Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA

References

• Knouff C , Auwerx J . Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology. Endocr Rev . 2004;25:899–918. doi:10.1210/er.2003-0036 15583022
   PubMed Web of Science ®Google Scholar
• Lehrke M , Lazar MA . The many faces of PPARgamma. Cell . 2005;123:993–999. doi:10.1016/j.cell.2005.11.026 16360030
   PubMed Web of Science ®Google Scholar
• Kamble PG , Gustafsson S , Pereira MJ , et al. Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers. Ups J Med Sci . 2017;122:234–242. doi:10.1080/03009734.2017.1405127 29303622
   PubMed Web of Science ®Google Scholar
• Deeb SS , Fajas L , Nemoto M , et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet . 1998;20:284–287. doi:10.1038/3099 9806549
   PubMed Web of Science ®Google Scholar
• Gouda HN , Sagoo GS , Harding AH , Yates J , Sandhu MS , Higgins JP . The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am J Epidemiol . 2010;171:645–655. doi:10.1093/aje/kwp450 20179158
   PubMed Web of Science ®Google Scholar
• Masud S , Ye S , Group SAS . Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis. J Med Genet . 2003;40:773–780. doi:10.1136/jmg.40.10.773 14569127
   PubMed Web of Science ®Google Scholar
• Heikkinen S , Argmann C , Feige JN , et al. The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface. Cell Metab . 2009;9:88–98. doi:10.1016/j.cmet.2008.11.007 19117549
   PubMed Web of Science ®Google Scholar
• Luan J , Browne PO , Harding AH , et al. Evidence for gene-nutrient interaction at the PPARgamma locus. Diabetes . 2001;50:686–689. doi:10.2337/diabetes.50.3.686 11246892
   PubMed Web of Science ®Google Scholar
• Pihlajamaki J , Schwab U , Kaminska D , et al. Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial. Genes Nutr . 2015;10:43. doi:10.1007/s12263-015-0493-z 26446033
   PubMed Web of Science ®Google Scholar
• Samane S , Christon R , Dombrowski L , et al. Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity. Metabolism . 2009;58:909–919. doi:10.1016/j.metabol.2009.02.013 19394055
   PubMed Web of Science ®Google Scholar
• de Luis D , Domingo JC , Izaola O , Casanueva FF , Bellido D , Sajoux I . Effect of DHA supplementation in a very low-calorie ketogenic diet in the treatment of obesity: a randomized clinical trial. Endocrine . 2016;54:111–122. doi:10.1007/s12020-016-0964-z 27117144
   PubMed Web of Science ®Google Scholar
• Munro IA , Garg ML . Prior supplementation with long chain omega-3 polyunsaturated fatty acids promotes weight loss in obese adults: a double-blinded randomised controlled trial. Food Funct . 2013;4:650–658. doi:10.1039/c3fo60038f 23396496
   PubMed Web of Science ®Google Scholar
• Hegele RA , Cao H , Harris SB , Zinman B , Hanley AJ , Anderson CM . Peroxisome proliferator-activated receptor-gamma2 P12A and type 2 diabetes in Canadian Oji-Cree. J Clin Endocrinol Metab . 2000;85:2014–2019. doi:10.1210/jcem.85.5.6610 10843190
   PubMed Web of Science ®Google Scholar
• Li S , Chen W , Srinivasan SR , Boerwinkle E , Berenson GS ; S. Bogalusa Heart. The peroxisome proliferator-activated receptor-gamma2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: the Bogalusa Heart Study. Diabetes . 2003;52:1265–1269. doi:10.2337/diabetes.52.5.1265 12716762
   PubMed Web of Science ®Google Scholar
• Ludovico O , Pellegrini F , Di Paola R , et al. Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk. Obesity (Silver Spring) . 2007;15:1076–1081. doi:10.1038/oby.2007.617 17495182
   PubMed Web of Science ®Google Scholar
• Florez JC , Jablonski KA , Sun MW , et al; Diabetes Prevention Program Research. Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. J Clin Endocrinol Metab . 2007;92:1502–1509. doi:10.1210/jc.2006-2275 17213274
   PubMed Web of Science ®Google Scholar
• Patel SD , Rajala MW , Rossetti L , Scherer PE , Shapiro L . Disulfide-dependent multimeric assembly of resistin family hormones. Science . 2004;304:1154–1158. doi:10.1126/science.1093466 15155948
   PubMed Web of Science ®Google Scholar
• Rajala MW , Qi Y , Patel HR , et al. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes . 2004;53:1671–1679. doi:10.2337/diabetes.53.7.1671 15220189
   PubMed Web of Science ®Google Scholar
• Tontonoz P , Spiegelman BM . Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem . 2008;77:289–312. doi:10.1146/annurev.biochem.77.061307.091829 18518822
   PubMed Web of Science ®Google Scholar
• Astapova O , Leff T . Adiponectin and PPARgamma: cooperative and interdependent actions of two key regulators of metabolism. Vitam Horm . 2012;90:143–162. doi:10.1016/B978-0-12-398313-8.00006-3 23017715
   PubMed Web of Science ®Google Scholar
• Aguayo-Armendariz J , Montalvo-Corral M , Gonzalez-Martinez KA , et al. Central obesity and body fat, but not body mass index, are associated with the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma gene in a population with a high consumption of saturated and trans-fatty acids. Nutr Res . 2018;57:28–35. doi:10.1016/j.nutres.2018.05.003 30122193
   PubMed Web of Science ®Google Scholar
• Rodrigues APS , Rosa LPS , Silveira EA . PPARG2 Pro12Ala polymorphism influences body composition changes in severely obese patients consuming extra virgin olive oil: a randomized clinical trial. Nutr Metab (Lond) . 2018;15:52. doi:10.1186/s12986-018-0289-4 30026785
   PubMed Web of Science ®Google Scholar