The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance

References

• Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus–present and future perspectives. Nat Rev Endocrinol. 2011;8(4):228–236. doi:10.1038/nrendo.2011.183
   PubMed Web of Science ®Google Scholar
• Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115(5):1111–1119. doi:10.1172/JCI25102
   PubMed Web of Science ®Google Scholar
• Lee BC, Lee J. Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta. 2014;1842(3):446–462. doi:10.1016/j.bbadis.2013.05.017
   PubMed Web of Science ®Google Scholar
• Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420(6913):333–336. doi:10.1038/nature01137
   PubMed Web of Science ®Google Scholar
• Seki E, Brenner DA, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012;143(2):307–320. doi:10.1053/j.gastro.2012.06.004
   PubMed Web of Science ®Google Scholar
• Sabio G, Davis RJ. TNF and MAP kinase signalling pathways. Semin Immunol. 2014;26(3):237–245. doi:10.1016/j.smim.2014.02.009
   PubMed Web of Science ®Google Scholar
• Evans JL, Goldfine ID, Maddux BA, et al. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev. 2002;23(5):599–622. doi:10.1210/er.2001-0039
   PubMed Web of Science ®Google Scholar
• Xu H, Xiong C, He L, et al. Trans-resveratrol attenuates high fatty acid-induced P2X7 receptor expression and IL-6 release in PC12 cells: possible role of P38 MAPK pathway. Inflammation. 2015;38(1):327–337. doi:10.1007/s10753-014-0036-6
   PubMedGoogle Scholar
• Trop-Steinberg S, Azar Y. AP-1 expression and its clinical relevance in immune disorders and cancer. Am J Med Sci. 2017;353(5):474–483. doi:10.1016/j.amjms.2017.01.019
   PubMed Web of Science ®Google Scholar
• Bumrungpert A, Kalpravidh RW, Chitchumroonchokchai C, et al. Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr. 2009;139(6):1185–1191. doi:10.3945/jn.109.106617
   PubMedGoogle Scholar
• Hotamisligil GS, Davis RJ. Cell signaling and stress responses. Cold Spring Harb Perspect Biol. 2016;8(10):a006072. doi:10.1101/cshperspect.a006072
   PubMed Web of Science ®Google Scholar
• Bennett BL, Satoh Y, Lewis AJ. JNK: a new therapeutic target for diabetes. Curr Opin Pharmacol. 2003;3(4):420–425. doi:10.1016/S1471-4892(03)00068-7
   PubMed Web of Science ®Google Scholar
• Nie J, Chang Y, Li Y, et al. Caffeic acid phenethyl ester (Propolis extract) ameliorates insulin resistance by inhibiting JNK and NF-kappaB inflammatory pathways in diabetic mice and HepG2 cell models. J Agric Food Chem. 2017;65(41):9041–9053. doi:10.1021/acs.jafc.7b02880
   PubMedGoogle Scholar
• Boden G, Duan X, Homko C, et al. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes. 2008;57(9):2438–2444. doi:10.2337/db08-0604
   PubMed Web of Science ®Google Scholar
• Carvalho BM, Oliveira AG, Ueno M, et al. Modulation of double-stranded RNA-activated protein kinase in insulin sensitive tissues of obese humans. Obesity (Silver Spring, Md). 2013;21(12):2452–2457. doi:10.1002/oby.20410
   PubMedGoogle Scholar
• Yang R, Wilcox DM, Haasch DL, et al. Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice. J Biol Chem. 2007;282(31):22765–22774. doi:10.1074/jbc.M700790200
   PubMed Web of Science ®Google Scholar
• Prada PO, Hirabara SM, Souza CT, et al. L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity. Diabetologia. 2007;50(9):1949–1959. doi:10.1007/s00125-007-0723-z
   PubMed Web of Science ®Google Scholar
• Lee YH, Giraud J, Davis RJ, et al. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem. 2003;278(5):2896–2902. doi:10.1074/jbc.M208359200
   PubMed Web of Science ®Google Scholar
• Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature. 2006;440(7086):944–948. doi:10.1038/nature04634
   PubMed Web of Science ®Google Scholar
• Randle PJ, Garland PB, Hales CN, et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet (London, England). 1963;1(7285):785–789. doi:10.1016/S0140-6736(63)91500-9
   PubMed Web of Science ®Google Scholar
• Aguirre V, Uchida T, Yenush L, et al. The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem. 2000;275(12):9047–9054. doi:10.1074/jbc.275.12.9047
   PubMed Web of Science ®Google Scholar
• Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121):840–846. doi:10.1038/nature05482
   PubMed Web of Science ®Google Scholar
• Solinas G, Becattini B. JNK at the crossroad of obesity, insulin resistance, and cell stress response. Mol Metab. 2017;6(2):174–184. doi:10.1016/j.molmet.2016.12.001
   PubMed Web of Science ®Google Scholar
• Han MS, Jung DY, Morel C, et al. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013;339(6116):218–222. doi:10.1126/science.1227568
   PubMed Web of Science ®Google Scholar
• Shen J, Yang T, Xu Y, et al. Delta-tocotrienol, isolated from rice bran, exerts an anti-inflammatory effect via MAPKs and PPARs signaling pathways in lipopolysaccharide-stimulated macrophages. Int J Mol Sci. 2018;19(10):3022. doi:10.3390/ijms19103022
   PubMedGoogle Scholar
• Boughanem H, Cabrera-Mulero A, Millan-Gomez M, et al. Transcriptional analysis of FOXO1, C/EBP-alpha and PPAR-gamma 2 genes and their association with obesity-related insulin resistance. Genes. 2019;10(9):706. doi:10.3390/genes10090706
   PubMedGoogle Scholar
• Zhang B, Shu M, Xu C, et al. Virtual screening, docking, synthesis and bioactivity evaluation of thiazolidinediones as potential PPAR gamma partial agonists for preparation of antidiabetic agents. Lett Drug Des Discov. 2019;16(6):608–617. doi:10.2174/1570180815666180827123512
   Google Scholar
• Blaschke F, Takata Y, Caglayan E, et al. Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006;26(1):28–40. doi:10.1161/01.ATV.0000191663.12164.77
   PubMedGoogle Scholar
• Kumar S, Sinha K, Sharma R, et al. Phloretin and phloridzin improve insulin sensitivity and enhance glucose uptake by subverting PPAR gamma/Cdk5 interaction in differentiated adipocytes. Exp Cell Res. 2019;383(1):111480. doi:10.1016/j.yexcr.2019.06.025
   PubMed Web of Science ®Google Scholar
• Camp HS, Tafuri SR. Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J Biol Chem. 1997;272(16):10811–10816. doi:10.1074/jbc.272.16.10811
   PubMed Web of Science ®Google Scholar
• Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–445.
   PubMed Web of Science ®Google Scholar
• Hosooka T, Noguchi T, Kotani K, et al. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med. 2008;14(2):188–193. doi:10.1038/nm1706
   PubMedGoogle Scholar
• Ye JP. Regulation of PPAR gamma function by TNF-alpha. Biochem Biophys Res Commun. 2008;374(3):405–408. doi:10.1016/j.bbrc.2008.07.068
   PubMedGoogle Scholar
• Sun Z, Miller RA, Patel RT, et al. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med. 2012;18(6):934-+. doi:10.1038/nm.2744
   Google Scholar
• Ruan H, Pownall HJ, Lodish HF. Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappa B. J Biol Chem. 2003;278(30):28181–28192. doi:10.1074/jbc.M303141200
   PubMedGoogle Scholar
• Trujillo ME, Scherer PE. Adiponectin - journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med. 2005;257(2):167–175. doi:10.1111/j.1365-2796.2004.01426.x
   PubMed Web of Science ®Google Scholar
• Gavrilova O, Haluzik M, Matsusue K, et al. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem. 2003;278(36):34268–34276. doi:10.1074/jbc.M300043200
   PubMed Web of Science ®Google Scholar
• Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest. 2000;106(4):467–472. doi:10.1172/JCI10843
   PubMed Web of Science ®Google Scholar
• Poulsen L, Siersbaek M, Mandrup S. PPARs: fatty acid sensors controlling metabolism. Semin Cell Dev Biol. 2012;23(6):631–639. doi:10.1016/j.semcdb.2012.01.003
   PubMed Web of Science ®Google Scholar
• Li P-Y, Hsu -C-C, Yin M-C, et al. Protective effects of red guava on inflammation and oxidative stress in streptozotocin-induced diabetic mice. Molecules. 2015;20(12):22341–22350. doi:10.3390/molecules201219831
   PubMedGoogle Scholar
• Mangali S, Bhat A, Udumula MP, et al. Inhibition of protein kinase R protects against palmitic acid-induced inflammation, oxidative stress, and apoptosis through the JNK/NF-kB/NLRP3 pathway in cultured H9C2 cardiomyocytes. J Cell Biochem. 2019;120(3):3651–3663. doi:10.1002/jcb.27643
   PubMed Web of Science ®Google Scholar
• Ruelas Cinco EDC, Ruiz Madrigal B, Dominguez Rosales JA, et al. Expression of the receptor of advanced glycation end-products (RAGE) and membranal location in peripheral blood mononuclear cells (PBMC) in obesity and insulin resistance. Iran J Basic Med Sci. 2019;22(6):623–630. doi:10.22038/ijbms.2019.34571.8206
   PubMedGoogle Scholar
• Ormazabal P, Scazzocchio B, Vari R, et al. Effect of protocatechuic acid on insulin responsiveness and inflammation in visceral adipose tissue from obese individuals: possible role for PTP1B. Int J Obes. 2018;42(12):2012–2021. doi:10.1038/s41366-018-0075-4
   Web of Science ®Google Scholar
• Yang R, Trevillyan JM. c-Jun N-terminal kinase pathways in diabetes. Int J Biochem Cell Biol. 2008;40(12):2702–2706. doi:10.1016/j.biocel.2008.06.012
   PubMed Web of Science ®Google Scholar
• Romeo G, Liu WL, Asnaghi V, et al. Activation of nuclear factor-kappa B induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes. 2002;51(7):2241–2248. doi:10.2337/diabetes.51.7.2241
   PubMed Web of Science ®Google Scholar
• Gadang V, Gilbert W, Hettiararchchy N, et al. Dietary bitter melon seed increases peroxisome proliferator-activated receptor-gamma gene expression in adipose tissue, down-regulates the nuclear factor-kappa B expression, and alleviates the symptoms associated with metabolic syndrome. J Med Food. 2011;14(1–2):86–93. doi:10.1089/jmf.2010.0010
   PubMedGoogle Scholar
• Kiechl S, Wittmann J, Giaccari A, et al. Blockade of receptor activator of nuclear factor-kappaB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 2013;19(3):358–363. doi:10.1038/nm.3084
   PubMed Web of Science ®Google Scholar
• Dodd GT, Xirouchaki CE, Eramo M, et al. Intranasal targeting of hypothalamic PTP1B and TCPTP reinstates leptin and insulin sensitivity and promotes weight loss in obesity. Cell Rep. 2019;28(11):2905–22 e5. doi:10.1016/j.celrep.2019.08.019
   PubMed Web of Science ®Google Scholar
• MohammadTaghvaei N, Taheripak G, Taghikhani M, et al. Palmitate-induced PTP1B expression is mediated by ceramide-JNK and nuclear factor kappaB (NF-kappaB) activation. Cell Signal. 2012;24(10):1964–1970. doi:10.1016/j.cellsig.2012.04.019
   PubMedGoogle Scholar
• Taheripak G, Bakhtiyari S, Rajabibazl M, et al. Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells. Free Radic Biol Med. 2013;65:1435–1446.
   PubMed Web of Science ®Google Scholar
• Elchebly M, Payette P, Michaliszyn E, et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (New York, NY). 1999;283(5407):1544–1548. doi:10.1126/science.283.5407.1544
   Google Scholar
• Straczkowski M, Kowalska I, Nikolajuk A, et al. Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle. Diabetes. 2004;53(5):1215–1221. doi:10.2337/diabetes.53.5.1215
   PubMedGoogle Scholar
• Peraldi P, Hotamisligil GS, Buurman WA, et al. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem. 1996;271(22):13018–13022. doi:10.1074/jbc.271.22.13018
   PubMed Web of Science ®Google Scholar