
   Web of Science ®Google Scholar
• García-Carpintero S, Domínguez-Bértalo J, Pedrero-Prieto C, et al. Ubiquinol supplementation improves gender-dependent cerebral vasoreactivity and ameliorates chronic inflammation and endothelial dysfunction in patients with mild cognitive impairment. Antioxidants. 2021;10(2):143. doi:10.3390/antiox10020143
   Web of Science ®Google Scholar
• Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22(9):607–615. doi:10.1080/1028415X.2017.1421039
   PubMed Web of Science ®Google Scholar
• Alimohammadi M, Rahimi A, Faramarzi F, et al. Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials. Inflammopharmacology. 2021;29(3):579–593. doi:10.1007/s10787-021-00817-8
   PubMed Web of Science ®Google Scholar
• Yuan S, Hahn SA, Miller MP, et al. Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation. Redox Biol. 2021;47:102166. doi:10.1016/j.redox.2021.102166
   PubMed Web of Science ®Google Scholar
• Chen S, Wang Y, Zhang H, et al. The antioxidant MitoQ protects against CSE-induced endothelial barrier injury and inflammation by inhibiting ROS and autophagy in human umbilical vein endothelial cells. Int J Biol Sci. 2019;15(7):1440–1451. doi:10.7150/ijbs.30193
   PubMed Web of Science ®Google Scholar
• Hu Q, Lu X, Li G, et al. Mitoquinone treatment for the prevention of surgical adhesions via regulation of the NRF2/HO-1 signaling pathway in mice. Surgery. 2022;171(2):428–436. doi:10.1016/j.surg.2021.08.053
   PubMedGoogle Scholar
• Shu C, Yu X, Cheng S, Jing J, Hu C, Pang B. Pristimerin suppresses trophoblast cell epithelial–mesenchymal transition via miR-542-5p/EGFR axis. Drug Des Devel Ther. 2020;14:4659–4670. doi:10.2147/DDDT.S274595
   PubMed Web of Science ®Google Scholar
• Hu C, Zhen Y, Ma Z, et al. Polyamines from myeloid-derived suppressor cells promote Th17 polarization and disease progression. Mol Ther. 2023;31(2):569–584. doi:10.1016/j.ymthe.2022.10.013
   PubMed Web of Science ®Google Scholar
• Pang B, Hu C, Li H, et al. Myeloidderived suppressor cells: escorts at the maternal–fetal interface. Front Immunol. 2023;14:1080391. doi:10.3389/fimmu.2023.1080391
   PubMed Web of Science ®Google Scholar
• Keefe D, Kumar M, Kalmbach K. Oocyte competency is the key to embryo potential. Fertil Steril. 2015;103(2):317–322. doi:10.1016/j.fertnstert.2014.12.115
   PubMed Web of Science ®Google Scholar
• Truong T, Gardner DK. Antioxidants improve IVF outcome and subsequent embryo development in the mouse. Hum Reprod. 2017;32(12):2404–2413. doi:10.1093/humrep/dex330
   PubMed Web of Science ®Google Scholar
• Truong TT, Gardner DK. Antioxidants increase blastocyst cryosurvival and viability post-vitrification. Hum Reprod. 2020;35(1):12–23. doi:10.1093/humrep/dez243
   PubMed Web of Science ®Google Scholar
• Truong TT, Soh YM, Gardner DK. Antioxidants improve mouse preimplantation embryo development and viability. Hum Reprod. 2016;31(7):1445–1454. doi:10.1093/humrep/dew098
   PubMed Web of Science ®Google Scholar
• Wang Y, Oxer D, Hekimi S. Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis. Nat Commun. 2015;6(1):6393. doi:10.1038/ncomms7393
   PubMedGoogle Scholar
• Akarsu S, Gode F, Isik AZ, Dikmen ZG, Tekindal MA. The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques. J Assist Reprod Genet. 2017;34(5):599–605. doi:10.1007/s10815-017-0882-x
   PubMed Web of Science ®Google Scholar
• Tan J, Zou Y, Huang Z-H, et al. C-kit signaling promotes human pre-implantation 3PN embryonic development and blastocyst formation. Reprod Biol Endocrinol. 2019;17(1):75. doi:10.1186/s12958-019-0521-8
   PubMed Web of Science ®Google Scholar
• Deluao JC, Winstanley Y, Robker RL, Pacella-Ince L, Gonzalez MB, McPherson NO. Oxidative stress and reproductive function: reactive oxygen species in the mammalian pre-implantation embryo. Reproduction. 2022;164(6):F95–F108. doi:10.1530/REP-22-0121
   PubMed Web of Science ®Google Scholar
• Leite RF, Annes K, Ispada J, et al. Oxidative stress alters the profile of transcription factors related to early development on in vitro produced embryos. Oxid Med Cell Longev. 2017;2017:1502489. doi:10.1155/2017/1502489
   PubMed Web of Science ®Google Scholar
• Heydarnejad A, Ostadhosseini S, Varnosfaderani SR, Jafarpour F, Moghimi A, Nasr-Esfahani MH. Supplementation of maturation medium with CoQ10 enhances developmental competence of ovine oocytes through improvement of mitochondrial function. Mol Reprod Dev. 2019;86:812–824. doi:10.1002/mrd.23159
   PubMed Web of Science ®Google Scholar
• Ruiz-Conca M, Vendrell M, Sabés-Alsina M, Mogas T, Lopez-Bejar M. Coenzyme Q10 supplementation during in vitro maturation of bovine oocytes (bos taurus) helps to preserve oocyte integrity after vitrification. Reprod Domest Anim. 2017;52(Suppl 4):52–54. doi:10.1111/rda.13056
   PubMedGoogle Scholar
• Maside C, Martinez CA, Cambra JM, et al. Supplementation with exogenous coenzyme Q10 to media for in vitro maturation and embryo culture fails to promote the developmental competence of porcine embryos. Reprod Domest Anim. 2019;54 Suppl 4:72–77. doi:10.1111/rda.13486
   PubMed Web of Science ®Google Scholar
• Gendelman M, Roth Z. Incorporation of coenzyme Q10 into bovine oocytes improves mitochondrial features and alleviates the effects of summer thermal stress on developmental competence. Biol Reprod. 2012;87:118. doi:10.1095/biolreprod.112.101881
   PubMed Web of Science ®Google Scholar
• Feng Y-Q, Wang -J-J, Li M-H, et al. Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes. Cell Mol Life Sci. 2022;79:258. doi:10.1007/s00018-022-04288-0
   PubMed Web of Science ®Google Scholar
• Gualtieri R, Barbato V, Fiorentino I, et al. Treatment with zinc, d-aspartate, and coenzyme Q10 protects bull sperm against damage and improves their ability to support embryo development. Theriogenology. 2014;82(4):592–598. doi:10.1016/j.theriogenology.2014.05.028
   PubMed Web of Science ®Google Scholar
• Omeljaniuk WJ, Socha K, Borawska MH, et al. Antioxidant status in women who have had a miscarriage. Adv Med Sci. 2015;60(2):329–334. doi:10.1016/j.advms.2015.06.003
   PubMed Web of Science ®Google Scholar
• El-Far M, El-Sayed IH, El-Motwally AE, Hashem IA, Bakry N. Serum levels of TNF-alpha and antioxidant enzymes and placental TNF-alpha expression in unexplained recurrent spontaneous miscarriage. J Physiol Biochem. 2009;65:175–181. doi:10.1007/BF03179068
   PubMed Web of Science ®Google Scholar
• Wang W, Sung N, Gilman-Sachs A, Kwak-Kim J. T Helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: th1/Th2/Th9/Th17/Th22/Tfh cells. Front Immunol. 2020;11:2025. doi:10.3389/fimmu.2020.02025
   PubMed Web of Science ®Google Scholar
• Talukdar A, Sharma KA, Rai R, Deka D, Rao DN. Effect of coenzyme Q10 on Th1/Th2 paradigm in females with idiopathic recurrent pregnancy loss. Am J Reprod Immunol. 2015;74:169–180. doi:10.1111/aji.12376
   PubMed Web of Science ®Google Scholar
• Smyth A, Oliveira GHM, Lahr BD, Bailey KR, Norby SM, Garovic VD. A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Clin J Am Soc Nephrol. 2010;5(11):2060–2068. doi:10.2215/CJN.00240110
   PubMed Web of Science ®Google Scholar
• Blanco LP, Pedersen HL, Wang X, et al. Improved mitochondrial metabolism and reduced inflammation following attenuation of murine lupus with coenzyme Q10 analog idebenone. Arthritis Rheumatol. 2020;72:454–464. doi:10.1002/art.41128
   PubMed Web of Science ®Google Scholar
• Perez-Sanchez C, Ruiz-Limon P, Aguirre MA, et al. Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment. Blood. 2012;119(24):5859–5870. doi:10.1182/blood-2011-12-400986
   PubMed Web of Science ®Google Scholar
• Vanya M, Nyari T, Bencsik K, Bartfai G. Pregnancy and perinatal outcomes among women with multiple sclerosis: a Retrospective Case-Controlled Study in South Hungary. J Matern Fetal Neonatal Med. 2014;27(6):577–581. doi:10.3109/14767058.2013.825596
   PubMed Web of Science ®Google Scholar
• Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: a double blind randomized clinical trial. Nutr Neurosci. 2016;19(3):138–143. doi:10.1179/1476830515Y.0000000002
   PubMed Web of Science ®Google Scholar
• Sanoobar M, Eghtesadi S, Azimi A, et al. Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial. Nutr Neurosci. 2015;18(4):169–176. doi:10.1179/1476830513Y.0000000106
   PubMed Web of Science ®Google Scholar
• Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Jazayeri S, Reza Gohari M. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. Int J Neurosci. 2013;123(11):776–782. doi:10.3109/00207454.2013.801844
   PubMed Web of Science ®Google Scholar
• Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ. Antioxidants for female subfertility. Cochrane Database Syst Rev. 2020;8:CD007807. doi:10.1002/14651858.CD007807.pub4
   PubMedGoogle Scholar
• Zhang Y, Zhang T, Wu L, Li TC, Wang CC, Chung JPW. Metabolomic markers of biological fluid in women with reproductive failure: a systematic review of current literatures. Biol Reprod. 2022;106(6):1049–1058. doi:10.1093/biolre/ioac038
   PubMed Web of Science ®Google Scholar
• Arenas-Jal M, Suñé-Negre JM, García-Montoya E. Coenzyme Q10 supplementation: efficacy, safety, and formulation challenges. Compr Rev Food Sci Food Saf. 2020;19:574–594. doi:10.1111/1541-4337.12539
   PubMed Web of Science ®Google Scholar
• Díaz-Casado ME, Quiles JL, Barriocanal-Casado E, et al. The paradox of coenzyme Q10 in aging. Nutrients. 2019;11(9):2221. doi:10.3390/nu11092221
   PubMed Web of Science ®Google Scholar
• Gueven N, Ravishankar P, Eri R, Rybalka E. Idebenone: when an antioxidant is not an antioxidant. Redox Biol. 2021;38:101812. doi:10.1016/j.redox.2020.101812
   PubMed Web of Science ®Google Scholar