Anti-Arthritic Effect of Edaravone Against Complete Freund Adjuvant Induced Arthritis via Osteoclast Differentiation and HIF-1α–VEGF–ANG-1 Axis

References

• Bakheet SA, Ansari MA, Nadeem A, et al. CXCR3 antagonist AMG487 suppresses rheumatoid arthritis pathogenesis and progression by shifting the Th17/Treg cell balance. Cell Signal. 2019;64:1. doi:10.1016/j.cellsig.2019.109395
   Web of Science ®Google Scholar
• Ahmad SF, Ansari MA, Nadeem A, et al. STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis. Immunobiology. 2017;222(2):206–217. doi:10.1016/j.imbio.2016.10.001
   PubMed Web of Science ®Google Scholar
• Ahmad SF, Ansari MA, Nadeem A, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces activation of inflammatory cells and increases Foxp3+ regulatory T cells during pathogenesis of rheumatoid arthritis. Mol Immunol. 2016;78:65–78. doi:10.1016/j.molimm.2016.08.017
   PubMed Web of Science ®Google Scholar
• Abd-Allah ARA, Ahmad SF, Alrashidi I, et al. Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis. Int Immunol. 2014;26(6):325–340. doi:10.1093/intimm/dxt075
   PubMed Web of Science ®Google Scholar
• Mahdi HJ, Khan NAK, Bin AMZ, Mahmud R, Murugaiyah V. In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund’s adjuvant (CFA)-induced arthritis in rats. Integr Med Res. 2018;7(1):85–94. doi:10.1016/j.imr.2017.11.002
   PubMed Web of Science ®Google Scholar
• Zhu L, Zhang Z, Xia N, et al. Anti-arthritic activity of ferulic acid in complete Freund’s adjuvant (CFA)-induced arthritis in rats: JAK2 inhibition. Inflammopharmacology. 2020;28(2):463–473. doi:10.1007/s10787-019-00642-0
   PubMed Web of Science ®Google Scholar
• He P, Hu Y, Huang C, et al. N -Butanol extract of gastrodia elata suppresses inflammatory responses in lipopolysaccharide-stimulated macrophages and Complete Freund’s Adjuvant- (CFA-) induced arthritis rats via inhibition of MAPK signaling pathway. Evid Based Complement Altern Med. 2020;2020:1–11. doi:10.1155/2020/1658618
   Web of Science ®Google Scholar
• Gutiérrez-Rebolledo GA, Garduño-Siciliano L, Chávez-Rueda AK, Siordia-Reyes AG, Zamilpa A, Jiménez-Arellanes MA. In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana. Rev Bras Farmacogn. 2018;28(2):198–206. doi:10.1016/j.bjp.2018.02.004
   Google Scholar
• Tong Z, Cheng L, Song J, et al. Therapeutic effects of Caesalpinia minax Hance on complete Freund’s adjuvant (CFA)-induced arthritis and the anti-inflammatory activity of cassane diterpenes as main active components. J Ethnopharmacol. 2018;226:90–96. doi:10.1016/j.jep.2018.08.011
   PubMed Web of Science ®Google Scholar
• Saad MA, El-Sahhar AE, Arab HH, Al-Shorbagy MY. Nicorandil abates arthritic perturbations induced by complete Freund’s adjuvant in rats via conquering TLR4-MyD88-TRAF6 signaling pathway. Life Sci. 2019;218:284–291. doi:10.1016/j.lfs.2019.01.002
   PubMed Web of Science ®Google Scholar
• Patel MG, Pundarikakshudu K. Anti-arthritic activity of a classical ayurvedic formulation Vatari Guggulu in rats. J Tradit Complement Med. 2016;6(4):389–394. doi:10.1016/j.jtcme.2015.08.007
   PubMedGoogle Scholar
• Abadi SSH, Gangadharappa HV, Balamuralidhara V. Development of colon-specific mucoadhesive meloxicam microspheres for the treatment of CFA-induced arthritis in rats. Int J Polym Mater Polym Biomater. 2021;70(12):849–869. doi:10.1080/00914037.2020.1765359
   Web of Science ®Google Scholar
• Liu JY, Hou YL, Cao R, et al. Protodioscin ameliorates oxidative stress, inflammation and histology outcome in Complete Freund’s adjuvant induced arthritis rats. Apoptosis. 2017;22(11):1454–1460. doi:10.1007/s10495-017-1420-0
   PubMed Web of Science ®Google Scholar
• Zhang Z, Chinnathambi A, Ali Alharbi S, Bai L. Copper oxide nanoparticles from Rabdosia rubescens attenuates the complete Freund’s adjuvant (CFA) induced rheumatoid arthritis in rats via suppressing the inflammatory proteins COX-2/PGE2. Arab J Chem. 2020;13(6):5639–5650. doi:10.1016/j.arabjc.2020.04.005
   Web of Science ®Google Scholar
• Koo ST, Lee CH, Choi H, et al. The effects of pressure on arthritic knees in a rat model of CFA-induced arthritis. Pain Phys. 2013;16(2):95–102.
   Web of Science ®Google Scholar
• Feng Z, Yang T, Hou X, et al. Sinomenine mitigates collagen-induced arthritis mice by inhibiting angiogenesis. Biomed Pharmacother. 2019;113:108759. doi:10.1016/j.biopha.2019.108759
   PubMed Web of Science ®Google Scholar
• Ali EAI, Barakat BM, Hassan R. Antioxidant and angiostatic effect of spirulina platensis suspension in complete Freund’s adjuvant-Induced arthritis in rats. PLoS One. 2015;10(4). doi:10.1371/journal.pone.0121523
   Web of Science ®Google Scholar
• Byram K, Chinratanalab S, Sergent J. Rheumatoid Arthritis. In: Essentials of Physical Medicine and Rehabilitation: Musculoskeletal Disorders, Pain, and Rehabilitation. UK: Oxford University Press; 2018:876–881.
   Google Scholar
• Barua CC, Bodduluru LN, Haloi P, et al. Anti-arthritic and anti-inflammatory activity of a polyherbal formulation against Freund’s complete adjuvant induced arthritis in Wistar rats. Indian J Tradit Knowl. 2017;16(3):482–489.
   Web of Science ®Google Scholar
• Ruckmani A, Meti V, Vijayashree R, et al. Anti-rheumatoid activity of ethanolic extract of Sesamum indicum seed extract in Freund’s complete adjuvant induced arthritis in Wistar albino rats. J Tradit Complement Med. 2018;8(3):377–386. doi:10.1016/j.jtcme.2017.06.003
   PubMedGoogle Scholar
• Veale DJ, Fearon U. Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting. Best Pract Res. 2006;20:941–947. doi:10.1016/j.berh.2006.05.004
   Web of Science ®Google Scholar
• Hanlon MM, Rakovich T, Cunningham CC, et al. STAT3 mediates the differential effects of oncostatin M and TNFα on RA synovial fibroblast and endothelial cell function. Front Immunol. 2019;10. doi:10.3389/fimmu.2019.02056
   PubMed Web of Science ®Google Scholar
• Noort AR, van Zoest KPM, Weijers EM, et al. NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis. J Pathol. 2014;234(3):375–385. doi:10.1002/path.4403
   PubMed Web of Science ®Google Scholar
• Wu G, Nie W, Wang Q, et al. Umbelliferone ameliorates complete Freund adjuvant–induced arthritis via reduction of NF-κB signaling pathway in osteoclast differentiation. Inflammation. 2021;44(4):1315–1329. doi:10.1007/s10753-021-01418-x
   PubMed Web of Science ®Google Scholar
• Luo XH, Guo LJ, Xie H, et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res. 2006;21(10):1648–1656. doi:10.1359/jbmr.060707
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Notoya K, Naito T, et al. Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist reduces inflammatory-induced alteration of bone structure in rat adjuvant polyarthritis: evidence for a bone protecting effect in inflammatory conditions. Osteoarthr Cartil. 2009;17:S93–4. doi:10.1016/S1063-4584(09)60178-3
   Google Scholar
• Kelchtermans H, Geboes L, Mitera T, Huskens D, Leclercq G, Matthys P. Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Ann Rheum Dis. 2009;68(5):744–750. doi:10.1136/ard.2007.086066
   PubMed Web of Science ®Google Scholar
• Berardi S, Corrado A, Maruotti N, Cici D, Cantatore FP. Osteoblast role in the pathogenesis of rheumatoid arthritis. Mol Biol Rep. 2021;48:2843–2852. doi:10.1007/s11033-021-06288-y
   PubMed Web of Science ®Google Scholar
• Komatsu N. Immune molecules and the mechanism of joint destruction. Clin Calcium. 2016;26:683–689.
   PubMedGoogle Scholar
• Cecchi I, Arias de la Rosa I, Menegatti E, et al. Neutrophils: novel key players in rheumatoid arthritis. Current and future therapeutic targets. Autoimmun Rev. 2018;17:1138–1149. doi:10.1016/j.autrev.2018.06.006
   PubMed Web of Science ®Google Scholar
• Wei J, Li Y, Liu Q, et al. betulinic acid protects from bone loss in ovariectomized mice and suppresses RANKL-associated osteoclastogenesis by inhibiting the MAPK and NFATc1 pathways. Front Pharmacol. 2020;11. doi:10.3389/fphar.2020.01025
   Web of Science ®Google Scholar
• Posa Krishnamoorthy P, Muthukumaran S. In vitro studies to determine the effect of boeravinone B on human dendritic cells. Pharmacogn Mag. 2018;14(56):465–470. doi:10.4103/pm.pm_625_17
   Web of Science ®Google Scholar
• Huang Y, Sun Y, Wang WW, Zhang L. Boeravinone B a natural rotenoid exerts anticancer activity via inducing internalization and degradation of inactivated EGFR and ERBB2 in human colon cancer cells. Am J Transl Res. 2018;10(12):4183–4192.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zong L, Bai D. Boeravinone b promotes fracture healing in ovariectomy-induced osteoporotic rats via the regulation of NF-κB p65/IκB-α/SIRT-1 signaling pathway. Trop J Pharm Res. 2019;18(5):955–960. doi:10.4314/tjpr.v18i5.7
   Web of Science ®Google Scholar
• Singh S, Kalia NP, Joshi P, et al. A novel dual inhibitor of Nora bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Front Microbiol. 2017;8. doi:10.3389/fmicb.2017.01868
   Web of Science ®Google Scholar
• Weng W, Wang F, He X, Zhou K, Wu X, Wu X. Protective effect of corynoline on the CFA induced rheumatoid arthritis via attenuation of oxidative and inflammatory mediators. Mol Cell Biochem. 2021;476(2):831–839. doi:10.1007/s11010-020-03948-8
   PubMed Web of Science ®Google Scholar
• Zeng Z, Yan K, Liu W. Specneuzhenide ameliorate complete Freund adjuvant induced arthritis in rats: involvement of NF-κB and HO-1/Nrf-2 pathway. J Oleo Sci. 2022;71(4):551–561. doi:10.5650/jos.ess21413
   PubMed Web of Science ®Google Scholar
• Kumar V, Bhatt PC, Rahman M, et al. Melastoma malabathricum Linn attenuates complete Freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response. BMC Complement Altern Med. 2016;16(1). doi:10.1186/s12906-016-1470-9
   Google Scholar
• Kumar V, Anwar F, Verma A, Mujeeb M. Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside on adjuvant-induced arthritic rats. J Food Sci Technol. 2015;52(6):3402–3411. doi:10.1007/s13197-014-1403-x
   PubMed Web of Science ®Google Scholar
• Kumar V, Al-Abbasi FA, Verma A, Mujeeb M, Anwar F. Umbelliferone β-d-galactopyranoside exerts an anti-inflammatory effect by attenuating COX-1 and COX-2. Toxicol Res. 2015;4(4):1072–1084. doi:10.1039/C5TX00095E
   Web of Science ®Google Scholar
• Yeom J, Yim DJ, Ma S, Lim YH. Propionibacterium freudenreichii inhibits rankl-induced osteoclast differentiation and ameliorates rheumatoid arthritis in collagen-induced arthritis mice. Microorganisms. 2022;10(1):1.
   Web of Science ®Google Scholar
• Wang T, Qiao H, Zhai Z, et al. Plumbagin ameliorates collagen-induced arthritis by regulating Treg/Th17 cell imbalances and suppressing osteoclastogenesis. Front Immunol. 2019;10:1.
   PubMedGoogle Scholar
• Ling Y, Yang J, Hua D, et al. ZhiJingSan inhibits osteoclastogenesis via regulating RANKL/NF-κB signaling pathway and ameliorates bone erosion in collagen-induced mouse arthritis. Front Pharmacol. 2021;12. doi:10.3389/fphar.2021.693777
   Web of Science ®Google Scholar
• Jia X, Zhu H, Li G, et al. Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition. Biomed Pharmacother. 2021;137:111321. doi:10.1016/j.biopha.2021.111321
   PubMed Web of Science ®Google Scholar
• Rahman M, Kumar V, Beg S, Sharma G, Katare OP, Anwar F. Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art. Artif Cells Nanomed Biotechnol. 2016;44(7):1597–1608. doi:10.3109/21691401.2015.1129617
   PubMed Web of Science ®Google Scholar
• Tanaka S. Emerging anti-osteoclast therapy for rheumatoid arthritis. J Orthop Sci. 2018;23:717–721. doi:10.1016/j.jos.2018.06.001
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen S, Du K, et al. Traditional herbal medicine: therapeutic potential in rheumatoid arthritis. J Ethnopharmacol. 2021;279:1.
   Web of Science ®Google Scholar
• Shen W, Guan YY, Wu RM, et al. Protective effects of Wang-Bi tablet on bone destruction in collagen-induced arthritis by regulating osteoclast-osteoblast functions. J Ethnopharmacol. 2019;238:111861. doi:10.1016/j.jep.2019.111861
   PubMed Web of Science ®Google Scholar
• Kim KW, Kim HR, Kim BM, La CM, Lee SH. Th17 cytokines regulate osteoclastogenesis in rheumatoid arthritis. Am J Pathol. 2015;185(11):3011–3024. doi:10.1016/j.ajpath.2015.07.017
   PubMed Web of Science ®Google Scholar
• Uehara IA, Soldi LR, Silva MJB. Current perspectives of osteoclastogenesis through estrogen modulated immune cell cytokines. Life Sci. 2020;256:117921. doi:10.1016/j.lfs.2020.117921
   PubMed Web of Science ®Google Scholar
• Chen Z, Buki K, Vääräniemi J, Gu G, Väänänen HK. The critical role of IL-34 in osteoclastogenesis. PLoS One. 2011;6(4):5.
   Web of Science ®Google Scholar
• Tanaka U, Kajioka S, Finoti LS, Palioto DB, Kinane DF, Benakanakere MR. Decitabine inhibits bone resorption in periodontitis by upregulating anti-inflammatory cytokines and suppressing osteoclastogenesis. Biomedicines. 2021;9(2):1–13. doi:10.3390/biomedicines9020199
   Web of Science ®Google Scholar
• Nirbhavane P, Sharma G, Singh B, et al. Preclinical explorative assessment of celecoxib-based biocompatible lipidic nanocarriers for the management of CFA-induced rheumatoid arthritis in Wistar rats. AAPS Pharm Sci Tech. 2018;19(7):3187–3198. doi:10.1208/s12249-018-1148-3
   PubMed Web of Science ®Google Scholar
• Kumar V, Al-Abbasi FA, Ahmed D, Verma A, Mujeeb M, Anwar F. Paederia foetida Linn. Inhibits adjuvant induced arthritis by suppression of PGE2 and COX-2 expression via nuclear factor-κB. Food Funct. 2015;6(5):1652–1666. doi:10.1039/C5FO00178A
   PubMed Web of Science ®Google Scholar
• Chauhan S, Devi U, Kumar VR, Kumar V, Anwar F, Kaithwas G. Dual inhibition of arachidonic acid pathway by mulberry leaf extract. Inflammopharmacology. 2015;23(1):65–70. doi:10.1007/s10787-014-0223-y
   PubMed Web of Science ®Google Scholar
• Alolga RN, Opoku-Damoah Y, Alagpulinsa DA, et al. Metabolomic and transcriptomic analyses of the anti-rheumatoid arthritis potential of xylopic acid in a bioinspired lipoprotein nanoformulation. Biomaterials. 2021;268:120482. doi:10.1016/j.biomaterials.2020.120482
   PubMed Web of Science ®Google Scholar
• Liu FC, Yu HP, Chen PJ, et al. A novel NOX2 inhibitor attenuates human neutrophil oxidative stress and ameliorates inflammatory arthritis in mice. Redox Biol. 2019;26:101273. doi:10.1016/j.redox.2019.101273
   PubMed Web of Science ®Google Scholar
• Ahmad SF, Zoheir KMA, Bakheet SA, Ashour AE, Attia SM. Poly (ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model. Cytokine. 2014;68(2):76–85. doi:10.1016/j.cyto.2014.04.006
   PubMed Web of Science ®Google Scholar
• Lai W-Q, Irwan AW, Goh HH, et al. Anti-inflammatory effects of sphingosine Kinase modulation in inflammatory arthritis. J Immunol. 2008;181(11):8010–8017. doi:10.4049/jimmunol.181.11.8010
   PubMed Web of Science ®Google Scholar
• Murakami M, Iwai S, Hirasuka S, Iwakura Y, Maru Y, Shibuya M. VEGFR-1(Flt-1) tyrosine kinase signaling enhances hematopoiesis, proliferation/differentiation and immunity of monocyte/macrophage from bone marrow hematopoietic stem cells, and promotes rheumatoid arthritis. Blood. 2004;104(11):778. doi:10.1182/blood.V104.11.778.778
   Web of Science ®Google Scholar
• Guo X, Ji J, Jose Kumar Sreena GS, et al. Computational prediction of antiangiogenesis synergistic mechanisms of total saponins of panax japonicus against rheumatoid arthritis. Front Pharmacol. 2020;11. doi:10.3389/fphar.2020.566129
   Web of Science ®Google Scholar
• Xu J, Feng Z, Chen S, et al. Taxol alleviates collagen-induced arthritis in mice by inhibiting the formation of microvessels. Clin Rheumatol. 2019;38(1):19–27.
   PubMed Web of Science ®Google Scholar
• Han CC, Liu Q, Zhang Y, et al. CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation. Clin Sci. 2020;134(3):331–347. doi:10.1042/CS20191032
   Web of Science ®Google Scholar