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Original Research

Qihu Preparation Ameliorates Diabetes by Activating the AMPK Signaling Pathway in db/db Mice

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Pages 3229-3241 | Published online: 14 Jul 2021

References

  • Carracher A , Marathe P , Close K . International Diabetes Federation 2017. J Diabetes . 2018;10:353–356. doi:10.1111/jdb.12644 29345068
  • Flannick J , Johansson S , Njølstad P . Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes. Nat Rev Endocrinol . 2016;12(7):394–406. doi:10.1038/nrendo.2016.50 27080136
  • Wu W , Hou J , Long H , Yang W , Liang J , Guo D . TCM-based new drug discovery and development in China. Chin J Nat Med . 2014;12:241–250.24863348
  • Liu M , Liu Z , Xu B , Zhang W , Cai J . Review of systematic reviews and Meta-analyses investigating Traditional Chinese Medicine treatment for type 2 diabetes mellitus. J Tradit Chin Med . 2016;36:555–563. doi:10.1016/s0254-6272(16)30074-7 29932626
  • Zhang Q , Peng W , Wei S , et al. Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts. Nat Rev Endocrinol . 2019;118:109367.
  • Chen Z , Li J , Liu J , et al. Saponins isolated from the root of Panax notoginseng showed significant anti-diabetic effects in KK-Ay mice. Am j Chinese Med . 2008;36:939–951. doi:10.1142/S0192415X08006363
  • Yang C , Wang J , Zhao Y , et al. Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components. J Ethnopharmacol . 2010;130:231–236. doi:10.1016/j.jep.2010.04.039 20435129
  • Li M, Zhang B, He S, Zheng R, Zhang Y, Wang Y . [Elucidating hypoglycemic mechanism of Dendrobium nobile through auxiliary elucidation system for traditional Chinese medicine mechanism]. Chin J Chin Mater Med . 2015;40:3709–3712. Chinese.
  • Teixeira da Silva J , Ng T . The medicinal and pharmaceutical importance of Dendrobium species. Appl Microbiol Biotechnol . 2017;101:2227–2239. doi:10.1007/s00253-017-8169-9 28197691
  • Commission. NP . Pharmacopoeia of the People’s Republic of China: І . Beijing, China: China Medical Science and Technology Press; 2015.
  • Zhang X , Zhang B , Zhang C , Sun G , Sun X . Panax notoginsengEffect of Saponins and Major Anti-Obesity Components on Weight Loss. Front Pharmacol . 2020;11:601751. doi:10.3389/fphar.2020.601751 33841133
  • Yang Q , Wang P , Cui J , Wang W , Chen Y , Zhang T . Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis. J Ethnopharmacol . 2016;193:255–265. doi:10.1016/j.jep.2016.08.040 27566197
  • Hu S , Liu T , Wu Y , et al. Panax notoginseng saponins suppress lipopolysaccharide-induced barrier disruption and monocyte adhesion on bEnd.3 cells via the opposite modulation of Nrf2 antioxidant and NF-κB inflammatory pathways. Phytother Research . 2019;33(12):3163–3176. doi:10.1002/ptr.6488
  • He T , Huang Y , Yang L , et al. Structural characterization and immunomodulating activity of polysaccharide from Dendrobium officinale. Biol Macromol . 2016;83:34–41. doi:10.1016/j.ijbiomac.2015.11.038
  • Ke Y , Zhan L , Lu T , et al. Dendrobium officinalePolysaccharides of Kimura & Migo Leaves Protect Against Ethanol-Induced Gastric Mucosal Injury the AMPK/mTOR Signaling Pathway and. Front Pharmacol . 2020;11:526349. doi:10.3389/fphar.2020.526349 33262700
  • Zhu Y , Liu M , Cao C , et al. Dendrobium officinale flos increases neurotrophic factor expression in the hippocampus of chronic unpredictable mild stress-exposed mice and in astrocyte primary culture and potentiates NGF-induced neuronal differentiation in PC12 cells. Phytother Research . 2021:1–13. doi: 10.1002/ptr.7013.
  • Zhang K , Zhou X , Wang J , et al. Dendrobium officinale polysaccharide triggers mitochondrial disorder to induce colon cancer cell death via ROS-AMPK-autophagy pathway. Carbohydr Polym . 2021;264:118018. doi:10.1016/j.carbpol.2021.118018 33910741
  • Zhang X , Li X , Wang N , Yao X , Zhou W. Pharmacodynamics of Qihu preparations for treatment of diabetes in mice. J Third Military Med Univ . 2017;39:1422–1427. doi:10.16016/j.1000-5404.201612006
  • Li X , Zhu G , Yao X , et al. Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells. Onco Targets Ther . 2018;11:8977–8985. doi:10.2147/OTT.S187315 30588010
  • Coughlan K , Valentine R , Ruderman N , Saha A . Nutrient Excess in AMPK Downregulation and Insulin Resistance. J Endocrinol, Diabetes Obesity . 2013;1:1008.
  • Salminen A , Hyttinen J , Kaarniranta K . AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med . 2011;89:667–676. doi:10.1007/s00109-011-0748-0 21431325
  • Parikh H , Carlsson E , Chutkow W , et al. TXNIP regulates peripheral glucose metabolism in humans. PLoS Med . 2007;4:e158. doi:10.1371/journal.pmed.0040158 17472435
  • Zhang Q , Pan Y , Wang R , et al. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. J Nutr Biochem . 2014;25:420–428. doi:10.1016/j.jnutbio.2013.11.014 24491314
  • Sharma B , Kim H , Rhyu D . Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling pathway in myocytes. J Transl Med . 2015;13:62. doi:10.1186/s12967-015-0412-5 25889508
  • Xu J , Wang S , Feng T , Chen Y , Yang G . Hypoglycemic and hypolipidemic effects of total saponins from Stauntonia chinensis in diabetic db/db mice. J Cell Mol Med . 2018;22:6026–6038. doi:10.1111/jcmm.13876 30324705
  • Zhuang M , Qiu H , Li P , Hu L , Wang Y , Rao L . Edgeworthia gardneriIslet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of. Drug Des Devel Ther . 2018;12:955–966. doi:10.2147/DDDT.S153898
  • Guo X , Sun W , Luo G , et al. Panax notoginseng saponins alleviate skeletal muscle insulin resistance by regulating the IRS1-PI3K-AKT signaling pathway and GLUT4 expression. FEBS Open Bio . 2019;9:1008–1019. doi:10.1002/2211-5463.12635
  • Tang H , Zhao T , Sheng Y , Zheng T , Fu L , Zhang Y . Dendrobium officinale Kimura et Migo: a Review on Its Ethnopharmacology, Phytochemistry, Pharmacology, and Industrialization. Evidence-Based Compl Alternative Med . 2017;2017:1–19. doi:10.1155/2017/7436259
  • Kumar S , Behl T , Sachdeva M , et al. Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus. Life Sci . 2021;264:118661.33121986
  • Lin S , Hardie D . AMPK: sensing Glucose as well as Cellular Energy Status. Cell Metab . 2018;27(2):299–313. doi:10.1016/j.cmet.2017.10.009 29153408
  • Jaiswal N , Gavin M , Quinn W , et al. The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. MOL METAB . 2019;28:1–13. doi:10.1016/j.molmet.2019.08.001 31444134
  • Gupta A , Behl T , Sehgal A , Bhatia S , Jaglan D , Bungau S . Therapeutic potential of Nrf-2 pathway in the treatment of diabetic neuropathy and nephropathy. Mol Biol Rep . 2021;48(3):2761–2774. doi:10.1007/s11033-021-06257-5 33754251
  • Behl T , Kaur I , Sehgal A , et al. Unfolding Nrf2 in diabetes mellitus. Mol Biol Rep . 2021;48(1):927–939. doi:10.1007/s11033-020-06081-3 33389540
  • Zhao Y , Li X , Tang S . Retrospective analysis of the relationship between elevated plasma levels of TXNIP and carotid intima-media thickness in subjects with impaired glucose tolerance and early Type 2 diabetes mellitus. Diabetes Res Clin Pract . 2015;109:372–377. doi:10.1016/j.diabres.2015.05.028 26026780
  • Sun H , Hu Y , Zhao X , et al. Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex. FEBS J . 2015;282:2758–2774. doi:10.1111/febs.13324 25996168
  • Shalev A , Pise-Masison C , Radonovich M , et al. Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway. Endocrinology . 2002;143:3695–3698. doi:10.1210/en.2002-220564 12193586
  • Wu N , Zheng B , Shaywitz A , et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell . 2013;49:1167–1175. doi:10.1016/j.molcel.2013.01.035 23453806
  • Li S , Zhang Y , Sun Y , et al. Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK. Nutr Diabetes . 2019;9(1):28. doi:10.1038/s41387-019-0095-8 31591391
  • Hou Y , Wang Q , Han B , et al. CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys. Cell Death Dis . 2021;12(6):523. doi:10.1038/s41419-021-03813-6 34021126
  • Nyandwi J , Ko Y , Jin H , Yun S , Park S , Kim H . Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway. Biochem Pharmacol . 2020;182:114246. doi:10.1016/j.bcp.2020.114246 33011160
  • Koenen T , Stienstra R , van Tits L , et al. Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue. Diabetes . 2011;60:517–524. doi:10.2337/db10-0266 21270263