128
Views
11
CrossRef citations to date
0
Altmetric
Original Research

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

, , , , , , , , , , , , & show all
Pages 1443-1451 | Published online: 13 Apr 2016

References

  • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. The Huntington’s Disease Collaborative Research GroupCell1993729719838458085
  • HoffnerGIslandMLDjianPPurification of neuronal inclusions of patients with Huntington’s disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymersJ Neurochem20059512513616181417
  • SchillingGSharpAHLoevSJExpression of the Huntington’s disease (IT15) protein product in HD patientsHum Mol Genet19954136513717581375
  • HoffnerGDjianPMonomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansionBrain Sci201449112224961702
  • QinZHGuZLHuntingtin processing in pathogenesis of Huntington diseaseActa Pharmacol Sin200425101243124915456523
  • Chánez-CárdenasMEVázquez-ContrerasEThe aggregation of Huntingtin and α-SynucleinJ Biophys2012201260617222899913
  • SwarnkarSChenYPryorWMShahaniNPageDTSubramaniamSEctopic expression of the striatal-enrich GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntinton’s diseaeNeurobiol Dis201582667726048156
  • LazarevVFBenkenKASemenyukPIGAPDH binders as potential drugs for the therapy of polyglutamine disease, design of a new screening assayFEBS Lett2015589558158725625921
  • LinYWuXFengSFive unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coastJ Org Chem2001666252625611559170
  • LongSMLiangFYWuQIdentification of marine neuroactive molecules in behaviour-based screens in the larval zebrafishMar Drugs2014123307332224886868
  • LiSShenCGuoWSynthesis and neuroprotective action of xyloketal derivatives in Parkinson’s disease modelsMar Drugs2013115159518924351912
  • XiaoAJChenWXuBSun. Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injuryMar Drugs201513294725546517
  • SuJChangCXiangQXyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal studyDrug Des Devel Ther2014825552602
  • PettigrewJDCadieuxJASoSSWilsonPDPhenylboronic acid mediated triple condensation reactions of phloroglucinol and unsaturated carbonyl compoundsOrg Lett2005746747015673266
  • LiJLeWModeling neurodegenerative diseases in Caenorhabditis elegansExp Neurol20132509410324095843
  • ParkerJAHolbertSLambertEAbderrahmaneSNeriCGenetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegansJ Mol Neurosci200423616815126693
  • VonsattelJPDiFigliaMHuntington diseaseJ Neuropathol Exp Neurol1998573693849596408
  • Gama SosaMADe GasperiRElderGAModeling human neurodegenerative diseases in transgenic systemsHum Genet201213153556322167414
  • FaberPWAlterJRMacDonaldMEHartACPolyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuronProc Natl Acad Sci U S A1999961791849874792
  • HolbertSDenghienIKiechleTThe Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington’s disease pathogenesisProc Natl Acad Sci U S A2001981811181611172033
  • GohilVMOffnerNWalkerJAMeclizine is neuroprotective in models of Huntington’s diseaseHum Mol Gen20112029430020977989
  • SteffanJSThompsonLMTargeting aggregation in the development of therapeutics for the treatment of Huntington’s disease and other polyglutamine repeat diseasesExpert Opin Ther Targets2003720121312667098
  • VoisineCVarmaHWalkerNBatesEAStockwellBRHartACIdentification of potential therapeutic drugs for Huntington’s disease using Caenorhabditis elegansPloS One20072e50417551584
  • WangHLimPJYinCRieckherMVogelBEMonteiroMJSuppression of polyglutamine-induced toxicity in cell and animal models of Huntington’s disease by ubiquilinHum Mol Gen2006151025104116461334
  • WaterstonRHEpsteinHFBrennerSParamyosin of Caenorhabditis elegansJ Mol Biol1974902852904217841
  • SatyalSHSchmidtEKitagawaKPolyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegansProc Natl Acad Sci U S A2000975750575510811890
  • MariolMCWalterLBelleminSGieselerKA Rapid Protocol for integrating extrachromosomal arrays with high transmission rate into the C. elegans genomeJ Vis Exp20138250773
  • StiernagleTCeenorhabditis Genetic Center. Maintenance of C. elegansWorm book2006111 in pubmed18050451
  • WangXYangCChaiJShiYXueDMechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegansScience20022981587159212446902
  • KahlemPGreenHDjianPTransglutaminase action imitates Huntington’s disease: selective polymerization of Huntingtin containing expanded polyglutamineMol Cell199815956019660943
  • IuchiSHoffnerGVerbekePDjianPGreenHOligomeric and polymeric aggregates formed by proteins containing expanded polyglutamineProc Natl Acad Sci U S A20031002409241412591956
  • TrottierYDevysDImbertGCellular localization of the Huntington’s disease protein and discrimination of the normal and mutated formNat Genet1995101041107647777
  • AndreWSandtCDumasPDjianPHoffnerGStructure of inclusions of Huntington’s disease brain revealed by synchrotron infrared microspectroscopy: polymorphism and relevance to cytotoxicityAnal Chem2013853765377323458159
  • BecherMWKotzukJASharpAHIntranuclear neuronal inclusions in Huntington’s disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat lengthNeurobiol Dis199843873979666478
  • LiangVUllrichMLamHAltered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteomeCell Mol Life Sci2013713339336124458371
  • KimMBeta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residuesPrion2013722122823370273
  • DavrancheAAviolatHZeder-LutzGHuntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactionsHum Mol Gen2011202795280621518730
  • GaoTCollinsREHortonJRThe ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine bindingProteins20097677277719434754
  • GuptaSMisraGPantMCSethPKPrediction of a new surface binding pocket and evaluation of inhibitors against huntingtin interacting protein 14: an insight using docking studiesJ Mol Model2011173047305621360185
  • PerutzMFStadenRMoensLDe BaereIPolar zippersCurr Biol1993324925315335744
  • De BaereILiuLMoensLPolar zipper sequence in the high-affinity hemoglobin of Ascaris suum: amino acid sequence and structural interpretationProc Natl Acad Sci U S A199289463846421584800
  • PerutzMFJohnsonTSuzukiMFinchJTGlutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseasesProc Natil Acad Sci U S A19949153555358
  • MangiariniLSathasivamKSellerMExon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceCell1996874935068898202
  • KimMWChelliahYKimSWOtwinowskiZBezprozvannyISecondary structure of Huntingtin amino-terminal regionStructure2009171205121219748341
  • DarnellGOrgelJPPahlRMeredithSCFlanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structureJ Mol Biol200737468870417945257
  • NakanoMWatanabeHStarikovEBRothsteinSMTanakaSMutation effects on structural stability of polyglutamine peptides by molecular dynamics simulationInterdiscip Sci20091212920640815