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ORIGINAL RESEARCH

Tongxieyaofang Decotion Alleviates IBS by Modulating CHRM3 and Gut Barrier

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Pages 3191-3208 | Received 26 Jan 2024, Accepted 10 Jul 2024, Published online: 24 Jul 2024

References

  • Ford AC, Lacy BE, Talley NJ. Irritable bowel syndrome. New Engl J Med. 2017;376(26):2566–2578. doi:10.1056/NEJMra1607547
  • Fukudo S, Okumura T, Inamori M, et al. Evidence-based clinical practice guidelines for irritable bowel syndrome 2020. J Gastroenterol. 2021;56(3):193–217. doi:10.1007/s00535-020-01746-z
  • Bonetto S, Fagoonee S, Battaglia E, Grassini M, Saracco GM, Pellicano R. Recent advances in the treatment of irritable bowel syndrome. Pol Arch Intern Med. 2021;131(7–8):709–715. doi:10.20452/pamw.16067
  • Holtmann GJ, Ford AC, Talley NJ. Pathophysiology of irritable bowel syndrome. Lancet Gastroenterol Hepatol. 2016;1(2):133–146. doi:10.1016/S2468-1253(16)30023-1
  • Chen M, Tang TC, Wang Y, et al. Randomised clinical trial: Tong-Xie-Yao-Fang granules versus placebo for patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2018;48(2):160–168. doi:10.1111/apt.14817
  • Liang S-B, Cao H-J, Kong L-Y, et al. Systematic review and meta-analysis of Chinese herbal formula tongxie yaofang for diarrhea-predominant irritable bowel syndrome: evidence for clinical practice and future trials. Front Pharmacol. 2022;13:904657.
  • Zhang M, Zheng Y, Li X, et al. Tong-Xie-Yao-Fang alleviates diarrhea-predominant irritable bowel syndrome in rats via the GCN2/PERK-eIF2α-ATF4 signaling pathway. Phytomedicine. 2022;107:154350.
  • Yin Y, Zhong L, Wang JW, Zhao XY, Zhao WJ, Kuang HX, Kuang H-X. Tong Xie Yao Fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P. World J Gastroenterol. 2015;21(15):4536–4546. doi:10.3748/wjg.v21.i15.4536
  • Li J, Cui H, Cai Y, et al. Tong-Xie-Yao-Fang regulates 5-ht level in diarrhea predominant irritable bowel syndrome through gut microbiota modulation. Front Pharmacol. 2018;9:1110. doi:10.3389/fphar.2018.01110
  • Chen H, Kan Q, Zhao L, et al. Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis. Biomed Pharmacother. 2023;161:114525.
  • Gallegos-Perez J-L, Limon A, Reyes-Ruiz JM, Alshanqeeti AS, Aljohi MA, Miledi R. Analysis of free ACh and 5-HT in milk from four different species and their bioactivity on 5-HT3and nACh receptors. Food Funct. 2014;5(7):1489–1494. doi:10.1039/C3FO60458F
  • Bennet SMP, Polster A, Törnblom H, et al. Global cytokine profiles and association with clinical characteristics in patients with irritable bowel syndrome. Am J Gastroenterol. 2016;111(8):1165–1176. doi:10.1038/ajg.2016.223
  • Zhao L, Zhang H, Li N, et al. Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula. J Ethnopharmacol. 2023;309:116306. doi:10.1016/j.jep.2023.116306
  • Qin K, Dong C, Wu G, Lambert NA. Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers. Nat Chem Biol. 2011;7(10):740–747. doi:10.1038/nchembio.642
  • Wess J. Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Annu Rev Pharmacol Toxicol. 2004;44(1):423–450. doi:10.1146/annurev.pharmtox.44.101802.121622
  • McLean LP, Smith A, Cheung L, et al. Type 3 muscarinic receptors contribute to clearance of citrobacter rodentium. Inflamm Bowel Dis. 2015;21(8):1860–1871. doi:10.1097/MIB.0000000000000408
  • Cheru L, Saylor CF, Lo J. Gastrointestinal barrier breakdown and adipose tissue inflammation. Curr Obes Rep. 2019;8(2):165–174. doi:10.1007/s13679-019-00332-6
  • Al-Sadi R, Engers J, Haque M, King S, Al-Omari D, Ma TY. Matrix metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-kappaB activation. PLoS One. 2021;16(4):e0249544. doi:10.1371/journal.pone.0249544
  • Zhang H-Y, Zeng H-R, Wei H-Z, et al. Tongxie-Yaofang formula regulated macrophage polarization to ameliorate DSS-induced colitis via NF-κB/NLRP3 signaling pathway. Phytomedicine. 2022;107:154455.
  • Zhou Y, Zhang F, Mao L, et al. Bifico relieves irritable bowel syndrome by regulating gut microbiota dysbiosis and inflammatory cytokines. Eur J Nutr. 2022;62(1):139–155. doi:10.1007/s00394-022-02958-0
  • Guo L, Chen Q, Gao Y, et al. CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease. Biochem Pharmacol. 2023;217:115845. doi:10.1016/j.bcp.2023.115845
  • Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome. JAMA. 2015;313(9):949–958—.
  • Gong S, Zheng J, Zhang J, et al. Taxifolin ameliorates lipopolysaccharide-induced intestinal epithelial barrier dysfunction via attenuating NF-kappa B/MLCK pathway in a Caco-2 cell monolayer model. Food Res Int. 2022;158:111502.
  • He WQ, Wang J, Sheng JY, Zha JM, Graham WV, Turner JR. Contributions of myosin light chain kinase to regulation of epithelial paracellular permeability and mucosal homeostasis. Int J Mol Sci. 2020;21(3):993. doi:10.3390/ijms21030993
  • Brzozowski B, Mazur-Bialy A, Pajdo R, et al. Mechanisms by which stress affects the experimental and clinical inflammatory bowel disease (ibd): role of brain-gut axis. Curr Neuropharmacol. 2016;14(8):892–900. doi:10.2174/1570159X14666160404124127
  • Alizadeh M, Schledwitz A, Cheng K, Raufman JP. Mechanistic clues provided by concurrent changes in the expression of genes encoding the m(1) muscarinic receptor, beta-catenin signaling Proteins, and downstream targets in adenocarcinomas of the colon. Front Physiol. 2022;13:857563. doi:10.3389/fphys.2022.857563
  • Gros M, Gros B, Mesonero JE, Latorre E. Neurotransmitter dysfunction in irritable bowel syndrome: emerging approaches for management. J Clin Med. 2021;10(15):3429. doi:10.3390/jcm10153429
  • Sun P, Zhou K, Wang S, et al. Involvement of MAPK/NF-kappaB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation. PLoS One. 2013;8(8):e69424. doi:10.1371/journal.pone.0069424
  • Kim JE, Lee MR, Park JJ, et al. Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. Pharm Biol. 2018;56(1):309–317. doi:10.1080/13880209.2018.1474932
  • Chen D, Xiong Y, Lin Y, et al. Capsaicin alleviates abnormal intestinal motility through regulation of enteric motor neurons and MLCK activity: relevance to intestinal motility disorders. Mol Nutr Food Res. 2015;59(8):1482–1490. doi:10.1002/mnfr.201500039
  • Kan W, Adjobo-Hermans M, Burroughs M, et al. M3 muscarinic receptor interaction with phospholipase C beta3 determines its signaling efficiency. J Biol Chem. 2014;289(16):11206–11218. doi:10.1074/jbc.M113.538546
  • Layunta E, Forcen R, Grasa L. TLR2 and TLR4 modulate mouse ileal motility by the interaction with muscarinic and nicotinic receptors. Cells. 2022;11(11):1791. doi:10.3390/cells11111791
  • Chen Q, Zhang H, Sun CY, et al. Evaluation of two laboratory model methods for diarrheal irritable bowel syndrome. Mol Med. 2023;29(1):5. doi:10.1186/s10020-022-00599-x
  • Reyes EA, Castillo-Azofeifa D, Rispal J, et al. Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis. J Clin Invest. 2023;133(20). doi:10.1172/JCI163591
  • Garg P, Ravi A, Patel NR, et al. Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation. Gastroenterology. 2007;132(5):1877–1889. doi:10.1053/j.gastro.2007.02.048
  • Dolan B, Ermund A, Martinez-Abad B, Johansson MEV, Hansson GC. Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. Sci Signaling. 2022;15(752):eabl5848. doi:10.1126/scisignal.abl5848
  • Liu S, Huang Q, Huang Q, et al. The protective effects of electroacupuncture on intestinal barrier lesions in IBS and UC model. Sci Rep. 2023;13(1):7276. doi:10.1038/s41598-023-34182-z
  • Yu J, Liu T, Guo Q, Wang Z, Chen Y, Dong Y. Disruption of the intestinal mucosal barrier induced by high fructose and restraint stress is regulated by the intestinal microbiota and microbiota metabolites. Microbiol Spectr. 2023;11(2):e0469822. doi:10.1128/spectrum.04698-22
  • Augoff K, Hryniewicz-Jankowska A, Tabola R, Stach K. MMP9: a tough target for targeted therapy for cancer. Cancers. 2022;14(7):1847. doi:10.3390/cancers14071847
  • He F, Peng J, Deng XL, et al. Mechanisms of tumor necrosis factor-alpha-induced leaks in intestine epithelial barrier. Cytokine. 2012;59(2):264–272. doi:10.1016/j.cyto.2012.04.008
  • Xing Y, Xue S, Wu J, et al. Serum exosomes derived from irritable bowel syndrome patient increase cell permeability via regulating mir-148b-5p/rgs2 signaling in human colonic epithelium cells. Gastroenterol Res Pract. 2021;2021:6655900. doi:10.1155/2021/6655900