Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

References

• HoffmannHHSchneiderWMRiceCMInterferons and viruses: an evolutionary arms race of molecular interactionsTrends Immunol201536312413825704559
   PubMed Web of Science ®Google Scholar
• ZitvogelLGalluzziLKeppOSmythMJKroemerGType I interferons in anticancer immunityNat Rev Immunol201515740541426027717
   PubMed Web of Science ®Google Scholar
• StiffACarson IiiWInvestigations of interferon-lambda for the treatment of cancerJ Innate Immun2015724325025661266
   PubMed Web of Science ®Google Scholar
• de WeerdNANguyenTThe interferons and their receptors – distribution and regulationImmunol Cell Biol201290548349122410872
   PubMed Web of Science ®Google Scholar
• SchneiderWMChevillotteMDRiceCMInterferon-stimulated genes: a complex web of host defensesAnnu Rev Immunol20143251354524555472
   PubMed Web of Science ®Google Scholar
• GibbertKSchlaakJFYangDDittmerUIFN-alpha subtypes: distinct biological activities in anti-viral therapyBr J Pharmacol201316851048105823072338
   PubMed Web of Science ®Google Scholar
• SchoenbornJRWilsonCBRegulation of interferon-gamma during innate and adaptive immune responsesAdv Immunol2007964110117981204
   PubMed Web of Science ®Google Scholar
• KotenkoSVGallagherGBaurinVVIFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complexNat Immunol200341697712483210
   PubMed Web of Science ®Google Scholar
• SheppardPKindsvogelWXuWIL-28, IL-29 and their class II cytokine receptor IL-28RNat Immunol200341636812469119
   PubMed Web of Science ®Google Scholar
• Prokunina-OlssonLMuchmoreBTangWA variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virusNat Genet201345216417123291588
   PubMed Web of Science ®Google Scholar
• OuyangWRutzSCrellinNKValdezPAHymowitzSGRegulation and functions of the IL-10 family of cytokines in inflammation and diseaseAnnu Rev Immunol2011297110921166540
   PubMed Web of Science ®Google Scholar
• ZdanovAStructural analysis of cytokines comprising the IL-10 familyCytokine Growth Factor Rev201021532533020846897
   PubMed Web of Science ®Google Scholar
• MiknisZJMagrachevaELiWZdanovAKotenkoSVWlodawerACrystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1J Mol Biol2010404465066420934432
   PubMed Web of Science ®Google Scholar
• GadHHDellgrenCHammingOJVendsSPaludanSRHartmannRInterferon-lambda is functionally an interferon but structurally related to the interleukin-10 familyJ Biol Chem200928431208692087519457860
   PubMed Web of Science ®Google Scholar
• BlouinCMLamazeCInterferon gamma receptor: the beginning of the journeyFront Immunol2013426724027571
   PubMed Web of Science ®Google Scholar
• LinFCYoungHAInterferons: success in anti-viral immunotherapyCytokine Growth Factor Rev201425436937625156421
   PubMed Web of Science ®Google Scholar
• GeorgePMBadigerRAlazawiWFosterGRMitchellJAPharmacology and therapeutic potential of interferonsPharmacol Ther20121351445322484806
   PubMed Web of Science ®Google Scholar
• YinZDaiJDengJType III IFNs are produced by and stimulate human plasmacytoid dendritic cellsJ Immunol201218962735274522891284
   PubMed Web of Science ®Google Scholar
• WolkKWitteKWitteEMaturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytesJ Leukoc Biol20088351181119318281438
   PubMed Web of Science ®Google Scholar
• KotenkoSVIFN-lambdasCurr Opin Immunol201123558359021840693
   PubMed Web of Science ®Google Scholar
• HermantPMichielsTInterferon-lambda in the context of viral infections: production, response and therapeutic implicationsJ Innate Immun20146556357424751921
   PubMed Web of Science ®Google Scholar
• EgliASanterDMO’SheaDTyrrellDLHoughtonMThe impact of the interferon-lambda family on the innate and adaptive immune response to viral infectionsEmerg Microbes Infect201437e5126038748
   PubMed Web of Science ®Google Scholar
• WitteKWitteESabatRWolkKIL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like propertiesCytokine Growth Factor Rev201021423725120655797
   PubMed Web of Science ®Google Scholar
• ZhouZHammingOJAnkNPaludanSRNielsenALHartmannRType III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinasesJ Virol200781147749775817507495
   PubMed Web of Science ®Google Scholar
• DoyleSESchreckhiseHKhuu-DuongKInterleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytesHepatology200644489690617006906
   PubMed Web of Science ®Google Scholar
• PottJMahlakoivTMordsteinMIFN-lambda determines the intestinal epithelial antiviral host defenseProc Natl Acad Sci U S A2011108197944794921518880
   PubMed Web of Science ®Google Scholar
• MordsteinMNeugebauerEDittVLambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infectionsJ Virol201084115670567720335250
   PubMed Web of Science ®Google Scholar
• SommereynsCPaulSStaeheliPMichielsTIFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivoPLoS Pathog200843e100001718369468
   PubMed Web of Science ®Google Scholar
• MuirAJShiffmanMLZamanAPhase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infectionHepatology201052382283220564352
   PubMed Web of Science ®Google Scholar
• MuirAJAroraSEversonGA randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infectionJ Hepatol20146161238124625064437
   PubMed Web of Science ®Google Scholar
• RamosELPreclinical and clinical development of pegylated interferon-lambda 1 in chronic hepatitis CJ Interferon Cytokine Res201030859159520645873
   PubMed Web of Science ®Google Scholar
• MahlakoivTHernandezPGronkeKDiefenbachAStaeheliPLeukocyte-derived IFN-alpha/beta and epithelial IFN-lambda constitute a compartmentalized mucosal defense system that restricts enteric virus infectionsPLoS Pathog2015114e100478225849543
   PubMed Web of Science ®Google Scholar
• HernandezPPMahlakoivTYangIInterferon-lambda and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infectionNat Immunol201516769870726006013
   PubMed Web of Science ®Google Scholar
• GallagherGMegjugoracNJYuRYThe lambda interferons: guardians of the immune-epithelial interface and the T-helper 2 responseJ Interferon Cytokine Res201030860361520712455
   PubMed Web of Science ®Google Scholar
• NiceTJBaldridgeMTMcCuneBTInterferon-lambda cures persistent murine norovirus infection in the absence of adaptive immunityScience2015347621926927325431489
   PubMed Web of Science ®Google Scholar
• ContoliMMessageSDLaza-StancaVRole of deficient type III interferon-lambda production in asthma exacerbationsNat Med20061291023102616906156
   PubMed Web of Science ®Google Scholar
• KochSFinottoSRole of interferon-lambda in allergic asthmaJ Innate Immun2015722423025592858
   PubMed Web of Science ®Google Scholar
• AngelJFrancoMAGreenbergHBBassDLack of a role for type I and type II interferons in the resolution of rotavirus-induced diarrhea and infection in miceJ Interferon Cytokine Res199919665565910433367
   PubMed Web of Science ®Google Scholar
• DellgrenCGadHHHammingOJMelchjorsenJHartmannRHuman interferon-lambda3 is a potent member of the type III interferon familyGenes Immun200910212513118987645
   PubMed Web of Science ®Google Scholar
• WeberHValenzuelaDLujberGGublerMWeissmannCSingle amino acid changes that render human IFN-alpha 2 biologically active on mouse cellsEMBO J1987635915983034596
   PubMed Web of Science ®Google Scholar
• SpanglerJBMoragaIMendozaJLGarciaKCInsights into cytokine–receptor interactions from cytokine engineeringAnnu Rev Immunol201533113916725493332
   PubMedGoogle Scholar
• GasteigerEHooglandCGattikerAProtein Identification and Analysis Tools on the ExPASy ServerWalkerJMThe Proteomics Protocols Handbook, Humana Press 2005Totowa, New JerseyHumana Press2005571607
   Google Scholar
• PaulsonMSGeneration and quantitation of infectious hepatitis C virus derived from cell culture (HCVcc)EnnaSJWilliamsMCurrent Protocols in PharmacologyNew YorkJohn Wiley & Sons, Inc201013B.14.1113B.14.19
   Google Scholar
• AmanzadaAKoppWSpenglerURamadoriGMihmSInterferon-lambda4 (IFNL4) transcript expression in human liver tissue samplesPLoS One2013812e8402624376784
   PubMed Web of Science ®Google Scholar
• LarocqueLBliuAXuRBioactivity determination of native and variant forms of therapeutic interferonsJ Biomed Biotechnol2011201117461521403871
   PubMedGoogle Scholar
• ChanHLAhnSHChangTTO115 PEGInterferon lambda for the treatment of chronic hepatitis B (CHB): a phase 2B comparison with PEGinterferon alfa in patients with HBeAg-positive diseaseJ Hepatol2014601S48
   Google Scholar
• WongSSYuenKYAntiviral therapy for respiratory tract infectionsRespirology200813795097118922142
   PubMed Web of Science ®Google Scholar
• JewellNAClineTMertzSELambda interferon is the predominant interferon induced by influenza A virus infection in vivoJ Virol20108421115151152220739515
   PubMed Web of Science ®Google Scholar
• MatzingerSRCarrollTDFrittsLMcChesneyMBMillerCJExogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaquesPLoS One2011612e2925522220209
   PubMed Web of Science ®Google Scholar
• LevinDSchneiderWMHoffmannHHMultifaceted activities of type I interferon are revealed by a receptor antagonistSci Signal20147327ra5024866020
   PubMed Web of Science ®Google Scholar
• BlattLMDavisJMKleinSBTaylorMWThe biologic activity and molecular characterization of a novel synthetic interferon-alpha species, consensus interferonJ Interferon Cytokine Res19961674894998836913
   PubMed Web of Science ®Google Scholar
• WitthoftTReview of consensus interferon in the treatment of chronic hepatitis CBiologics20082463564319707444
   PubMedGoogle Scholar
• ChangCCChenTTCoxBWEvolution of a cytokine using DNA family shufflingNat Biotechnol199917879379710429246
   PubMed Web of Science ®Google Scholar
• Brideau-AndersenADHuangXSunSCDirected evolution of gene-shuffled IFN-alpha molecules with activity profiles tailored for treatment of chronic viral diseasesProc Natl Acad Sci U S A2007104208269827417494769
   PubMed Web of Science ®Google Scholar
• Kimchi-SarfatyCSchillerTHamasaki-KatagiriNKhanMAYanoverCSaunaZEBuilding better drugs: developing and regulating engineered therapeutic proteinsTrends Pharmacol Sci2013341053454824060103
   PubMed Web of Science ®Google Scholar