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Perspectives

Development of Obesity: The Driver and the Passenger

Pages 4631-4642 | Published online: 27 Nov 2020

References

  • GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27. doi:10.1056/NEJMoa1614362.
  • Seidell JC, Halberstadt J. The global burden of obesity and the challenges of prevention. Ann Nutr Metab. 2015;66(suppl 2):7–12. doi:10.1159/000375143
  • Abarca-Gómez L, Abdeen ZA, Hamid ZA, et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet. 2017;390(10113):2627–2642. doi:10.1016/S0140-6736(17)32129-3
  • Singh RK, Kumar P, Mahalingam K. Molecular genetics of human obesity: a comprehensive review. C R Biol. 2017;340(2):87–108. doi:10.1016/j.crvi.2016.11.007
  • Hall KD. Did the food environment cause the obesity epidemic? Obesity (Silver Spring). 2018;26(1):11–13. doi:10.1002/oby.22073
  • Wolfram G, Bechthold A, Boeing H, et al. Evidence-based guideline of the German Nutrition Society: fat intake and prevention of selected nutrition-related diseases. Ann Nutr Metab. 2015;67(3):141–204. doi:10.1159/000437243
  • Kopp W. High-insulinogenic nutrition - an etiologic factor for obesity and the metabolic syndrome? Metabolism. 2003;52(7):840–844. doi:10.1016/s0026-0495(02)05294-0
  • Ludwig DS, Ebbeling CB. The carbohydrate-insulin model of obesity: beyond “calories in, calories out”. JAMA Intern Med. 2018;178(8):1098–1103. doi:10.1001/jamainternmed.2018.2933
  • Alberts B, Bray D, Johnson A, et al. How cells obtain energy from food. In: Alberts B, Bray D, Johnson A, et al. editors. Essential Cell Biology. An Introduction to the Molecular Biology of the Cell. Vol. 4, New York: Garland Publishing Inc; 2014:419–466.
  • Westman EC, Feinman RD, Mavropoulos JC, et al. Low-carbohydrate nutrition and metabolism. Am J Clin Nutr. 2007;86(2):276–284. doi:10.1093/ajcn/86.2.276
  • Cordain L, Eaton SB, Sebastian A, et al. Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr. 2005;81(2):341–354. doi:10.1093/ajcn.81.2.341
  • Kopp W. Significant dietary changes during human evolution and the development of cancer: from cells in trouble to cells causing trouble. J Carcinog Mutagen. 2017;8(04):303. doi:10.4172/2157-2518
  • Muoio DM. Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell. 2014;159(6):1253–1262. doi:10.1016/j.cell.2014.09.052
  • Nordmann AJ, Nordmann A, Briel M, et al. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006;166(3):285–293. doi:10.1001/archinte.166.3.285
  • Brehm BJ, Seeley RJ, Daniels SR, D’Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low-fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab. 2003;88(4):1617–1623. doi:10.1210/jc.2002-021480
  • McSwiney FT, Wardrop B, Hyde PN, Lafountain RA, Volek JS, Doyle L. Keto-adaptation enhances exercise performance and body composition responses to training in endurance athletes. Metabolism. 2018;81:25–34. doi:10.1016/j.metabol.2017.10.010
  • Greene DA, Varley BJ, Hartwig TB, Chapman P, Rigney M. A low-carbohydrate ketogenic diet reduces body mass without compromising performance in powerlifting and olympic weightlifting athletes. J Strength Cond Res. 2018;32(12):3373–3382. doi:10.1519/JSC.0000000000002904
  • Rolls BJ. Dietary energy density: applying behavioural science to weight management. Nutr Bull. 2017;42(3):246–253. doi:10.1111/nbu.12280
  • Stubbs BJ, Cox PJ, Evans RD, Cyranka M, Clarke K, de Wet H. A ketone ester drink lowers human ghrelin and appetite. Obesity (Silver Spring). 2018;26(2):269–273. doi:10.1002/oby.22051
  • Page MM, Johnson JD. Mild suppression of hyperinsulinemia to treat obesity and insulin resistance. Trends Endocrinol Metab. 2018;29(6):389–399. doi:10.1016/j.tem.2018.03.018
  • Björk I, Liljeberg H, Östan E. Low-glycemic index foods. Br J Nutr. 2000;83(Suppl 1):S149–S155. doi:10.1017/s0007114500001094
  • Wolever TM, Bolognesi C. Prediction of glucose and insulin responses of normal subjects after consuming mixed meals varying in energy, protein, fat, carbohydrate and glycemic index. J Nutr. 1996;126(11):2807–2812. doi:10.1093/jn/126.11.280
  • McDevitt RM, Bott SJ, Harding M, Coward WA, Bluck LJ, Prentice AM. De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women. Am J Clin Nutr. 2001;74(6):737–746. doi:10.1093/ajcn/74.6.737
  • Proserpi C, Sparti A, Schutz Y, Di Vetta V, Milon H, Jéquier E. Ad libitum intake of a high-carbohydrate or high-fat diet in young men: effects on nutrient balances. Am J Clin Nutr. 1997;66(3):539–545. doi:10.1093/ajcn/66.3.539
  • Poppitt SD, Keogh GF, Prentice AM, et al. Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight subjects with metabolic syndrome. Am J Clin Nutr. 2002;75(1):11–20. doi:10.1093/ajcn/75.1.11
  • Hays NP, Starling RD, Liu X, et al. Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial. Arch Intern Med. 2004;164(2):210–217. doi:10.1001/archinte.164.2.210
  • Mueller-Cunningham WM, Quintana R, Kasim-Karakas SE. An ad libitum, very low-fat diet results in weight loss and changes in nutrient intakes in postmenopausal women. J Am Diet Assoc. 2003;103(12):1600–1606. doi:10.1016/j.jada.2003.09.017
  • Astrup A, Astrup A, Buemann B, Flint A, Raben A. Low-fat diets and energy balance: how does the evidence stand in 2002? Proc Nutr Soc. 2002;61(2):299–309. doi:10.1079/PNS2002149
  • Gajda AM. High fat diets for diet-induced obesity models. Research Diets, Inc.; 2008. Available from: http://www.researchdiets.com. Accessed November 12, 2020.
  • Dalby MJ, Ross AW, Walker AW, Morgan PJ. Dietary uncoupling of gut microbiota and energy harvesting from obesity and glucose tolerance in mice. Cell Rep. 2017;21(6):1521–1533. doi:10.1016/j.celrep.2017.10.056
  • Argueta DA, DiPatrizio NV. Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity. Physiol Behav. 2017;171:32–39. doi:10.1016/j.physbeh.2016.12.044
  • Lissner L, Levitsky DA, Strupp BJ, Kalkwarf HJ, Roe DA. Dietary fat and the regulation of energy intake in human subjects. Am J Clin Nutr. 1987;46(6):886–892. doi:10.1093/ajcn/46.6.886
  • Takahashi M, Ikemoto S, Ezaki O. Effect of the fat/carbohydrate ratio in the diet on obesity and oral glucose tolerance in C57BL/6J mice. J Nutr Sci Vitaminol (Tokyo). 1999;45(5):583–593. doi:10.3177/jnsv.45.583
  • Campbell PJ, Carlson MG, Hill JO, Nurjhan N. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol. 1992;263(6 Pt 1):E1063–E1069. doi:10.1152/ajpendo.2006.263.6.E1063
  • Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC. Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women. Am J Clin Nutr. 2007;85(3):910–918. doi:10.1093/ajcn/85.3.910
  • Brand-Miller J, McMillan-Price J, Steinbeck K, Caterson I. Carbohydrates–the good, the bad and the whole grain. Asia Pac J Clin Nutr. 2008;17(Suppl 1):16–19.
  • Ebbeling CB, Leidig MM, Feldman HA, Lovesky MM, Ludwig DS. Effects of a low–glycemic load vs low-fat diet in obese young adults: a randomized trial. JAMA. 2007;297(19):2092–2102. doi:10.1001/jama.297.19.2092
  • Kopp W. How Western diet and lifestyle drive the pandemic of obesity and civilization diseases. Diabetes Metab Syndr Obes. 2019;12:2221–2236. doi:10.2147/DMSO.S216791
  • Mehran AE, Templeman NM, Brigidi GS, et al. Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. Cell Metab. 2012;16(6):723–737. doi:10.1016/j.cmet.2012.10.019
  • Le Stunff C, Bougneres P. Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity. Diabetes. 1994;43(5):696–702. doi:10.2337/diab.43.5.696
  • Schofield CJ, Sutherland C. Disordered insulin secretion in the development of insulin resistance and type 2 diabetes. Diabet Med. 2012;29(8):972–979. doi:10.1111/j.1464-5491.2012.03655.x
  • Nolan CJ, Prentki M. Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: time for a conceptual framework shift. Diab Vasc Dis Res. 2019;16(2):118–127. doi:10.1177/1479164119827611
  • Paris M, Bernard-Kargar C, Berthault MF, Bouwens L, Ktorza A. Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats. Endocrinology. 2003;144(6):2717–2727. doi:10.1210/en.2002-221112
  • Mahler RJ. The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity. Acta Diabetol Lat. 1981;18(1):1–17. doi:10.1007/BF02056101
  • Polonsky KS, Given BD, Van Cauter E. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest. 1988;81(2):442–448. doi:10.1172/JCI113339
  • Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G. Insulin resistance and hypersecretion in obesity. J Clin Invest. 1997;100:1166–1173. doi:10.1172/JCI119628
  • Ferrannini E, Camastra S, Gastaldelli A, et al. Beta-cell function in obesity: effects of weight loss. Diabetes. 2004;53(Suppl 3):S26–S33. doi:10.2337/diabetes.53.suppl_3.s26
  • Erion KA, Corkey BE. Hyperinsulinemia: a cause of obesity? Curr Obes Rep. 2017;6(2):178–186. doi:10.1007/s13679-017-0261-z
  • Templeman NM, Skovsø S, Page MM, Lim GE, Johnson JD. A causal role for hyperinsulinemia in obesity. J Endocrinol. 2017;232(3):R173–183. doi:10.1530/JOE-16-0449
  • Cusin I, Rohner-Jeanrenaud F, Terrettaz J, Jeanrenaud B. Hyperinsulinemia and its impact on obesity and insulin resistance. Int J Obes. 1992;16(Suppl 4):S1–11.
  • Lustig RH. Autonomic dysfunction of the b-cell and the pathogenesis of obesity. Rev Endocr Metab Dis. 2003;4(1):23–32. doi:10.1023/A:1021819318484
  • Sigal RJ, El-Hashimy M, Martin BC, Soeldner JS, Krolewski AS, Warram JH. Acute post-challenge hyperinsulinemia predicts weight gain. Diabetes. 1997;46(6):1025–1029. doi:10.2337/diab.46.6.1025
  • Chen YY, Wang JP, Jiang YY, et al. Fasting plasma insulin at 5 years of age predicted subsequent weight increase in early childhood over a 5-year period: the Da Qing children cohort study. PLoS One. 2015;10(6):e0127389. doi:10.1371/journal.pone.0127389
  • Pénicaud L, Kinebanyan MF, Ferré P, et al. Development of VMH obesity: in vivo insulin secretion and tissue insulin sensitivity. Am J Physiol. 1989;257:E255–E260. doi:10.1152/ajpendo.1989.257.2.E255
  • Barnard RJ, Roberts CK, Varon SM, Berger JJ. Diet-induced insulin resistance precedes other aspects of the metabolic syndrome. J Appl Physiol. 1998;84(4):1311–1315. doi:10.1152/jappl.1998.84.6.1967
  • Grimditch GK, Barnard RJ, Hendricks L, Weitzman D. Peripheral insulin sensitivity as modified by diet and exercise training. Am J Clin Nutr. 1988;48(1):38–43. doi:10.1093/ajcn/48.1.38
  • Tokunaga K, Fukushima M, Kemnitz JW, Bray GA. Effect of vagotomy on serum insulin in rats with paraventricular or ventromedial hypothalamic lesions. Endocrinology. 1986;119:1708–1711.
  • Inoue S, Bray GA. The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity. Endocrinology. 1977;100(1):108–114. doi:10.1210/endo-100-1-108
  • Johnson MS, Figueroa-Colon R, Huang TT, Dwyer JH, Goran MI. Longitudinal changes in body fat in African American and Caucasian children: influence of fasting insulin and insulin sensitivity. J Clin Endocrinol Metab. 2001;86(7):3182–3187. doi:10.1210/jcem.86.7.7665
  • Odeleye OE, de Courten M, Pettitt DJ, Ravussin E. Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children. Diabetes. 1997;46(8):1341–1345. doi:10.2337/diab.46.8.1341
  • Preeyasombat C, Bacchetti P, Lazar AA, Lustig RH. Racial and etiopathologic dichotomies in insulin hypersecretion and resistance in obese children. J Pediatr. 2005;146(4):474–481. doi:10.1016/j.jpeds.2004.12.014
  • Folsom AR, Jacobs DR Jr., Wagenknecht LE, et al. Increase in fasting insulin and glucose over seven years with increasing weight and inactivity of young adults. The CARDIA study. Coronary artery risk development in young adults. Am J Epidemiol. 1996;144(3):235–246. doi:10.1093/oxfordjournals.aje.a008918
  • Sinha A, Formica C, Tsalamandris C, et al. Effects of insulin on body composition in patients with insulin-dependent and non-insulin-dependent diabetes. Diabet Med. 1996;13(1):40–46. doi:10.1002/(SICI)1096-9136(199601)13:1<40::AID-DIA991>3.0.CO;2-U
  • Lustig RH, Rose SR, Burghen GA, et al. Hypothalamic obesity in children caused by cranial insult: altered glucose and insulin dynamics, and reversal by a somatostatin agonist. J Pediatr. 1999;135(2):162–168. doi:10.1016/s0022-3476(99)70017-x
  • Velasquez-Mieyer PA, Cowan PA, Buffington CK, et al. Suppression of insulin secretion promotes weight loss and alters macronutrient preference in a subset of obese adults. Int J Obes. 2003;27:219–226. doi:10.1038/sj.ijo.802227
  • Stein DT, Stevenson BE, Chester MW, et al. The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation. J Clin Invest. 1997;100(2):398–403. doi:10.1172/JCI119546
  • Gonzalez A, Merino B, Marroquí L, et al. Insulin hypersecretion in islets from diet-induced hyperinsulinemic obese female mice is associated with several functional adaptations in individual β-cells. Endocrinology. 2013;154(10):3515–3524. doi:10.1210/en.2013-1424
  • Pawlak DB, Bryson JM, Denyer GS, Brand-Miller JC. High glycemic index starch promotes hypersecretion of insulin and higher body fat in rats without affecting insulin sensitivity. J Nutr. 2001;131(1):99–104. doi:10.1093/jn/131.1.99
  • Gonsolin D, Couturier K, Garait B, et al. High dietary sucrose triggers hyperinsulinemia, increases myocardial beta-oxidation, reduces glycolytic flux and delays post-ischemic contractile recovery. Mol Cell Biochem. 2007;295(1–2):217–228. doi:10.1007/s11010-006-9291-7
  • Shively CA, Appt SE, Vitolins MZ, et al. Mediterranean versus Western diet effects on caloric intake, obesity, metabolism, and hepatosteatosis in nonhuman primates [published correction appears in obesity (silver spring)]. Obesity (Silver Spring). 2019;27(5):777–784. doi:10.1002/oby.22436
  • Patel MS, Srinivasan M. Metabolic programming in the immediate postnatal life. Ann Nutr Metab. 2011;58(Suppl 2):18–28. doi:10.1159/000328040
  • Templeman NM, Clee SM, Johnson JD. Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity. Diabetologia. 2015;58(10):2392–2402. doi:10.1007/s00125-015-3676-7
  • Eckel RA. Insulin resistance: an adaptation for weight maintenance. Lancet. 1992;340(8833):1452–1453. doi:10.1016/0140-6736(92)92633-q
  • Karpe F, Dickmann JR, Frayn KN. Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes. 2011;60(10):2441–2449. doi:10.2337/db11-0425
  • Swinburn BA, Nyomba BL, Saad MF, et al. Insulin resistance associated with lower rates of weight gain in Pima Indians. J Clin Invest. 1991;88(1):168–173. doi:10.1172/JCI115274
  • Wedick NM, Mayer-Davis EJ, Wingard DL, Addy CL, Barrett-Connor E. Insulin resistance precedes weight loss in adults without diabetes: the Rancho Bernardo study. Am J Epidemiol. 2001;153(12):1199–1205. doi:10.1093/aje/153.12.1199
  • Sleder J, Chen YD, Cully MD, Reaven GM. Hyperinsulinemia in fructose-induced hypertriglyceridemia in the rat. Metabolism. 1980;29(4):303–305. doi:10.1016/0026-0495(80)90001-3
  • Galderisi A, Giannini C, Van Name M, Caprio S. Fructose consumption contributes to hyperinsulinemia in adolescents with obesity through a GLP-1-mediated mechanism. J Clin Endocrinol Metab. 2019;104(8):3481–3490. doi:10.1210/jc.2019-00161
  • Corkey BE. Diabetes: have we got it all wrong? Insulin hypersecretion and food additives: cause of obesity and diabetes? Diabetes Care. 2012;35(12):2432–2437. doi:10.2337/dc12-0825
  • Saadeh M, Ferrante TC, Kane A, et al. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One. 2012;7(1):e30200. doi:10.1371/journal.pone.0030200
  • Erdelyi I, Levenkova N, Lin EY, et al. Western-Style diets induce oxidative stress and dysregulate immune responses in the colon in a mouse model of sporadic colon cancer. J Nutr. 2009;139(11):2072–2078. doi:10.3945/jn.108.104125
  • Busserolles J, Rock E, Gueux E, Mazur A, Grolier P, Rayssiguier Y. Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats. Br J Nutr. 2002;87(4):337–342. doi:10.1079/BJNBJN2002524
  • Anderson C, Milne GL, Park YM, Sandler DP, Nichols HB. Dietary glycemic index and glycemic load are positively associated with oxidative stress among premenopausal women. J Nutr. 2018;148(1):125–130. doi:10.1093/jn/nxx022
  • Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295(14):1681–1687. doi:10.1001/jama.295.14
  • Whalen KA, McCullough ML, Flanders WD, Hartman TJ, Judd S, Bostick RM. Paleolithic and mediterranean diet pattern scores are inversely associated with biomarkers of inflammation and oxidative balance in adults. J Nutr. 2016;146(6):1217–1226. doi:10.3945/jn.115.224048
  • Greco T, Glenn TC, Hovda DA, Prins ML. Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity. J Cereb Blood Flow Metab. 2016;36(9):1603–1613. doi:10.1177/0271678X15610584
  • Astley CM, Todd JN, Salem RM, et al. Genetic evidence that carbohydrate-stimulated insulin secretion leads to obesity. Clin Chem. 2018;64(1):192–200. doi:10.1373/clinchem.2017.280727
  • LeStunff C, Fallin D, Schork NJ, Bougneres P. The insulin gene VNTR is associated with fasting insulin levels and the development of juvenile obesity. Nat Genet. 2000;26:444–446.
  • Simeoni U, Armengaud JB, Siddeek B, Tolsa JF. Perinatal origins of adult disease. Neonatology. 2018;113(4):393–399. doi:10.1159/000487618
  • Moosavi A, Motevalizadeh Ardekani A. Role of epigenetics in biology and human diseases. Iran Biomed J. 2016;20(5):246–258. doi:10.22045/ibj.2016.01.185
  • Kwon EJ, Kim YJ. What is fetal programming?: a lifetime health is under the control of in utero health. Obstet Gynecol Sci. 2017;60(6):506–519. doi:10.5468/ogs.2017.60.6
  • Jones RH, Ozanne SE. Fetal programming of glucose-insulin metabolism. Mol Cell Endocrinol. 2009;297(1–2):4–9. doi:10.1016/j.mce.2008.06.020
  • Gali Ramamoorthy T, Allen TJ, Davies A, et al. Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats. Int J Obes (Lond). 2018;42(8):1431–1444. doi:10.1038/s41366-018-0094-1
  • Clapp JF. Diet, exercise and feto-placental growth. Arch Gynecol Obstet. 1997;261:101–107.
  • Clapp JF. Maternal carbohydrate intake and pregnancy outcome. Proc Nutr Soc. 2002;61(1):45–50. doi:10.1079/pns2001129
  • Paknahad Z, Fallah A, Moravejolahkami AR. Maternal dietary patterns and their association with pregnancy outcomes. Clin Nutr Res. 2019;8(1):64–73. doi:10.7762/cnr.2019.8.1.64
  • Damasceno DC, Dallaqua B, Lovizutto Iessi I, Volpato GT, Campos KE. Impact of maternal over-nutrition during pregnancy on maternal oxidative stress and fetal skeletal/visceral anomalies of the rats. J Nutr Disord Ther. 2016;6(01):1. doi:10.4172/2161-0509.1000185
  • Borengasser SJ, Zhong Y, Kang P, et al. Maternal obesity enhances white adipose tissue differentiation and alters genome-scale DNA methylation in male rat offspring. Endocrinology. 2013;154(11):4113–4125. doi:10.1210/en.2012-2255
  • Jornayvaz FR, Vollenweider P, Bochud M, Mooser V, Waeber G, Marques-Vidal P. Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study. Cardiovasc Diabetol. 2016;15(1):73. doi:10.1186/s12933-016-0389-2
  • Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359(1):61–73. doi:10.1056/NEJMra0708473
  • Tzanetakou IP, Mikhailidis DP, Perrea DN. Nutrition during pregnancy and the effect of carbohydrates on the offspring’s metabolic profile: in search of the “perfect maternal diet”. Open Cardiovasc Med J. 2011;5(1):103–109. doi:10.2174/1874192401105010103
  • Srinivasan M, Katewa SD, Palaniyappan A, Pandya JD, Patel MS. Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am J Physiol Endocrinol Metab. 2006;291(4):E792–799. doi:10.1152/ajpendo.00078.2006
  • Elsakr JM, Dunn JC, Tennant K, et al. Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition. Mol Metab. 2019;25:73–82. doi:10.1016/j.molmet.2019.03.010
  • Parretti E, Mecacci F, Papini M, et al. Third-trimester maternal glucose levels from diurnal profiles in nondiabetic pregnancies: correlation with sonographic parameters of fetal growth. Diabetes Care. 2001;24(8):1319–1323. doi:10.2337/diacare.24.8.1319
  • Sonagra AD, Biradar SM, Murthy KD. Normal pregnancy- a state of insulin resistance. J Clin Diagn Res. 2014;8(11):CC01–CC3. doi:10.7860/JCDR/2014/10068.5081
  • Pedersen J. Hyperglycaemia-hyperinsulinism theory and birthweight. In: The Pregnant Diabetic and Her Newborn: Problems and Management. Baltimore: Williams and Wilkins; 1977:211–220.
  • Susa JB, Schwarz R. Hyperinsulinemia in the primate fetus. Diabetes. 1985;34(Supplement_2):36–41. doi:10.2337/diab.34.2.S36
  • Simental-Mendía LE, Castañeda-Chacón A, Rodríguez-Morán M, Guerrero-Romero F. Birth-weight, insulin levels, and HOMA-IR in newborns at term. BMC Pediatr. 2012;12(1):94. doi:10.1186/1471-2431-12-94
  • Yamashita H, Yasuh I, Fukuda M, et al. The association between maternal insulin resistance in mid-pregnancy and neonatal birthweight in uncomplicated pregnancies. Endocr J. 2014;61(10):1019–1024. doi:10.1507/endocrj.EJ14-0163
  • Catalano PM, Hauguel-de Mouzon S. Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic? Am J Obstet Gynecol. 2011;204(6):479–487. doi:10.1016/j.ajog.2010.11.039
  • Shankar K, Harrell A, Liu X, Gilchrist JM, Ronis MJ, Badger TM. Maternal obesity at conception programs obesity in the offspring. Am J Physiol Regul Integr Comp Physiol. 2008;294(2):R528–R538. doi:10.1152/ajpregu.00316.2007
  • Shrestha N, Ezechukwu HC, Holland OJ, Hryciw DH. Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy. Am J Physiol Regul Integr Comp Physiol. 2020;319(5):R507–R516. doi:10.1152/ajpregu.00214.2020
  • McDowell M, Cain MA, Brumley J. Excessive gestational weight gain. J Midwifery Women's Health. 2019;64(1):46–54. doi:10.1111/jmwh.12927
  • Moses RG, Luebcke M, Davis WS, et al. Effect of a low-glycemic-index diet during pregnancy on obstetric outcomes. Am J Clin Nutr. 2006;84(4):807–812. doi:10.1093/ajcn/84.4.807
  • Hillesund ER, Bere E, Haugen M, Øverby NC. Development of a new nordic diet score and its association with gestational weight gain and fetal growth - a study performed in the Norwegian mother and child cohort study (MoBa). Public Health Nutr. 2014;17(9):1909–1918. doi:10.1017/S1368980014000421
  • Timmermans S, Steegers-Theunissen RP, Vujkovic M, et al. The Mediterranean diet and fetal size parameters: the Generation R Study. Br J Nutr. 2012;108(8):1399–1409. doi:10.1017/S000711451100691X
  • Bayol SA, Farrington SJ, Stickland NC. A maternal ‘junk food’ diet in pregnancy and lactation promotes an exacerbated taste for ‘junk food’ and a greater propensity for obesity in rat offspring. Br J Nutr. 2007;98(04):843–851. doi:10.1017/S0007114507812037
  • Ong KK, Emmett PM, Noble S, Ness A, Dunger DB. Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index. Pediatrics. 2006;117(3):e503–e508. doi:10.1542/peds.2005-1668
  • Rodríguez-Rodríguez P, Ramiro-Cortijo D, Reyes-Hernández CG. Implication of oxidative stress in fetal programming of cardiovascular disease. Front Physiol. 2018;9:602. doi:10.3389/fphys.2018.00602
  • Hu Y, Block G, Norkus EP, Morrow JD, Dietrich M, Hudes M. Relations of glycemic index and glycemic load with plasma oxidative stress markers. Am J Clin Nutr. 2006;84(1):70–76. doi:10.1093/ajcn/84.1.70
  • Smethers AD, Rolls BJ. Dietary management of obesity: cornerstones of healthy eating patterns. Med Clin N Am. 2018;102(1):107–124. doi:10.1016/j.mcna.2017.08.009
  • Reynolds A, Mann J, Cummings J, Winter N, Mete E, Te Morenga L. Carbohydrate quality and human health: a series of systematic reviews and meta-analyses. Lancet. 2019;393(10170):434–445. doi:10.1016/s0140-6736(18)31809-9