2
Views
0
CrossRef citations to date
0
Altmetric
REVIEW

Therapeutic Potential of Solanum Alkaloids with Special Emphasis on Cancer: A Comprehensive Review

, , , , , & ORCID Icon show all
Pages 3063-3074 | Received 27 Mar 2024, Accepted 07 Jun 2024, Published online: 23 Jul 2024

References

  • He L, Gu J, Ly L, Zx Y, Mo J. Nanomedicine-mediated therapies to target breast cancer stem cells. Front Pharmacol. 2016;7:313. doi:10.3389/fphar.2016.00313
  • Qin W, Huang G, Chen Z, Zhang Y. Nanomaterials in targeting cancer stem cells for cancer therapy. Front Pharmacol. 2017;8:239639. doi:10.3389/fphar.2017.00001
  • Zhang LQ, Lv RW, Qu XD, Chen XJ, Lu HS, Wang Y. Aloesin suppresses cell growth and metastasis in ovarian cancer SKOV3 cells through the inhibition of the MAPK signaling pathway. Anal Cell Pathol. 2017. doi:10.1155/2017/8158254
  • American Cancer Society. Cancer Facts & Figures 2016. Atlanta. GA, https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2016.html.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. Ca a Cancer J Clinicians. 2018;68(1):7–30. doi:10.3322/caac.21442
  • Krishnamurthi K. Screening of natural products for anticancer and antidiabetic properties. Health Admin. 2000;20(1&2):69. doi:10.12691/ajps-1-6-1
  • Chaudhary A. Natural herbs as anticancer drugs: back to the future. Chem Sci Rev Lett. 2020;9(34):481–495. doi:10.37273/chesci.CS205101126
  • Zhou Z, Tang M, Liu Y, Zhang Z, Lu R, Lu J. Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. Anti-Cancer Drugs. 2017;28(4):446–456. doi:10.1097/CAD.0000000000000479
  • Patra CR, Mukherjee S, Kotcherlakota R. Biosynthesized silver nanoparticles: a step forward for cancer theranostics? Nanomedicine. 2014;9(10):1445–1448. doi:10.2217/nnm.14.89
  • Mukherjee S, Patra CR. Therapeutic application of anti-angiogenic nanomaterials in cancers. Nanoscale. 2016;8(25):12444–12470. doi:10.1039/C5NR07887C
  • Weaver BA. How Taxol/paclitaxel kills cancer cells. ?mol Biol Cell. 2014;25(18):2677–2681. doi:10.1091/mbc.e14-04-0916
  • Caruso M, Colombo AL, Fedeli L, et al. Isolation of endophytic fungi and actinomycetes taxane producers. Ann Microbiol. 2000;50(1):3–14.
  • James A, Akash K, Sharma A, et al. Himalayan flora: targeting various molecular pathways in lung cancer. Med Oncol. 2023;40(11):314. doi:10.1007/s12032-023-02171-x
  • Ishaq H, Rajendran K, Nisar K. A comprehensive review of medicinal uses and phytochemicals isolated from Caralluma tuberculata. Innova Agricu. 2023;6:e32873. doi:10.25081/ia.2023-06
  • Thakore P, Mani RK, Kavitha SJ. A brief review of plants having anti-cancer property. Int J Pharm Res Dev. 2012;3(1):129–136. doi:10.3390/molecules27123863
  • Aung TN, Qu Z, Kortschak RD, Adelson DL. Understanding the effectiveness of natural compound mixtures in cancer through their molecular mode of action. Int J Mol Sci. 2017;18(3):656. doi:10.3390/ijms18030656
  • Tariq A, Sadia S, Pan K, et al. A systematic review on ethnomedicines of anti‐cancer plants. Phytother Res. 2017;31(2):202–264. doi:10.1002/ptr.5751
  • Dang TT, Facchini PJ. CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy. J Biol Chem. 2014;289(4):2013–2026. doi:10.1074/jbc.M113.505099
  • Reed JW, Hudlicky T. The quest for a practical synthesis of morphine alkaloids and their derivatives by chemoenzymatic methods. Acc Chem Res. 2015;48(3):674–687. doi:10.1021/ar500427k
  • Jiang QW, Chen MW, Cheng KJ, Yu PZ, Wei X, Shi Z. Therapeutic potential of steroidal alkaloids in cancer and other diseases. Med Res Rev. 2016;36(1):119–143. doi:10.1002/med.21346
  • Wu H, Li W, Wang T, et al. α-Tomatine, a novel early-stage autophagy inhibitor, inhibits autophagy to enhance apoptosis via Beclin-1 in Skov3 cells. Fitoterapia. 2021;152:104911. doi:10.1016/j.fitote.2021.104911
  • Chowański S, Adamski Z, Marciniak P, et al. A review of bioinsecticidal activity of Solanaceae alkaloids. Toxins. 2016;8(3):60. doi:10.3390/toxins8030060
  • Dey P, Kundu A, Chakraborty HJ, et al. Therapeutic value of steroidal alkaloids in cancer: current trends and future perspectives. Inter J Cancer. 2019;145(7):1731–1744. doi:10.1002/ijc.31965
  • Meng-Zhen Z, Li-Juan G, Shi-Fang XU, Wen-Kang H, Xiao-Yu LI, Yi-Ping YE. Advances in studies on steroidal alkaloids and their pharmacological activities in genus veratrum. Zhongguo zhong yao za zhi= Zhongguo zhongyao zazhi=. China J Chinese Materia Med. 2020;45(21):5129–5142. doi:10.19540/j.cnki.cjcmm.20200612.201
  • Yang L, Stöckigt J. Trends for diverse production strategies of plant medicinal alkaloids. Natural Prod Rep. 2010;27(10):1469–1479. doi:10.1039/C005378C
  • Thakur M, Verma R, Kumar D, et al. Revisiting the ethnomedicinal, ethnopharmacological, phytoconstituents and phytoremediation of the plant Solanum viarum Dunal. Naunyn-Schmiedeberg’s Arch Pharmacol. 2024;18:1–9. doi:10.1007/s00210-024-03034-6
  • Yadav R, Rathi M, Pednekar A, Rewachandani Y. A detailed review on Solanaceae family. European J Pharma Med Res. 2016;3(1):369–378. doi:10.1007/s00122-016-2804-1
  • Al-Rehaily AJ, Ahmad MS, Mustafa J, et al. Solanopubamine, a rare steroidal alkaloid from Solanum schimperianum: synthesis of some new alkyl and acyl derivatives, their anticancer and antimicrobial evaluation. J Saudi Chem Soc. 2013;17(1):67–76. doi:10.1016/j.jscs.2011.10.003
  • Gazaliev AM, Fazylov SD, Balitskii SN, Kasenov RZ. Synthesis of organophosphorus derivatives of lupinine and solasodine and investigation of their cholinergic activities. Chem. Nat. Compd. 1992;28(5):472–473. doi:10.1007/BF00630654
  • Sato Y, Latham HG. New Dihydro Derivatives Of Tomatidine And Solasodine1. J Am Chem Soc. 1956;78(13):3150–3153. doi:10.1021/ja01594a048
  • Yun HJ, Jung JH, Hyun SK, Kim BW, Kwon HJ. Isolation and identification of a novel anticancer compound from Solanum nigrum. J Life Sci. 2014;24(3):234–241. doi:10.5352/JLS.2014.24.3.234
  • Matsushita S, Yanai Y, Fusyuku A, et al. Efficient conversion of tomatidine into neuritogenic pregnane derivative. Chem Pharm Bull. 2007;55(7):1077–1078. doi:10.1248/cpb.55.1077
  • Wei G, Wang J, Du Y. Total synthesis of solamargine. Bioorg. Med. Chem. Lett. 2011;21(10):2930–2933. doi:10.1016/j.bmcl.2011.03.064
  • Sun F, Li S, He D, et al. Effects of glycoalkaloids from Solanum plants on cucumber root growth. Phytochemistry. 2010;71(13):1534–1538. doi:10.1016/j.phytochem.2010.06.002
  • Zhang Y, Han G, Cao Y, Zhang Y, Zhang X, Gong H. Solasonine inhibits gastric cancer proliferation and enhances chemosensitivity through microRNA-486-5p. Am J Transl Res. 2020;12(7):3522.
  • Azmir J, Zaidul IS, Rahman MM, et al. Techniques for extraction of bioactive compounds from plant materials: a review. Journal of Food Engineering. 2013;117(4):426–436. doi:10.1016/j.jfoodeng.2013.01.014
  • Yubin JI, Miao Y, Bing W, Yao Z. The extraction, separation and purification of alkaloids in natural medicine. J Chem Pharm Res. 2014;6(1):338–345.
  • Pan Z, Qin XJ, Liu YP, Wu T, Luo XD, Alstoscholarisines H–J XC. indole alkaloids from Alstonia scholaris: structural evaluation and bioinspired synthesis of alstoscholarisine H. Org Let. 2016;18(4):654–657. doi:10.1021/acs.orglett.5b03583
  • Chang LC, Tsai TR, Wang JJ, Lin CN, Kuo KW. The rhamnose moiety of solamargine plays a crucial role in triggering cell death by apoptosis. Biochem Biophys Res Commun. 1998;242(1):21–25. doi:10.1006/bbrc.1997.7903
  • Coseri S. Natural products and their analogues as efficient anticancer drugs. Mini Reviews in Med Chem. 2009;9(5):560–571. doi:10.2174/138955709788167592
  • Shih YW, Chen PS, Wu CH, Jeng YF, Wang CJ. α-Chaconine-reduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-κB in human lung adenocarcinoma A549 cells. Journal of Agricultural and Food Chemistry. 2007;55(26):11035–11043. doi:10.1021/jf072423r
  • Lu MK, Shih YW, Chien TT, Fang LH, Huang HC, Chen PS. α-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities. Biol Pharm Bull. 2010;33(10):1685–1691. doi:10.1248/bpb.33.1685
  • Reddivari L, Vanamala J, Safe SH, Miller JC. The bioactive compounds α-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells. Nutr Cancer. 2010;62(5):601–610. doi:10.1080/01635580903532358
  • Lim TK. Edible Medicinal and Non-Medicinal Plants. Dordrecht, The Netherlands: Springer; 2012. doi:10.1007/978-90-481-8661-7
  • Zha X, Zhang F, Shan J, et al. Synthesis and in vitro antitumor activities of novel soladulcidine derivatives. J China Pharma Univer. 2010;1:493–498.
  • Munari CC, de Oliveira PF, Campos JC, et al. Antiproliferative activity of Solanum lycocarpum alkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines. J Nat Med. 2014;68(1):236–241. doi:10.1007/s11418-013-0757-0
  • Li TC, Chen NJ, Chen YY, He BJ, Zhou ZF. Solasonine induces apoptosis of the SGC‐7901 human gastric cancer cell line in vitro via the mitochondria‐mediated pathway. J Cell & Mol Med. 2022;26(12):3387–3395. doi:10.1111/jcmm.17343
  • Liang X, Hu C, Han M, et al. Solasonine inhibits pancreatic cancer progression with involvement of ferroptosis induction. Front Oncol. 2022;12:834729. doi:10.3389/fonc.2022.834729
  • Zhang H, Tian F, Jiang P, et al. Solasonine suppresses the proliferation of acute monocytic leukemia through the activation of the AMPK/FOXO3A axis. Front Oncol. 2021;10:614067. doi:10.3389/fonc.2020.614067
  • Sun L, Zhao Y, Li X, Yuan H, Cheng A, Lou H. A lysosomal–mitochondrial death pathway is induced by solamargine in human K562 leukemia cells. Toxicol in vitro. 2010;24(6):1504–1511. doi:10.1016/j.tiv.2010.07.013
  • Ding X, Zhu FS, Li M, Gao SG. Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. J Ethnopharmacol. 2012;139(2):599–604. doi:10.1016/j.jep.2011.11.058
  • Al Sinani SS, Eltayeb EA, Coomber BL, Adham SA. Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway. Can Cell Inter. 2016;16(1):1–2. doi:10.1186/s12935-016-0287-4
  • Chaube S, Swinyard CA. Teratological and toxicological studies of alkaloidal and phenolic compounds from Solanum tuberosum L. Toxicol Appl Pharmacol. 1976;36(2):227–237. doi:10.1016/0041-008X(76)90002-8
  • Ji YB, Gao SY, Ji CF, Zou X. Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein. J Ethnopharmacol. 2008;115(2):194–202. doi:10.1016/j.jep.2007.09.023
  • Mohsenikia M, Farhangi B, Alizadeh AM, et al. Therapeutic effects of dendrosomal solanine on a metastatic breast tumor. Life Sci. 2016;148:260–267. doi:10.1016/j.lfs.2016.02.008
  • Lin CN, Lu CM, Cheng MK, Gan KH, Won SJ. The cytotoxic principles of Solanum incanum. J Natural Prod. 1990;53(2):513–516. doi:10.1021/np50068a041
  • Trouillas P, Corbière C, Liagre B, Duroux JL, Beneytout JL. Structure–function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin. Bioorg Med Chem. 2005;13(4):1141–1149. doi:10.1016/j.bmc.2004.11.031
  • Yelken BÖ, Balcı T, Süslüer SY, et al. The effect of tomatine on metastasis related matrix metalloproteinase (MMP) activities in breast cancer cell model. Gene. 2017;627:408–411. doi:10.1016/j.gene.2017.06.054
  • Huang H, Chen S, Van Doren J, et al. α-Tomatine inhibits growth and induces apoptosis in HL-60 human myeloid leukemia cells. Molecular Med Rep. 2015;11(6):4573–4578. doi:10.3892/mmr.2015.3238
  • Thi Thuy Luyen B, Thi Thu Trang B. New solasodine‐type glycoalkaloids isolated from Solanum nigrum and their cytotoxic activity. Chem Bio 2024. e202400872. doi:10.1002/cbdv.202400872
  • Wu T, Du X, Liu HH, et al. Bioactive solanidane steroidal alkaloids from Solanum lyratum. Fitoterapia. 2024;175:105916. doi:10.1016/j.fitote.2024.105916
  • Zhang Q, Liu D, Cui Y, et al. Bioactivities and chemical profiling comparison and metabolomic variations of polyphenolics and steroidal glycoalkaloids in different parts of Solanum nigrum L. Phyto Anal. 2024;35(2):350–368. doi:10.1002/pca.3294
  • Sharma T, Airao V, Panara N, et al. Solasodine protects rat brain against ischemia/reperfusion injury through its antioxidant activity. Eur J Pharmacol. 2014;725:40–46. doi:10.1016/j.ejphar.2014.01.005
  • Roddick JG, Weissenberg M, Leonard AL. Membrane disruption and enzyme inhibition by naturally-occurring and modified chacotriose-containing Solanum steroidal glycoalkaloids. Phytochemistry. 2001;56(6):603–610. doi:10.1016/S0031-9422(00)00420-9
  • Garcia ME, Borioni JL, Cavallaro V, et al. Solanocapsine derivatives as potential inhibitors of acetylcholinesterase: synthesis, molecular docking and biological studies. Steroids. 2015;104:95–110. doi:10.1016/j.steroids.2015.09.001
  • Niño J, Correa YM, Mosquera OM. Biological activities of steroidal alkaloids isolated from Solanum leucocarpum. Pharm Biol. 2009;47(3):255–259. doi:10.1080/13880200802434484
  • Irondi AE, Iweala EJ, Agboola OS, Akintunde JK, Ajiboye JA. Distribution of metabolites and antioxidant activity in the berry and shoot of Solanum pseudocapsicum grown in Nigeria. Interna J Biochem Res Rev. 2015;8(1):1–9. doi:10.9734/IJBCRR/2015/18760
  • Dai L, Jacob MR, Khan SI, Khan IA, Clark AM, Li XC. Synthesis and antifungal activity of natural product-based 6-alkyl-2, 3, 4, 5-tetrahydropyridines. J Natural Prod. 2011;74(9):2023–2026. doi:10.1021/np200644s
  • Miranda MA, Magalhães LG, Tiossi RF, et al. Evaluation of the schistosomicidal activity of the steroidal alkaloids from Solanum lycocarpum fruits. Parasitol Res. 2012;111(1):257–262. doi:10.1007/s00436-012-2827-8
  • Kenny OM, McCarthy CM, Brunton NP, et al. Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages. Life Sci. 2013;92(13):775–782. doi:10.1016/j.lfs.2013.02.006
  • Jacob IIIP, Hatsukami D, Severson H, Hall S, Yu L, Benowitz NL. Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy. Cancer Epidemiol Biomarkers Prev. 2002;11(12):1668–1673.
  • Alarcón L, Velasco J, Usubillaga A. Determinacion de la actividad antibacteriana de los Alcaloides presentes en los frutos verdes del Solanum hypomalocophillum Bitter. Revista Latinoamericana de Química. 2006;34(1/3):13.
  • Gan KH, Lin CN, Won SJ. Cytotoxic principles and their derivatives of Formosan Solanum plants. J Natural Prod. 1993;56(1):15–21. doi:10.1021/np50091a003
  • Jain R, Sharma A, Gupta S, Sarethy IP, Gabrani R. Solanum nigrum: current perspectives on therapeutic properties. Altern Med Rev. 2011;16(1):78–85.
  • Chiu FL, Lin JK. Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett. 2008;582(16):2407–2412. doi:10.1016/j.febslet.2008.05.049
  • Pesewu GA, Cutler RR, Humber DP. Antibacterial activity of plants used in traditional medicines of Ghana with particular reference to MRSA. J Ethnopharmacol. 2008;116(1):102–111. doi:10.1016/j.jep.2007.11.005
  • Peng CH, Cheng JJ, Yu MH, Chung DJ, Huang CN, Wang CJ. Solanum nigrum polyphenols reduce body weight and body fat by affecting adipocyte and lipid metabolism. Food Funct. 2020;11(1):483–492. doi:10.1039/C9FO02240F
  • Chiamah OC, Atieno D, Karani L, et al. Evaluation of the antimalarial properties of Solanum incanum L. leaf extract fractions and its ability to downregulate delta aminolevulinate dehydratase to prevent the establishment of malaria infection. J Ethnopharmacol. 2024;323:117613. doi:10.1016/j.jep.2023.117613
  • Adewunmi RF, Gidado A, Yusuf HB, Zanna H. Neutralizing effect of Solanum dasyphyllum schumach. &thonn extract against naja nigricollis venom-induced toxicity. International Journal of TROPICAL DISEASE & Health. 2024;45(6):217–226. doi:10.2139/ssrn.4777192.