Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis

References

• Scherer H, Häupl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun. 2020;110:102400. doi:10.1016/j.jaut.2019.102400
   PubMed Web of Science ®Google Scholar
• Finckh A, Gilbert B, Hodkinson B, et al. Global epidemiology of rheumatoid arthritis. Nat Rev Rheumatol. 2022;18(10):591–602. doi:10.1038/s41584-022-00827-y
   PubMed Web of Science ®Google Scholar
• Venetsanopoulou AI, Alamanos Y, Voulgari PV, Drosos AA. Epidemiology of rheumatoid arthritis: genetic and environmental influences. Expert Rev Clin Immunol. 2022;18(9):923–931. doi:10.1080/1744666x.2022.2106970
   PubMed Web of Science ®Google Scholar
• Weyand CM, Goronzy JJ. The immunology of rheumatoid arthritis. Nat Immunol. 2021;22(1):10–18. doi:10.1038/s41590-020-00816-x
   PubMed Web of Science ®Google Scholar
• Cush JJ. Rheumatoid arthritis: early diagnosis and treatment. Rheum Dis Clin North Am. 2022;48(2):537–547. doi:10.1016/j.rdc.2022.02.010
   PubMed Web of Science ®Google Scholar
• Athanassiou P, Athanassiou L, Kostoglou-Athanassiou I. Nutritional pearls: diet and rheumatoid arthritis. Mediterr J Rheumatol. 2020;31(3):319–324. doi:10.31138/mjr.31.3.319
   PubMedGoogle Scholar
• Padyukov L. Genetics of rheumatoid arthritis. Semin Immunopathol. 2022;44(1):47–62. doi:10.1007/s00281-022-00912-0
   PubMed Web of Science ®Google Scholar
• Azizov V, Zaiss MM. Alcohol consumption in rheumatoid arthritis: a path through the immune system. Nutrients. 2021;13:4. doi:10.3390/nu13041324
   Web of Science ®Google Scholar
• Bergström U, Jacobsson LT, Nilsson J, Wirfält E, Turesson C. Smoking, low formal level of education, alcohol consumption, and the risk of rheumatoid arthritis. Scand J Rheumatol. 2013;42(2):123–130. doi:10.3109/03009742.2012.723744
   PubMed Web of Science ®Google Scholar
• Smolen JS. Insights into the treatment of rheumatoid arthritis: a paradigm in medicine. J Autoimmun. 2020;110:102425. doi:10.1016/j.jaut.2020.102425
   PubMed Web of Science ®Google Scholar
• Komatsu N, Takayanagi H. Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions. Nat Rev Rheumatol. 2022;18(7):415–429. doi:10.1038/s41584-022-00793-5
   PubMed Web of Science ®Google Scholar
• Auréal M, Machuca-Gayet I, Coury F. Rheumatoid arthritis in the view of osteoimmunology. Biomolecules. 2020;11:1. doi:10.3390/biom11010048
   PubMed Web of Science ®Google Scholar
• Tanaka S, Tanaka Y. RANKL as a therapeutic target of rheumatoid arthritis. J Bone Miner Metab. 2021;39(1):106–112. doi:10.1007/s00774-020-01159-1
   PubMed Web of Science ®Google Scholar
• Tanaka S, Tanaka Y, Ishiguro N, Yamanaka H, Takeuchi T. RANKL: a therapeutic target for bone destruction in rheumatoid arthritis. Mod Rheumatol. 2018;28(1):9–16. doi:10.1080/14397595.2017.1369491
   PubMed Web of Science ®Google Scholar
• Gruber HE, Ingram JA, Hoelscher GL, Zinchenko N, Norton HJ, Hanley EN Jr. Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand. Arthritis Res Ther. 2011;13(4):R140. doi:10.1186/ar3454
   PubMed Web of Science ®Google Scholar
• Rooney CM, Mankia K, Mitra S, Moura IB, Emery P, Wilcox MH. Perturbations of the gut microbiome in anti-CCP positive individuals at risk of developing rheumatoid arthritis. Rheumatology. 2021;60(7):3380–3387. doi:10.1093/rheumatology/keaa792
   PubMed Web of Science ®Google Scholar
• Hu T, Liu Y, Tan L, et al. Value of serum collagen triple helix repeat containing-1 (CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis. Br J Biomed Sci. 2021;78(2):67–71. doi:10.1080/09674845.2020.1810400
   PubMed Web of Science ®Google Scholar
• Thakur S, Riyaz B, Patil A, Kaur A, Kapoor B, Mishra V. Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: an overview. Biomed Pharmacother. 2018;106:1011–1023. doi:10.1016/j.biopha.2018.07.027
   PubMed Web of Science ®Google Scholar
• Gunasekera WM, Kirwan JR. Rheumatoid arthritis: previously untreated early disease. BMJ Clin Evid. 2016;2016:1.
   Google Scholar
• Li R, Du Y, Gao Z, Shen J. Molecular modeling studies on carbazole carboxamide based BTK inhibitors using docking and structure-based 3D-QSAR. Int J Mol Sci. 2018;19:4. doi:10.3390/ijms19041244
   Web of Science ®Google Scholar
• Berardicurti O, Ruscitti P, Pavlych V, Conforti A, Giacomelli R, Cipriani P. Glucocorticoids in rheumatoid arthritis: the silent companion in the therapeutic strategy. Expert Rev Clin Pharmacol. 2020;13(6):593–604. doi:10.1080/17512433.2020.1772055
   PubMed Web of Science ®Google Scholar
• Caporali R, Todoerti M, Sakellariou G, Montecucco C. Glucocorticoids in rheumatoid arthritis. Drugs. 2013;73(1):31–43. doi:10.1007/s40265-013-0008-4
   PubMed Web of Science ®Google Scholar
• Riley TR, George MD. Risk for infections with glucocorticoids and DMARDs in patients with rheumatoid arthritis. RMD Open. 2021;7:1. doi:10.1136/rmdopen-2020-001235
   Google Scholar
• Girman C, Panaccio MP, Hayes K, Niewoehner J, Wan GJ. Pain and fatigue improvements in patients treated with repository corticotropin injection across five indications: a narrative review. Adv Ther. 2022;39(7):3072–3087. doi:10.1007/s12325-022-02176-4
   PubMed Web of Science ®Google Scholar
• Braverman G, Bridges SL, Moreland LW. Tapering biologic DMARDs in rheumatoid arthritis. Curr Opin Pharmacol. 2022;67:102308. doi:10.1016/j.coph.2022.102308
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen S, Du K, et al. Traditional herbal medicine: therapeutic potential in rheumatoid arthritis. J Ethnopharmacol. 2021;279:114368. doi:10.1016/j.jep.2021.114368
   PubMed Web of Science ®Google Scholar
• de Seabra Rodrigues Dias IR, Lo HH, Zhang K, et al. Potential therapeutic compounds from traditional Chinese medicine targeting endoplasmic reticulum stress to alleviate rheumatoid arthritis. Pharmacol Res. 2021;170:105696. doi:10.1016/j.phrs.2021.105696
   PubMed Web of Science ®Google Scholar
• Liu WJ, Jiang ZM, Chen Y, et al. Network pharmacology approach to elucidate possible action mechanisms of Sinomenii Caulis for treating osteoporosis. J Ethnopharmacol. 2020;257:112871. doi:10.1016/j.jep.2020.112871
   PubMed Web of Science ®Google Scholar
• Sun D, Han Y, Wang W, et al. Screening and identification of Caulis Sinomenii bioactive ingredients with dual-target NF-κB inhibition and β (2-) AR agonizing activities. Biomed Chromatogr. 2016;30(11):1843–1853. doi:10.1002/bmc.3761
   PubMed Web of Science ®Google Scholar
• Liu W, Zhang Y, Zhu W, et al. Sinomenine Inhibits the progression of rheumatoid arthritis by regulating the secretion of inflammatory cytokines and monocyte/macrophage subsets. Front Immunol. 2018;9:2228. doi:10.3389/fimmu.2018.02228
   PubMed Web of Science ®Google Scholar
• Liu L, Chu X, Tian C, et al. Chemo proling and simultaneous analysis of different combinations of sinomenii caulis and ramulus cinnamomi using UHPLC-Q-TOF-MS, GC-MS and HPLC methods. J Chromatogr Sci. 2021;59(7):606–617. doi:10.1093/chromsci/bmab048
   PubMed Web of Science ®Google Scholar
• Ahmad Khan M, Sarwar A, Rahat R, Ahmed R, Umar S. Stigmasterol protects rats from collagen induced arthritis by inhibiting proinflammatory cytokines. Int Immunopharmacol. 2020;85:106642. doi:10.1016/j.intimp.2020.106642
   PubMed Web of Science ®Google Scholar
• Chen W, Yu C, Hu P, Bao J, Tang J, Wu LJ. Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis. Acta Biochim Pol. 2012;59(4):537–541.
   PubMed Web of Science ®Google Scholar
• Zhang GB, Li QY, Chen QL, Su SB. Network pharmacology: a new approach for Chinese herbal medicine research. Evid Based Complement Alternat Med. 2013;2013:621423. doi:10.1155/2013/621423
   PubMed Web of Science ®Google Scholar
• Liu J, Liu J, Tong X, et al. Network pharmacology prediction and molecular docking-based strategy to discover the potential pharmacological mechanism of Huai Hua San against ulcerative colitis. Drug Des Devel Ther. 2021;15:3255–3276. doi:10.2147/dddt.S319786
   PubMed Web of Science ®Google Scholar
• Prodinger B, Coenen M, Hammond A, Küçükdeveci AA, Tennant A. Scale-banking for patient reported outcome measures (proms) measuring functioning in rheumatoid arthritis: a daily activities metric. Arthritis Care Res. 2020. doi:10.1002/acr.24503
   Google Scholar
• Guo B, Zhao C, Zhang C, et al. Elucidation of the anti-inflammatory mechanism of Er Miao San by integrative approach of network pharmacology and experimental verification. Pharmacol Res. 2022;175:106000. doi:10.1016/j.phrs.2021.106000
   PubMed Web of Science ®Google Scholar
• Wang X, Wang ZY, Zheng JH, Li S. TCM network pharmacology: a new trend towards combining computational, experimental and clinical approaches. Chin J Nat Med. 2021;19(1):1–11.
   PubMed Web of Science ®Google Scholar
• Shi Y, Shu H, Wang X, et al. Potential advantages of bioactive compounds extracted from traditional Chinese medicine to inhibit bone destructions in rheumatoid arthritis. Front Pharmacol. 2020;11:561962. doi:10.3389/fphar.2020.561962
   PubMed Web of Science ®Google Scholar
• Luo TT, Lu Y, Yan SK, Xiao X, Rong XL, Guo J. Network pharmacology in research of Chinese medicine formula: methodology, application and prospective. Chin J Integr Med. 2020;26(1):72–80. doi:10.1007/s11655-019-3064-0
   PubMed Web of Science ®Google Scholar
• Guo X, Ji J, Feng Z, Hou X, Luo Y, Mei Z. A network pharmacology approach to explore the potential targets underlying the effect of sinomenine on rheumatoid arthritis. Int Immunopharmacol. 2020;80:106201. doi:10.1016/j.intimp.2020.106201
   PubMed Web of Science ®Google Scholar
• Sano T, Matsumura I, Nakamura R, et al. Genetic and chemical comparison of Boi (Sinomeni Caulis et Rhizoma) and Seifuto (Caulis Sinomenii). J Nat Med. 2010;64(3):257–265. doi:10.1007/s11418-010-0397-6
   PubMed Web of Science ®Google Scholar
• Sampath SJP, Rath SN, Kotikalapudi N, Venkatesan V. Beneficial effects of secretome derived from mesenchymal stem cells with stigmasterol to negate IL-1β-induced inflammation in-vitro using rat chondrocytes-OA management. Inflammopharmacology. 2021;29(6):1701–1717. doi:10.1007/s10787-021-00874-z
   PubMed Web of Science ®Google Scholar
• Yokota K, Sato K, Miyazaki T, et al. Characterization and function of tumor necrosis factor and interleukin-6-induced osteoclasts in rheumatoid arthritis. Arthritis Rheumatol. 2021;73(7):1145–1154. doi:10.1002/art.41666
   PubMed Web of Science ®Google Scholar
• Portal-Núñez S, Mediero A, Esbrit P, et al. Unexpected Bone formation produced by RANKL blockade. Trends Endocrinol Metab. 2017;28(10):695–704. doi:10.1016/j.tem.2017.06.003
   PubMed Web of Science ®Google Scholar
• Pohl S, Angermann A, Jeschke A, et al. The lysosomal protein arylsulfatase B is a key enzyme involved in skeletal turnover. J Bone Miner Res. 2018;33(12):2186–2201. doi:10.1002/jbmr.3563
   PubMed Web of Science ®Google Scholar
• Ilchovska D, Barrow DJ. An overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions. Autoimmun Rev. 2021;20(2):102741. doi:10.1016/j.autrev.2020.102741
   PubMed Web of Science ®Google Scholar