MTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and Reproduction

References

• Guna A, Stevens TA, Inglis AJ, et al. MTCH2 is a mitochondrial outer membrane protein insertase. Science. 2022;378(6617):317–322. doi:10.1126/science.add1856
   PubMed Web of Science ®Google Scholar
• Li D, Schilling -R-RC, Reinisch MA, Vanni KM. Lipid scrambling is a general feature of protein insertases. bioRxiv. doi:10.1101/2023.09.01.555937
   Google Scholar
• Alexander Brandis TM, Malitsky S, Itkin M, et al. High-energy demand and nutrient exhaustion in MTCH2 knockout cells. bioRxiv Preprint. 2023.
   Google Scholar
• Bartoš L, Vácha MA, Vácha R. Insertases Scramble Lipids: molecular Simulations of MTCH2. bioRxiv. 2023. doi:10.1101/2023.08.14.553169
   PubMedGoogle Scholar
• Zaltsman Y, Shachnai L, Yivgi-Ohana N, et al. MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol. 2010;12(6):553–562. doi:10.1038/ncb2057
   PubMed Web of Science ®Google Scholar
• Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol Cell Biol. 2005;25(11):4579–4590. doi:10.1128/MCB.25.11.4579-4590.2005
   PubMed Web of Science ®Google Scholar
• Shamas-Din A, Bindner S, Zhu W, et al. tBid undergoes multiple conformational changes at the membrane required for Bax activation. J Biol Chem. 2013;288(30):22111–22127. doi:10.1074/jbc.M113.482109
   PubMed Web of Science ®Google Scholar
• Zhang QH, Ye M, Wu XY, et al. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. 2000;10(10):1546–1560. doi:10.1101/gr.140200
   PubMed Web of Science ®Google Scholar
• Schwarz M, Andrade-Navarro MA, Gross A. Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program? Apoptosis. 2007;12(5):869–876. doi:10.1007/s10495-007-0748-2
   PubMed Web of Science ®Google Scholar
• Manjunath LE, Singh A, Sahoo S, et al. Stop codon read-through of mammalian MTCH2 leading to an unstable isoform regulates mitochondrial membrane potential. J Biol Chem. 2020;295(50):17009–17026. doi:10.1074/jbc.RA120.014253
   PubMed Web of Science ®Google Scholar
• Veresov VG, Davidovskii AI. Structural insights into proapoptotic signaling mediated by MTCH2, VDAC2, TOM40 and TOM22. Cell Signal. 2014;26(2):370–382. doi:10.1016/j.cellsig.2013.11.016
   PubMed Web of Science ®Google Scholar
• Hung CL, Chang HH, Lee SW, et al. Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes. Cell Death Differ. 2021;28(6):1910–1925. doi:10.1038/s41418-020-00716-5
   PubMed Web of Science ®Google Scholar
• Katz C, Zaltsman-Amir Y, Mostizky Y, et al. Molecular basis of the interaction between proapoptotic truncated Bid (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway. J Biol Chem. 2012;287(18):15016–15023. doi:10.1074/jbc.M111.328377
   PubMed Web of Science ®Google Scholar
• Shamas-Din A, Satsoura D, Khan O, et al. Multiple partners can kiss-and-run: bax transfers between multiple membranes and permeabilizes those primed by tBid. Cell Death Dis. 2014;5(6):e1277. doi:10.1038/cddis.2014.234
   PubMedGoogle Scholar
• Tan CT, Zhou QL, Su YC, et al. MOAP-1 mediates fas-induced apoptosis in liver by facilitating tbid recruitment to mitochondria. Cell Rep. 2016;16(1):174–185. doi:10.1016/j.celrep.2016.05.068
   PubMed Web of Science ®Google Scholar
• Raemy E, S, Montessuit S, Pierredon S, van Kampen AH, Vaz FM, Martinou J-C. Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis. Cell Death Differ. 2016;23(7):1165–1174. doi:10.1038/cdd.2015.166
   PubMed Web of Science ®Google Scholar
• Shamas-Din A, Bindner S, Chi X, et al. Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax. Biochem J. 2015;467(3):495–505. doi:10.1042/BJ20141291
   PubMedGoogle Scholar
• Rome S, Clement K, Rabasa-Lhoret R, et al. Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp. J Biol Chem. 2003;278(20):18063–18068. doi:10.1074/jbc.M300293200
   PubMed Web of Science ®Google Scholar
• Kulyté A, Rydén M, Mejhert N, et al. MTCH2 in human white adipose tissue and obesity. J Clin Endocrinol Metab. 2011;96(10):E1661–5. doi:10.1210/jc.2010-3050
   PubMed Web of Science ®Google Scholar
• Bernhard F, Landgraf K, Klöting N, et al. Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia. 2013;56(2):311–322. doi:10.1007/s00125-012-2773-0
   PubMed Web of Science ®Google Scholar
• Ng MC, Tam CH, So WY, et al. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab. 2010;95(5):2418–2425. doi:10.1210/jc.2009-2077
   PubMed Web of Science ®Google Scholar
• He M, Cornelis MC, Franks PW, et al. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2010;30(2):327–332. doi:10.1161/ATVBAHA.109.196196
   PubMed Web of Science ®Google Scholar
• Graff M, North KE, Richardson AS, et al. BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort. Int J Obes Lond. 2017;41(5):759–768. doi:10.1038/ijo.2016.233
   PubMed Web of Science ®Google Scholar
• Pei YF, Tian Q, Zhang L, et al. Exploring the major sources and extent of heterogeneity in a genome-wide association meta-analysis. Ann Hum Genet. 2016;80(2):113–122. doi:10.1111/ahg.12143
   PubMed Web of Science ®Google Scholar
• Kong X, Xing X, Zhang X, et al. Sexual Dimorphism of a Genetic Risk Score for Obesity and Related Traits among Chinese Patients with Type 2 Diabetes. Obes Facts. 2019;12(3):328–343. doi:10.1159/000500490
   PubMed Web of Science ®Google Scholar
• Rönn T, Volkov P, Gillberg L, et al. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood. Hum Mol Genet. 2015;24(13):3792–3813. doi:10.1093/hmg/ddv124
   PubMed Web of Science ®Google Scholar
• Jiang Q, Sun B, Liu Q, et al. MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m(6)A-YTHDF1-dependent mechanism. FASEB j. 2019;33(2):2971–2981. doi:10.1096/fj.201801393RRR
   PubMed Web of Science ®Google Scholar
• van Vliet-Ostaptchouk JV, den Hoed M, Luan J, et al. Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. Diabetologia. 2013;56(10):2134–2146. doi:10.1007/s00125-013-2985-y
   PubMed Web of Science ®Google Scholar
• Melka MG, Bernard M, Mahboubi A, et al. Genome-wide scan for loci of adolescent obesity and their relationship with blood pressure. J Clin Endocrinol Metab. 2012;97(1):E145–50. doi:10.1210/jc.2011-1801
   PubMed Web of Science ®Google Scholar
• Hotta K, Kitamoto T, Kitamoto A, et al. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. J Hum Genet. 2011;56(9):647–651. doi:10.1038/jhg.2011.74
   PubMed Web of Science ®Google Scholar
• Louwers YV, Rayner NW, Herrera BM, et al. BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study. PLoS One. 2014;9(1):e87335. doi:10.1371/journal.pone.0087335
   PubMed Web of Science ®Google Scholar
• Gockley J, Montgomery KS, Poehlman WL, et al. Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s disease. Genome Med. 2021;13(1):76. doi:10.1186/s13073-021-00890-2
   PubMed Web of Science ®Google Scholar
• Bauer F, Elbers CC, Adan RA, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009;90(4):951–959. doi:10.3945/ajcn.2009.27781
   PubMed Web of Science ®Google Scholar
• Turcot V, Lu Y, Highland HM, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018;50(1):26–41. doi:10.1038/s41588-017-0011-x
   PubMed Web of Science ®Google Scholar
• Kilpeläinen TO, den Hoed M, Ong KK, et al. Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. Am J Clin Nutr. 2011;93(4):851–860. doi:10.3945/ajcn.110.000828
   PubMed Web of Science ®Google Scholar
• Warrington NM, Wu YY, Pennell CE, et al. Modelling BMI trajectories in children for genetic association studies. PLoS One. 2013;8(1):e53897. doi:10.1371/journal.pone.0053897
   PubMed Web of Science ®Google Scholar
• Zhao J, Bradfield JP, Li M, et al. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity. 2009;17(12):2254–2257. doi:10.1038/oby.2009.159
   PubMed Web of Science ®Google Scholar
• Wang J, Mei H, Chen W, et al. Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty. Int J Obes Lond. 2012;36(4):542–547. doi:10.1038/ijo.2011.218
   PubMed Web of Science ®Google Scholar
• Graff M, Gordon-Larsen P, Lim U, et al. The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study. Diabetes. 2013;62(5):1763–1767. doi:10.2337/db12-0863
   PubMed Web of Science ®Google Scholar
• Elks CE, Loos RJ, Hardy R, et al. Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study. Am J Clin Nutr. 2012;95(5):1150–1156. doi:10.3945/ajcn.111.027870
   PubMed Web of Science ®Google Scholar
• Mumby HS, Elks CE, Li S, et al. Mendelian randomisation study of childhood BMI and early menarche. J Obes. 2011;2011:180729. doi:10.1155/2011/180729
   PubMedGoogle Scholar
• Rottiers V, Francisco A, Platov M, et al. MTCH2 is a conserved regulator of lipid homeostasis. Obesity. 2017;25(3):616–625. doi:10.1002/oby.21751
   PubMed Web of Science ®Google Scholar
• Fischer JA, Monroe TO, Pesce LL, et al. Opposing effects of genetic variation in MTCH2 for obesity versus heart failure. Hum Mol Genet. 2023;32(1):15–29. doi:10.1093/hmg/ddac176
   PubMed Web of Science ®Google Scholar
• Bar-Lev Y, Moshitch-Moshkovitz S, Tsarfaty G, et al. Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice. PLoS One. 2016;11(6):e0157850. doi:10.1371/journal.pone.0157850
   PubMed Web of Science ®Google Scholar
• Labbé K, Mookerjee S, Le Vasseur M, et al. The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis. J Cell Biol. 2021;220(11). doi:10.1083/jcb.202103122
   PubMed Web of Science ®Google Scholar
• Albers M, Kranz H, Kober I, et al. Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005;4(2):205–213. doi:10.1074/mcp.M400169-MCP200
   PubMed Web of Science ®Google Scholar
• Bandstein M, Voisin S, Nilsson EK, et al. A genetic risk score is associated with weight loss following roux-en y gastric bypass surgery. Obes Surg. 2016;26(9):2183–2189. doi:10.1007/s11695-016-2072-9
   PubMed Web of Science ®Google Scholar
• Hinney A, Wolters B, Pütter C, et al. No impact of obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children. J Pediatr Endocrinol Metab. 2013;26(11–12):1209–1213. doi:10.1515/jpem-2013-0179
   PubMed Web of Science ®Google Scholar
• Buzaglo-Azriel L, Kuperman Y, Tsoory M, et al. Loss of muscle mtch2 increases whole-body energy utilization and protects from diet-induced obesity. Cell Rep. 2016;14(7):1602–1610. doi:10.1016/j.celrep.2016.01.046
   PubMed Web of Science ®Google Scholar
• Sharifi S, Daghighi S, Motazacker MM, et al. Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes. Sci Rep. 2013;3:2173. doi:10.1038/srep02173
   PubMed Web of Science ®Google Scholar
• Delahanty LM, Pan Q, Jablonski KA, et al. Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care. 2012;35(2):363–366. doi:10.2337/dc11-1328
   PubMed Web of Science ®Google Scholar
• Shi Z, Long W, Zhao C, et al. Comparative proteomics analysis suggests that placental mitochondria are involved in the development of pre-eclampsia. PLoS One. 2013;8(5):e64351. doi:10.1371/journal.pone.0064351
   PubMed Web of Science ®Google Scholar
• Lein ES, Hawrylycz MJ, Ao N, et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature. 2007;445(7124):168–176. doi:10.1038/nature05453
   PubMed Web of Science ®Google Scholar
• Escott-Price V, Bellenguez C, Wang LS, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer’s disease. PLoS One. 2014;9(6):e94661. doi:10.1371/journal.pone.0094661
   PubMed Web of Science ®Google Scholar
• Karch CM, Ezerskiy LA, Bertelsen S, et al. Alzheimer’s Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One. 2016;11(2):e0148717. doi:10.1371/journal.pone.0148717
   PubMed Web of Science ®Google Scholar
• Zhuang QS, Zheng H, Gu XD, et al. Detecting the genetic link between Alzheimer’s disease and obesity using bioinformatics analysis of GWAS data. Oncotarget. 2017;8(34):55915–55919. doi:10.18632/oncotarget.19115
   PubMedGoogle Scholar
• Purcell SM, Moran JL, Fromer M, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506(7487):185–190. doi:10.1038/nature12975
   PubMed Web of Science ®Google Scholar
• Cornelis MC, Rimm EB, Curhan GC, et al. Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women. Obesity (Silver Spring. 2014;22(5):E135–41. doi:10.1002/oby.20592
   PubMed Web of Science ®Google Scholar
• Xu M, Liu Q, Bi R, et al. Co-existence of multiple functional variants and genes underlie genetic risk locus 11p11.2 of Alzheimer’s disease. Biol Psychiatry. 2023;94:743–759. doi:10.1016/j.biopsych.2023.05.020
   PubMed Web of Science ®Google Scholar
• Broce IJ, Tan CH, Fan CC, et al. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease. Acta Neuropathol. 2019;137(2):209–226. doi:10.1007/s00401-018-1928-6
   PubMed Web of Science ®Google Scholar
• Zheng C, Liu S, Zhang X, et al. Shared genetic architecture between the two neurodegenerative diseases: alzheimer’s disease and glaucoma. Front Aging Neurosci. 2022;14:880576. doi:10.3389/fnagi.2022.880576
   PubMed Web of Science ®Google Scholar
• D’Orsi B, Niewidok N, Düssmann H, et al. Mitochondrial carrier homolog 2 functionally co-operates with bh3 interacting-domain death agonist in promoting Ca(2+)-Induced Neuronal Injury. Front Cell Dev Biol. 2021;9:750100. doi:10.3389/fcell.2021.750100
   PubMed Web of Science ®Google Scholar
• Ruggiero A, Aloni E, Korkotian E, et al. Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions. Sci Rep. 2017;7:44401. doi:10.1038/srep44401
   PubMed Web of Science ®Google Scholar
• Aloni E, Ruggiero A, Gross A, et al. Learning deficits in adult mitochondria carrier homolog 2 forebrain knockout mouse. Neuroscience. 2018;394:156–163. doi:10.1016/j.neuroscience.2018.10.035
   PubMed Web of Science ®Google Scholar
• Aman Y, Erinjeri AP, Tataridas-Pallas N, et al. Loss of MTCH-1 suppresses age-related proteostasis collapse through the inhibition of programmed cell death factors. Cell Rep. 2022;41(8):111690. doi:10.1016/j.celrep.2022.111690
   PubMed Web of Science ®Google Scholar
• Xu B, Zhang Y, Zhan S, et al. proteomic profiling of brain and testis reveals the diverse changes in ribosomal proteins in fmr1 knockout mice. Neuroscience. 2018;371:469–483. doi:10.1016/j.neuroscience.2017.12.023
   PubMed Web of Science ®Google Scholar
• Landgraf K, Strobach A, Kiess W, et al. Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae. FEBS Lett. 2016;590(17):2852–2861. doi:10.1002/1873-3468.12330
   PubMed Web of Science ®Google Scholar
• Yu K, Ganesan K, Tan LK, et al. A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers. PLoS Genet. 2008;4(7):e1000129. doi:10.1371/journal.pgen.1000129
   PubMed Web of Science ®Google Scholar
• Khan DH, Mullokandov M, Wu Y, et al. Mitochondrial carrier homolog 2 is necessary for AML survival. Blood. 2020;136(1):81–92. doi:10.1182/blood.2019000106
   PubMed Web of Science ®Google Scholar
• Khan I, Işık EB, Mahfooz S, et al. Identification of genetic alterations in rapid progressive glioblastoma by use of whole exome sequencing. Diagnostics. 2023;13(6).
   Web of Science ®Google Scholar
• Yuan Q, Yang W, Zhang S, et al. Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma. Mol Med. 2021;27(1):7. doi:10.1186/s10020-020-00261-4
   PubMed Web of Science ®Google Scholar
• Zhao Y, Zhou L, Li H, et al. Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway. Mol Ther Nucleic Acids. 2021;23:264–276. doi:10.1016/j.omtn.2020.09.040
   PubMedGoogle Scholar
• Robinson AJ, Kunji ER, Gross A. Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis. Exp Cell Res. 2012;318(11):1316–1323. doi:10.1016/j.yexcr.2012.01.026
   PubMed Web of Science ®Google Scholar
• Li R, He H, He X. APOC1 promotes the progression of osteosarcoma by binding to MTCH2. Exp Ther Med. 2023;25(4):163. doi:10.3892/etm.2023.11862
   PubMed Web of Science ®Google Scholar
• Fu D, Liu S, Liu J, et al. iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells. J Clin Lab Anal. 2021;35(3):e23653. doi:10.1002/jcla.23653
   PubMed Web of Science ®Google Scholar
• Huang B, Belharazem D, Li L, et al. Anti-apoptotic signature in thymic squamous cell carcinomas - functional relevance of anti-apoptotic birc3 expression in the thymic carcinoma cell line 1889c. Front Oncol. 2013;3:316. doi:10.3389/fonc.2013.00316
   PubMedGoogle Scholar
• Zhang T, Hu Y, Wang T, et al. Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation. Int J Mol Med. 2017;40(1):21–30. doi:10.3892/ijmm.2017.2980
   PubMed Web of Science ®Google Scholar
• Ren BJ, Zhou ZW, Zhu DJ, et al. Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells. Int J Mol Sci. 2015;17(1):41. doi:10.3390/ijms17010041
   PubMed Web of Science ®Google Scholar
• Lim U, Wilkens LR, Monroe KR, et al. Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies. Int J Cancer. 2012;131(6):E1038–43. doi:10.1002/ijc.27592
   PubMed Web of Science ®Google Scholar
• Djajawi TM, Liu L, Gong JN, et al. MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex. Cell Death Differ. 2020;27(8):2484–2499. doi:10.1038/s41418-020-0517-0
   PubMed Web of Science ®Google Scholar
• Conceição TO, Cabral L, Laveli-Silva MG, et al. New potential antiproliferative monophosphoester 2-aminoethyl dihydrogen phosphate in K-562 and K-562 MDR(+) leukemia cells. Biomed Pharmacother. 2021;142:112054. doi:10.1016/j.biopha.2021.112054
   PubMed Web of Science ®Google Scholar
• Huang T, Huang X, Nie Y, et al. A combined effect of expression levels of obesity-related genes and clinical factors on cancer survival rate. Biomed Res Int. 2020;2020:8838676. doi:10.1155/2020/8838676
   PubMed Web of Science ®Google Scholar
• Yoshihara K, Wang Q, Torres-Garcia W, et al. The landscape and therapeutic relevance of cancer-associated transcript fusions. Oncogene. 2015;34(37):4845–4854. doi:10.1038/onc.2014.406
   PubMed Web of Science ®Google Scholar
• Dachy G, Fraitag S, Boulouadnine B, et al. Novel COL4A1-VEGFD gene fusion in myofibroma. J Cell Mol Med. 2021;25(9):4387–4394. doi:10.1111/jcmm.16502
   PubMed Web of Science ®Google Scholar
• Arigoni M, Barutello G, Riccardo F, et al. miR-135b coordinates progression of ErbB2-driven mammary carcinomas through suppression of MID1 and MTCH2. Am J Pathol. 2013;182(6):2058–2070. doi:10.1016/j.ajpath.2013.02.046
   PubMed Web of Science ®Google Scholar
• Wang Q, Karvelsson ST, Johannsson F, et al. UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines. Mol Oncol. 2022;16(9):1816–1840. doi:10.1002/1878-0261.13172
   PubMed Web of Science ®Google Scholar
• Kisaki CY, Arcos SSS, Montoni F, et al. Bothrops Jararaca snake venom modulates key cancer-related proteins in breast tumor cell lines. Toxins. 2021;13(8):519. doi:10.3390/toxins13080519
   PubMed Web of Science ®Google Scholar
• Delahanty RJ, Beeghly-Fadiel A, Xiang YB, et al. Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study. Am J Epidemiol. 2011;174(10):1115–1126. doi:10.1093/aje/kwr233
   PubMed Web of Science ®Google Scholar
• Maryanovich M, Zaltsman Y, Ruggiero A, et al. An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nat Commun. 2015;6:7901. doi:10.1038/ncomms8901
   PubMed Web of Science ®Google Scholar
• Li P, Gao L, Cui T, et al. Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair. Proc Natl Acad Sci U S A. 2020;117(5):2519–2525. doi:10.1073/pnas.1915079117
   PubMed Web of Science ®Google Scholar
• Bahat A, Goldman A, Zaltsman Y, et al. MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells. Nat Commun. 2018;9(1):5132. doi:10.1038/s41467-018-07519-w
   PubMedGoogle Scholar
• Goldman A, Mullokandov M, Zaltsman Y, et al. MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion. EMBO Rep. 2024;25(1):45–67. doi:10.1038/s44319-023-00009-1
   PubMed Web of Science ®Google Scholar
• Zhou X, Zhang K, He Z, et al. Downregulated miR-150 in bone marrow mesenchymal stem cells attenuates the apoptosis of LPS-stimulated RAW264.7 via MTCH2-dependent mitochondria transfer. Biochem Biophys Res Commun. 2020;526(3):560–567. doi:10.1016/j.bbrc.2020.03.098
   PubMed Web of Science ®Google Scholar
• Goldman A, Rodríguez-Casuriaga R, González-López E, et al. MTCH2 is differentially expressed in rat testis and mainly related to apoptosis of spermatocytes. Cell Tissue Res. 2015;361(3):869–883. doi:10.1007/s00441-015-2163-2
   PubMed Web of Science ®Google Scholar
• Wu SX, Wan RD, Wang GW, et al. Comparative proteomic analysis identifies differentially expressed proteins associated with meiotic arrest in cattle-yak hybrids. Proteomics. 2023;23(12):e2300107. doi:10.1002/pmic.202300107
   PubMed Web of Science ®Google Scholar
• Zhou G, Liu J, Li X, et al. Silica nanoparticles inducing the apoptosis via microRNA-450b-3p targeting MTCH2 in mice and spermatocyte cell. Environ Pollut. 2021;277:116771. doi:10.1016/j.envpol.2021.116771
   PubMed Web of Science ®Google Scholar