miR-7a Targets Insulin Receptor Substrate-2 Gene and Suppresses Viability and Invasion of Cells in Diabetic Retinopathy Mice via PI3K-Akt-VEGF Pathway

References

• Congdon NG , Friedman DS , Lietman T . Important causes of visual impairment in the world today. JAMA . 2003;290(15):2057–2060. doi:10.1001/jama.290.15.2057 14559961
   PubMed Web of Science ®Google Scholar
• Armulik A , Abramsson A , Betsholtz C . Endothelial/pericyte interactions. Circ Res . 2005;97(6):512–523. doi:10.1161/01.RES.0000182903.16652.d7 16166562
   PubMed Web of Science ®Google Scholar
• Caldwell RB , Bartoli M , Behzadian MA , et al. Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab Res Rev . 2003;19(6):442–455. doi:10.1002/dmrr.415 14648803
   PubMed Web of Science ®Google Scholar
• Saltiel AR , Pessin JE . Insulin signaling pathways in time and space. Trends Cell Biol . 2002;12(2):65–71. doi:10.1016/S0962-8924(01)02207-3 11849969
   PubMed Web of Science ®Google Scholar
• White MF . IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab . 2002;283(3):413–422. doi:10.1152/ajpendo.00514.2001
   Web of Science ®Google Scholar
• Ferrara N . Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol . 2001;280(6):C1358–C1366. doi:10.1152/ajpcell.2001.280.6.C1358 11350730
   PubMed Web of Science ®Google Scholar
• Behl T , Kotwani A . Exploring the various aspects of the pathological role of vascular endothelial growth factor (VEGF) in diabetic retinopathy. Pharmacol Res . 2015;99:137–148. doi:10.1016/j.phrs.2015.05.013 26054568
   PubMed Web of Science ®Google Scholar
• Poulaki V , Qin W , Joussen AM , et al. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. J Clin Invest . 2002;109(6):805–815. doi:10.1172/JCI0213776 11901189
   PubMed Web of Science ®Google Scholar
• Jiang ZY , He Z , King BL , et al. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem . 2003;278(34):31964–31971. doi:10.1074/jbc.M303314200 12775712
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. Peripheral arterial disease in people with diabetes. Diabetes Care . 2003;26(12):3333–3341. doi:10.2337/diacare.26.12.3333 14633825
   PubMed Web of Science ®Google Scholar
• Waltenberger J . Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications. Cardiovasc Res . 2001;49(3):554–560. doi:10.1016/S0008-6363(00)00228-5 11166268
   PubMed Web of Science ®Google Scholar
• Carlsson PO , Jansson L . Disruption of insulin receptor signaling in endothelial cells shows the central role of an intact islet blood flow for in vivo β-cell function. Diabetes . 2015;64(3):700–702. doi:10.2337/db14-1523 25713194
   PubMed Web of Science ®Google Scholar
• Tardif K , Hertig V , Dumais C , et al. Nestin downregulation in rat vascular smooth muscle cells represents an early marker of vascular disease in experimental type I diabetes. Cardiovasc Diabetol . 2014;13(1):119. doi:10.1186/s12933-014-0119-6 25139503
   PubMed Web of Science ®Google Scholar
• Park SW , Yun JH , Kim JH , Kim KW , Cho CH , Kim JH . Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy. Diabetes . 2014;63(9):3057–3068. doi:10.2337/db13-1942 24722242
   PubMed Web of Science ®Google Scholar
• Jiang ZY , Lin YW , Clemont A , et al. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest . 1999;104(4):447–457. doi:10.1172/JCI5971 10449437
   PubMed Web of Science ®Google Scholar
• Bartel DP . MicroRNAs: target recognition and regulatory functions. Cell . 2009;136(2):215–233. doi:10.1016/j.cell.2009.01.002 19167326
   PubMed Web of Science ®Google Scholar
• Chen WQ , Hu L , Chen GX , Deng HX . Role of microRNA-7 in digestive system malignancy. World J Gastrointest Oncol . 2016;8(1):121–127. doi:10.4251/wjgo.v8.i1.121 26798443
   PubMed Web of Science ®Google Scholar
• Li YZ , Wen L , Wei X , et al. Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4. Oncol Rep . 2016;36(3):1569–1575. doi:10.3892/or.2016.4912 27431648
   PubMed Web of Science ®Google Scholar
• Ye T , Yang M , Wang HD . MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer. J Exp Clin Cancer Res .2019;38(1):55. doi:10.1186/s13046-019-1074-6 30728051
   PubMed Web of Science ®Google Scholar
• Bandello F , Lattanzio R , Zucchiatti I , Del Turco C . Pathophysiology and treatment of diabetic retinopathy. Acta Diabetol . 2013;50(1):1–20. doi:10.1007/s00592-012-0449-3 23277338
   PubMed Web of Science ®Google Scholar
• Suto T , Yokobori T , Yajima R , et al. MicroRNA-7 expression in colorectal cancer is associated with poor prognosis and regulates cetuximab sensitivity via EGFRregulation. Carcinogenesis . 2015;36(3):338–345. doi:10.1093/carcin/bgu242 25503932
   PubMed Web of Science ®Google Scholar
• Li Y , Li Y , Liu Y , Xie P , Li F , Li G . PAX6, a novel target of microRNA-7, promotes cellular proliferation and invasion in human colorectal cancer cells. Dig Dis Sci . 2014;59(3):598–606. doi:10.1007/s10620-013-2929-x 24185687
   PubMed Web of Science ®Google Scholar
• Su X , Sorenson CM , Sheibani N . Isolation and characterization of murine retinal endothelial cells. Mol Vis . 2003;9:171–178.12740568
   PubMed Web of Science ®Google Scholar
• Buzney SM , Massicotte SJ , Hetu N , Zetter BR . Retinal vascular endothelial cells and pericytes. Differential growth characteristics in vitro. Invest Ophthalmol Vis Sci . 1983;24(4):470–480.6299992
   PubMed Web of Science ®Google Scholar
• Zhang J , Du YY , Lin YF , Chen YT , Yang L , Wang HJ . The cell growth suppressor, mir-126, targets IRS-1. Biochem Biophys Res Commun . 2008;377(1):136–140. doi:10.1016/j.bbrc.2008.09.089 18834857
   PubMed Web of Science ®Google Scholar
• Hoeppner LH , Sinha S , Wang Y , et al. RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. J Cell Sci . 2015;128(19):3556–3568. doi:10.1242/jcs.167601 26136364
   PubMed Web of Science ®Google Scholar
• King GL , Goodman AD , Buzney S , Moses A , Kahn CR . Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest . 1985;75(3):1028–1036. doi:10.1172/JCI111764 2984251
   PubMed Web of Science ®Google Scholar
• Withers DJ , Gutierrez JS , Towery H , et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature . 1998;391(6670):900–904. doi:10.1038/36116 9495343
   PubMed Web of Science ®Google Scholar
• Latreille M , Hausser J , Stützer I , et al. MicroRNA-7a regulates pancreatic β cell function. J Clin Invest . 2014;124(6):2722–2735. doi:10.1172/JCI73066 24789908
   PubMed Web of Science ®Google Scholar
• Saydam O , Senol O , Würdinger T , et al. miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Cancer Res . 2011;71(3):852–861. doi:10.1158/0008-5472.CAN-10-1219 21156648
   PubMed Web of Science ®Google Scholar
• Giles KM , Barker A , Zhang PM , Epis MR , Leedman PJ . MicroRNA regulation of growth factor receptor signaling in human cancer cells. Methods Mol Biol . 2011;676:147–163.20931396
   PubMedGoogle Scholar
• Fernández-de Frutos M , Galán-Chilet I , Goedeke L , et al. MicroRNA 7 impairs insulin signaling and regulates Aβ levels through posttranscriptional regulation of the insulin receptor substrate 2, insulin receptor, insulin-degrading enzyme, and liver X receptor pathway. Mol Cell Biol . 2019;39(22):e00170–19. doi:10.1128/MCB.00170-19 31501273
   PubMed Web of Science ®Google Scholar
• Shibuya M , Claessonwelsh L . Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res . 2006;312(5):549–560. doi:10.1016/j.yexcr.2005.11.012 16336962
   PubMed Web of Science ®Google Scholar
• Simó R , Sundstrom JM , Antonetti DA . Ocular anti-VEGF therapy for diabetic retinopathy: the role of VEGF in the pathogenesis of diabetic retinopathy. Diabetes Care . 2014;37(4):893–899. doi:10.2337/dc13-2002 24652720
   PubMed Web of Science ®Google Scholar