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ORIGINAL RESEARCH

Thymopentapeptide Affects T-Cell Subsets by Modulating the Flora of the Skin Surface to Alleviate Psoriasis

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Pages 2775-2791 | Received 07 Nov 2023, Accepted 25 May 2024, Published online: 03 Jul 2024

References

  • Lebwohl M. Advances in biologic therapy of psoriasis. J Eur Acad Dermatol Venereol. 2023;37(9):1689–1690. doi:10.1111/jdv.19287
  • Subedi S, Gong Y, Chen Y, et al. Infliximab and biosimilar infliximab in psoriasis: efficacy, loss of efficacy, and adverse events. Drug Des Devel Ther. 2019;13:2491–2502. doi:10.2147/DDDT.S200147
  • McDonald BD, Jabri B, Bendelac A. Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2018;18(8):514–525. doi:10.1038/s41577-018-0013-7
  • Chang HW, Yan D, Singh R, et al. Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome. 2018;6(1):154. doi:10.1186/s40168-018-0533-1
  • Navarro-Compan V. The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases. Front Immunol. 2023;14:1191782. doi:10.3389/fimmu.2023.1191782
  • Whitley SK, Li M, Kashem SW, et al. Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells. Sci Immunol. 2022;7(77):eabq3254. doi:10.1126/sciimmunol.abq3254
  • Sun R, Hedl M, Abraham C. IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes. Gut. 2020;69(2):264–273. doi:10.1136/gutjnl-2018-316830
  • Fu Y. Transcriptomic study on ovine immune responses to fasciola hepatica infection. PLoS Negl Trop Dis. 2016;10(9):e0005015. doi:10.1371/journal.pntd.0005015
  • Yang C. STAT4: an immunoregulator contributing to diverse human diseases. Int J Biol Sci. 2020;16(9):1575–1585.
  • Chen K, Eddens T, Trevejo-Nunez G, et al. IL-17 receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against K. pneumoniae. Cell Host Microbe. 2016;20(5):596–605. doi:10.1016/j.chom.2016.10.003
  • Lang T, Lee JPW, Elgass K, et al. Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation. Nat Commun. 2018;9(1):2223. doi:10.1038/s41467-018-04581-2
  • Dutzan N, Kajikawa T, Abusleme L, et al. A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans. Sci Transl Med. 2018;10(463). doi:10.1126/scitranslmed.aat0797
  • Kobayashi T, Naik S, Nagao K. Choreographing immunity in the skin epithelial barrier. Immunity. 2019;50(3):552–565. doi:10.1016/j.immuni.2019.02.023
  • Liu C, Liu H, Lu C, et al. Kaempferol attenuates imiquimod-induced psoriatic skin inflammation in a mouse model. Clin Exp Immunol. 2019;198(3):403–415. doi:10.1111/cei.13363
  • Zhang L, Guo L, Wang L, et al. The efficacy and safety of tofacitinib, peficitinib, solcitinib, baricitinib, abrocitinib and deucravacitinib in plaque psoriasis - A network meta-analysis. J Eur Acad Dermatol Venereol. 2022;36(11):1937–1946. doi:10.1111/jdv.18263
  • Muddasani S, Fleischer AB, Feldman SR. Treatment practices for psoriasis and how they are changing. J Am Acad Dermatol. 2021;84(2):579–581. doi:10.1016/j.jaad.2020.09.064
  • Hahn J, Cook NR, Alexander EK, et al. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ. 2022;376:e066452. doi:10.1136/bmj-2021-066452
  • Lebwohl MG, Stein Gold L, Papp K, et al. Long-term safety and efficacy of a fixed-combination halobetasol propionate 0.01%/tazarotene 0.045% lotion in moderate-to-severe plaque psoriasis: Phase 3 open-label study. J Eur Acad Dermatol Venereol. 2021;35(5):1152–1160. doi:10.1111/jdv.17113
  • Rendon A, Schakel K. Psoriasis Pathogenesis and Treatment. Int J Mol Sci. 2019;20(6):1475. doi:10.3390/ijms20061475
  • Fahlen A, Engstrand L, Baker BS, et al. Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin. Arch Dermatol Res. 2012;304(1):15–22. doi:10.1007/s00403-011-1189-x
  • Olejniczak-Staruch I, Ciążyńska M, Sobolewska-Sztychny D, et al. Alterations of the skin and gut microbiome in psoriasis and psoriatic arthritis. Int J Mol Sci. 2021;22(8):3998. doi:10.3390/ijms22083998
  • Alekseyenko AV, Perez-Perez GI, De Souza A, et al. Community differentiation of the cutaneous microbiota in psoriasis. Microbiome. 2013;1(1):31. doi:10.1186/2049-2618-1-31
  • Fry L, Baker BS, Powles AV, et al. Is chronic plaque psoriasis triggered by microbiota in the skin? Br J Dermatol. 2013;169(1):47–52. doi:10.1111/bjd.12322
  • Zhang L, Wei X, Zhang R, et al. Design and Development of a Novel Peptide for Treating Intestinal Inflammation. Front Immunol. 2019;10:1841. doi:10.3389/fimmu.2019.01841
  • Yuan XL, Wen Q, Ni M-D, et al. Immune formulation-assisted conventional therapy on anti-infective effectiveness of multidrug-resistant Mycobacterium tuberculosis infection mice. Asian Pac J Trop Med. 2016;9(3):293–297. doi:10.1016/j.apjtm.2016.01.031
  • Han YR, Wang T-H, Gong W-P, et al. Clinical efficacy of a combination of thymopentin and antituberculosis drugs in treating drug-resistant pulmonary tuberculosis: meta analysis. Ther Clin Risk Manag. 2022;18:287–298. doi:10.2147/TCRM.S351317
  • Zhang L, Wei X, Zhang R, et al. C-Terminal amination of a cationic anti-inflammatory peptide improves bioavailability and inhibitory activity against LPS-induced inflammation. Front Immunol. 2020;11:618312. doi:10.3389/fimmu.2020.618312
  • Guo W-J, Wang Y, Deng Y. Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61. J Integr Med. 2022;20(4):376–384. doi:10.1016/j.joim.2022.04.004
  • Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–457. doi:10.1038/nmeth.3337
  • Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782–795. doi:10.1016/j.immuni.2013.10.003
  • Hanzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinf. 2013;14(1):7. doi:10.1186/1471-2105-14-7
  • Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18(1):220. doi:10.1186/s13059-017-1349-1
  • Burns EM, Ahmed H, Isedeh PN, et al. Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome. Exp Dermatol. 2019;28(2):136–141. doi:10.1111/exd.13854
  • Shinno-Hashimoto H, Hashimoto Y, Wei Y, et al. Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice. Sci Rep. 2021;11(1):11265. doi:10.1038/s41598-021-90480-4
  • Camela E, Potestio L, Fabbrocini G, et al. The holistic approach to psoriasis patients with comorbidities: the role of investigational drugs. Expert Opin Investig Drugs. 2023;32(6):537–552. doi:10.1080/13543784.2023.2219387
  • Langan EA, Griffiths CEM, Solbach W, et al. The role of the microbiome in psoriasis: moving from disease description to treatment selection? Br J Dermatol. 2018;178(5):1020–1027. doi:10.1111/bjd.16081
  • Rigon RB, de Freitas ACP, Bicas JL, et al. Skin microbiota as a therapeutic target for psoriasis treatment: trends and perspectives. J Cosmet Dermatol. 2021;20(4):1066–1072. doi:10.1111/jocd.13752
  • Liang X, Ou C, Zhuang J, et al. Interplay between skin microbiota dysbiosis and the host immune system in psoriasis: potential pathogenesis. Front Immunol. 2021;12:764384. doi:10.3389/fimmu.2021.764384
  • Singh VK, Biswas S, Mathur KB, et al. Thymopentin and splenopentin as immunomodulators. Current Status Immunol Res. 1998;17(3):345–368. doi:10.1007/BF02786456
  • Leung DY, Hirsch RL, Schneider L, et al. Thymopentin therapy reduces the clinical severity of atopic dermatitis. J Allergy Clin Immunol. 1990;85(5):927–933. doi:10.1016/0091-6749(90)90079-J
  • Hsieh KH, Shaio MF, Liao TN. Thymopentin treatment in severe atopic dermatitis--clinical and immunological evaluations. Arch Dis Child. 1992;67(9):1095–1102. doi:10.1136/adc.67.9.1095
  • Roekevisch E, Spuls PI, Kuester D, et al. Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review. J Allergy Clin Immunol. 2014;133(2):429–438. doi:10.1016/j.jaci.2013.07.049
  • Malaise MG, Franchimont P, Bach-Andersen R, et al. Treatment of active rheumatoid arthritis with slow intravenous injections of thymopentin. A double-blind placebo-controlled randomised study. Lancet. 1985;1(8433):832–836. doi:10.1016/S0140-6736(85)92205-6
  • Lee HJ, Kim M. Skin barrier function and the microbiome. Int J Mol Sci. 2022;23:21.
  • Visser MJE, Kell DB, Pretorius E. Bacterial dysbiosis and translocation in psoriasis vulgaris. Front Cell Infect Microbiol. 2019;9:7. doi:10.3389/fcimb.2019.00007