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Original Research

2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione isolated from Averrhoa carambola L. root ameliorates diabetic nephropathy by inhibiting the TLR4/MyD88/NF-κB pathway

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Pages 1355-1363 | Published online: 07 Aug 2019

References

  • Allison SJ. Acute kidney injury:Mechanism of AKI sensitivity in diabetic nephropathy. Nat Rev Nephrol . 2014;10(9):484.
  • Kawai T , Akira S . TLR signaling. Semin Immunol . 2007;19(1):24–32. doi:10.1016/j.smim.2006.12.004 17275323
  • Kawai T , Akira S . Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med . 2007;13(11):460–469. doi:10.1016/j.molmed.2007.09.002 18029230
  • Kaur H , Chien A , Jialal I . Hyperglycemia induces Toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy. Am J Physiol Renal Physiol . 2012;303(8):F1145–F1150. doi:10.1152/ajprenal.00319.2012 22874765
  • Zheng N , Lin X , Wen Q , et al. Effect of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L. (Oxalidaceae) roots, on advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice. Toxicol Lett . 2013;219(1):77–84. doi:10.1016/j.toxlet.2013.03.001 23500658
  • Wen Q , Lin X , Liu Y , et al. Phenolic and lignan glycosides from the butanol extract of Averrhoa carambola L. root. Molecules . 2012;17(10):12330–12340. doi:10.3390/molecules171012330 23085667
  • Zimmet PZ , Magliano DJ , Herman WH , Shaw JE . Diabetes: a 21st century challenge. Lancet Diabetes Endocrinol . 2014;2(1):56–64. doi:10.1016/S2213-8587(13)70112-8 24622669
  • Guariguata L , Whiting DR , Hambleton I , Beagley J , Linnenkamp U , Je S . Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract . 2014;103(2):137–149. doi:10.1016/j.diabres.2013.11.002 24630390
  • Bhalla V , Zhao B , Azar KM , et al. Racial/ethnic differences in the prevalence of proteinuric and nonproteinuric diabetic kidney disease. Diabetes Care . 2013;36(5):1215–1221. doi:10.2337/dc12-0951 23238659
  • Rivero A , Mora C , Muros M , Garcia J , Herrera H , Navarro-Gonzalez JF . Pathogenic perspectives for the role of inflammation in diabetic nephropathy. Clin Sci . 2009;116(6):479–492. doi:10.1042/CS20080394 19200057
  • Mora C , Navarro JF . Inflammation and diabetic nephropathy. Curr Diab Rep . 2006;6(6):463–468.17118230
  • Tuttle KR . Linking metabolism and immunology: diabetic nephropathy is an inflammatory disease. J Am Society Nephrol . 2005;16(6):1537–1538. doi:10.1681/ASN.2005040393
  • Navarro-Gonzalez JF , Mora-Fernandez C , Muros de Fuentes M , Garcia-Perez J. Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nature Rev Endocrinol . 2011;7(6):327–340. doi:10.1038/nrneph.2011.51
  • Lin M , Yiu WH , Wu HJ , et al. Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. J Am Society Nephrol . 2012;23(1):86–102. doi:10.1681/ASN.2010111210
  • Devaraj S , Tobias P , Jialal I . Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes. Cytokine . 2011;55(3):441–445. doi:10.1016/j.cyto.2011.03.023 21498084
  • Lin M , Yiu WH , Li RX , et al. The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy. Kidney Int . 2013;83(5):887–900. doi:10.1038/ki.2013.11 23423259
  • Kuwabara T , Mori K , Mukoyama M , et al. Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice. Diabetologia . 2012;55(8):2256–2266. doi:10.1007/s00125-012-2578-1 22610400
  • Feng Y , Yang S , Ma Y , Bai XY , Chen X . Role of Toll-like receptors in diabetic renal lesions in a miniature pig model. Sci Adv . 2015;1(5):e1400183. doi:10.1126/sciadv.1400183 26601192
  • Mukherjee S , Karmakar S , Babu SP . TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review. Braz J Infect Dis . 2016;20(2):193–204. doi:10.1016/j.bjid.2015.10.011 26775799
  • Brancato SK , Thomay AA , Daley JM , et al. Toll-like receptor 4 signaling regulates the acute local inflammatory response to injury and the fibrosis/neovascularization of sterile wounds. Wound Repair Regener . 2013;21(4):624–633. doi:10.1111/wrr.12061
  • Zeng KW , Zhang T , Fu H , Liu GX , Wang XM . Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-kappaB signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol . 2012;692(1–3):29–37. doi:10.1016/j.ejphar.2012.05.030 22698579
  • Ma J , Chadban SJ , Zhao CY , et al. TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy. PLoS One . 2014;9(5):e97985. doi:10.1371/journal.pone.0097985 24842252
  • Shi H , Kokoeva MV , Inouye K , Tzameli I , Yin H , Flier JS . TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest . 2006;116(11):3015–3025. doi:10.1172/JCI28898 17053832
  • Liu P , Li F , Qiu M , He L . Expression and cellular distribution of TLR4, MyD88, and NF-kappaB in diabetic renal tubulointerstitial fibrosis, in vitro and in vivo. Diabetes Res Clin Pract . 2014;105(2):206–216. doi:10.1016/j.diabres.2014.04.020 24894085
  • Cooper ME . Diabetes: treating diabetic nephropathy-still an unresolved issue. Nature Rev Endocrinol . 2012;8(9):515–516. doi:10.1038/nrendo.2012.125 22825399
  • Cazarolli LH , Kappel VD , Pereira DF , et al. Anti-hyperglycemic action of apigenin-6-C-beta-fucopyranoside from Averrhoa carambola. Fitoterapia . 2012;83(7):1176–1183. doi:10.1016/j.fitote.2012.07.003 22796400
  • Carolino RO , Beleboni RO , Pizzo AB , et al. Convulsant activity and neurochemical alterations induced by a fraction obtained from fruit Averrhoa carambola (Oxalidaceae: geraniales). Neurochem Int . 2005;46(7):523–531. doi:10.1016/j.neuint.2005.02.002 15843046
  • Xie Q , Zhang S , Chen C , et al. Protective Effect of 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione, isolated from averrhoa carambola L., Against palmitic acid-induced inflammation and apoptosis in Min6 cells by inhibiting the TLR4-MyD88-NF-kappaB Signaling Pathway. Cell Physiol Biochem . 2016;39(5):1705–1715. doi:10.1159/000447871 27643515
  • Li J , Wei X , Xie Q , et al. Protective Effects of 2-dodecyl-6-methoxycyclohexa-2,5 -diene-1,4-dione isolated from Averrhoa Carambola L. (Oxalidaceae) roots on high-fat diet-induced obesity and insulin resistance in Mice. Cell Physiol Biochem . 2016;40(5):993–1004. doi:10.1159/000453156 27941348