References
- DeSantisCMaJBryanLJemalABreast cancer statistics, 2013CA Cancer J Clin2014641526224114568
- KasamiMUematsuTHondaMSugimura, Comparison of estrogen receptor, progesterone receptor and Her-2 status in breast cancer pre-and post-neoadjuvant chemotherapyBreast200817552352718534850
- MorganGWardRBartonMThe contribution of cytotoxic chemotherapy to 5-year survival in adult malignanciesClin Oncol (R Coll Radiol)200416854956015630849
- OkadaHMakTWPathways of apoptotic and non-apoptotic death in tumour cellsNat Rev Cancer20044859260315286739
- FuJBianMJiangQZhangCRoles of Aurora kinases in mitosis and tumorigenesisMol Cancer Res20075111017259342
- BarrARGergelyFAurora-A: the maker and breaker of spindle polesJ Cell Sci2007120Pt 172987299617715155
- MarumotoTHondaSHaraTAurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cellsJ Biol Chem200327851517865179514523000
- QiWCookeLSLiuXMahadevan, Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphomaBiochem Pharmacol201181788189021291867
- FalchookGKurzrockRGouwLInvestigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: Phase 1 dose-escalation studyInvest New Drugs20143261181118724879333
- FriedbergJWMahadevanDCebulaEPhase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomasJ Clin Oncol2014321445024043741
- GoldbergSLFenauxPCraigMDAn exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromesLeuk Res Rep201432586125068104
- MatulonisUASharmaSGhamandeSPhase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinomaGynecol Oncol20121271636922772063
- LeontovichAASalisburyJLVerouxMInhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cellsOncol Rep20132951785178823446853
- JensenJSOmarsdottirSThorsteinsdottirJBOgmundsdottirHMOlafsdottirESSynergistic cytotoxic effect of the microtubule inhibitor marchantin A from Marchantia polymorpha and the Aurora kinase inhibitor MLN8237 on breast cancer cells in vitroPlanta Med201278544845422331811
- HuckJJZhangMMettetalJTranslational exposure-efficacy modeling to optimize the dose and schedule of taxanes combined with the investigational Aurora A kinase inhibitor MLN8237 (alisertib)Mol Cancer Ther20141392170218324980948
- LiYCHeSMHeZXPlumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cellsCancer Lett2014344223925924280585
- KangRZehHJLotzeMTTangDThe Beclin 1 network regulates autophagy and apoptosisCell Death Differ201118457158021311563
- KabeyaYMizushimaNUenoTLC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingEMBO J200019215720572811060023
- ZhangCKawauchiJAdachiMTActivation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteineBiochem Biophys Res Commun2001289371872411726207
- FerlayJSoerjomataramIDikshitRCancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Int J Cancer20151365E359E38625220842
- DarAAGoffLWMajidSBerlinJEl-RifaiWAurora kinase inhibitors – rising stars in cancer therapeutics?Mol Cancer Ther20109226827820124450
- CheungCHSarvagallaSLeeJYHuangYCCoumarMSAurora kinase inhibitor patents and agents in clinical testing: an update (2011–2013)Expert Opin Ther Pat20142491021103824965505
- HengartnerMOThe biochemistry of apoptosisNature2000407680577077611048727
- ChoHJOhYJHanSHCdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survivalJ Biol Chem201328863768377623264621
- PawlikTMKeyomarsiKRole of cell cycle in mediating sensitivity to radiotherapyInt J Radiat Oncol Biol Phys200459492894215234026
- MontenegroMFSanchez-Del-CampoLFernandez-PerezMPSaez-AyalaMCabezas-HerreraJRodriguez-LopezJNTargeting the epigenetic machinery of cancer cellsOncogene201534213514324469033
- SancarALindsey-BoltzLAUnsal-KacmazKLinnSMolecular mechanisms of mammalian DNA repair and the DNA damage checkpointsAnnu Rev Biochem200473398515189136
- GalluzziLBravo-San PedroJMVitaleIEssential versus accessory aspects of cell death: recommendations of the NCCD 2015Cell Death Differ2015221587325236395
- CotterTGApoptosis and cancer: the genesis of a research fieldNat Rev Cancer20099750150719550425
- LeeMJYeASGardinoAKSequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networksCell2012149478079422579283
- ThornberryNALazebnikYCaspases: enemies withinScience19982815381131213169721091
- LakhaniSAMasudAKuidaKCaspases 3 and 7: key mediators of mitochondrial events of apoptosisScience2006311576284785116469926
- ThornberryNACaspases: key mediators of apoptosisChem Biol199855R97R1039578633
- MiyashitaTKrajewskiSKrajewskaMTumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivoOncogene199496179918058183579
- TaylorRCCullenSPMartinSJApoptosis: controlled demolition at the cellular levelNat Rev Mol Cell Biol20089323124118073771
- BeseNSRadiochemotherapy in the treatment of breast cancerClin Oncol (R Coll Radiol)200921753253519464156
- OakmanCVialeGDi LeoAManagement of triple negative breast cancerBreast201019531232120382530
- KungCPBudinaABalaburskiGBergenstockMKMurphyMAutophagy in tumor suppression and cancer therapyCrit Rev Eukaryot Gene Expr20112117110021967333
- LiJLHanSLFanXModulating autophagy: a strategy for cancer therapyChin J Cancer2011301065566821959043
- YangZJCheeCEHuangSSinicropeFAutophagy modulation for cancer therapyCancer Biol Ther201111216917621263212
- MaycottePThorburnAAutophagy and cancer therapyCancer Biol Ther201111212713721178393
- LiangCFengPKuBAutophagic and tumour suppressor activity of a novel Beclin 1-binding protein UVRAGNat Cell Biol20068768869916799551
- MathewRKarpCMBeaudoinBAutophagy suppresses tumorigenesis through elimination of p62Cell200913761062107519524509
- KondoYKanzawaTSawayaRKondoSThe role of autophagy in cancer development and response to therapyNat Rev Cancer20055972673416148885
- XuZXLiangJHaridasVA plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinaseCell Death Differ200714111948195717690712
- LiangXHJacksonSSeamanetMInduction of autophagy and inhibition of tumorigenesis by beclin 1Nature1999402676267267610604474
- WangWFanHZhouYDuanPZhaoGWuGKnockdown of autophagy-related gene BECLIN1 promotes cell growth and inhibits apoptosis in the A549 human lung cancer cell lineMol Med Rep2013751501150523525201
- LeeYJHahYJKangYNThe autophagy-related marker LC3 can predict prognosis in human hepatocellular carcinomaPLoS One2013811e8154024282606
- VivancoISawyersCLThe phosphatidylinositol 3-kinase AKT pathway in human cancerNat Rev Cancer20022748950112094235
- LuoJManningBDCantleyLCTargeting the PI3K-Akt pathway in human cancer: rationale and promiseCancer Cell20034425726214585353
- RavikumarBVacherCBergerZInhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington diseaseNat Genet200436658559515146184
- YamamotoACremonaMLRothmanJEAutophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathwayJ Cell Biol2006172571973116505167
- DingYHZhouZWHaCFThe Aurora kinase A inhibitor alisertib induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cellsDrug Des Devel Ther20159425464
- SuMMeiYSinhaSRole of the crosstalk between autophagy and apoptosis in cancerJ Oncol2013201310273523840208
- BhogalRHWestonCJCurbishleySMAdamsDHAffordSCAutophagy: a cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stressAutophagy20128454555822302008
- LevineBSinhaSKroemerGBcl-2 family members: dual regulators of apoptosis and autophagyAutophagy20084560060618497563
- YousefiSSimonHUApoptosis regulation by autophagy gene 5Crit Rev Oncol Hematol200763324124417644402
- MarquezRTXuLBcl-2: Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switchAm J Cancer Res20122221422122485198
- BranchoDTanakaNJaeschkeAMechanism of p38 MAP kinase activation in vivoGenes Dev200317161969197812893778
- BranchoDVenturaJJJaeschkeADoranBFlavellRADavisRJRole of MLK3 in the regulation of mitogen-activated protein kinase signaling cascadesMol Cell Biol20052593670368115831472
- QinYZhouZWPanSTGraphene quantum dots induce apoptosis, autophagy, and inflammatory response via p38 mitogen-activated protein kinase and nuclear factor-kB mediated signaling pathways in activated THP-1 macrophagesToxicology2015327627625446327