References
- RoccoANardoneGDiet, H pylori infection and gastric cancer: evidence and controversiesWorld J Gastroenterol200713212901291217589938
- WagnerADGrotheWHaertingJKleberGGrotheyAFleigWEChemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate dataJ Clin Oncol200624182903290916782930
- LaiAZCorySZhaoHDynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancerSci Signal20147322ra3824757178
- ZhaoQWangJZouMJWogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolismToxicol Lett2010197320121020570612
- LiQVermaIMNF-kappaB regulation in the immune systemNat Rev Immunol200221072573412360211
- DiDonatoJAMercurioFKarinMNF-kappaB and the link between inflammation and cancerImmunol Rev2012246137940022435567
- KarinMCaoYGretenFRLiZWNF-kappaB in cancer: from innocent bystander to major culpritNat Rev Cancer20022430131012001991
- AggarwalBBSungBNF-kappaB in cancer: a matter of life and deathCancer Discov20111646947122586649
- RuanHHacohenNGolubTRVan ParijsLLodishHFTumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatoryDiabetes20025151319133611978627
- ChoiKCLeeYHJungMGGallic acid suppresses lipopolysaccharide-induced nuclear factor-kappaB signaling by preventing RelA acetylation in A549 lung cancer cellsMol Cancer Res20097122011202119996305
- NakaharaCNakamuraKYamanakaNCyclosporin-A enhances docetaxel-induced apoptosis through inhibition of nuclear factor-kappaB activation in human gastric carcinoma cellsClin Cancer Res20039145409541614614027
- KarinMYamamotoYWangQMThe IKK NF-kappa B system: a treasure trove for drug developmentNat Rev Drug Discov200431172614708018
- HaydenMSGhoshSSignaling to NF-kappaBGenes Dev200418182195222415371334
- SasakiNMorisakiTHashizumeKNuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissueClin Cancer Res20017124136414211751513
- WeichertWBoehmMGekelerVHigh expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosisBr J Cancer200797452353017622249
- FradetVLessardLBeginLRKarakiewiczPMassonAMSaadFNuclear factor-kappaB nuclear localization is predictive of biochemical recurrence in patients with positive margin prostate cancerClin Cancer Res200410248460846415623625
- SakamotoKMaedaSHikibaYConstitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growthClin Cancer Res20091572248225819276252
- IzzoJGMalhotraUWuTTAssociation of activated transcription factor nuclear factor kappab with chemoradiation resistance and poor outcome in esophageal carcinomaJ Clin Oncol200624574875416401681
- SourbierCDanilinSLindnerVTargeting the nuclear factor-kappaB rescue pathway has promising future in human renal cell carcinoma therapyCancer Res20076724116681167618089796
- YemelyanovAGasparianALindholmPEffects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cellsOncogene200625338739816170348
- YangJAmiriKIBurkeJRSchmidJARichmondABMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathwaysClin Cancer Res2006123 Pt 195096016467110
- NobiliSLippiDWitortENatural compounds for cancer treatment and preventionPharmacol Res200959636537819429468
- Lopez-LazaroMAnticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agentMol Nutr Food Res200852Suppl 1S103S12718496811
- HatcherHPlanalpRChoJTortiFMTortiSVCurcumin: from ancient medicine to current clinical trialsCell Mol Life Sci200865111631165218324353
- ShishodiaSPotdarPGairolaCGAggarwalBBCurcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1Carcinogenesis20032471269127912807725
- SandurSKDeorukhkarAPandeyMKCurcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activityInt J Radiat Oncol Biol Phys200975253454219735878
- AggarwalBBShishodiaSTakadaYCurcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude miceClin Cancer Res200511207490749816243823
- SiwakDRShishodiaSAggarwalBBKurzrockRCurcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathwayCancer2005104487989016007726
- AnandPKunnumakkaraABNewmanRAAggarwalBBBioavailability of curcumin: problems and promisesMol Pharm20074680781817999464
- ZhaoCLiuZLiangGPromising curcumin-based drug design: mono-carbonyl analogues of curcumin (MACs)Curr Pharm Des201319112114213523116317
- WangYXiaoJZhouHA novel monocarbonyl analogue of curcumin, (1E,4E)-1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one, induced cancer cell H460 apoptosis via activation of endoplasmic reticulum stress signaling pathwayJ Med Chem201154113768377821504179
- KasinskiALDuYThomasSLInhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene) piperidin-4-one (EF24), a novel monoketone analog of curcuminMol Pharmacol200874365466118577686
- WuJZhangYCaiYDiscovery and evaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agentsBioorg Med Chem201321113058306523611769
- XiaoJWangYPengJA synthetic compound, 1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one (B63), induces apoptosis and activates endoplasmic reticulum stress in non-small cell lung cancer cellsInt J Cancer201213161455146522189907
- OrtisFPirotPNaamaneNInduction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cellsDiabetologia20085171213122518463842
- ChoHJBaekKEParkSMRhoGDI2 confers gastric cancer cells resistance against cisplatin-induced apoptosis by upregulation of Bcl-2 expressionCancer Lett20113111485621752536
- OnoyamaMKitadaiYTanakaYCombining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cancerNeoplasia201315121391139924403861
- LordickFKangYKChungHCArbeitsgemeinschaft Internistische Onkologie and EXPAND InvestigatorsCapecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trialLancet Oncol201314649049923594786
- KangYKRhaSYTassonePA phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancerBr J Cancer2014111466066624960402
- ZhengLTanWZhangJYuanDYangJLiuHCombining trastuzumab and cetuximab combats trastuzumab-resistant gastric cancer by effective inhibition of EGFR/ErbB2 heterodimerization and signalingCancer Immunol Immunother201463658158624668364
- KangYKMuroKRyuMHA phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancerInvest New Drugs201432235536124337769
- LeeKHLeeJHHanSWAntitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteinsCancer Sci201110271388139521453385
- ShinVYJinHNgEKNF-kappaB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptorsCarcinogenesis201132224024521081469
- MaedaSYoshidaHOguraKH. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cellsGastroenterology200011919710810889159
- WuCYWangCJTsengCCHelicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathwayWorld J Gastroenterol200511213197320315929167
- ZhouWFuXQZhangLLThe AKT1/NF-kappaB/Notch1/PTEN axis has an important role in chemoresistance of gastric cancer cellsCell Death Dis20134e84724113181
- UetsukaHHaisaMKimuraMInhibition of inducible NF-kappaB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell lineExp Cell Res20032891273512941601
- YuLLWuJGDaiNYuHGSiJMCurcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-kappaB transcription factorOncol Rep20112651197120321811763
- BhartiACDonatoNSinghSAggarwalBBCurcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosisBlood200310131053106212393461
- ShakibaeiMMobasheriALuedersCBuschFShayanPGoelACurcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathwaysPLoS One201382e5721823451189
- ZhouBZuoYLiBDeubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-kappaB inhibition and p53 reactivation in human lung cancer cellsMol Cancer Ther20131281381139223696216
- VazquezABondEELevineAJBondGLThe genetics of the p53 pathway, apoptosis and cancer therapyNat Rev Drug Discov200871297998719043449
- VassilevLTVuBTGravesBIn vivo activation of the p53 pathway by small-molecule antagonists of MDM2Science2004303565984484814704432
- SubramaniamDNatarajanGRamalingamSTranslation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2Am J Physiol Gastrointest Liver Physiol20082944G1025G103218292181
- CastedoMPerfettiniJLRoumierTAndreauKMedemaRKroemerGCell death by mitotic catastrophe: a molecular definitionOncogene200423162825283715077146
- CorySAdamsJMThe Bcl2 family: regulators of the cellular life-or-death switchNat Rev Cancer20022964765612209154
- OlaMSNawazMAhsanHRole of Bcl-2 family proteins and caspases in the regulation of apoptosisMol Cell Biochem20113511–2415821210296