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Original Research

The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes

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Pages 3831-3837 | Published online: 07 Sep 2021

References

  • Li Y , Teng D , Shi X , et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study. BMJ 2020;369:m997. doi:10.1136/bmj.m997 32345662
  • Cho NH , Shaw JE , Karuranga S , et al. IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract . 2018;138:271–281. doi:10.1016/j.diabres.2018.02.023 29496507
  • Hooper SR , Johnson RJ , Gerson AC , et al. Overview of the findings and advances in the neurocognitive and psychosocial functioning of mild to moderate pediatric CKD: perspectives from the Chronic Kidney Disease in Children (CKiD) cohort study. Pediatr Nephrol . 2021;1. doi:10.1007/s00467-021-05158-w 32458135
  • de Boer IH , Rue TC , Hall YN , Heagerty PJ , Weiss NS , Himmelfarb J . Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA . 2011;305(24):2532–2539. doi:10.1001/jama.2011.861 21693741
  • Tonelli M , Muntner P , Lloyd A , et al. Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study. Lancet . 2012;380(9844):807–814. doi:10.1016/S0140-6736(12)60572-8 22717317
  • Choi SW , Kim HY , Ahn HR , et al. Association of bone mineral density with albuminuria and estimated glomerular filtration rate: the Dong-gu Study. Kidney Blood Press Res . 2013;37(2–3):132–141. doi:10.1159/000350067 23615166
  • De Ritis F , Coltorti M , Giusti G . An enzymic test for the diagnosis of viral hepatitis: the transaminase serum activities. 1957. Clinica chimica acta . 2006;369(2):148–152. doi:10.1016/j.cca.2006.05.001
  • Wang J , Li J , Ren Y , et al. Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and coronary artery injury in children with Kawasaki disease. Cardiol Res Pract . 2020;2020:8743548. doi:10.1155/2020/8743548 32274211
  • Ochiai H , Shirasawa T , Yoshimoto T , et al. Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study. BMC Nephrol . 2020;21(1):471. doi:10.1186/s12882-020-02144-6 33172399
  • Lin S , Tang L , Jiang R , et al. The relationship between aspartate aminotransferase to alanine aminotransferase ratio and metabolic syndrome in adolescents in Northeast China. Diabetes Metabol Syndr Obes . 2019;12:2387–2394. doi:10.2147/DMSO.S217127
  • Wada J , Makino H . Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci . 2013;124(3):139–152. doi:10.1042/CS20120198
  • Tesch GH . Role of macrophages in complications of type 2 diabetes. Clin Exp Pharmacol Physiol . 2007;34(10):1016–1019. doi:10.1111/j.1440-1681.2007.04729.x 17714088
  • Pichler R , Afkarian M , Dieter BP , Tuttle KR . Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets. Am J Physiol Renal Physiol . 2017;312(4):F716–F731. doi:10.1152/ajprenal.00314.2016 27558558
  • Mora C , Navarro JF . Inflammation and pathogenesis of diabetic nephropathy. Metabol Clin Experimen . 2004;53(2):265–266; author reply 266–267.
  • Anders HJ . Innate versus adaptive immunity in kidney immunopathology. BMC Nephrol . 2013;14:138. doi:10.1186/1471-2369-14-138 23835035
  • Nguyen D , Ping F , Mu W , Hill P , Atkins RC , Chadban SJ . Macrophage accumulation in human progressive diabetic nephropathy. Nephrology . 2006;11(3):226–231. doi:10.1111/j.1440-1797.2006.00576.x 16756636
  • Al-Lamki RS , Mayadas TN . TNF receptors: signaling pathways and contribution to renal dysfunction. Kidney Int . 2015;87(2):281–296. doi:10.1038/ki.2014.285 25140911
  • Al-Lamki RS , Wang J , Skepper JN , Thiru S , Pober JS , Bradley JR . Expression of tumor necrosis factor receptors in normal kidney and rejecting renal transplants. Labor Investig . 2001;81(11):1503–1515. doi:10.1038/labinvest.3780364
  • Pavkov ME , Weil EJ , Fufaa GD , et al. Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int . 2016;89(1):226–234. doi:10.1038/ki.2015.278 26398493
  • De Ritis F , Coltorti M , Giusti G . An enzymic test for the diagnosis of viral hepatitis; the transaminase serum activities. Clinica Chimica Acta . 1957;2(1):70–74. doi:10.1016/0009-8981(57)90027-X
  • Feng X , Wen Y , Peng FF , Wang N , Zhan X , Wu X . Association between aminotransferase/alanine aminotransferase ratio and cardiovascular disease mortality in patients on peritoneal dialysis: a multi-center retrospective study. BMC Nephrol . 2020;21(1):209. doi:10.1186/s12882-020-01840-7 32487078
  • Yokoyama M , Watanabe T , Otaki Y , et al. Association of the aspartate aminotransferase to alanine aminotransferase ratio with BNP level and cardiovascular mortality in the general population: the Yamagata study 10-year follow-up. Dis Markers . 2016;2016:4857917. doi:10.1155/2016/4857917 27872510
  • Zhao L , Cheng J , Chen Y , et al. Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population. Nutr Metab . 2017;14:64. doi:10.1186/s12986-017-0219-x
  • Weng SF , Kai J , Guha IN , Qureshi N . The value of aspartate aminotransferase and alanine aminotransferase in cardiovascular disease risk assessment. Open Heart . 2015;2(1):e000272. doi:10.1136/openhrt-2015-000272 26322236
  • Canat L , Ataly HA , Agalarov S , Alkan I , Altunrende F . The effect of AST/ALT (De Ritis) ratio on survival and its relation to tumor histopathological variables in patients with localized renal cell carcinoma. Int Braz J Urol . 2018;44(2):288–295. doi:10.1590/s1677-5538.ibju.2017.0173 29211398
  • Goessling W , Friedman LS . Increased liver chemistry in an asymptomatic patient. Clin Gastroenterol Hepatol . 2005;3(9):852–858. doi:10.1016/S1542-3565(05)00416-7 16234021
  • Francque SM , van der Graaff D , Kwanten WJ . Non-alcoholic fatty liver disease and cardiovascular risk: pathophysiological mechanisms and implications. J Hepatol . 2016;65(2):425–443. doi:10.1016/j.jhep.2016.04.005 27091791
  • Targher G , Byrne CD . Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease. Nat Rev Nephrol . 2017;13(5):297–310. doi:10.1038/nrneph.2017.16 28218263