Risk analysis of systemic levels of estrogen and adipokines as well as estrogen receptors from PBMCs in childbearing and perimenopausal women with obesity

References

• Chu DT , Minh Nguyet NT , Dinh TC , et al. An update on physical health and economic consequences of overweight and obesity. Diabetes Metab Syndr . 2018;12(6):1095–1100. doi:10.1016/j.dsx.2018.05.004 29799416
   PubMed Web of Science ®Google Scholar
• Lizcano F , Guzman G . Estrogen deficiency and the origin of obesity during menopause. Biomed Res Int . 2014;2014:757461. doi:10.1155/2014/757461 24734243
   PubMed Web of Science ®Google Scholar
• Ingelsson E , McCarthy MI . Human genetics of obesity and type 2 diabetes mellitus: past, present, and future. Circ Genom Precis Med . 2018;11(6):e002090. doi:10.1161/CIRCGEN.118.002090 29899044
   PubMed Web of Science ®Google Scholar
• Wong CM , Xu L , Yau MY . Alternative mRNA splicing in the pathogenesis of obesity. Int J Mol Sci . 2018;19:2. doi:10.3390/ijms19020632
   Web of Science ®Google Scholar
• Voss JD , Goodson MS , Leon JC . Phenotype diffusion and one health: a proposed framework for investigating the plurality of obesity epidemics across many species. Zoonoses Public Health . 2018;65(3):279–290. doi:10.1111/zph.12490 29430857
   PubMed Web of Science ®Google Scholar
• Moran-Ramos S , Lopez-Contreras BE , Canizales-Quinteros S . Gut microbiota in obesity and metabolic abnormalities: a matter of composition or functionality? Arch Med Res . 2017;48(8):735–753. doi:10.1016/j.arcmed.2017.11.003 29292011
   PubMed Web of Science ®Google Scholar
• Grantham JP , Henneberg M , Rosenfeld CS . The estrogen hypothesis of obesity. PLoS One . 2014;9(6):e99776. doi:10.1371/journal.pone.0099776 24915457
   PubMed Web of Science ®Google Scholar
• Flegal KM , Carroll MD , Ogden CL , Curtin LR . Prevalence and trends in obesity among US adults, 1999–2008. JAMA . 2010;303(3):235–241. doi:10.1001/jama.2009.2014 20071471
   PubMed Web of Science ®Google Scholar
• Oh KJ , Lee DS , Kim WK , Han BS , Lee SC , Bae KH . Metabolic adaptation in obesity and type II diabetes: myokines, adipokines and hepatokines. Int J Mol Sci . 2016;18(1):8. doi:10.3390/ijms18010008
   Web of Science ®Google Scholar
• Jung UJ , Choi MS . Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci . 2014;15(4):6184–6223. doi:10.3390/ijms15046184 24733068
   PubMed Web of Science ®Google Scholar
• Arnoldussen IA , Kiliaan AJ , Gustafson DR . Obesity and dementia: adipokines interact with the brain. Eur Neuropsychopharmacol . 2014;24(12):1982–1999. doi:10.1016/j.euroneuro.2014.03.002 24704273
   PubMed Web of Science ®Google Scholar
• Zhu L , Martinez MN , Emfinger CH , Palmisano BT , Stafford JM . Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity. Am J Physiol Endocrinol Metab . 2014;306(10):E1188–E1197. doi:10.1152/ajpendo.00579.2013 24691030
   PubMed Web of Science ®Google Scholar
• Liu S , Mauvais-Jarvis F . Minireview: estrogenic protection of beta-cell failure in metabolic diseases. Endocrinology . 2010;151(3):859–864. doi:10.1210/en.2010-0412 19966178
   PubMed Web of Science ®Google Scholar
• Park CJ , Zhao Z , Glidewell-Kenney C , et al. Genetic rescue of nonclassical ERalpha signaling normalizes energy balance in obese Eralpha-null mutant mice. J Clin Invest . 2011;121(2):604–612. doi:10.1172/JCI57873 21245576
   PubMed Web of Science ®Google Scholar
• Santos RS , Frank AP , Fatima LA , Palmer BF , Clegg DJ . Activation of estrogen receptor alpha induces beiging of adipocytes. Mol Metab . 2018. doi:10.1016/j.molmet.2018.09.002
   Web of Science ®Google Scholar
• Morselli E , Santos RS , Gao S , et al. Impact of estrogens and estrogen receptor-alpha in brain lipid metabolism. Am J Physiol Endocrinol Metab . 2018;315(1):E7–E14. doi:10.1152/ajpendo.00473.2017 29509437
   PubMed Web of Science ®Google Scholar
• Shi H , Kumar SP , Liu X . G protein-coupled estrogen receptor in energy homeostasis and obesity pathogenesis. Prog Mol Biol Transl Sci . 2013;114:193–250.23317786
   PubMed Web of Science ®Google Scholar
• Gonzalez-Granillo M , Savva C , Li X , et al. ERbeta activation in obesity improves whole body metabolism via adipose tissue function and enhanced mitochondria biogenesis. Mol Cell Endocrinol . 2019;479(5):147–158. doi:10.1016/j.mce.2018.10.007
   Web of Science ®Google Scholar
• Chen S , Asakawa T , Ding S , et al. Chaihu-Shugan-San administration ameliorates perimenopausal anxiety and depression in rats. PLoS One . 2013;8(8):e72428. doi:10.1371/journal.pone.0072428 24015243
   PubMed Web of Science ®Google Scholar
• Sharma G , Mauvais-Jarvis F , Prossnitz ER . Roles of G protein-coupled estrogen receptor GPER in metabolic regulation. J Steroid Biochem Mol Biol . 2018;176:31–37. doi:10.1016/j.jsbmb.2017.02.012 28223150
   PubMed Web of Science ®Google Scholar
• Pelekanou V , Kampa M , Kiagiadaki F , et al. Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERalpha36 and GPR30/GPER1. J Leukoc Biol . 2016;99(2):333–347. doi:10.1189/jlb.3A0914-430RR 26394816
   PubMed Web of Science ®Google Scholar
• Woods NF , Mitchell ES . Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women’s lives. Am J Med . 2005;118(Suppl 12B):14–24.16414323
   PubMedGoogle Scholar
• Chen C , Lu FC , Department of Disease Control Ministry of Health PRC. The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci . 2004;17:1–36.
   PubMed Web of Science ®Google Scholar
• Hiuge-Shimizu A , Kishida K , Funahashi T , et al. Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study). Ann Med . 2012;44(1):82–92. doi:10.3109/07853890.2010.526138 20964583
   PubMed Web of Science ®Google Scholar
• Zhang X , Chen Q , Chen B , Wang F , Chen XH . Herb formula ZhenRongDan balances sex hormones, modulates organ atrophy, and restores ERalpha and ERbeta expressions in ovariectomized rats. Evid Based Complement Alternat Med . 2018;2018:5896398. doi:10.1155/2018/9567061 30008786
   PubMed Web of Science ®Google Scholar
• Kural B , Deger O , Erem C , Balaban Yucesan F , Aliyazicioglu R , Barlak Y . Is the combined use of insulin resistance indices, including adipokines, more reliable in metabolic syndrome? Turk J Med Sci . 2014;44(6):1021–1028. doi:10.3906/sag-1310-90 25552156
   PubMed Web of Science ®Google Scholar
• Taşdemir E , Şermet A . The relationship between plasma adipsin, adiponectin, vaspin, visfatin, and leptin levels with glucose metabolism and diabetes parameters. diabetes . 2019;15:21.
   Google Scholar
• Mastorakos G , Valsamakis G , Papatheodorou DC , et al. The role of adipocytokines in insulin resistance in normal pregnancy: visfatin concentrations in early pregnancy predict insulin sensitivity. Clin Chem . 2007;53(8):1477–1483. doi:10.1373/clinchem.2007.085654 17586594
   PubMed Web of Science ®Google Scholar
• Plati E , Kouskouni E , Malamitsi-Puchner A , Boutsikou M , Kaparos G , Baka S . Visfatin and leptin levels in women with polycystic ovaries undergoing ovarian stimulation. Fertil Steril . 2010;94(4):1451–1456. doi:10.1016/j.fertnstert.2009.04.055 19523615
   PubMed Web of Science ®Google Scholar
• Garaulet M , Perez-Llamas F , Baraza JC , et al. Body fat distribution in pre-and post-menopausal women: metabolic and anthropometric variables. J Nutr Health Aging . 2002;6(2):123–126.12166365
   PubMedGoogle Scholar
• Toth MJ , Poehlman ET , Matthews DE , Tchernof A , MacCoss MJ . Effects of estradiol and progesterone on body composition, protein synthesis, and lipoprotein lipase in rats. Am J Physiol Endocrinol Metab . 2001;280(3):E496–501. doi:10.1152/ajpendo.2001.280.3.E496 11171605
   PubMed Web of Science ®Google Scholar
• Elbers JM , de Jong S , Teerlink T , Asscheman H , Seidell JC , Gooren LJ . Changes in fat cell size and in vitro lipolytic activity of abdominal and gluteal adipocytes after a one-year cross-sex hormone administration in transsexuals. Metabolism . 1999;48(11):1371–1377. doi:10.1016/S0026-0495(99)90146-4 10582544
   PubMed Web of Science ®Google Scholar
• Elbers JM , Asscheman H , Seidell JC , Gooren LJ . Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals. Am J Physiol . 1999;276(2 Pt 1):E317–E325.9950792
   PubMedGoogle Scholar
• Chedraui P , Perez-Lopez FR , Escobar GS , et al. Circulating leptin, resistin, adiponectin, visfatin, adipsin and ghrelin levels and insulin resistance in postmenopausal women with and without the metabolic syndrome. Maturitas . 2014;79(1):86–90. doi:10.1016/j.maturitas.2014.06.008 25015014
   PubMed Web of Science ®Google Scholar
• Arao Y , Hamilton KJ , Lierz SL , Korach KS . N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure. Mol Metab . 2018;18:68–78. doi:10.1016/j.molmet.2018.09.006
   Web of Science ®Google Scholar
• Lu Y , Lu X , Wang L , Yang W . Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor-alpha. Eur J Pharmacol . 2019;843(15):88–95. doi:10.1016/j.ejphar.2018.10.018
   Web of Science ®Google Scholar
• Leonetti D , Soleti R , Clere N , et al. Extract enriched in flavan-3-ols and mainly procyanidin dimers improves metabolic alterations in a mouse model of obesity-related disorders partially via estrogen receptor alpha. Front Pharmacol . 2018;9:406. doi:10.3389/fphar.2018.00406 29740325
   PubMed Web of Science ®Google Scholar
• Miao YF , Su W , Dai YB , et al. An ERbeta agonist induces browning of subcutaneous abdominal fat pad in obese female mice. Sci Rep . 2016;6:38579. doi:10.1038/srep38579 27922125
   PubMed Web of Science ®Google Scholar
• Ponnusamy S , Tran QT , Harvey I , et al. Pharmacologic activation of estrogen receptor beta increases mitochondrial function, energy expenditure, and brown adipose tissue. Faseb J . 2017;31(1):266–281. doi:10.1096/fj.201600787RR 27733447
   PubMed Web of Science ®Google Scholar