References
- TurnerNGroseRFibroblast growth factor signalling: from development to cancerNature Reviews Cancer201010211612920094046
- HaugstenEMWiedlochaAOlsnesSWescheJRoles of fibroblast growth factor receptors in carcinogenesisMolecular Cancer Research20108111439145221047773
- WescheJHaglundKHaugstenEMFibroblast growth factors and their receptors in cancerBiochemical Journal2011437219921321711248
- BrooksANKilgourESmithPDMolecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancerClinical Cancer Research20121871855186222388515
- FengSZhouLNiceECHuangCFibroblast growth factor receptors: multifactorial-contributors to tumor initiation and progressionHistology and Histopathology201530133125053532
- TiongKHMahLYLeongCOFunctional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancersApoptosis201318121447146823900974
- LiangGChenGWeiXSmall molecule inhibition of fibroblast growth factor receptors in cancerCytokine & Growth Factor Reviews201324546747523830577
- GökeFBodeMFranzenAFibroblast growth factor receptor 1 amplification is a common event in squamous cell carcinoma of the head and neckModern Pathology201326101298130623619603
- WuJWeiTTangQWengBDiscovery and anti-cancer evaluation of two novel non-ATP-competitive FGFR1 inhibitors in non-small-cell lung cancerBMC Cancer20151527625880284
- IrschickRTrostTKarpGSorting of the FGF receptor 1 in a human glioma cell lineHistochemistry and Cell Biology2013139113514822903848
- WeissJSosMLSeidelDFrequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancerScience Translational Medicine201026262ra93
- TurnerNPearsonASharpeRFGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancerCancer Research20107052085209420179196
- YangFZhangYResslerSJFGFR1 is essential for prostate cancer progression and metastasisCancer Research201373123716372423576558
- LiangGLiuZWuJAnticancer molecules targeting fibroblast growth factor receptorsTrends in Pharmacological Sciences2012331053154122884522
- ChiangCCLinYHLinSFDiscovery of pyrrole-indoline-2-ones as Aurora kinase inhibitors with a different inhibition profileJournal of Medicinal Chemistry201053165929594120681538
- MohammadiMMcMahonGSunLStructures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitorsScience199727653149559609139660
- GuagnanoVFuretPSpankaCDiscovery of 3-(2, 6-dichloro-3, 5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinaseJournal of Medicinal Chemistry201154207066708321936542
- YeFChenLHuLDesign, synthesis and preliminary biological evaluation of C-8 substituted guanine derivatives as small molecular inhibitors of FGFRsBioorganic & Medicinal Chemistry Letters20152571556156025736993
- YeFWangYNianSSynthesis and evaluation of biological and antitumor activities of 5, 7-dimethyl-oxazolo [5, 4-d] pyrimidine-4, 6 (5 H, 7 H)-dione derivatives as novel inhibitors of FGFR1Journal of Enzyme Inhibition and Medicinal Chemistry201530696196625683078
- RavindranathanKPMandiyanVEkkatiARDiscovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screeningJournal of Medicinal Chemistry20105341662167220121196
- FearonAEGouldCRGroseRPFGFR signalling in women’s cancersThe International Journal of Biochemistry & Cell Biology201345122832284224148254
- WangYCaiYJiJDiscovery and identification of new non-ATP competitive FGFR1 inhibitors with therapeutic potential on non-small-cell lung cancerCancer Letters20143441828924513267
- ChanSLWongCHLauCPYPreclinical evaluation of combined TKI-258 and RAD001 in hepatocellular carcinomaCancer Chemotherapy and Pharmacology20137161417142523546591
- Lopes de MenezesDHollenbachPTangYTKI258 is an effective multitargeted receptor tyrosine kinase (RTK) inhibitor against prostate cancer models via potent inhibition of FGFR kinaseEJC Supplements2006412175175
- TrudelSLiZHWeiECHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myelomaBlood200510572941294815598814
- KimJLeeGKimSIdentification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cellsBiochemical Journal200337352352912689331
- IssaDAEHabibNSWahabAEADesign, synthesis and biological evaluation of novel 1, 2, 4-triazolo and 1, 2, 4-triazino [4, 3-a] quinoxalines as potential anticancer and antimicrobial agentsMedicinal Chemistry Communication201561202211
- HoHKYeoAHLKangTSChuaBTCurrent strategies for inhibiting FGFR activities in clinical applications: opportunities, challenges and toxicological considerationsDrug Discovery Today2014191515623932951
- MorrisGMHueyRLindstromWAutoDock4 and AutoDock-Tools4: automated docking with selective receptor flexibilityJournal of Computational Chemistry200930162785279119399780
- WissnerAFraserHLCharlesLDual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2Bioorganic & Medicinal Chemistry2007153635364817416531
- BunneyTDWanSThiyagarajanNThe effect of mutations on drug sensitivity and kinase activity of fibroblast growth factor receptors: a combined experimental and theoretical studyEBioMedicine20152319420426097890
- BadranMMMoneerAARefaatHMEl-MalahAASynthesis and antimicrobial activity of novel quinoxaline derivativesJournal of the Chinese Chemical Society200754469478
- NoolviMNPatelHMBhardwajVChauhanASynthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: search for anticancer agentEuropean Journal of Medicinal Chemistry2011462327234621458891
- YangJZhaoHXinYMicroRNA-198 inhibits proliferation and induces apoptosis of lung cancer cells via targeting FGFR1Journal of Cellular Biochemistry2014115598799524357456
- WuXHuangHWangCIdentification of a novel peptide that blocks basic fibroblast growth factor-mediated cell proliferationOncotarget2013410181924142482