254
Views
18
CrossRef citations to date
0
Altmetric
Original Research

Exosomes from β-cells alleviated hyperglycemia and enhanced angiogenesis in islets of streptozotocin-induced diabetic mice

, , , ORCID Icon &
Pages 2053-2064 | Published online: 08 Oct 2019

References

  • International Diabetes Federation. IDF Diabetes Atlas . 8th ed. 2017.
  • Bannier K , Lichtenauer M , Franz M , et al. Impact of diabetes mellitus and its complications: survival and quality-of-life in critically ill patients. J Diabetes Complications . 2015;29(8):1130–1135. doi:10.1016/j.jdiacomp.2015.08.010 26361811
  • Wang L , Gao P , Zhang M , et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA . 2017;317(24):2515–2523. doi:10.1001/jama.2017.7596 28655017
  • Chen C , Cohrs CM , Stertmann J , Bozsak R , Speier S . Human beta cell mass and function in diabetes: recent advances in knowledge and technologies to understand disease pathogenesis. Mol Metab . 2017;6(9):943–957. doi:10.1016/j.molmet.2017.06.019 28951820
  • Accili D , Ahren B , Boitard C , Cerasi E , Henquin JC , Seino S . What ails the beta-cell? Diabetes Obes Metab . 2010;12(Suppl 2):1–3. doi:10.1111/j.1463-1326.2010.01296.x
  • Meier JJ , Breuer TG , Bonadonna RC , et al. Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans. Diabetologia . 2012;55(5):1346–1354. doi:10.1007/s00125-012-2466-8 22286529
  • Talchai C , Xuan S , Lin HV , Sussel L , Accili D . Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell . 2012;150(6):1223–1234. doi:10.1016/j.cell.2012.07.029 22980982
  • Accili D , Talchai SC , Kim-Muller JY , et al. When beta-cells fail: lessons from dedifferentiation. Diabetes Obes Metab . 2016;18(Suppl 1):117–122. doi:10.1111/dom.12723 27615140
  • Shapiro AM , Lakey JR , Ryan EA , et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med . 2000;343(4):230–238. doi:10.1056/NEJM200007273430401 10911004
  • Bellin MD , Barton FB , Heitman A , et al. Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes. Am J Transplant . 2012;12(6):1576–1583. doi:10.1111/j.1600-6143.2011.03977.x 22494609
  • Khosravi-Maharlooei M , Hajizadeh-Saffar E , Tahamtani Y , et al. Therapy Of Endocrine Disease: islet transplantation for type 1 diabetes: so close and yet so far away. Eur J Endocrinol . 2015;173(5):R165–R183. doi:10.1530/EJE-15-0094 26036437
  • Vendrame F , Hopfner YY , Diamantopoulos S , et al. Risk factors for type 1 diabetes recurrence in immunosuppressed recipients of simultaneous pancreas-kidney transplants. Am J Transplant . 2016;16(1):235–245. doi:10.1111/ajt.13426 26317167
  • Lakkaraju A , Rodriguez-Boulan E . Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol . 2008;18(5):199–209. doi:10.1016/j.tcb.2008.03.002 18396047
  • Colombo M , Raposo G , Thery C . Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol . 2014;30:255–289. doi:10.1146/annurev-cellbio-101512-122326 25288114
  • Valadi H , Ekstrom K , Bossios A , Sjostrand M , Lee JJ , Lotvall JO . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol . 2007;9(6):654–659. doi:10.1038/ncb1596 17486113
  • Zhang J , Guan J , Niu X , et al. Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J Transl Med . 2015;13:49. doi:10.1186/s12967-015-0417-0 25638205
  • Record M , Carayon K , Poirot M , Silvente-Poirot S . Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochim Biophys Acta . 2014;1841(1):108–120. doi:10.1016/j.bbalip.2013.10.004 24140720
  • Osier N , Motamedi V , Edwards K , et al. Exosomes in acquired neurological disorders: new insights into pathophysiology and treatment. Mol Neurobiol . 2018;55(12):9280–9293. doi:10.1007/s12035-018-1054-4 29663285
  • Zhang S , Eitan E , Wu TY , Mattson MP . Intercellular transfer of pathogenic alpha-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal. Neurobiol Aging . 2018;61:52–65. doi:10.1016/j.neurobiolaging.2017.09.016 29035751
  • Nakamura Y , Miyaki S , Ishitobi H , et al. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Lett . 2015;589(11):1257–1265. doi:10.1016/j.febslet.2015.03.031 25862500
  • Sahoo S , Losordo DW . Exosomes and cardiac repair after myocardial infarction. Circ Res . 2014;114(2):333–344. doi:10.1161/CIRCRESAHA.114.300639 24436429
  • Deng S , Zhou X , Ge Z , et al. Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization. Int J Biochem Cell Biol . 2019;114:105564. doi:10.1016/j.biocel.2019.105564 31276786
  • Jiang ZZ , Liu YM , Niu X , et al. Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats. Stem Cell Res Ther . 2016;7:24. doi:10.1186/s13287-016-0287-2 26852014
  • Luo Y , He F , Hu L , et al. Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic beta-cells. PLoS One . 2014;9(6):e99049. doi:10.1371/journal.pone.0099049 24897113
  • Thery C , Amigorena S , Raposo G , Clayton A . Isolation and characterization of exosomes from cell culture supernatants and biological fluids Current Protocols in Cell Biology. John Wiley and Sons;2006:3.22.1-3.22.29.
  • Lobb RJ , Becker M , Wen SW , et al. Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles . 2015;4:27031. doi:10.3402/jev.v4.27031 26194179
  • Ronnebaum SM , Ilkayeva O , Burgess SC , et al. A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem . 2006;281(41):30593–30602. doi:10.1074/jbc.M511908200 16912049
  • Zhao T , Luo D , Sun Y , et al. Human urine-derived stem cells play a novel role in the treatment of STZ-induced diabetic mice. J Mol Histol . 2018;49(4):419–428. doi:10.1007/s10735-018-9772-5 29675567
  • Su D , Zhang N , He J , et al. Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis. Diabetes . 2007;56(9):2274–2283. doi:10.2337/db07-0371 17596403
  • van der Pol E , Coumans FA , Grootemaat AE , et al. Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J Thromb Haemost . 2014;12(7):1182–1192. doi:10.1111/jth.12602 24818656
  • Hayashi K , Kojima R , Ito M . Strain differences in the diabetogenic activity of streptozotocin in mice. Biol Pharm Bull . 2006;29(6):1110–1119. doi:10.1248/bpb.29.1110 16755002
  • Chandirasegaran G , Elanchezhiyan C , Ghosh K , Sethupathy S . Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats. Biomed Pharmacother . 2017;95:175–185. doi:10.1016/j.biopha.2017.08.040 28843149
  • Calderon B , Suri A , Pan XO , Mills JC , Unanue ER . IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes. J Immunol . 2008;181(10):6964–6974. doi:10.4049/jimmunol.181.10.6964 18981116
  • Altevogt P , Bretz NP , Ridinger J , Utikal J , Umansky V . Novel insights into exosome-induced, tumor-associated inflammation and immunomodulation. Semin Cancer Biol . 2014;28:51–57. doi:10.1016/j.semcancer.2014.04.008 24769223
  • Chaput N , Thery C . Exosomes: immune properties and potential clinical implementations. Semin Immunopathol . 2011;33(5):419–440.21174094
  • Alexander M , Hu R , Runtsch MC , et al. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nat Commun . 2015;6:7321. doi:10.1038/ncomms8321 26084661
  • Danesh A , Inglis HC , Jackman RP , et al. Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro. Blood . 2014;123(5):687–696. doi:10.1182/blood-2013-10-530469 24335232
  • Deng ZB , Poliakov A , Hardy RW , et al. Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Diabetes . 2009;58(11):2498–2505. doi:10.2337/db09-0216 19675137
  • Aswad H , Forterre A , Wiklander OP , et al. Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice. Diabetologia . 2014;57(10):2155–2164. doi:10.1007/s00125-014-3337-2 25073444
  • Jalabert A , Vial G , Guay C , et al. Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice. Diabetologia . 2016;59(5):1049–1058. doi:10.1007/s00125-016-3882-y 26852333
  • Chen W , Huang Y , Han J , et al. Immunomodulatory effects of mesenchymal stromal cells-derived exosome. Immunol Res . 2016;64(4):831–840. doi:10.1007/s12026-016-8798-6 27115513
  • El-Shemi AG , Kensara OA , Alsaegh A , Mukhtar MH . Pharmacotherapy with thymoquinone improved pancreatic beta-cell integrity and functional activity, enhanced islets revascularization, and alleviated metabolic and hepato-renal disturbances in streptozotocin-induced diabetes in rats. Pharmacology . 2018;101(1–2):9–21. doi:10.1159/000480018 28926842
  • Watanabe H , Sumi S , Urushihata T , et al. Immunohistochemical studies on vascular endothelial growth factor and platelet endothelial cell adhesion molecule-1/CD-31 in islet transplantation. Pancreas . 2000;21(2):165–173. doi:10.1097/00006676-200008000-00010 10975711
  • Narang AS , Cheng K , Henry J , et al. Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets. Pharm Res . 2004;21(1):15–25. doi:10.1023/B:PHAM.0000012147.52900.b8 14984253
  • Shabbir A , Cox A , Rodriguez-Menocal L , Salgado M , Van Badiavas E . Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro. Stem Cells Dev . 2015;24(14):1635–1647. doi:10.1089/scd.2014.0316 25867197
  • Venkat P , Chopp M , Cell-Based CJ . Exosome therapy in diabetic stroke. Stem Cells Transl Med . 2018;7(6):451–455. doi:10.1002/sctm.18-0014 29498242
  • Ribeiro-Rodrigues TM , Laundos TL , Pereira-Carvalho R , et al. Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. Cardiovasc Res . 2017;113(11):1338–1350. doi:10.1093/cvr/cvx118 28859292
  • Nakashima K , Kanda Y , Hirokawa Y , Kawasaki F , Matsuki M , Kaku K . MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones. Endocr J . 2009;56(1):45–53. doi:10.1507/endocrj.K08E-172 18845907
  • Yang S , Li X , Wang N , et al. GPR109A expression in the murine min6 pancreatic beta cell line, and its relation with glucose metabolism and inflammation. Ann Clin Lab Sci . 2015;45(3):315–322.26116596