Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFκB signal-transduction pathways

References

• ChastreJFagonJVentilator-associated pneumoniaAm J Respir Crit Care Med2002165786790311934711
   PubMed Web of Science ®Google Scholar
• de Oliveira CostaPAttaEHda SilvaARPredictors of 7- and 30-day mortality in pediatric intensive care unit patients with cancer and hematologic malignancy infected with Gram-negative bacteriaBraz J Infect Dis201418659159925051279
   PubMed Web of Science ®Google Scholar
• BanerjeeDKhairOAHoneybourneDImpact of sputum bacteria on airway inflammation and health status in clinical stable COPDEur Respir J200423568569115176680
   PubMed Web of Science ®Google Scholar
• HauserARJainMBar-MeirMMcColleySAClinical significance of microbial infection and adaptation in cystic fibrosisClin Microbiol Rev2011241297021233507
   PubMed Web of Science ®Google Scholar
• WahmanSEmaraMShawkyRMEl-DomanyRAAboulwafaMMInhibition of quorum sensing-mediated biofilm formation in Pseudomonas aeruginosa by a locally isolated Bacillus cereusJ Basic Microbiol Epub2015819
   PubMed Web of Science ®Google Scholar
• PearsonJPVan DeldenCIglewskiBHActive efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signalsJ Bacteriol19991814120312109973347
   PubMed Web of Science ®Google Scholar
• RasmussenTBGivskovMQuorum sensing inhibitors: a bargain of effectsMicrobiology2006152Pt 489590416549654
   PubMed Web of Science ®Google Scholar
• SenturkSUlusoySBosgelmez-TinazGYagciAQuorum sensing and virulence of Pseudomonas aeruginosa during urinary tract infectionsJ Infect Dev Ctries20126650150722706193
   PubMed Web of Science ®Google Scholar
• VeesenmeyerJLHauserARLisboaTRelloJPseudomonas aeruginosa virulence and therapy: evolving translational strategiesCrit Care Med20093751777178619325463
   PubMed Web of Science ®Google Scholar
• KlausenMHeydornARagasPBiofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutantsMol Microbiol20034861511152412791135
   PubMed Web of Science ®Google Scholar
• DöringGConwaySPHeijermanHGAntibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensusEur Respir J200016474976711106223
   PubMed Web of Science ®Google Scholar
• RaskoDASperandioVAnti-virulence strategies to combat bacteria-mediated diseaseNat Rev Drug Discov20109211712820081869
   PubMed Web of Science ®Google Scholar
• CohenTSPrinceASActivation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumoniaJ Clin Invest201312341630163723478406
   PubMed Web of Science ®Google Scholar
• LunaCMBaqueroSGandoSExperimental severe Pseudomonas aeruginosa pneumonia and antibiotic therapy in piglets receiving mechanical ventilationChest2007132252353117699131
   PubMed Web of Science ®Google Scholar
• LeeJShinHKimYPaekSJinSHaUPseudomonas aeruginosa-induced IL-1β production is inhibited by Sophora flavescens via the NF-κB/inflammasome pathwaysJ Microbiol201452121044104925467122
   PubMed Web of Science ®Google Scholar
• SadlonAELamsonDWImmune-modifying and antimicrobial effects of eucalyptus oil and simple inhalation devicesAltern Med Rev2010151334720359267
   PubMedGoogle Scholar
• ChaudharyAHarminderAKSinghVA review on the taxonomy, ethnobotany, chemistry and pharmacology of Oroxylum indicum VentIndian J Pharm Sci201173548349022923859
   PubMed Web of Science ®Google Scholar
• ZhangHChenQZhouWChinese medicine injection shuanghuanglian for treatment of acute upper respiratory tract infection: a systematic review of randomized controlled trialsEvid Based Complement Alternat Med2013201398732623606893
   PubMed Web of Science ®Google Scholar
• CaoYDaiBWangYIn vitro activity of baicalein against Candida albicans biofilmsInt J Antimicrob Agents2008321737718374543
   PubMed Web of Science ®Google Scholar
• WuJAAtteleASZhangLYuanCAnti-HIV activity of medicinal herbs: usage and potential developmentAm J Chin Med2001291698111321482
   PubMed Web of Science ®Google Scholar
• ChenHGaoYWuJExploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignanciesCancer Lett2014354151125128647
   PubMed Web of Science ®Google Scholar
• SahuBDKumarJMSistlaRBaicalein, a bioflavonoid, prevents cisplatin-induced acute kidney injury by up-regulating antioxidant defenses and down-regulating the MAPKs and NF-κB pathwaysPLoS One2015107e013413926222683
   PubMed Web of Science ®Google Scholar
• ZhangZCuiWLiGBaicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathwaysJ Agric Food Chem201260338171818222838648
   PubMed Web of Science ®Google Scholar
• FujitaMShiotaSKurodaTRemarkable synergies between baicalein and tetracycline, and baicalein and β-lactams against methicillin-resistant Staphylococcus aureusMicrobiol Immunol200549439139615840965
   PubMed Web of Science ®Google Scholar
• ZengZQianLCaoLVirtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosaAppl Microbiol Biotechnol200879111912618330563
   PubMed Web of Science ®Google Scholar
• BalaAKumarRHarjaiKInhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infectionsJ Med Microbiol201160330030621127154
   PubMed Web of Science ®Google Scholar
• EssarDWEberlyLHaderoACrawfordIPIdentification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implicationsJ Bacteriol199017228849002153661
   PubMed Web of Science ®Google Scholar
• HentzerMRiedelKRasmussenTBInhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compoundMicrobiology2002148Pt 18710211782502
   PubMedGoogle Scholar
• OhmanDECryzSJIglewskiBHIsolation and characterization of Pseudomonas aeruginosa PAO mutant that produces altered elastaseJ Bacteriol198014238368426769912
   PubMed Web of Science ®Google Scholar
• PhamTHWebbJSRehmBHThe role of polyhydroxyalkanoate biosynthesis by Pseudomonas aeruginosa in rhamnolipid and alginate production as well as stress tolerance and biofilm formationMicrobiology2004150Pt 103405341315470118
   PubMedGoogle Scholar
• WuHLeeBYangLEffects of ginseng on Pseudomonas aeruginosa motility and biofilm formationFEMS Immunol Med Microbiol2011621495621303421
   PubMed Web of Science ®Google Scholar
• AlipourMSuntresZELafrenieRMOmriAAttenuation of Pseudomonas aeruginosa virulence factors and biofilms by co-encapsulation of bismuth-ethanedithiol with tobramycin in liposomesJ Antimicrob Chemother201065468469320159770
   PubMed Web of Science ®Google Scholar
• GooderhamWJBainsMMcPheeJBWiegandIHancockREInduction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation, and swarming motility of PsrA in Pseudomonas aeruginosaJ Bacteriol2008190165624563418556795
   PubMed Web of Science ®Google Scholar
• FranklinMJOhmanDEIdentification of algI and algJ in the Pseudomonas aeruginosa alginate biosynthetic gene cluster which are required for alginate O acetylationJ Bacteriol19961788218621958636017
   PubMed Web of Science ®Google Scholar
• KnutsonCAJeanesAA new modification of the carbazole analysis: application to heteropolysaccharidesAnal Biochem19682434704815723302
   PubMed Web of Science ®Google Scholar
• SarabhaiSHarjaiKSharmaPCapalashNEllagic acid derivatives from Terminalia chebula Retz increase the susceptibility of Pseudomonas aeruginosa to stress by inhibiting polyphosphate kinaseJ Appl Microbiol2015118481782525640983
   PubMed Web of Science ®Google Scholar
• MakemsonJEberhardAMatheeKSimple electrospray mass spectrometry detection of acylhomoserine lactonesLuminescence20062111616078303
   PubMed Web of Science ®Google Scholar
• Ortega-GonzálezMSánchez de MedinaFMolina-SantiagoCFructooligosacharides reduce Pseudomonas aeruginosa PAO1 pathogenicity through distinct mechanismsPLoS One201491e8577224465697
   PubMed Web of Science ®Google Scholar
• SinghSBarrHLiuYCGranulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-γ-treated macrophages to Pseudomonas aeruginosa infectionPLoS One2015102e011744725706389
   PubMed Web of Science ®Google Scholar
• ZhaoZYanSYuYAn aqueous extract of Yunnan baiyao inhibits the quorum-sensing-related virulence of Pseudomonas aeruginosaJ Microbiol201351220721223625222
   PubMed Web of Science ®Google Scholar
• RashidMHKornbergAInorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosaProc Natl Acad Sci U S A20009794885489010758151
   PubMed Web of Science ®Google Scholar
• RasamiravakaTLabtaniQDuezPEl JaziriMThe formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanismsBioMed Res Int2015201575934825866808
   PubMed Web of Science ®Google Scholar
• EpelmanSStackDBellCDifferent domains of Pseudomonas aeruginosa exoenzyme S activate distinct TLRsJ Immunol200417332031204015265938
   PubMed Web of Science ®Google Scholar
• TrinchieriGSherACooperation of Toll-like receptor signals in innate immune defenceNat Rev Immunol20077317919017318230
   PubMed Web of Science ®Google Scholar
• PollardAJCurrieARosenbergerCMHealeJFinlayBBSpeertDPDifferential post-transcriptional activation of human phagocytes by different Pseudomonas aeruginosa isolatesCell Microbiol20046763965015186400
   PubMed Web of Science ®Google Scholar
• WangWZhouPXuCZhouXHuWZhangJBaicalein attenuates renal fibrosis by inhibiting inflammation via down-regulating NF-κB and MAPK signal pathwaysJ Mol Histol201546328329025981879
   PubMed Web of Science ®Google Scholar
• Gómez-GarcésJLGil-RomeroYSanz-RodríguezNMuñoz-ParaísoCRegodón-DomínguezM[In vitro activity of fosfomycin, alone or in combination, against clinical isolates of carbapenem resistant Pseudomonas aeruginosa] Actividad in-vitro de fosfomicina, sola o en combinaciones, frente a aislamientos clínicos de Pseudomonas aeruginosa resistentes a carbapenémicosEnferm Infecc Microbiol Clin Epub2015812 Spanish
   Google Scholar
• HentzerMWuHAndersenJBAttenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitorsEMBO J200322153803381512881415
   PubMed Web of Science ®Google Scholar
• RasmussenTBBjarnsholtTSkindersoeMEScreening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selectorJ Bacteriol200518751799181415716452
   PubMed Web of Science ®Google Scholar
• RasmussenTBSkindersoeMEBjarnsholtTIdentity and effects of quorum-sensing inhibitors produced by Penicillium speciesMicrobiology2005151Pt 51325134015870443
   PubMedGoogle Scholar
• StehlingEGda SilveiraWDda Silva LeiteDStudy of biological characteristics of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis and from patients with extra-pulmonary infectionsBraz J Infect Dis2008121868818553021
   PubMed Web of Science ®Google Scholar
• LauGWHassettDJRanHKongFThe role of pyocyanin in Pseudomonas aeruginosa infectionTrends Mol Med2004101259960615567330
   PubMed Web of Science ®Google Scholar
• O’MayCTufenkjiNThe swarming motility of Pseudomonas aeruginosa is blocked by cranberry proanthocyanidins and other tannin-containing materialsAppl Environ Microb201177930613067
   PubMed Web of Science ®Google Scholar
• DaviesDGParsekMRPearsonJPIglewskiBHCostertonJWGreenbergEPThe involvement of cell-to-cell signals in the development of a bacterial biofilmScience199828053612952989535661
   PubMed Web of Science ®Google Scholar
• GlessnerASmithRSIglewskiBHRobinsonJBRoles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motilityJ Bacteriol199918151623162910049396
   PubMed Web of Science ®Google Scholar
• LappalainenUWhitsettJAWertSETichelaarJWBryKInterleukin-1β causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lungAm J Respir Cell Mol Biol200532431131815668323
   PubMed Web of Science ®Google Scholar
• MedzhitovRJanewayCJJrInnate immune recognition: mechanisms and pathwaysImmunol Rev20001731899710719670
   PubMedGoogle Scholar
• GirardinEGrauGEDayerJRoux-LombardPLambertPTumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpuraN Engl J Med198831973974003135497
   PubMed Web of Science ®Google Scholar
• HeXWeiZZhouEBaicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-κB and MAPK signaling pathways in LPS-induced mastitis in miceInt Immunopharmacol201528147047626202808
   PubMed Web of Science ®Google Scholar