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Review

Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

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Pages 483-507 | Published online: 28 Jan 2016

References

  • ChirraHDDesaiTAEmerging microtechnologies for the development of oral drug delivery devicesAdv Drug Deliv Rev201264141569157822981755
  • Des RieuxAFievezVGarinotMSchneiderYJPreatVNanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approachJ Control Release2006116112717050027
  • SahooSKParveenSPandaJJThe present and future of nanotechnology in human health careNanomedicine200731203117379166
  • ParkJHLeeSKimJHParkKKimKKwonICPolymeric nanomedicine for cancer therapyProg Polym Sci2008331113137
  • SumerBGaoJTheranostic nanomedicine for cancerNanomedicine20083213714018373419
  • DassCRChoongPThe use of chitosan formulations in cancer therapyJ Microencapsul200825427527918465306
  • PrabaharanMReview paper: chitosan derivatives as promising materials for controlled drug deliveryJ Biomater Appl200823153618593819
  • AugstADKongHJMooneyDJAlginate hydrogels as biomaterialsMacromol Biosci20066862363316881042
  • GombotzWRWeeSFProtein release from alginate matricesAdv Drug Deliv Rev199831326728510837629
  • PiyakulawatPPraphairaksitNChantarasiriNMuangsinNPreparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenacAAPS PharmSciTech200784E9718181557
  • SantoVEFriasAMCaridaMCarrageenan-based hydrogels for the controlled delivery of PDGF-BB in bone tissue engineering applicationsBiomacromolecules20091061392140119385660
  • GrenhaAGomesMERodriguesMDevelopment of new chitosan/carrageenan nanoparticles for drug delivery applicationsJ Biomed Mater Res A20109241265127219322874
  • AgnihotriSAMallikarjunaNNAminabhaviTMRecent advances on chitosan-based micro- and nanoparticles in drug deliveryJ Control Release2004100152815491807
  • RobertsGAFStructure of chitin and chitosanRobertsGAFChitin ChemistryHoundmills, BasingstokeMacmillan1992153
  • LeHouxJGGrondinFSome effects of chitosan on liver function in the ratEndocrinology1993132107810847679967
  • ChandyTSharmaCPChitosan – as a biomaterialBiomater Artif Cells Artif Organs19901811242185854
  • SuganoMWatanabeSKishiAIzumeMOhtakaraAHypocholesterolemic action of chitosans with different viscosity in ratsLipids19882331871912836688
  • AzadAKSermsinthamNChandrkrachangSStevensWFChitosan membrane as a wound-healing dressing: characterization and clinical applicationJ Biomed Mater Res B Appl Biomater200469221622215116411
  • FeltOBuriPGurnyRChitosan: a unique polysaccharide for drug deliveryDrug Dev Ind Pharm199824119799939876553
  • RabeaEIBadawyMESteurbautWFungicidal effect of chitosan derivatives containing an N-alkyl group on grey mould Botryti77s cinerea and rice leaf blast Pyricularia griseaCommun Agric Appl Biol Sci200570321922316637181
  • KockischSReesGDYoungSATsibouklisJSmartJDPolymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potentialJ Pharm Sci2003921614162312884248
  • SinhaVRSinglaAKWadhawanSChitosan microspheres as a potential carrier for drugsInt J Pharm20042741–213315072779
  • HuoMZhangYZhouJSynthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drugInt J Pharm20103941–216217320457237
  • DashaMChielliniaFOttenbritebRMChielliniEChitosan – a versatile semi-synthetic polymer in biomedical applicationsProg Polym Sci2011369811014
  • CalderónLHarrisRCordoba-DiazMNano and microparticulate chitosan-based systems for antiviral topical deliveryEur J Pharm Sci2013481–221622223159663
  • AiedehKTahaMOSynthesis of chitosan succinate and chitosan phthalate and their evaluation as suggested matrices in orallyadministered, colon-specific drug delivery systemsArch Pharm (Weinheim)1999332310310710228455
  • FloreaBIThanouMGeldofMMeaneyCJungingerHEBorchardGModified chitosan oligosaccharides as transfection agents for gene therapy of cystic fibrosisProc Int Symp Control Release Bioact Mater200027846847
  • SievalABThanouMKotzeAFVerhoefJEBrusseeJJungingerHEPreparation and NMR characterization of highly substituted N-trimethyl chitosanchlorideCarbohydr Polym199836157165
  • VerheulRJAmidiMvan der WalSvan RietEJiskootWHenninkWESynthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosanBiomaterials2008293642364918556059
  • HammanJHStanderMKotzeAFEffect of the degree of quaternisation of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epitheliaInt J Pharm200223223524211790507
  • ThanouMVerhoefJCMarbachPJungingerHEIntestinal absorption of octreotide: N-trimethyl chitosan chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivoJ Pharm Sci20008995195710861597
  • ThanouMNihotMTJansenMVerhoefJCJungingerHEMono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivoJ Pharm Sci200190384611064377
  • XuYDuYHuangRGaoLPreparation and modification of N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a protein carrierBiomaterials2003245015502214559015
  • Bernkop-SchnurchAHornofMZoidlTThiolated polymers–thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugatesInt J Pharm200326022923712842342
  • HornofMDKastCEBernkop-SchnurchAIn vitro evaluation of the viscoelastic properties of chitosan-thioglycolic acid conjugatesEur J Pharm Biopharm20035518519012637095
  • RoldoMHornofMCalicetiPBernkop-SchnurchAMucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluationEur J Pharm Biopharm20045711512114729087
  • YinLDingJHeCCuiLTangCYinCDrug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin deliveryBiomaterials200930295691570019615735
  • UbaidullaUKharRKAhmadFJSultanaYPandaAKDevelopment and characterization of chitosan succinate microspheres for the improved oral bioavailability of insulinJ Pharm Sci200796113010302317588259
  • UbaidullaUSultanaYAhmedFJKharRKPandaAKChitosan phthalate microspheres for oral delivery of insulin: preparation, characterization, and in vitro evaluationDrug Deliv2007141192317107927
  • RekhaMRSharmaCPSynthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorptionJ Control Release2009135214415119331862
  • TomitaMHayashiMHorieTIshizawaTAwazuSEnhancement of colonic drug absorption by the transcellular permeation routePharm Res19885127867893247289
  • Le TienCLacroixMIspas-SzaboPMateescuMAN-acylated chitosan: hydrophobic matrices for controlled drug releaseJ Control Release200393111314602417
  • SoniaTASharmaCPChitosan and its derivatives for drug delivery perspectiveAdv Polym Sci20112432354
  • ThanouMNihotMTJansenMVerhoefJCJungingerHEMono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivoJ Pharm Sci200190384611064377
  • JayakumarRPrabaharanMReisRLManoJFGraft copolymerized chitosan-present status and applicationsCarbohydr Polym200562142158
  • ShantaKLHardingDRKSynthesis and characterization of chemically modified chitosan microspheresCarbohydr Polym200248247253
  • ZhangCPingQDingYChengYShenJSynthesis, characterization and microsphere formation of galactosylated chitosanJ Appl Polym Sci200491659665
  • SezerADCevherETopical drug delivery using chitosan nano- and microparticlesExpert Opin Drug Deliv2012991129114622769587
  • ChaudhuryADasSRecent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agentsAAPS PharmSciTech2011121102021153572
  • KumariAYadavSKYadavSCBiodegradable polymeric nanoparticles based drug delivery systemsColloids Surf B Biointerfaces20107511819782542
  • RaoSBSharmaCPUse of chitosan as biomaterial: studies on its safety and hemostatic potentialJ Biomed Mater Res19973421288978649
  • LehrCMBouwstraJASchachtEHJungingerHEIn vitro evaluation of mucoadhesive properties of chitosan and some other natural polymersInt J Pharm1992784348
  • ChowdaryKPRaoYSDesign and in vitro and in vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: a technical noteAAPS PharmSciTech200343E3914621971
  • DastanTTuranKIn vitro characterization and delivery of chitosan-DNA microparticles into mammalian cellsJ Pharm Pharm Sci20047220521415367377
  • LiYHFanMWBianZChenZZhangQYangHRChitosan-DNA microparticles as mucosal delivery system: synthesis, characterization and release in vitroChin Med J (Engl)20051181193694115978195
  • ChuaBYAl KobaisiMZengWMainwaringDJacksonDCChitosan microparticles and nanoparticles as biocompatible delivery vehicles for peptide and protein-based immunocontraceptive vaccinesMol Pharm201291819022149016
  • VarshosazJSadraiHAlinagariRNasal delivery of insulin using chitosan microspheresJ Microencapsul200421776177415799226
  • AcikgozMKasHSOrmanMHincalAAChitosan microspheres of diclofenac sodium: I. Application for factorial design and evaluation of release kineticsJ Microencapsul1996131411608999120
  • AkbugaJBergisadiN5-fluorouracil-loaded chitosan microspheres: preparation and release characteristicsJ Microencapsul1996131611688999121
  • WangYHSatoHAdachiIHorikoshiIOptimisation of the formulation design of chitosan microspheres containing cisplatinJ Pharm Sci19968512048923326
  • KoJAParkHJHwangSJParkJBLeeJSPreparation and characterization of chitosan microparticles intended for controlled drug deliveryInt J Pharm20022491–216517412433445
  • DiniEAlexandridouSKiparissidesCSynthesis and characterization of cross-linked chitosan microspheres for drug delivery applicationsJ Microencapsul200320337538512881117
  • JansenJMaibachHIEncapsulation to deliver topical activesHandbook of Cosmetic Science and TechnologyNew York, NYMarcel Dekker2001
  • KofujiKQianCJMurataYKawashimaSPreparation of chitosan microparticles by water-in-vegetable oil emulsion coalescence techniqueReact Funct Polym2005627783
  • GiunchediPJulianoCGaviniECossuMSorrentiMFormulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheresEur J Pharm Biopharm200253223323911880008
  • CorriganDOHealyAMCorriganOIPreparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulatesEur J Pharm Biopharm200662329530516314079
  • AlhalawehAAnderssonSVelagaSPPreparation of zolmitriptan-chitosan microparticles by spray drying for nasal deliveryEur J Pharm Sci200938320621419616094
  • LiXKongXShiSPreparation of alginate coated chitosan microparticles for vaccine deliveryBMC Biotechnol200888919019229
  • AbreuFOMSForteMMCKistTBLHonaiserLPEffect of the preparation method on the drug loading of alginate-chitosan microsphereseXPRESS Polym Lett201048456464
  • ZhangYWeiWLvPWangLMaGPreparation and evaluation of alginate–chitosan microspheres for oral delivery of insulinEur J Pharm Biopharm2011771111920933083
  • WangQXieXZhangXZhangJWangAPreparation and swelling properties of pH-sensitive composite hydrogel beads based on chitosan-g-poly(acrylic acid)/vermiculite and sodium alginate for diclofenac controlled releaseInt J Biol Macromol201046335636220096301
  • KrekelerMPSGuggenheimSDefects in microstructure in palygorskite-sepiolite minerals: a transmission electron microscopy (TEM) studyAppl Clay Sci2008391–298105
  • WangQWuJWangWWangAPreparation, characterization and drug-release behaviors of crosslinked chitosan/attapulgite hybrid microspheres by a facile spray-drying techniqueJ Biomater Nanobiotechnol20112250257
  • ZhangFKohGYJeansonneDPA novel solubility enhanced curcumin formulation showing stability and maintenance of anticancer activityJ Pharm Sci201110072778278921312196
  • YallapuMMGuptaBKJaggiMChauhanSCFabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cellsJ Colloid Interface Sci20103511192920627257
  • DasRKKasojuNBoraUEncapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cellsNanomedicine20106115316019616123
  • ThangapazhamRLPuriATeleSBlumenthalRMaheshwariKEvaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cellsInt J Oncol20083251119112318425340
  • Guzman-VillanuevaDEl-SherbinyIMHerrera-RuizDSmythHDDesign and in vitro evaluation of a new nano-microparticulate system for enhanced aqueous-phase solubility of curcuminBiomed Res Int2013201372476323984402
  • MaestrelliFGarcia-FuentesMMuraPAlonsoMJA new drug nanocarrier consisting of chitosan and hydoxypropylcyclodextrinEur J Pharm Biopharm2006632798616527473
  • WangJTanHYuAPreparation of chitosan-based nanoparticles for delivery of low molecular weight heparinJ Biomed Nanotechnol20117569670322195488
  • LeeSJParkKOhYKTumor specificity and therapeutic efficacy of photosensitizer-encapsulated glycol chitosan-based nanoparticles in tumor-bearing miceBiomaterials200930152929293919254811
  • PrabaharanMChitosan-based nanoparticles for tumor-targeted drug deliveryInt J Biol Macromol2014721313132225450550
  • KwonICChitosan-based nanoparticles for cancer therapy; tumor specificity and enhanced therapeutic efficacy in tumor-bearing miceJ Control Release20081323e69e70
  • Garcia-FuentesMPregoCTorresDAlonsoMJA comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin deliveryEur J Pharm Sci20052513314315854809
  • VilaASanchezATobıoMCalvoPAlonsoMJDesign of biodedegradable particles for protein deliveryJ Control Release200278152411772445
  • PanYLiYJZhaoHYBioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivoInt J Pharm200224913914712433442
  • KatasHRajaMALamKLDevelopment of chitosan nanoparticles as a stable drug delivery system for protein/siRNAInt J Biomater2013201314632024194759
  • GanQWangTChitosan nanoparticle as protein delivery carrier – systematic examination of fabrication conditions for efficient loading and releaseColloids Surf B Biointerfaces2007591243417555948
  • CuiZMumperRJChitosan-based nanoparticles for topical genetic immunizationJ Control Release200175340941911489327
  • PregoCPaolicelliPDíazBChitosan-based nanoparticles for improving immunization against hepatitis B infectionVaccine201028142607261420096389
  • MaZLimTMLimLYPharmacological activity of peroral chitosan–insulin nanoparticles in diabetic ratsInt J Pharm20052931–227128015778065
  • QuJBShaoHHJingGLHuangFPEG-chitosan-coated iron oxide nanoparticles with high saturated magnetization as carriers of 10-hydroxycamptothecin: preparation, characterization and cytotoxicity studiesColloids Surf B Biointerfaces2013102374423000675
  • ChronopoulouLMassimiMGiardiMFChitosan-coated PLGA nanoparticles: a sustained drug release strategy for cell culturesColloids Surf B Biointerfaces201310331031723261553
  • BagreAPJainKJainNKAlginate coated chitosan core shell nanoparticles for oral delivery of enoxaparin: in vitro and in vivo assessmentInt J Pharm20134561314023994363
  • ZhangYChanHFLeongKWAdvanced materials and processing for drug delivery: the past and the futureAdv Drug Deliv Rev201365110412023088863
  • Luangtana-ananMOpanasopitPNgawhirunpatTEffect of chitosan salts and molecular weight on a nanoparticulate carrier for therapeutic proteinPharm Dev Technol20051018919615926667
  • ChanHKKwokPCProduction methods for nanodrug particles using the bottom-up approachAdv Drug Deliv Rev20116340641621457742
  • HenninkWEvan NostrumCFNovel crosslinking methods to design hydrogelsAdv Drug Deliv Rev2002541133611755704
  • MaoSBakowskyUJintapattanakitAKisselTSelf-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulinJ Pharm Sci2006951035104816565978
  • KoJAParkHJHwangSJParkJBLeeJSPreparation and characterization of chitosan microparticles intended for controlled drug deliveryInt J Pharm200224916517412433445
  • VilaASánchezAJanesKLow molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in miceEur J Pharm Biopharm200457112313114729088
  • AmidiMRomeijnSGBorchardGJungingerHEHenninkWEJiskootWPreparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery systemJ Control Release20061111–210711616380189
  • AmidiMRomeijnSGVerhoefJCN-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse modelVaccine200725114415316973248
  • Ozbas-TuranSAkbugaJAralCControlled release of interleukin-2 from chitosan microspheresJ Pharm Sci2002911245125111977100
  • KizilayEKayitmazerABDubinPLComplexation and coacervation of polyelectrolytes with oppositely charged colloidsAdv Colloid Interface Sci20111671–2243721803318
  • BozkirASakaOMChitosan nanoparticles for plasmid DNA delivery: effect of chitosan molecular structure on formulation and release characteristicsDrug Deliv200411210711215200009
  • MoorenFCBertholdADomschkeWKreuterJInfluence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cell monolayersPharm Res199815158659487547
  • BasuSKKavithaKRupeshkumarMEvaluation of ketorolac tromethamine microspheres by chitosan/gelatin B complex coacervationSci Pharm201078799221179371
  • SarmentoBRibeiroAVeigaFFerreiraDDevelopment and characterization of new insulin containing polysaccharide nanoparticlesColloids Surf B Biointerfaces20065319320217049214
  • HuangMVitharanaSNPeekLJCoopTBerklandCPolyelectrolyte complexes stabilize and controllably release vascular endothelial growth factorBiomacromolecules200781607161417428030
  • LinYHChungCKChenCTLiangHFChenSCSungHWPreparation of nanoparticles composed of chitosan/poly-γ-glutamic acid and evaluation of their permeability through Caco-2 cellsBiomacromolecules200561104111215762683
  • Alonso-SandeMCunaMRemunan-LopezCFormation of new glucomannan–chitosan nanoparticles and study of their ability to associate and deliver proteinsMacromolecules20063941524158
  • BoddohiSMooreNJohnsonPAKipperMJPolysaccharide-based polyelectrolyte complex nanoparticles from chitosan, heparin, and hyaluronanBiomacromolecules2009101402140919371056
  • HuangMVitharanaSNPeekLJCoopTBerklandCPolyelectrolyte complexes stabilize and controllably release vascular endothelial growth factorBiomacromolecules200781607161417428030
  • ZhuSYQianFZhangYTangCYinCHSynthesis and characterization of PEG modified N-trimethylaminoethylmethacrylate chitosan nanoparticlesEur Polym J20074322442253
  • SchatzCBionazALucasJMFormation of polyelectrolyte complex particles from self-complexation of N-sulfated chitosanBiomacromolecules200561642164715877389
  • OrientiIAiedehKGianasiEBertasiVZecchiVIndomethacin loaded chitosan microspheres. Correlation between the erosion process and release kineticsJ Microencapsul1996134634728808782
  • BugamelliFRaggiMAOrientiIZecchiVControlled insulin release from chitosan microparticlesArch Pharm (Weinheim)19983311331389648521
  • JameelaSRKumaryTVLalAVJayakrishnanAProgesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery systemJ Control Release19985217249685932
  • AhmedTAEl-SayKMDevelopment of alginate-reinforced chitosan nanoparticles utilizing W/O nanoemulsification/internal crosslinking technique for transdermal delivery of rabeprazoleLife Sci2014110354324997393
  • WangLYGuYHZhouQZMaGHWanYHSuZGPreparation and characterization of uniform-sized chitosan microspheres containing insulin by membrane emulsification and a two-step solidification processColloids Surf B Biointerfaces20065012613516787743
  • WeiWYuanLHuGMonodisperse chitosan microspheres with interesting structures for protein drug deliveryAdv Mater20082022922296
  • TokumitsuHIchikawaHFukumoriYChitosan–gadopentetic acid complex nanoparticles for gadolinium neutron capture therapy of cancer: preparation by novel emulsion droplet coalescence technique and characterizationPharm Res199916121830183510644070
  • ChawlaATaylorKMGNewtonJMJohnsonMCRProduction of spray dried salbutamol sulphate for use in dry powder aerosol formulationsInt J Pharm1994108233240
  • GanderBWehrliEAlderRMerkleHPQuality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selectionJ Microencapsul19951283977730960
  • LeeHKParkJHKwonKCDouble-walled microparticles for single shot vaccineJ Control Release199744283293
  • BodmeierRChenHPreparation of biodegradable poly(±)-lactide microspheres using a spray-drying techniqueJ Pharm Pharmacol1988407547572907552
  • YangMVelagaSYamamotoHCharacterisation of salmon calcitonin in spray-dried powder for inhalation. Effect of chitosanInt J Pharm200733117618117126507
  • KusonwiriyawongCLipipunVVardhanabhutiNZhangQRitthidejGCSpray-dried chitosan microparticles for cellular delivery of an antigenic protein: physico-chemical properties and cellular uptake by dendritic cells and macrophagesPharm Res20133061677169723483441
  • HePDavisSSIllumLChitosan microspheres prepared by spray dryingInt J Pharm1999187536510502613
  • ShiXYTanTWPreparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of vitamin D-2Biomaterials2002234469447312322966
  • HarshaSNAldhubiabBENairABNanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesionDrug Des Devel Ther20159273282
  • ReverchonEDagheroJMarroneCMatteaMPolettoMSupercritical fractional extraction of fennel seed oil and essential oil: experiments and mathematical modelingInd Eng Chem Res19993830693075
  • AmidiMPellikaanHCde BoerAHCrommelinDJHenninkWEJiskootWPreparation and physicochemical characterization of supercritically dried insulin loaded microparticles for pulmonary deliveryEur J Pharm Biopharm200868219120017576056
  • de DiegoYPPellikaanHCWubboltsFEBorchardGWitkampGJJansensPJOpening new operating windows for polymer and protein micronization using the PCA processJ Supercrit Fluids200636216224
  • OkamotoHNishidaSTodoHSakakuraYIidaKDanjoKPulmonary gene delivery by chitosan–pDNA complex powder prepared by a supercritical carbon dioxide processJ Pharm Sci20039237138012532386
  • MeloEPAires-BarrosMRCabralJMReverse micelles and protein biotechnologyBiotechnol Annu Rev200178712911686050
  • KrishnaSAAmareshwarPPreparation of bovine serum albumin loaded chitosan nanoparticle using reverse micelle methodRes J Pharm Biol Chem Sci201123837846
  • MitraSGaurUGhoshPCMaitraANTumor targeted delivery of encapsulated dextran–doxorubicin conjugate using chitosan nanoparticles as carrierJ Control Release20017431732311489513
  • AgnihotriSAAminabhaviTMControlled release of clozapine through chitosan microparticles prepared by a novel methodJ Control Release20049624525915081216
  • GarudNGarudAPreparation and in-vitro evaluation of metformin microspheres using non-aqueous solvent evaporation techniqueTrop J Pharm Res2012114577583
  • Particle size distributions from sub-nanometer to millimeters Available from: http://www.malvern.com/en/products/measurement-type/particle-size/Accessed December 31, 2015
  • El-SayKMEl-HelwAMAhmedOAAHosnyKMAhmedTANovel controlled release of antihypertensive drug: preparation, in-vitro and in-vivo evaluationAfr J Pharm Pharmacol201372517441756
  • MerkusHGParticle Size Measurements: Fundamentals, Practice, QualityNew York, NYSpringer Science & Business Media200915
  • AhmedTAEl-SayKMMahmoudMFSamyAMBadawiAAMiconazole nitrate oral disintegrating tablets: in vivo performance and stability studyAAPS PharmSciTech201213376077122585373
  • MaZYeohHHLimLYFormulation pH modulates the interaction of insulin with chitosan nanoparticlesJ Pharm Sci20029161396140412115839
  • GazoriTKhoshayandMRAziziEYazdizadePNomaniAHaririanIEvaluation of alginate/chitosan nanoparticles as antisense delivery vector: formulation, optimization and in vitro characterizationCarbohydr Polym200977599606
  • CoverNFLai-YuenSParsonsAKKumarASynergetic effects of doxycycline-loaded chitosan nanoparticles for improving drug delivery and efficacyInt J Nanomedicine201272411241922811601
  • RodriguesSda CostaAMGrenhaAChitosan/carrageenan nanoparticles: effect of cross-linking with tripolyphosphate and charge ratiosCarbohydr Polym201289128228924750635
  • CasettariLCastagninoEStolnikSLewisAHowdleSMIllumLSurface characterisation of bioadhesive PLGA/chitosan microparticles produced by supercritical fluid technologyPharm Res20112871668168221394661
  • KimKKimJHParkHTumor-homing multifunctional nanoparticles for cancer theragnosis: simultaneous diagnosis, drug delivery, and therapeutic monitoringJ Control Release2010146221922720403397
  • NishimuraKNishimuraSNishiNAdjuvant activity of chitin derivatives in mice and guinea pigsVaccine198533793843936299
  • NishimuraKIshiharaCUkeiSTokuraSAzumaIStimulation of cytokine production in mice using deacetylated chitinVaccine198641511562429471
  • ZaharoffDARogersCJHanceKWSchlomJGreinerJWChitosan solution enhances the immunoadjuvant properties of GM-CSFVaccine2007258673868618037196
  • ZaharoffDARogersCJHanceKWSchlomJGreinerJWChitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccinationVaccine2007252085209417258843
  • ReadRCNaylorSCPotterCWEffective nasal influenza vaccine delivery using chitosanVaccine2005234367437415916838
  • NagamotoTHattoriYTakayamaKMaitaniYNovel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine deliveryPharm Res200421467167415139524
  • JaganathanKSVyasSPStrong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasallyVaccine200624194201421116446012
  • ZhaoHWuBWuHProtective immunity in rats by intranasal immunization with Streptococcus mutans glucan-binding protein D encapsulated into chitosan-coated poly(lactic-co-glycolic acid) microspheresBiotechnol Lett200628161299130416804764
  • AmidiMMastrobattistaEJiskootWHenninkWEChitosan-based delivery systems for protein therapeutics and antigensAdv Drug Deliv Rev2010621598219925837
  • JayakumarRChennazhiKPMuzzarelliRAATamuraHNairSVSelvamuruganNChitosan conjugated DNA nanoparticles in gene therapyCarbohydr Polym201079118
  • KatasHAlparHDevelopment and characterization of chitosan nanoparticles for siRNA deliveryJ Control Release2006115221622516959358
  • LiuXDChitosan-siRNA complex nanoparticles for gene silencingJ Biomed Engin201027197101
  • GaoSChenJXuXGalactosylated low molecular weight chitosan as DNA carrier for hepatocyte-targetingInt J Pharm2003255576812672602
  • Dautry-VarsatAReceptor-mediated endocytosis: the intracellular journey of transferrin and its receptorBiochimie1986683753812874839
  • LeeDLockeyRMohapatraSFolate receptor-mediated cancer cell specific gene delivery using folic acid-conjugated oligochitosansJ Nanosci Nanotechnol200662860286617048492
  • LavertuMMethotSTrankhanhNBuschmannMHigh efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylationBiomaterials200627274815482416725196
  • MansouriSCuieYWinnikFCharacterization of folate chitosan-DNA nanoparticles for gene therapyBiomaterials20062792060206516202449
  • YousefpourPAtyabiFVasheghani-FarahaniEMovahediAADinarvandRTargeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumabInt J Nanomedicine201161977199021976974
  • LinAChenJLiuYPreparation and evaluation of N-caproyl chitosan nanoparticles surface modified with glycyrrhizin for hepatocyte targetingDrug Dev Ind Pharm200935111348135519832635
  • KimJHKimYSParkKAntitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing miceJ Control Release20081271414918234388
  • MinKHParkKKimYSHydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapyJ Control Release2008127320821818336946
  • YaoQStudy on the Two-Ligand Modified Chitosan Nanoparticles Actively Targeting to Malignant Liver Cells [PhD thesis]Chengdu, People’s Republic of ChinaSichuan University. Doctoral Paper of Sichuan University2006 Available from: http://www.globethesis.com/?t=1104360185994553Accessed December 31, 2015
  • TabataYIkadaYMacrophage phagocytosis of biodegradable microspheres composed of L-lactic acid/glycolic acid homo- and copolymersJ Biomed Mater Res198822108378583220838
  • TiyaboonchaiWChitosan nanoparticles: a promising system for drug deliveryNaresuan Univ J20031135166
  • GuoSHuangLNanoparticles escaping RES and endosome: challenges for siRNA delivery for cancer therapyJ Nanomater2011201111221808638
  • OwensDIIIPeppasNOpsonization, biodistribution, and pharmacokinetics of polymeric nanoparticlesInt J Pharm200630719310216303268
  • PatelKShrimankerMDaveRModiHAnandJBhadaniSPreparation and in vivo study of doxorubicin HCl loaded chitosan nanoparticles prepared by W/O emulsion methodInt J Curr Res2012412438440
  • HuoMZhangYZhouJSynthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drugInt J Pharm20103941–216217320457237
  • AshfordMBiopharmaceutical principles of drug deliveryAultonMEPharmaceutics: The Science of Dosage Form Design2nd edNew York, NYChurchill Livingstone2001211253
  • ChangCHLinYHYehCLNanoparticles incorporated in pH-sensitive hydrogels as amoxicillin delivery for eradication of Helicobacter pyloriBiomacromolecules201011113314219924885
  • GisbertJPTorradoGTorradoSOlivaresDPajaresJMClinical trial evaluating amoxicillin and clarithromycin hydrogels (chitosan-polyacrylic acid polyionic complex) for H. pylori eradicationJ Clin Gastroenterol200640761862216917404
  • DhaliwalSJainSSinghHPTiwaryAKMucoadhesive microspheres for gastroretentive delivery of acyclovir: in vitro and in vivo evaluationAAPS J200810232233018523891
  • WeiWMaGHWangLYWuJSuZGHollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulinActa Biomater20106120520919505595
  • HejaziRAmijiMChitosan-based gastrointestinal delivery systemsJ Control Release20038915116512711440
  • VarshosazJJaffarian DehkordiAGolafshanSColon-specific delivery of mesalazine chitosan microspheresJ Microencapsul20062332933916801244
  • MladenovskaKRaickiRSJanevikEIColon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticlesInt J Pharm20073421–212413617590293
  • OosegiTOnishiHMachidaYNovel preparation of enteric-coated chitosan–prednisolone conjugate microspheres and in vitro evaluation of their potential as a colonic delivery systemEur J Pharm Biopharm20086826026617703928
  • JainSKJainAGuptaYAhirwarMDesign and development of hydrogel beads for targeted drug delivery to the colonAAPS PharmSciTech20078E5617915806
  • ElzatahryAAEldinMSMPreparation and characterization of metronidazole loaded chitosan nanoparticles for drug delivery applicationPolym Adv Technol20081917871791
  • KublikHVidgrenMTNasal delivery systems and their effect on deposition and absorptionAdv Drug Deliv Rev19982915717710837586
  • CostantinoHRIllumLBrandtGJohnsonPHQuaySCIntranasal delivery: physicochemical and therapeutic aspectsInt J Pharm200733712417475423
  • BaigAMKhanNANovel chemotherapeutic strategies in the management of primary amoebic meningoencephalitis due to Naegleria fowleriCNS Neurosci Ther201420328929024456292
  • McMartinCHutchinsonLEHydeRPetersGEAnalysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavityJ Pharm Sci1987765355402889824
  • VarshosazJSadraiHAlinagariRNasal delivery of insulin using chitosan microspheresJ Microencapsul20042176177415799226
  • Fernandez-UrrusunoRRomaniDCalvoPVila-JatoJLAlonsoMJDevelopment of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administrationSTP Pharma Sci19999429436
  • JiangHLKangMLQuanJSThe potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunizationBiomaterials200829121931193918221992
  • KangMLJiangHLKangSGPluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxinVaccine200725234602461017485148
  • HolmgrenJCzerkinskyCMucosal immunity and vaccinesNat Med2005114S45S5315812489
  • de la FuenteMRaviñaMPaolicelliPSanchezASeijoBAlonsoMJChitosan-based nanostructures: a delivery platform for ocular therapeuticsAdv Drug Deliv Rev201062110011719958805
  • De CamposAMSanchezAAlonsoMJChitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin AInt J Pharm20012241–215916811472825
  • WadhwaSPaliwalRPaliwalSRVyasSPHyaluronic acid modified chitosan nanoparticles for effective management of glaucoma: development, characterization, and evaluationJ Drug Target201018429230219943753
  • PurasGZarateJAcevesMLow molecular weight oligochitosans for non-viral retinal gene therapyEur J Pharm Biopharm201383213114023059418
  • KlausnerEAZhangZChapmanRLMultackRFVolinMVUltrapure chitosan oligomers as carriers for corneal gene transferBiomaterials20103171814182019879644
  • de la FuenteMSeijoBAlonsoMJBioadhesive hyaluronan-chitosan nanoparticles can transport genes across the ocular mucosa and transfect ocular tissueGene Ther200815966867618305575
  • GronebergDAWittCWagnerUChungKFFischerAFundamentals of pulmonary drug deliveryRespir Med20039738238712693798
  • PatilJSSarasijaSPulmonary drug delivery strategies: a concise, systematic reviewLung India2012291444922345913
  • EvansCMKooJSAirway mucus: the good, the bad, the stickyPharmacol Ther200912133234819059283
  • PalecandaAKobzikLReceptors for unopsonized particles: the role of alveolarmacrophages scavenger receptorsCurr Mol Med2001158959511899233
  • ChonoSTaninoTSekiTMorimotoKInfluence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomesJ Drug Target20061455756617043040
  • FerinJOberdorsterGSoderholmSCGeleinRPulmonary tissue access of ultrafine particlesJ Aerosol Med199145768
  • GrenhaARemunan-LopezCCarvalhoELSeijoBMicrospheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteinsEur J Pharm Biopharm2008691839318166446
  • SungJCPadillaDJGarcia-ContrerasLFormulation and pharmacokinetics of self-assembled rifampicin nanoparticle systems for pulmonary deliveryPharm Res20092681847185519407933
  • BharatwajBWuLWhittum-HudsonJAda RochaSRThe potential for the noninvasive delivery of polymeric nanocarriers using propellant-based inhalers in the treatment of Chlamydial respiratory infectionsBiomaterials201031287376738520615546
  • GrenhaAGraingerCIDaileyLAChitosan nanoparticles are compatible with respiratory epithelial cells in vitroEur J Pharm Sci2007312738417408932
  • HuangYCVieiraAHuangKLYehMKChiangCHPulmonary inflammation caused by chitosan microparticlesJ Biomed Mater Res A200575228328716059899
  • ChoiMChoMHanBSChitosan nanoparticles show rapid extrapulmonary tissue distribution and excretion with mild pulmonary inflammation to miceToxicol Lett2010199214415220816729
  • RodriguesSCordeiroCSeijoBRemunán-LópezCGrenhaAHybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: stability and toxicological evaluationCarbohydr Polym201512336938025843870
  • PaudelKSMilewskiMSwadleyCLBrogdenNKGhoshPStinchcombALChallenges and opportunities in dermal/transdermal deliveryTher Deliv2010110913121132122
  • BosJDMeinardiMMThe 500 Dalton rule for the skin penetration of chemical compounds and drugsExp Dermatol2000916516910839713
  • KimDGJeongYIChoiCRetinol-encapsulated low molecular water-soluble chitosan nanoparticlesInt J Pharm200631913013816713152
  • HasanovicAZehlMReznicekGValentaCChitosan-tripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stabilityJ Pharm Pharmacol2009611609161619958582
  • Ozbas-TuranSAkbugaJSezerADTopical application of antisense oligonucleotide-loaded chitosan nanoparticles to ratsOligonucleotides20102014715320180684
  • Ozbas-TuranSAkbugaJPlasmid DNA-loaded chitosan/TPP nanoparticles for topical gene deliveryDrug Deliv20111821522221226549
  • UsmanMSEl ZowalatyMEShameliKZainuddinNSalamaMIbrahimNASynthesis, characterization, and antimicrobial properties of copper nanoparticlesInt J Nanomedicine201384467447924293998
  • SanpuiPMurugadossADurga PrasadPVGhoshSSChattopadhyayaAThe antibacterial properties of a novel chitosan–Ag nanoparticle compositeInt J Food Microbiol200812414214618433906
  • HonarySGhajarKKhazaeliPShalchianPPreparation, characterization and antibacterial properties of silver-chitosan nanocomposites using different molecular weight grades of chitosanTrop J Pharm Res201110169
  • BhumkarDRJoshiHMSastryMPokharkarVBChitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulinPharm Res20072481415142617380266
  • SalehizadehHHekmatianESadeghiMKennedyKSynthesis and characterization of core-shell Fe3O4-gold-chitosan nanostructureJ Nanobiotechnology201210310.1186/1477-3155-10-322221555
  • QiLXuZJiangXHuCZouXPreparation and antibacterial activity of chitosan nanoparticlesCarbohydr Res2004339162693270015519328
  • TokarekKHuesoJLKuśtrowskiPStochelGKyziołAGreen synthesis of chitosan-stabilized copper nanoparticlesEur J Inorg Chem201320132849404947
  • ChattopadhyaySDashSKKar MahapatraSChitosan-modified cobalt oxide nanoparticles stimulate TNF-α-mediated apoptosis in human leukemic cellsJ Biol Inorg Chem201419339941424445996