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Original Research

Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model

ORCID Icon, , ORCID Icon &
Pages 1953-1962 | Published online: 01 Oct 2019

References

  • Giorda C , Forlani G , Manti R , et al. Occurrence over time and regression of nonalcoholic fatty liver disease in type 2 diabetes. Diabetes Metab Res Rev . 2017;33(4):e2878. doi:10.1002/dmrr.2878
  • Younossi ZM , Koenig AB , Abdelatif D , Fazel Y , Henry L , Wymer M . Global epidemiology of nonalcoholic fatty liver disease – meta‐analytic assessment of prevalence, incidence, and outcomes. Hepatology . 2016;64(1):73–84. doi:10.1002/hep.28431 26707365
  • Saponaro C , Gaggini M , Gastaldelli A . Nonalcoholic fatty liver disease and type 2 diabetes: common pathophysiologic mechanisms. Curr Diab Rep . 2015;15(6):34. doi:10.1007/s11892-015-0607-4
  • Kleiner DE , Brunt EM , Van Natta M , et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology . 2005;41(6):1313–1321. doi:10.1002/hep.20701 15915461
  • Liver E.A.f.S.o. Easl-aleh clinical practice guidelines: non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol . 2015;63(1):237.25911335
  • Jung UJ , Choi M-S . Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci . 2014;15(4):6184–6223. doi:10.3390/ijms15046184 24733068
  • Diraison F , Moulin P , Beylot M . Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab . 2003;29(5):478–485.14631324
  • Softic S , Cohen DE , Kahn CR . Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Dig Dis Sci . 2016;61(5):1282–1293. doi:10.1007/s10620-016-4054-0 26856717
  • Labrie M , Lalonde S , Najyb O , et al. Apolipoprotein D transgenic mice develop hepatic steatosis through activation of PPARγ and fatty acid uptake. PLoS One . 2015;10(6):e0130230.26083030
  • Angulo P , Kleiner DE , Dam-Larsen S , et al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology . 2015;149(2):389–97. e10. doi:10.1053/j.gastro.2015.04.043 25935633
  • Imajo K , Kessoku T , Honda Y , et al. Magnetic resonance imaging more accurately classifies steatosis and fibrosis in patients with nonalcoholic fatty liver disease than transient elastography. Gastroenterology . 2016;150(3):626–37.e7. doi:10.1053/j.gastro.2015.11.048 26677985
  • Fabbrini E , Mohammed BS , Magkos F , Korenblat KM , Patterson BW , Klein S . Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology . 2008;134(2):424–431. doi:10.1053/j.gastro.2007.11.038 18242210
  • Mazzotti A , Caletti MT , Marchignoli F , Forlani G , Marchesini G . Which treatment for type 2 diabetes associated with non-alcoholic fatty liver disease? Digestive Liver Dis . 2017;49(3):235–240. doi:10.1016/j.dld.2016.12.028
  • Kunkel SD , Elmore CJ , Bongers KS , et al. Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS One . 2012;7(6):e39332. doi:10.1371/journal.pone.0039332 22745735
  • Gamede M , Mabuza L , Ngubane P , Khathi A . The effects of plant-derived oleanolic acid on selected parameters of glucose homeostasis in a diet-induced pre-diabetic rat model. Molecules . 2018;23(4):794. doi:10.3390/molecules23040794
  • Gamede M , Mabuza L , Ngubane P , Khathi A . Plant-derived oleanolic acid (oa) ameliorates risk factors of cardiovascular diseases in a diet-induced pre-diabetic rat model: effects on selected cardiovascular risk factors. Molecules . 2019;24(2):340. doi:10.3390/molecules24020340
  • Mabuza L , Gamede M , Maikoo S , Booysen I , Ngubane P , Khathi A . Effects of a ruthenium schiff base complex on glucose homeostasis in diet-induced pre-diabetic rats. Molecules . 2018;23(7):1721. doi:10.3390/molecules23071721
  • Luvuno M , Khathi A , Mabandla M . Voluntary ingestion of a high-fat high-carbohydrate diet: a model for prediabetes. Ponte Int Sci Res J . 2018;74(5):119–143.
  • Mzimela NC , Ngubane PS , Khathi A . The changes in immune cell concentration during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat model. Autoimmunity . 2019;52(1):1–10.30835561
  • Lu Z-Y , Shao Z , Li Y-L , Wulasihan M , Chen X-H . Prevalence of and risk factors for non-alcoholic fatty liver disease in a chinese population: an 8-year follow-up study. World J Gastroenterol . 2016;22(13):3663. doi:10.3748/wjg.v22.i37.8314 27053858
  • Kohli R , Sunduram S , Mouzaki M , et al. Pediatric nonalcoholic fatty liver disease: a report from the expert committee on nonalcoholic fatty liver disease (econ). J Pediatr . 2016;172:9–13. doi:10.1016/j.jpeds.2015.12.016 26749112
  • Romero-Gómez M , Zelber-Sagi S , Trenell M . Treatment of NAFLD with diet, physical activity and exercise. J Hepatol . 2017;67(4):829–846. doi:10.1016/j.jhep.2017.05.016 28545937
  • Asgharpour A , Cazanave SC , Pacana T , et al. A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. J Hepatol . 2016;65(3):579–588. doi:10.1016/j.jhep.2016.05.005 27261415
  • Fernández-Real JM , McClain D , Manco M . Mechanisms linking glucose homeostasis and iron metabolism toward the onset and progression of type 2 diabetes. Diabetes Care . 2015;38(11):2169–2176. doi:10.2337/dc14-3082 26494808
  • Mazza A , Fruci B , Garinis GA , Giuliano S , Malaguarnera R , Belfiore A . The role of metformin in the management of NAFLD. Exp Diabetes Res . 2011;(2012)1–14.
  • Sullivan S . Implications of diet on nonalcoholic fatty liver disease. Curr Opin Gastroenterol . 2010;26(2):160. doi:10.1097/MOG.0b013e3283358a58 20010099
  • Angulo P . Obesity and nonalcoholic fatty liver disease. Nutr Rev . 2007;65:S57–S63. doi:10.1111/j.1753-4887.2007.tb00329.x 17605315
  • Brunt EM , Wong VW-S , Nobili V , et al. Nonalcoholic fatty liver disease. Nature Rev Dis Primers . 2015;1:15080. doi:10.1038/nrdp.2015.80 27188459
  • Marino L , Jornayvaz FR . Endocrine causes of nonalcoholic fatty liver disease. World J Gastroenterol . 2015;21(39):11053.26494962
  • Granér M , Nyman K , Siren R , et al. Ectopic fat depots and left ventricular function in nondiabetic men with nonalcoholic fatty liver diseaseclinical perspective. Circulation . 2015;8(1):e001979.25550397
  • Heilbronn L , Smith S , Ravussin E . Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type ii diabetes mellitus. Int J Obes . 2004;28(S4):S12.
  • Hannah WN , Harrison SA . Lifestyle and dietary interventions in the management of nonalcoholic fatty liver disease. Dig Dis Sci . 2016;61(5):1365–1374.27052013
  • Kumar S , Kelly AS . Review of childhood obesity: from epidemiology, etiology, and comorbidities to clinical assessment and treatment. Mayo Clinic Proceedings; 2017;92(2):251–265
  • Cali AM , Zern TL , Taksali SE , et al. Intrahepatic fat accumulation and alterations in lipoprotein composition in obese adolescents: a perfect pro-atherogenic state. Diabetes Care . 2007.30(12):3093–3098
  • Huang C-Z , Tung Y-T , Hsia S-M , Wu C-H , Yen G-C . The hepatoprotective effect of phyllanthus emblica l. Fruit on high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in SD rats. Food Funct . 2017;8(2):842–850.28128372
  • Shimabukuro M . Leptin resistance and lipolysis of white adipose tissue: an implication to ectopic fat disposition and its consequences. J Atheroscler Thromb . 2017;24(11):1088–1089.28781341
  • Ngubane PS , Masola B , Musabayane CT . The effects of syzygium aromaticum-derived oleanolic acid on glycogenic enzymes in streptozotocin-induced diabetic rats. Ren Fail . 2011;33(4):434–439.21529273
  • Woo S-L , Xu H , Li H , et al. Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity. PLoS One . 2014;9(3):e91111.24638078
  • Yang L , Miura K , Zhang B , et al. Trif differentially regulates hepatic steatosis and inflammation/fibrosis in mice. Cell Mol Gastroenterol Hepatol . 2017;3(3):469–483.28462384
  • Kawano Y , Cohen DE . Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol . 2013;48(4):434–441.23397118
  • Ashraf N , Sheikh T . Endoplasmic reticulum stress and oxidative stress in the pathogenesis of non-alcoholic fatty liver disease. Free Radic Res . 2015;49(12):1405–1418.26223319
  • Ferre P , Foufelle F . Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP‐1c. Diabetes Obesity Metab . 2010;12:83–92.
  • Mota M , Banini BA , Cazanave SC , Sanyal AJ . Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. Metabolism . 2016;65(8):1049–1061.26997538
  • Wang X , Liu R , Zhang W , et al. Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects. Mol Cell Endocrinol . 2013;376(1–2):70–80.23791844
  • Morigny P , Houssier M , Mouisel E , Langin D . Adipocyte lipolysis and insulin resistance. Biochimie . 2016;125:259–266.26542285
  • de Melo CL , Queiroz MGR , Fonseca SG , et al. Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. Chem Biol Interact . 2010;185(1):59–65.20188082
  • Wang X , Li YL , Wu H , et al. Antidiabetic effect of oleanolic acid: a promising use of a traditional pharmacological agent. Phytother Res . 2011;25(7):1031–1040.21254272
  • Ou-Yang Q , Xuan C-X , Wang X , et al. 3-acetyl-oleanolic acid ameliorates non-alcoholic fatty liver disease in high fat diet-treated rats by activating ampk-related pathways. Acta Pharmacol Sin . 2018.39(8):1284–1293.
  • Hauck AK , Bernlohr DA . Oxidative stress and lipotoxicity. J Lipid Res . 2016;57(11):1976–1986.27009116
  • Law BA , Liao X , Moore KS , et al. Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes. Faseb J . 2018;32(3):1403–1416.29127192
  • Machado MV , Diehl AM . Pathogenesis of nonalcoholic steatohepatitis. Gastroenterology . 2016;150(8):1769–1777.26928243
  • Houldsworth A , Hodgkinson A , Demaine A , Millward A . Catalase polymorphism may influence the pathogenesis of diabetes mellitus. J Endocrinol Diab . 2016;3(1):1–7.
  • Marseglia L , Manti S , D’Angelo G , et al. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci . 2015;16(1):378–400.
  • Pijls KE , Jonkers A , Daisy M , et al. Is intestinal oxidative stress involved in patients with compensated liver cirrhosis? Ann Hepatol . 2016;15(3):402–409.
  • Faria A , Persaud SJ . Cardiac oxidative stress in diabetes: mechanisms and therapeutic potential. Pharmacol Ther . 2017;172:50–62.27916650
  • Yi J , Xia W , Wu J , et al. Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice. J Vet Sci . 2014;15(1):141–148.24378582
  • Kwak M-S , Kim D , Chung GE , et al. Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease. Clin Mol Hepatol . 2012;18(4):383.23323254
  • Dani C , Poggi C , Pratesi S . Bilirubin and oxidative stress in term and preterm infants. Free Radic Res . 2019;53(1):2–7.29768941
  • Hjelkrem M , Morales A , Williams C , Harrison S . Unconjugated hyperbilirubinemia is inversely associated with non‐alcoholic steatohepatitis (nash). Aliment Pharmacol Ther . 2012;35(12):1416–1423.22540836
  • Tian J , Zhong R , Liu C , et al. Association between bilirubin and risk of non-alcoholic fatty liver disease based on a prospective cohort study. Sci Rep . 2016;6:31006.27484402
  • Kim S-M , Grenert JP , Patterson C , Correia MA . Chip−/−-mouse liver: adiponectin-ampk-foxo-activation overrides cyp2e1-elicited jnk1-activation, delaying onset of nash: therapeutic implications. Sci Rep . 2016;6:29423.27406999
  • Liu W , Baker SS , Baker R. D , Zhu L . Antioxidant mechanisms in nonalcoholic fatty liver disease. Curr Drug Targets . 2015;16(12):1301–1314.25915484
  • Koneru M , Sahu BD , Kumar JM , et al. Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (mmps) and oxidative stress. J Funct Foods . 2016;22:588–601.
  • Dowman JK , Tomlinson J , Newsome P . Systematic review: the diagnosis and staging of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis. Aliment Pharmacol Ther . 2011;33(5):525–540.21198708
  • Ameer F , Scandiuzzi L , Hasnain S , Kalbacher H , Zaidi N . De novo lipogenesis in health and disease. Metabolism . 2014;63(7):895–902.24814684
  • Caldwell SH , Argo CK , Al-Osaimi AM . Therapy of nafld: insulin sensitizing agents. J Clin Gastroenterol . 2006;40:S61–S66.
  • Li Y , Liu L , Wang B , Wang J , Chen D . Metformin in non-alcoholic fatty liver disease: a systematic review and meta‑analysis. Biomed Rep . 2013;1(1):57–64.24648894