BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

References

• GebelECancer Deaths Declining in Developed CountriesUSAInternational Organizations Coordinating Research Efforts2008 Available from http://iipdigital.usembassy.gov/st/english/article/2008/06/20080625175712abretnuh0.8982965.html#axzz3pp2fHsCmAccessed on Oct 28, 2015
   Google Scholar
• ShafiMABresalierRSThe gastrointestinal complications of oncologic therapyGastroenterol Clin North Am20103962964720951921
   PubMed Web of Science ®Google Scholar
• Sanches JuniorJABrandtHRMoureERPereiraGLCriadoPRAdverse mucocutaneous reactions to chemotherapeutic agents: part IAn Bras Dermatol20108542543720944902
   PubMed Web of Science ®Google Scholar
• RebucciMMichielsCMolecular aspects of cancer cell resistance to chemotherapyBiochem Pharmacol2013851219122623435357
   PubMed Web of Science ®Google Scholar
• SzebeniJNanomedicine: application of nanotechnology in medicine. Opportunities in neuropsychiatryNeuropsychopharmacol Hung2011131524 Hungarian21451188
   PubMedGoogle Scholar
• XuJMaJYangGDifferentiation of human leukemia cell (HL-60) induced by Sophora flavescens ait. DecoctionZhongguo Zhong Yao Za Zhi199015625–626641 Chinese
   PubMedGoogle Scholar
• LuoCSunJSunBHeZProdrug-based nanoparticulate drug delivery strategies for cancer therapyTrends Pharmacol Sci20143555656625441774
   PubMed Web of Science ®Google Scholar
• SannaVPalaNSechiMTargeted therapy using nanotechnology: focus on cancerInt J Nanomedicine2014946748324531078
   PubMed Web of Science ®Google Scholar
• FakharzadehSKalanakySHafiziMThe new nano-complex, Hep-c, improves the immunogenicity of the hepatitis B vaccineVaccine201331222591259723583463
   PubMed Web of Science ®Google Scholar
• FakharzadehSSahraianMAHafiziMThe therapeutic effects of MSc1 nano-complex, synthesized by nanochelating technology, on experimental autoimmune encephalomyelitis C57/BL6 miceInt J Nanomedicine201493841385325143732
   PubMed Web of Science ®Google Scholar
• MaghsoudiAFakharzadehSHafiziMNeuroprotective effects of three different sizes nanochelating based nano complexes in MPP(+) induced neurotoxicityApoptosis20152029830925451011
   PubMed Web of Science ®Google Scholar
• ZacharskiLRChowBKHowesPSDecreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trialJ Natl Cancer Inst2008100996100218612130
   PubMed Web of Science ®Google Scholar
• ToyokuniSRole of iron in carcinogenesis: cancer as a ferrotoxic diseaseCancer Sci200910091619018762
   PubMed Web of Science ®Google Scholar
• AyeYLiMLongMJWeissRSRibonucleotide reductase and cancer: biological mechanisms and targeted therapiesOncogene2015342011202124909171
   PubMed Web of Science ®Google Scholar
• SiriwardanaGSeligmanPAIron depletion results in Src kinase inhibition with associated cell cycle arrest in neuroblastoma cellsPhysiol Rep20153e1234125825542
   PubMedGoogle Scholar
• HosoiFIzumiHKawaharaAN-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expressionCancer Res2009694983499119491262
   PubMed Web of Science ®Google Scholar
• FurukawaTNaitohYKohnoHTokunagaRTaketaniSIron deprivation decreases ribonucleotide reductase activity and DNA synthesisLife Sci199250205920651608289
   PubMed Web of Science ®Google Scholar
• GaoJRichardsonDRThe potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: the mechanisms involved in inhibiting cell-cycle progressionBlood20019884285011468187
   PubMed Web of Science ®Google Scholar
• MaruyamaYOnoMKawaharaATumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesisCancer Res2006666233624216778198
   PubMed Web of Science ®Google Scholar
• de BeçaFFCaetanoPGerhardRCancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological typesJ Clin Pathol20136618719123112116
   PubMed Web of Science ®Google Scholar
• GodarSInceTABellGWGrowth-inhibitory and tumor-suppressive functions of p53 depend on its repression of CD44 expressionCell2008134627318614011
   PubMed Web of Science ®Google Scholar
• ReuterSGuptaSCChaturvediMMAggarwalBBOxidative stress, inflammation, and cancer: how are they linked?Free Radic Biol Med2010491603161620840865
   PubMed Web of Science ®Google Scholar
• SosaVMolineTSomozaRPaciucciRKondohHMELLOxidative stress and cancer: an overviewAgeing Res Rev20131237639023123177
   PubMed Web of Science ®Google Scholar
• WuFJXueYLiuXFThe protective effect of eicosapentaenoic acid-enriched phospholipids from sea cucumber Cucumaria frondosa on oxidative stress in PC12 cells and SAMP8 miceNeurochem Int20146491724231470
   PubMed Web of Science ®Google Scholar
• NazaranMHChelate compoundsGoogle PatentsUS82885872012
   Google Scholar
• RiccardiCNicolettiIAnalysis of apoptosis by propidium iodide staining and flow cytometryNat Protoc200611458146117406435
   PubMed Web of Science ®Google Scholar
• WangXWZhanQCoursenJDGADD45 induction of a G2/M cell cycle checkpointProc Natl Acad Sci U S A1999963706371110097101
   PubMed Web of Science ®Google Scholar
• SiCLShenTJiangYYAntioxidant properties and neuroprotective effects of isocampneoside II on hydrogen peroxide-induced oxidative injury in PC12 cellsFood Chem Toxicol20135914515223770344
   PubMed Web of Science ®Google Scholar
• LangroudiLHassanZMEbtekarMMahdaviMPakravanNNooriSA comparison of low-dose cyclophosphamide treatment with artemisinin treatment in reducing the number of regulatory T cells in murine breast cancer modelInt Immunopharmacol20101091055106110.1016/j.intimp.2010.06.005 2010 July 220601187
   PubMed Web of Science ®Google Scholar
• LiuMBryantMSChenJAntitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wapras transgenic miceCancer Res199858494749569810004
   PubMed Web of Science ®Google Scholar
• GottesmanMMMechanisms of cancer drug resistanceAnnu Rev Med20025361562711818492
   PubMed Web of Science ®Google Scholar
• ApisarnthanaraxNDuvicMDermatologic Complications of Cancer ChemotherapyBastRCJrKufeDWPollockREHolland-Frei Cancer Medicine5th editionHamilton (ON)BC Decker2000144
   Google Scholar
• RecalcatiSAlberghiniACampanellaAIron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiencyHaematologica20069130331016503547
   PubMed Web of Science ®Google Scholar
• GazittYReddySVAlcantaraOYangJBoldtDHA new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetateJ Cell Physiol200118712413511241357
   PubMed Web of Science ®Google Scholar
• FukuchiKTomoyasuSWatanabeHKaetsuSTsuruokaNGomiKIron deprivation results in an increase in p53 expressionBiol Chem Hoppe Seyler19953766276308590632
   PubMed Web of Science ®Google Scholar
• LiangSXRichardsonDRThe effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1Carcinogenesis2003241601161412869419
   PubMed Web of Science ®Google Scholar
• SalettaFSuryo RahmantoYNoulsriERichardsonDRIron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53Mol Pharmacol20107744345820023006
   PubMed Web of Science ®Google Scholar
• DuLWangHHeLCD44 is of functional importance for colorectal cancer stem cellsClin Cancer Res2008146751676018980968
   PubMed Web of Science ®Google Scholar
• LeungELFiscusRRTungJWNon-small cell lung cancer cells expressing CD44 are enriched for stem cell-like propertiesPLoS One20105e1406221124918
   PubMed Web of Science ®Google Scholar
• WeberGFBronsonRTIlaganJCantorHSchmitsRMakTWAbsence of the CD44 gene prevents sarcoma metastasisCancer Res2002622281228611956084
   PubMed Web of Science ®Google Scholar
• GünthertUHofmannMRudyWA new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cellsCell19916513241707342
   PubMed Web of Science ®Google Scholar
• HiragaTItoSNakamuraHCancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan productionCancer Res2013734112412223633482
   PubMed Web of Science ®Google Scholar
• ShiozawaYNieBPientaKJMorganTMTaichmanRSCancer stem cells and their role in metastasisPharmacol Ther201313828529323384596
   PubMed Web of Science ®Google Scholar
• NelAXiaTMadlerLLiNToxic potential of materials at the nano-levelScience200631162262716456071
   PubMed Web of Science ®Google Scholar
• LinWHuangYWZhouXDMaYIn vitro toxicity of silica nano-particles in human lung cancer cellsToxicol Appl Pharmacol200621725225917112558
   PubMed Web of Science ®Google Scholar
• YangHLiuCYangDZhangHXiZComparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and compositionJ Appl Toxicol200929697818756589
   PubMed Web of Science ®Google Scholar
• BurnsAAViderJOwHFluorescent silica nanoparticles with efficient urinary excretion for nanomedicineNano Lett2009944244819099455
   PubMed Web of Science ®Google Scholar
• RuggieroAVillaCHBanderEParadoxical glomerular filtration of carbon nanotubesProc Natl Acad Sci U S A2010107123691237420566862
   PubMed Web of Science ®Google Scholar