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Original Research

The Association Between Insulin Resistance, Leptin, and Resistin and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients with Different Body Mass Indexes

, , , & ORCID Icon
Pages 2357-2365 | Published online: 24 May 2021

References

  • Yang W , Lu J , Weng J , et al. Prevalence of diabetes among men and women in China. N Engl J Med . 2010;362(12):1090–1101. doi:10.1056/NEJMoa0908292 20335585
  • Hu C , Jia W . Diabetes in China: epidemiology and Genetic Risk Factors and Their Clinical Utility in Personalized Medication. Diabetes . 2018;67(1):3–11. doi:10.2337/dbi17-0013 29263166
  • Pagidipati NJ , Zheng Y , Green JB , et al. Association of obesity with cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease: insights from TECOS. Am Heart J . 2020;219:47–57. doi:10.1016/j.ahj.2019.09.016 31707324
  • Mohan V , Vijayaprabha R , Rema M , et al. Clinical profile of lean NIDDM in South India. Diabetes Res Clin Pract . 1997;38(2):101–108. doi:10.1016/S0168-8227(97)00088-0 9483373
  • Zhang L , Long J , Jiang W , et al. Trends in Chronic Kidney Disease in China. N Engl J Med . 2016;375(9):905–906. doi:10.1056/NEJMc1602469 27579659
  • Halaas JL , Gajiwala KS , Maffei M , et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science . 1995;269(5223):543–546. doi:10.1126/science.7624777 7624777
  • Pelleymounter MA , Cullen MJ , Baker MB , et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science . 1995;269(5223):540–543. doi:10.1126/science.7624776 7624776
  • Denroche HC , Levi J , Wideman RD , et al. Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes . 2011;60(5):1414–1423. doi:10.2337/db10-0958 21464443
  • Perry RJ , Zhang XM , Zhang D , et al. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nat Med . 2014;20(7):759–763. doi:10.1038/nm.3579 24929951
  • Hanai K , Babazono T , Mugishima M , et al. Association of serum leptin levels with progression of diabetic kidney disease in patients with type 2 diabetes. Diabetes Care . 2011;34(12):2557–2559. doi:10.2337/dc11-1039 21994433
  • Wilson C , Nelson R , Nicolson M , Pratley R . Plasma leptin concentrations: no difference between diabetic Pima Indians with and without nephropathy. Diabetologia . 1998;41(7):861–862. doi:10.1007/s001250051001 9686932
  • Acquarone E , Monacelli F , Borghi R , Nencioni A , Odetti P . Resistin: a reappraisal. Mech Ageing Dev . 2019;178:46–63. doi:10.1016/j.mad.2019.01.004 30650338
  • Emamalipour M , Seidi K , Jahanban-Esfahlan A , Jahanban-Esfahlan R . Implications of resistin in type 2 diabetes mellitus and coronary artery disease: impairing insulin function and inducing pro-inflammatory cytokines. J Cell Physiol . 2019;234(12):21758–21769. doi:10.1002/jcp.28913 31187484
  • Sato H , Muraoka S , Kusunoki N , et al. Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Res Ther . 2017;19(1):263. doi:10.1186/s13075-017-1472-0 29191223
  • Bonito B , Silva AP , Rato F , Santos N , Neves PL . Resistin as a predictor of cardiovascular hospital admissions and renal deterioration in diabetic patients with chronic kidney disease. J Diabetes Complications . 2019;33(11):107422. doi:10.1016/j.jdiacomp.2019.107422 31484628
  • Saltiel AR , Olefsky JM . Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest . 2017;127(1):1–4. doi:10.1172/JCI92035 28045402
  • Navarro-González JF , Mora-Fernández C . The role of inflammatory cytokines in diabetic nephropathy. J Am Soc Nephrol . 2008;19(3):433–442. doi:10.1681/ASN.2007091048 18256353
  • American Diabetes Association. Standards of medical care in diabetes–2010. Diabetes Care . 2010;33(Suppl 1):S11–61. doi:10.2337/dc10-S011 20042772
  • Fineberg D , Jandeleit-Dahm KA , Cooper ME . Diabetic nephropathy: diagnosis and treatment. Nat Rev Endocrinol . 2013;9(12):713–723. doi:10.1038/nrendo.2013.184 24100266
  • Huang J , Chen Z , Yuan J , et al. Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: a Community-Based Cross-Section Study in North China. Med Sci Monitor . 2019;25:5241–5257. doi:10.12659/MSM.914881
  • Cheng TO . Chinese body mass index is much lower as a risk factor for coronary artery disease. Circulation . 2004;109(14):e184. doi:10.1161/01.CIR.0000124888.14804.D2 15078813
  • Sun X , Xiao Y , Wang B , et al. Associations of pancreatic β-cell function and insulin resistance with microalbuminuria in type 2 diabetes. Diabetes Res Clin Pract . 2015;110(3):e22–26. doi:10.1016/j.diabres.2015.09.012 26428073
  • Sarafidis PA , Ruilope LM . Insulin resistance, microalbuminuria, and chronic kidney disease. Curr Hypertens Rep . 2008;10(4):249–251. doi:10.1007/s11906-008-0046-6 18625151
  • Fruehwald-Schultes B , Kern W , Beyer J , Forst T , Pfützner A , Peters A . Elevated serum leptin concentrations in type 2 diabetic patients with microalbuminuria and macroalbuminuria. Metabolism . 1999;48(10):1290–1293. doi:10.1016/S0026-0495(99)90270-6 10535393
  • Carnethon MR , De Chavez PJ , Biggs ML , et al. Association of weight status with mortality in adults with incident diabetes. JAMA . 2012;308(6):581–590. doi:10.1001/jama.2012.9282 22871870
  • Lavie CJ , De Schutter A , Parto P , et al. Obesity and Prevalence of Cardiovascular Diseases and Prognosis-The Obesity Paradox Updated. Prog Cardiovasc Dis . 2016;58(5):537–547. doi:10.1016/j.pcad.2016.01.008 26826295
  • Mallipattu SK , Gallagher EJ , LeRoith D , et al. Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus. Am J Physiol Renal Physiol . 2014;306(9):F1008–1017. doi:10.1152/ajprenal.00597.2013 24598803
  • Gatti A , Morini E , De Cosmo S , et al. Metabolic syndrome is not a risk factor for kidney dysfunction in obese non-diabetic subjects. Obesity . 2008;16(4):899–901. doi:10.1038/oby.2007.59 18239564
  • McLaughlin T , Allison G , Abbasi F , Lamendola C , Reaven G . Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism . 2004;53(4):495–499. doi:10.1016/j.metabol.2003.10.032 15045698
  • Hanai K , Babazono T , Takagi M , et al. Obesity as an effect modifier of the association between leptin and diabetic kidney disease. J Diabetes Investig . 2014;5(2):213–220. doi:10.1111/jdi.12138
  • Stenvinkel P , Lindholm B , Lönnqvist F , Katzarski K , Heimbürger O . Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J Am Soc Nephrol . 2000;11(7):1303–1309.10864587
  • Scott RA , Fall T , Pasko D , et al. Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity. Diabetes . 2014;63(12):4378–4387. doi:10.2337/db14-0319 24947364
  • Olaogun I , Farag M , Hamid P . The Pathophysiology of Type 2 Diabetes Mellitus in Non-obese Individuals: an Overview of the Current Understanding. Cureus . 2020;12(4):e7614.32399348
  • Liu W , Zhou X , Li Y , et al. Serum leptin, resistin, and adiponectin levels in obese and non-obese patients with newly diagnosed type 2 diabetes mellitus: a population-based study. Medicine . 2020;99(6):e19052. doi:10.1097/MD.0000000000019052 32028423
  • Liu J , Yang X , Yu S , Zheng R . The Leptin Resistance. Adv Exp Med Biol . 2018;1090:145–163.30390289
  • Huang X , Yang Z . Resistin’s, obesity and insulin resistance: the continuing disconnect between rodents and humans. J Endocrinol Invest . 2016;39(6):607–615. doi:10.1007/s40618-015-0408-2 26662574
  • Fouque D , Kalantar-Zadeh K , Kopple J , et al. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int . 2008;73(4):391–398. doi:10.1038/sj.ki.5002585 18094682
  • Mafra D , Guebre-Egziabher F , Fouque D . Body mass index, muscle and fat in chronic kidney disease: questions about survival. Nephrol Dial Transplant . 2008;23(8):2461–2466. doi:10.1093/ndt/gfn053 18390566
  • Nazare JA , Smith JD , Borel AL , et al. Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk/Intra-Abdominal Adiposity. Am J Clin Nutr . 2012;96(4):714–726. doi:10.3945/ajcn.112.035758 22932278
  • Mathis D . Immunological goings-on in visceral adipose tissue. Cell Metab . 2013;17(6):851–859. doi:10.1016/j.cmet.2013.05.008 23747244
  • Foster MC , Hwang SJ , Massaro JM , et al. Association of subcutaneous and visceral adiposity with albuminuria: the Framingham Heart Study. Obesity . 2011;19(6):1284–1289. doi:10.1038/oby.2010.308 21183930