198
Views
3
CrossRef citations to date
0
Altmetric
Original Research

Exosomes from β-Cells Promote Differentiation of Induced Pluripotent Stem Cells into Insulin-Producing Cells Through microRNA-Dependent Mechanisms

, , , , , , , & show all
Pages 4767-4782 | Published online: 11 Dec 2021

References

  • Sinclair A , Saeedi P , Kaundal A , et al. Diabetes and global ageing among 65-99-year-old adults: findings from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract . 2020;162:108078. doi:10.1016/j.diabres.2020.108078 32068097
  • He X , Zhang Y , Zhou Y , et al. Direct medical costs of incident complications in patients newly diagnosed with type 2 diabetes in China. Diabetes Ther . 2021;12(1):275–288. doi:10.1007/s13300-020-00967-y 33206365
  • Rezania A , Bruin J , Arora P , et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol . 2014;32(11):1121–1133. doi:10.1038/nbt.3033 25211370
  • Maxwell K , Millman J . Applications of iPSC-derived beta cells from patients with diabetes. Cell Rep Med . 2021;2(4):100238. doi:10.1016/j.xcrm.2021.100238 33948571
  • Agrawal A , Narayan G , Gogoi R , et al. Recent advances in the generation of β-cells from induced pluripotent stem cells as a potential cure for diabetes mellitus. Adv Exp Med Biol . 2021. doi:10.1007/5584_2021_653
  • Lu J , Xia Q , Zhou Q . How to make insulin-producing pancreatic β cells for diabetes treatment. Sci China Life Sci . 2017;60(3):239–248. doi:10.1007/s11427-016-0211-3 27796637
  • Bellin M , Barton F , Heitman A , et al. Potent induction immunotherapy promotes long-term insulin Independence after islet transplantation in type 1 diabetes. Am J Transplant . 2012;12(6):1576–1583. doi:10.1111/j.1600-6143.2011.03977.x 22494609
  • Shapiro A , Lakey J , Ryan E , et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med . 2000;343(4):230–238. doi:10.1056/NEJM200007273430401 10911004
  • Croon A , Karlsson R , Bergström C , et al. Lack of donors limits the use of islet transplantation as treatment for diabetes. Transplant Proc . 2003;35(2):764.12644124
  • Williams M , Joglekar M , Satoor S , et al. Epigenetic and transcriptome profiling identifies a population of visceral adipose-derived progenitor cells with the potential to differentiate into an endocrine pancreatic lineage. Cell Transplant . 2019;28(1):89–104. doi:10.1177/0963689718808472 30376726
  • Haridhasapavalan K , Borgohain M , Dey C , et al. An insight into non-integrative gene delivery approaches to generate transgene-free induced pluripotent stem cells. Gene . 2019;686:146–159. doi:10.1016/j.gene.2018.11.069 30472380
  • Borgohain M , Haridhasapavalan K , Dey C , et al. An insight into DNA-free reprogramming approaches to generate integration-free induced pluripotent stem cells for prospective biomedical applications. Stem Cell Rev Rep . 2019;15(2):286–313. doi:10.1007/s12015-018-9861-6 30417242
  • Dey C , Raina K , Haridhasapavalan KK , et al. An overview of reprogramming approaches to derive integration-free induced pluripotent stem cells for prospective biomedical applications. Recent Adv iPSC Technol . 2021;231–287. doi:10.1016/B978-0-12-822231-7.00011-4
  • Zhou Q , Melton D . Pancreas regeneration. Nature . 2018;557(7705):351–358. doi:10.1038/s41586-018-0088-0 29769672
  • Katsuda T , Ochiya T . Molecular signatures of mesenchymal stem cell-derived extracellular vesicle-mediated tissue repair. Stem Cell Res Ther . 2015;6:212. doi:10.1186/s13287-015-0214-y 26560482
  • Moradi S , Asgari S , Baharvand H . Concise review: harmonies played by microRNAs in cell fate reprogramming. Stem Cells . 2014;32(1):3–15. doi:10.1002/stem.1576 24155164
  • Bashratyan R , Sheng H , Regn D , et al. Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice. Eur J Immunol . 2013;43(10):2588–2597. doi:10.1002/eji.201343376 23817982
  • Castaño C , Novials A , Párrizas M . Exosomes and diabetes. Diabetes Metab Res Rev . 2019;35(3):e3107. doi:10.1002/dmrr.3107 30513130
  • Pardo F , Villalobos-Labra R , Sobrevia B , et al. Extracellular vesicles in obesity and diabetes mellitus. Mol Aspects Med . 2018;60:81–91. doi:10.1016/j.mam.2017.11.010 29175307
  • Li J , Tong C , Sung T , et al. CMEP: a database for circulating microRNA expression profiling. Bioinformatics . 2019;35(17):3127–3132. doi:10.1093/bioinformatics/btz042 30668638
  • LaPierre M , Stoffel M . MicroRNAs as stress regulators in pancreatic beta cells and diabetes. Mol Metab . 2017;6(9):1010–1023. doi:10.1016/j.molmet.2017.06.020 28951825
  • Zhang A , Li D , Liu Y , et al. Islet β cell: an endocrine cell secreting miRNAs. Biochem Biophys Res Commun . 2018;495(2):1648–1654. doi:10.1016/j.bbrc.2017.12.028 29223394
  • Eliasson L . The small RNA miR-375 - A pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function. Mol Cell Endocrinol . 2017;456:95–101. doi:10.1016/j.mce.2017.02.043 28254488
  • Kaviani M , Azarpira N , Karimi M , et al. The role of microRNAs in islet β-cell development. Cell Biol Int . 2016;40(12):1248–1255. doi:10.1002/cbin.10691 27743454
  • Ha M , Kim V . Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol . 2014;15(8):509–524. doi:10.1038/nrm3838 25027649
  • Tattikota S , Rathjen T , McAnulty S , et al. Argonaute2 mediates compensatory expansion of the pancreatic β cell. Cell Metab . 2014;19(1):122–134. doi:10.1016/j.cmet.2013.11.015 24361012
  • Guduric-Fuchs J , O’Connor A , Camp B , et al. Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genom . 2012;13:357. doi:10.1186/1471-2164-13-357
  • Zhang Y , Chopp M , Liu X , et al. Exosomes derived from mesenchymal stromal cells promote axonal growth of cortical neurons. Mol Neurobiol . 2017;54(4):2659–2673. doi:10.1007/s12035-016-9851-0 26993303
  • Mead B , Tomarev S . Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms. Stem Cells Transl Med . 2017;6(4):1273–1285. doi:10.1002/sctm.16-0428 28198592
  • Xu Y , Huang Y , Guo Y , et al. microRNA-690 regulates induced pluripotent stem cells (iPSCs) differentiation into insulin-producing cells by targeting Sox9. Stem Cell Res Ther . 2019;10(1):59. doi:10.1186/s13287-019-1154-8 30767782
  • Jeon K , Lim H , Kim J , et al. Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model. Stem Cells Dev . 2012;21(14):2642–2655. doi:10.1089/scd.2011.0665 22512788
  • Kondo Y , Toyoda T , Ito R , et al. Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia . 2017;60(8):1454–1466. doi:10.1007/s00125-017-4302-7 28534195
  • Mandal P , De D , Yun K , et al. Improved differentiation of human adipose stem cells to insulin-producing β-like cells using PDFGR kinase inhibitor Tyrphostin9. Biochem Biophys Res Commun . 2020;533(1):132–138. doi:10.1016/j.bbrc.2020.08.090 32933751
  • Li D , Zhang W , Chen X , et al. Proteomic profiling of MIN6 cell-derived exosomes. J Proteomics . 2020;224:103841. doi:10.1016/j.jprot.2020.103841 32461166
  • Mandal P , De D , Im D , et al. Exosome-mediated differentiation of mouse embryonic fibroblasts and exocrine cells into β-like cells and the identification of key miRNAs for differentiation. Biomedicines . 2020;8(11):485. doi:10.3390/biomedicines8110485
  • Pan F , Brissova M . Pancreas development in humans. Curr Opin Endocrinol Diabetes Obes . 2014;21(2):77–82. doi:10.1097/MED.0000000000000047 24569548
  • Ray J , Kener K , Bitner B , et al. Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos. FEBS Lett . 2016;590(12):1791–1803. doi:10.1002/1873-3468.12208 27164028
  • Guay C , Menoud V , Rome S , et al. Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells. Cell Commun Signal . 2015;13:17. doi:10.1186/s12964-015-0097-7 25880779
  • Valadi H , Ekström K , Bossios A , et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol . 2007;9(6):654–659. doi:10.1038/ncb1596 17486113
  • Gon Y , Maruoka S , Inoue T , et al. Selective release of miRNAs via extracellular vesicles is associated with house-dust mite allergen-induced airway inflammation. Clin Exp Allergy . 2017;47(12):1586–1598. doi:10.1111/cea.13016 28859242
  • Zhang J , Zhang F , Didelot X , et al. Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring. BMC Genom . 2009;10:478. doi:10.1186/1471-2164-10-478
  • Garavelli S , Bruzzaniti S , Tagliabue E , et al. Blood co-circulating extracellular microRNAs and immune cell subsets associate with type 1 diabetes severity. Int J Mol Sci . 2020;21(2):477. doi:10.3390/ijms21020477
  • Xu Y , Zhang J , Fan L , et al. miR-423-5p suppresses high-glucose-induced podocyte injury by targeting Nox4. Biochem Biophys Res Commun . 2018;505(2):339–345. doi:10.1016/j.bbrc.2018.09.067 30245133
  • Yang W , Wang J , Chen Z , et al. NFE2 induces miR-423-5p to promote gluconeogenesis and hyperglycemia by repressing the hepatic FAM3A-ATP-Akt pathway. Diabetes . 2017;66(7):1819–1832. doi:10.2337/db16-1172 28411267
  • Hashemi J , Kajbafzadeh A , Ghorbani F , et al. Application of iPSCs derived pancreatic β-like cells using pancreatic bio-scaffold. Exp Cell Res . 2021;405(2):112667. doi:10.1016/j.yexcr.2021.112667 34107273