Early Predictors in the Onset of Type 2 Diabetes at Different Fasting Blood Glucose Levels

References

• Gallwitz B , Kazda C , Kraus P , Nicolay C , Schernthaner G . Contribution of insulin deficiency and insulin resistance to the development of type 2 diabetes: nature of early stage diabetes. Acta Diabetol . 2013;50(1):39–45. doi:10.1007/s00592-011-0319-4 21861172
   PubMed Web of Science ®Google Scholar
• Palermo A , Maggi D , Maurizi AR , Pozzilli P , Buzzetti R . Prevention of type 2 diabetes mellitus: is it feasible? Diabetes Metab Res Rev . 2014;30(Suppl 1):4–12. doi:10.1002/dmrr.2513 24353270
   PubMed Web of Science ®Google Scholar
• World Health Organisation. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. Geneva: World Health Organization; 1999.
   Google Scholar
• Shoelson SE , Lee J , Goldfine AB . Inflammation and insulin resistance. J Clin Invest . 2006;116(7):1793–1801. doi:10.1172/JCI29069 16823477
   PubMed Web of Science ®Google Scholar
• Zhao YC , Zhu J , Song GY , Li XS . Relationship between thioredoxin-interacting protein (TXNIP) and islet β-cell dysfunction in patients with impaired glucose tolerance and hypertriglyceridemia. Int J Clin Exp Med . 2015;8(3):4363–4368.26064354
   PubMed Web of Science ®Google Scholar
• Lenzen S , Drinkgern J , Tiedge M . Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med . 1996;20(3):463–466. doi:10.1016/0891-5849(96)02051-5.8720919
   PubMed Web of Science ®Google Scholar
• Charles-Messance H , Sheedy FJ . Train to lose: innate immune memory in metaflammation. Mol Nutr Food Res . 2020;65(1):e1900480. doi:10.1002/mnfr.201900480 32529783
   PubMed Web of Science ®Google Scholar
• Jiang H , He H , Chen Y , et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med . 2017;214(11):3219–3238. doi:10.1084/jem.20171419 29021150
   PubMed Web of Science ®Google Scholar
• Lee HM , Kim JJ , Kim HJ , Shong M , Ku BJ , Jo EK . Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes . 2013;62(1):194–204. doi:10.2337/db12-0420.23086037
   PubMed Web of Science ®Google Scholar
• Ishida M , Shima M , Seino Y . 1,25(OH)2D and 24,25(OH)2D production in the developing kidney. Pediatr Nephrol . 1988;2(1):166–170. doi:10.1007/BF00870399.3152992
   PubMed Web of Science ®Google Scholar
• Lu L , Lu Q , Chen W , Li J , Li C , Zheng Z . Vitamin D3 protects against diabetic retinopathy by inhibiting high-glucose-induced activation of the ROS/TXNIP/NLRP3 inflammasome pathway. J Diabetes Res . 2018;2018:8193523. doi:10.1155/2018/8193523 29682582
   PubMed Web of Science ®Google Scholar
• Deleskog A , Hilding A , Brismar K , Hamsten A , Efendic S , Ostenson CG . Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia . 2012;55(6):1668–1678. doi:10.1007/s00125-012-2529-x 22426800
   PubMed Web of Science ®Google Scholar
• Park SK , Garland CF , Gorham ED , BuDoff L , Barrett-Connor E . Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study. PLoS One . 2018;13(4):e0193070. doi:10.1371/journal.pone.0193070 29672520
   PubMed Web of Science ®Google Scholar
• Omar DF , Kamal MM , El-Hefnawy MH , El-Mesallamy HO . Serum vitamin D and its upregulated protein, thioredoxin interacting protein, are associated with beta-cell dysfunction in adult patients with Type 1 and Type 2 diabetes. Can J Diabetes . 2018;42(6):588–594. doi:10.1016/j.jcjd.2018.02.012 29980378
   PubMed Web of Science ®Google Scholar
• Lai Y , Brandhorst H , Hossain H , et al. Activation of NFkappaB dependent apoptotic pathway in pancreatic islet cells by hypoxia. Islets . 2009;1(1):19–25. doi:10.4161/isl.1.1.8530 21084845
   PubMed Web of Science ®Google Scholar
• Hanschmann EM , Petry SF , Eitner S , et al. Paracrine regulation and improvement of beta-cell function by thioredoxin. Redox Biol . 2020;34:101570. doi:10.1016/j.redox.2020.101570 32473461
   PubMed Web of Science ®Google Scholar
• Hanschmann EM , Godoy JR , Berndt C , Hudemann C , Lillig CH . Thioredoxins, glutaredoxins, and peroxiredoxins–molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal . 2013;19(13):1539–1605. doi:10.1089/ars.2012.4599 23397885
   PubMed Web of Science ®Google Scholar
• Hirota K , Murata M , Sachi Y , et al. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappa B. J Biol Chem . 1999;274(39):27891–27897. doi:10.1074/jbc.274.39.27891 10488136
   PubMed Web of Science ®Google Scholar
• Chou FC , Sytwu HK . Overexpression of thioredoxin in islets transduced by a lentiviral vector prolongs graft survival in autoimmune diabetic NOD mice. J Biomed Sci . 2009;16(1):71. doi:10.1186/1423-0127-16-71 19671194
   PubMed Web of Science ®Google Scholar
• Matthews DR , Hosker JP , Rudenski AS , Naylor BA , Treacher DF , Turner RC . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia . 1985;28(7):412–419. doi:10.1007/BF00280883 3899825
   PubMed Web of Science ®Google Scholar
• Tang Q , Li X , Song P , Xu L . Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening: developments in research and prospects for the future. Drug Discov Ther . 2015;9(6):380–385. doi:10.5582/ddt.2015.01207 26781921
   PubMed Web of Science ®Google Scholar
• Lindström J , Tuomilehto J . The diabetes risk score: a practical tool to predict type 2 diabetes risk. Diabetes Care . 2003;26(3):725–731. doi:10.2337/diacare.26.3.725 12610029
   PubMed Web of Science ®Google Scholar
• Wilson PW , Meigs JB , Sullivan L , Fox CS , Nathan DM , D’Agostino RB Sr . Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Arch Intern Med . 2007;167(10):1068–1074. doi:10.1001/archinte.167.10.1068 17533210
   PubMed Web of Science ®Google Scholar
• Di Camillo B , Hakaste L , Sambo F , et al. HAPT2D: high accuracy of prediction of T2D with a model combining basic and advanced data depending on availability. Eur J Endocrinol . 2018;178(4):331–341. doi:10.1530/EJE-17-0921 29371336
   PubMed Web of Science ®Google Scholar
• Li X , Liu Y , Zheng Y , Wang P , Zhang Y . The effect of vitamin d supplementation on glycemic control in Type 2 diabetes patients: a systematic review and meta-analysis. Nutrients . 2018;10(3):375. doi:10.3390/nu10030375
   Web of Science ®Google Scholar
• Shaked M , Ketzinel-Gilad M , Cerasi E , Kaiser N , Leibowitz G . AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells. PLoS One . 2011;6(12):e28804. doi:10.1371/journal.pone.0028804 22194917
   PubMed Web of Science ®Google Scholar
• Shao W , Yu Z , Fantus IG , Jin T . Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic beta-cells. Cell Signal . 2010;22(8):1240–1246. doi:10.1016/j.cellsig.2010.04.001 20385228
   PubMed Web of Science ®Google Scholar
• Chai TF , Hong SY , He H , et al. A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression. Cell Signal . 2012;24(8):1700–1705. doi:10.1016/j.cellsig.2012.04.017 22561086
   PubMed Web of Science ®Google Scholar
• Schroder K , Zhou R , Tschopp J . The NLRP3 inflammasome: a sensor for metabolic danger? Science . 2010;327(5963):296–300. doi:10.1126/science.1184003 20075245
   PubMed Web of Science ®Google Scholar
• Oslowski CM , Hara T , O’Sullivan-Murphy B , et al. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab . 2012;16(2):265–273. doi:10.1016/j.cmet.2012.07.005 22883234
   PubMed Web of Science ®Google Scholar
• Lerner AG , Upton JP , Praveen PV , et al. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab . 2012;16(2):250–264. doi:10.1016/j.cmet.2012.07.007 22883233
   PubMed Web of Science ®Google Scholar
• Zhou R , Tardivel A , Thorens B , Choi I , Tschopp J . Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol . 2010;11(2):136–140. doi:10.1038/ni.1831 20023662
   PubMed Web of Science ®Google Scholar
• Luo B , Li B , Wang W , et al. Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model. Cardiovasc Drugs Ther . 2014;28(1):33–43. doi:10.1007/s10557-013-6498-1 24254031
   PubMed Web of Science ®Google Scholar
• Parikh H , Carlsson E , Chutkow WA , et al. TXNIP regulates peripheral glucose metabolism in humans. PLoS Med . 2007;4(5):e158. doi:10.1371/journal.pmed.0040158 17472435
   PubMed Web of Science ®Google Scholar
• Masutani H , Yoshihara E , Masaki S , Chen Z , Yodoi J . Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus. J Clin Biochem Nutr . 2012;50(1):23–34. doi:10.3164/jcbn.11-36SR 22247597
   PubMed Web of Science ®Google Scholar
• Shalev A , Pise-Masison CA , Radonovich M , et al. Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGF beta signaling pathway. Endocrinology . 2002;143(9):3695–3698. doi:10.1210/en.2002-220564 12193586
   PubMed Web of Science ®Google Scholar
• Volpe CMO , Villar-Delfino PH , Dos Anjos PMF , Nogueira-Machado JA . Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis . 2018;9(2):119. doi:10.1038/s41419-017-0135-z 29371661
   PubMed Web of Science ®Google Scholar
• Davis BK . 1,25(OH)2D and 24,25(OH)2D production in the developing kidney. Nat Immunol . 2018;2018(1):105–106. doi:10.1155/2018/8193523
   Web of Science ®Google Scholar
• Minn AH , Hafele C , Shalev A . Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology . 2005;146(5):2397–2405. doi:10.1210/en.2004-1378 15705778
   PubMed Web of Science ®Google Scholar
• Chen J , Saxena G , Mungrue IN , Lusis AJ , Shalev A . Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes . 2008;57(4):938–944. doi:10.2337/db07-0715 18171713
   PubMed Web of Science ®Google Scholar