Kukoamine B Ameliorate Insulin Resistance, Oxidative Stress, Inflammation and Other Metabolic Abnormalities in High-Fat/High-Fructose-Fed Rats

References

• Mancini MC, Edna de Melo M. The burden of obesity in the current world and the new treatments available: focus on liraglutide 3.0 mg. Diabetol Metab Syndr. 2017;9:44. doi:10.1186/s13098-017-0242-0
   PubMed Web of Science ®Google Scholar
• Berrington de Gonzalez A, Hartge P, Cerhan JR, et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med. 2010;363:2211–2219. doi:10.1056/NEJMoa1000367
   PubMed Web of Science ®Google Scholar
• Kopelman PG. Obesity as a medical problem. Nature. 2002;404(6778):635–643. doi:10.1038/35007508
   Google Scholar
• Sah SP, Singh B, Choudhary S, Kumar Aff. Animal models of insulin resistance: a review. Pharmacol Rep. 2016;68(6):1165–1177. doi:10.1016/j.pharep.2016.07.010
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010;140:900–917. doi:10.1016/j.cell.2010.02.034
   PubMed Web of Science ®Google Scholar
• Henriksen EJ, Diamond-Stanic MK, Marchionne EM. Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic Biol Med. 2011;51(5):993–999. doi:10.1016/j.freeradbiomed.2010.12.005
   PubMed Web of Science ®Google Scholar
• Kang JG, Park CY. Anti-obesity drugs: a review about their effects and safety. Diabetes Metab J. 2012;36(1):13–25. doi:10.4093/dmj.2012.36.1.13
   PubMedGoogle Scholar
• Rodgers RJ, Tschop MH, Wilding JPH, Rodgers RJ, Tschöp MH, Wilding JP. Anti-obesity drugs: past, present and future. Dis Model Mech. 2012;5:621–626. doi:10.1242/dmm.009621
   PubMed Web of Science ®Google Scholar
• Sergent T, Vanderstraeten J, Winand J, Beguin P, Schneider YJ. Phenolic compounds and plant extracts as potential natural anti-obesity substances. Food Chem. 2012;135(1):68–73. doi:10.1016/j.foodchem.2012.04.074
   Web of Science ®Google Scholar
• de Freitas Junior LM, de Almeida EB Jr. Medicinal plants for the treatment of obesity: ethnopharmacological approach and chemical and biological studies. Am J Transl Res. 2017;9:2050–2064.
   PubMed Web of Science ®Google Scholar
• Potterat O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76:7–19. doi:10.1055/s-0029-1186218
   PubMed Web of Science ®Google Scholar
• Yao X, Peng Y, Xu LJ, Li L, Wu QL, Xiao PG. Phytochemical and biological studies of Lycium medicinal plants. Chem Biodivers. 2011;8:976–1010. doi:10.1002/cbdv.201000018
   PubMed Web of Science ®Google Scholar
• Yao R, Heinrich M, Weckerle CS. The genus Lycium as food and medicine: a botanical, ethnobotanical and historical review. J Ethnopharmacol. 2018;212:50–66. doi:10.1016/j.jep.2017.10.010
   PubMed Web of Science ®Google Scholar
• Xie LW, Atanasov AG, Guo DA, et al. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller. J Ethnopharmacol. 2014;152:470–477. doi:10.1016/j.jep.2014.01.029
   PubMed Web of Science ®Google Scholar
• Cho SH, Park EJ, Kim EO, Choi SW. Study on the hypocholesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chinense Miller. Nutr Res Pract. 2011;5:412–420. doi:10.4162/nrp.2011.5.5.412
   PubMed Web of Science ®Google Scholar
• Chen H, Olatunji OJ, Zhou Y. Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice. J Nat Med. 2016;70:610–619. doi:10.1007/s11418-016-0984-2
   PubMed Web of Science ®Google Scholar
• Li YY, Stewart DA, Ye XM, et al. A metabolomics approach to investigate Kukoamine B-A potent natural product with anti-diabetic properties. Front Pharmacol. 2019;9:1575. doi:10.3389/fphar.2018.01575
   PubMedGoogle Scholar
• Gheibi S, Bakhtiarzadeh F, Jeddi S, Farrokhfall K, Zardooz H, Ghasemi A. Nitrite increases glucose-stimulated insulin secretion and islet insulin content in obese type 2 diabetic male rats. Nitric Oxide. 2017;64:39–51. doi:10.1016/j.niox.2017.01.003
   PubMedGoogle Scholar
• Esteghamati A, Ashraf H, Khalilzadeh O, et al. Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007). Nutr Metab (Lond). 2010;7:26. doi:10.1186/1743-7075-7-26
   PubMedGoogle Scholar
• Folch J, Lees M, Solane GM. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497–509.
   PubMed Web of Science ®Google Scholar
• Zheng X, Wang N, Yang Y, Chen Y, Liu X, Zheng J. Insight into the inhibition mechanism of kukoamine B against CpG DNA via binding and molecular docking analysis. RSC Adv. 2016;6:85756–85762.
   Google Scholar
• Yang D, Zheng X, Wang N, et al. Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes. Oncotarget. 2016;7:57498–57513. doi:10.18632/oncotarget.11292
   PubMedGoogle Scholar
• Hu XL, Guo LP, Song Q, et al. Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro. Neurochem Int. 2015;87:66–76. doi:10.1016/j.neuint.2015.06.001
   PubMedGoogle Scholar
• Li X, Lin J, Chen B, Xie H, Chen D. Antioxidant and cytoprotective effects of kukoamines A and B: comparison and positional isomeric effect. Molecules. 2018;23:4.
   Web of Science ®Google Scholar
• Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005;111:448–1454. doi:10.1161/01.CIR.0000158483.13093.9D
   Google Scholar
• Zivkovic AM, German JB, Sanyal AJ. Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am J Clin Nutr. 2007;86(2):285–300. doi:10.1093/ajcn/86.2.285
   PubMed Web of Science ®Google Scholar
• Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 2014;510(7503):84–91. doi:10.1038/nature13478
   PubMed Web of Science ®Google Scholar
• Petersen MC, Shulman GI. Roles of diacylglycerols and ceramides in hepatic insulin resistance. Trends Pharmacol Sci. 2017;38(7):649–665. doi:10.1016/j.tips.2017.04.004
   PubMed Web of Science ®Google Scholar
• Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006;116(7):1793–1801. doi:10.1172/JCI29069
   PubMed Web of Science ®Google Scholar
• Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012;148(5):852–871. doi:10.1016/j.cell.2012.02.017
   PubMed Web of Science ®Google Scholar
• Ye J. Mechanisms of insulin resistance in obesity. Front Med. 2013;7(1):14–24. doi:10.1007/s11684-013-0262-6
   PubMed Web of Science ®Google Scholar
• Naples M, Federico LM, Xu E, Nelken J, Adeli K. Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance: evidence for statin-induced hepatic insulin sensitization. Atherosclerosis. 2008;198(1):94–103. doi:10.1016/j.atherosclerosis.2007.11.003
   PubMedGoogle Scholar
• Maithilikarpagaselvi N, Sridhar MG, Swaminathan RP, Zachariah B. Curcumin prevents inflammatory response, oxidative stress and insulin resistance in high fructose fed male Wistar rats: potential role of serine kinases. Chem Biol Interact. 2016;244:187–194. doi:10.1016/j.cbi.2015.12.012
   PubMedGoogle Scholar
• Reaven GM. Banting lecture role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–1607. doi:10.2337/diab.37.12.1595
   PubMed Web of Science ®Google Scholar
• Duque-Guimaraes DE, Ozanne SE. Nutritional programming of insulin resistance: causes and consequences. Trends Endocrinol Metab. 2013;24(10):525–535. doi:10.1016/j.tem.2013.05.006
   PubMed Web of Science ®Google Scholar
• Hishinuma A, Majima M, Kurabayashi H. Insulin resistance in patients with stroke is related to visceral fat obesity and adipocytokines. J Stroke Cerebrovasc Dis. 2008;17(4):175–180. doi:10.1016/j.jstrokecerebrovasdis.2008.01.004
   PubMedGoogle Scholar
• Shimizu I, Yoshida Y, Minamino T. Pathological role of adipose tissue dysfunction in cardio-metabolic disorders. Int Heart J. 2015;56(3):255–259. doi:10.1536/ihj.14-401
   PubMedGoogle Scholar
• Sripetchwandee J, Chattipakorn N, Chattipakorn SC. Links between obesity-induced brain insulin resistance, brain mitochondrial dysfunction, and dementia. Front Endocrinol. 2018;9:496. doi:10.3389/fendo.2018.00496
   PubMed Web of Science ®Google Scholar
• Hurrle S, Hsu WH. The etiology of oxidative stress in insulin resistance. Biomed J. 2017;40(5):257–262. doi:10.1016/j.bj.2017.06.007
   PubMed Web of Science ®Google Scholar
• Maciejczyk M, Żebrowska E, Chabowski A. Insulin resistance and oxidative stress in the brain: what’s new? Int J Mol Sci. 2019;20(4):4. doi:10.3390/ijms20040874
   Google Scholar
• Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752–1761. doi:10.1172/JCI21625
   PubMed Web of Science ®Google Scholar
• Keaney JF Jr, Larson MG, Vasan RS, et al., Framingham Study. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study. Arterioscler Thromb Vasc Biol. 2003;23(3):434–439. doi:10.1161/01.ATV.0000058402.34138.11
   PubMed Web of Science ®Google Scholar
• Tangvarasittichai S. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World J Diabetes. 2015;6(3):456–480. doi:10.4239/wjd.v6.i3.456
   PubMed Web of Science ®Google Scholar
• Ropelle ER, Flores MB, Cintra DE, et al. IL-6 and IL10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKb and ER stress inhibition. PLoS Biol. 2010;8(8):1812. doi:10.1371/journal.pbio.1000465
   Google Scholar
• Davis JE, Braucher DR, Walker-Daniels J, Spurlock ME. Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes. J Nutr Biochem. 2011;22(2):136–141. doi:10.1016/j.jnutbio.2009.12.008
   PubMed Web of Science ®Google Scholar
• Lee Y, Fluckey JD, Chakraborty S, Muthuchamy M. Hyperglycemia and hyperinsulinemia induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle. FASEB J. 2017;31(7):2744–2759. doi:10.1096/fj.201600887R
   PubMed Web of Science ®Google Scholar
• Asrih M, Jornayvaz FR. Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance. J Endocrinol. 2013;218(3):25–36. doi:10.1530/JOE-13-0201
   PubMed Web of Science ®Google Scholar
• Peng Y, Rideout D, Rakita S, Lee J, Murr M. Diet induced obesity associated with steatosis, oxidative stress, and inflammation in liver. Surg Obes Relat Dis. 2012;8:73–81. doi:10.1016/j.soard.2011.07.019
   PubMedGoogle Scholar
• Feillet-Coudray C, Fouret G, Vigor C, et al. Long-term measures of dyslipidemia, inflammation, and oxidative stress in rats fed a high-fat/high-fructose diet. Lipids. 2019;54:81–97. doi:10.1002/lipd.12128
   PubMed Web of Science ®Google Scholar
• Basaranoglu M, Basaranoglu G, Sabuncu T, Sentürk H. Fructose as a key player in the development of fatty liver disease. World J Gastroenterol. 2013;19(8):1166–1172. doi:10.3748/wjg.v19.i8.1166
   PubMed Web of Science ®Google Scholar
• Aguilera-Mendez A, Hernández-Equihua MG, Rueda-Rocha AC, et al. Protective effect of supplementation with biotin against high-fructose-induced metabolic syndrome in rats. Nutr Res. 2018;57:86–96. doi:10.1016/j.nutres.2018.06.007
   PubMed Web of Science ®Google Scholar
• Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17(1):4–12.
   PubMed Web of Science ®Google Scholar
• Hariri N, Thibault L. High-fat diet-induced obesity in animal models. Nutr Res Rev. 2010;23(2):270–299. doi:10.1017/S0954422410000168
   PubMed Web of Science ®Google Scholar